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1. Discovery of Very High Energy Gamma-Ray Emissions from the Low-luminosity AGN NGC 4278 by LHAASO

Author

Zhen Cao, F. Aharonian, Axikegu, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, W. Bian, A. V. Bukevich, Q. Cao, W. Y. Cao, Zhe Cao, J. Chang, J. F. Chang, A. M. Chen, E. S. Chen, H. X. Chen, Liang Chen, Lin Chen, Long Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, M. Y. Cui, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, Danzengluobu, X. Q. Dong, K. K. Duan, J. H. Fan, Y. Z. Fan, J. Fang, J. H. Fang, K. Fang, C. F. Feng, H. Feng, L. Feng, S. H. Feng, X. T. Feng, Y. Feng, Y. L. Feng, S. Gabici, B. Gao, C. D. Gao, Q. Gao, W. Gao, W. K. Gao, M. M. Ge, L. S. Geng, G. Giacinti, G. H. Gong, Q. B. Gou, M. H. Gu, F. L. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, M. Hasan, H. H. He, H. N. He, J. Y. He, Y. He, Y. K. Hor, B. W. Hou, C. Hou, X. Hou, H. B. Hu, Q. Hu, S. C. Hu, D. H. Huang, T. Q. Huang, W. J. Huang, X. T. Huang, X. Y. Huang, Y. Huang, X. L. Ji, H. Y. Jia, K. Jia, K. Jiang, X. W. Jiang, Z. J. Jiang, M. Jin, M. M. Kang, I. Karpikov, D. Kuleshov, K. Kurinov, B. B. Li, C. M. Li, Cheng Li, Cong Li, D. Li, F. Li, H. B. Li, H. C. Li, Jian Li, Jie Li, K. Li, S. D. Li, W. L. Li, X. R. Li, Xin Li, Y. Z. Li, Zhe Li, Zhuo Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, D. B. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. Liu, Y. N. Liu, Q. Luo, Y. Luo, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, Z. Min, W. Mitthumsiri, H. J. Mu, Y. C. Nan, A. Neronov, L. J. Ou, P. Pattarakijwanich, Z. Y. Pei, J. C. Qi, M. Y. Qi, B. Q. Qiao, J. J. Qin, A. Raza, D. Ruffolo, A. Sáiz, M. Saeed, D. Semikoz, L. Shao, O. Shchegolev, X. D. Sheng, F. W. Shu, H. C. Song, Yu. V. Stenkin, V. Stepanov, Y. Su, D. X. Sun, Q. N. Sun, X. N. Sun, Z. B. Sun, J. Takata, P. H. T. Tam, Q. W. Tang, R. Tang, Z. B. Tang, W. W. Tian, C. Wang, C. B. Wang, G. W. Wang, H. G. Wang, H. H. Wang, J. C. Wang, Kai Wang, L. P. Wang, L. Y. Wang, P. H. Wang, R. Wang, W. Wang, X. G. Wang, X. Y. Wang, Y. Wang, Y. D. Wang, Y. J. Wang, Z. H. Wang, Z. X. Wang, Zhen Wang, Zheng Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, Q. W. Wu, S. Wu, X. F. Wu, Y. S. Wu, S. Q. Xi, J. Xia, G. M. Xiang, D. X. Xiao, G. Xiao, Y. L. Xin, Y. Xing, D. R. Xiong, Z. Xiong, D. L. Xu, R. F. Xu, R. X. Xu, W. L. Xu, L. Xue, D. H. Yan, J. Z. Yan, T. Yan, C. W. Yang, C. Y. Yang, F. Yang, F. F. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, W. X. Yang, Y. H. Yao, Z. G. Yao, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. Yue, H. D. Zeng, T. X. Zeng, W. Zeng, M. Zha, B. B. Zhang, F. Zhang, H. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, Li Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. B. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. F. Zhang, Yi Zhang, Yong Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, X. H. Zhao, F. Zheng, W. J. Zhong, B. Zhou, H. Zhou, J. N. Zhou, M. Zhou, P. Zhou, R. Zhou, X. X. Zhou, B. Y. Zhu, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, Y. C. Zou, X. Zuo, and The LHAASO Collaboration

Subjects
High energy astrophysics, Gamma-ray astronomy, Low-luminosity active galactic nuclei, LINER galaxies, Blazars, Fanaroff-Riley radio galaxies, Astrophysics, QB460-466
Abstract

The first source catalog of the Large High Altitude Air Shower Observatory (LHAASO) reported the detection of a very high energy gamma-ray source, 1LHAASO J1219+2915. This Letter presents a further detailed study of the spectral and temporal behavior of this pointlike source. The best-fit position of the TeV source (R.A. = 185.°05 ± 0.°04, decl. = 29.°25 ± 0.°03) is compatible with NGC 4278 within ∼0.°03. Variation analysis shows an indication of variability on a timescale of a few months in the TeV band, which is consistent with low-frequency observations. Based on these observations, we report the detection of TeV γ -ray emissions from this low-luminosity active galactic nucleus. The observation by LHAASO's Water Cherenkov Detector Array during the active period has a significance level of 8.8 σ with a best-fit photon spectral index Γ = 2.56 ± 0.14 and a flux f _1–10 TeV = (7.0 ± 1.1 _sta ± 0.35 _syst ) × 10 ^−13 photons cm ^−2 s ^−1 , or approximately 5% of the Crab Nebula. The discovery of VHE gamma-ray emission from NGC 4278 indicates that compact, weak radio jets can efficiently accelerate particles and emit TeV photons.

Published
2024
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2. The First LHAASO Catalog of Gamma-Ray Sources

Author

Zhen Cao, F. Aharonian, Q. An, Axikegu, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, J. T. Cai, Q. Cao, W. Y. Cao, Zhe Cao, J. Chang, J. F. Chang, A. M. Chen, E. S. Chen, Liang Chen, Lin Chen, Long Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, M. Y. Cui, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, Danzengluobu, D. della Volpe, X. Q. Dong, K. K. Duan, J. H. Fan, Y. Z. Fan, J. Fang, K. Fang, C. F. Feng, L. Feng, S. H. Feng, X. T. Feng, Y. L. Feng, S. Gabici, B. Gao, C. D. Gao, L. Q. Gao, Q. Gao, W. Gao, W. K. Gao, M. M. Ge, L. S. Geng, G. Giacinti, G. H. Gong, Q. B. Gou, M. H. Gu, F. L. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, H. H. He, H. N. He, J. Y. He, X. B. He, Y. He, M. Heller, Y. K. Hor, B. W. Hou, C. Hou, X. Hou, H. B. Hu, Q. Hu, S. C. Hu, D. H. Huang, T. Q. Huang, W. J. Huang, X. T. Huang, X. Y. Huang, Y. Huang, Z. C. Huang, X. L. Ji, H. Y. Jia, K. Jia, K. Jiang, X. W. Jiang, Z. J. Jiang, M. Jin, M. M. Kang, T. Ke, D. Kuleshov, K. Kurinov, B. B. Li, Cheng Li, Cong Li, D. Li, F. Li, H. B. Li, H. C. Li, H. Y. Li, J. Li, Jian Li, Jie Li, K. Li, W. L. Li, X. R. Li, Xin Li, Y. Z. Li, Zhe Li, Zhuo Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, J. Y. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. Liu, Y. N. Liu, R. Lu, Q. Luo, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, Z. Min, W. Mitthumsiri, H. J. Mu, Y. C. Nan, A. Neronov, Z. W. Ou, B. Y. Pang, P. Pattarakijwanich, Z. Y. Pei, M. Y. Qi, Y. Q. Qi, B. Q. Qiao, J. J. Qin, D. Ruffolo, A. Sáiz, D. Semikoz, C. Y. Shao, L. Shao, O. Shchegolev, X. D. Sheng, F. W. Shu, H. C. Song, Yu. V. Stenkin, V. Stepanov, Y. Su, Q. N. Sun, X. N. Sun, Z. B. Sun, P. H. T. Tam, Q. W. Tang, Z. B. Tang, W. W. Tian, C. Wang, C. B. Wang, G. W. Wang, H. G. Wang, H. H. Wang, J. C. Wang, K. Wang, L. P. Wang, L. Y. Wang, P. H. Wang, R. Wang, W. Wang, X. G. Wang, X. Y. Wang, Y. Wang, Y. D. Wang, Y. J. Wang, Z. H. Wang, Z. X. Wang, Zhen Wang, Zheng Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, S. Wu, X. F. Wu, Y. S. Wu, S. Q. Xi, J. Xia, J. J. Xia, G. M. Xiang, D. X. Xiao, G. Xiao, G. G. Xin, Y. L. Xin, Y. Xing, Z. Xiong, D. L. Xu, R. F. Xu, R. X. Xu, W. L. Xu, L. Xue, D. H. Yan, J. Z. Yan, T. Yan, C. W. Yang, F. Yang, F. F. Yang, H. W. Yang, J. Y. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, S. B. Yang, Y. H. Yao, Z. G. Yao, Y. M. Ye, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. Yue, H. D. Zeng, T. X. Zeng, W. Zeng, M. Zha, B. B. Zhang, F. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, L. X. Zhang, Li Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. B. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. F. Zhang, Yi Zhang, Yong Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, F. Zheng, B. Zhou, H. Zhou, J. N. Zhou, M. Zhou, P. Zhou, R. Zhou, X. X. Zhou, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, X. Zuo, and (The LHAASO Collaboration)

Subjects
Gamma-ray astronomy, Gamma-ray observatories, Catalogs, Astrophysics, QB460-466
Abstract

We present the first catalog of very-high-energy and ultra-high-energy gamma-ray sources detected by the Large High Altitude Air Shower Observatory. The catalog was compiled using 508 days of data collected by the Water Cherenkov Detector Array from 2021 March to 2022 September and 933 days of data recorded by the Kilometer Squared Array from 2020 January to 2022 September. This catalog represents the main result from the most sensitive large coverage gamma-ray survey of the sky above 1 TeV, covering decl. from −20° to 80°. In total, the catalog contains 90 sources with an extended size smaller than 2° and a significance of detection at >5 σ . Based on our source association criteria, 32 new TeV sources are proposed in this study. Among the 90 sources, 43 sources are detected with ultra-high energy ( E > 100 TeV) emission at >4 σ significance level. We provide the position, extension, and spectral characteristics of all the sources in this catalog.

Published
2024
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3. Construction and on-site performance of the LHAASO WFCTA camera

Author

F. Aharonian, Q. An, Axikegu, L. X. Bai, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, H. Cai, J. T. Cai, Z. Cao, J. Chang, J. F. Chang, X. C. Chang, B. M. Chen, J. Chen, L. Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, X. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, Danzengluobu, D. della Volpe, B. D’Ettorre Piazzoli, X. J. Dong, J. H. Fan, Y. Z. Fan, Z. X. Fan, J. Fang, K. Fang, C. F. Feng, L. Feng, S. H. Feng, Y. L. Feng, B. Gao, C. D. Gao, Q. Gao, W. Gao, M. M. Ge, L. S. Geng, G. H. Gong, Q. B. Gou, M. H. Gu, J. G. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, H. H. He, H. N. He, J. C. He, S. L. He, X. B. He, Y. He, M. Heller, Y. K. Hor, C. Hou, X. Hou, H. B. Hu, S. Hu, S. C. Hu, X. J. Hu, D. H. Huang, Q. L. Huang, W. H. Huang, X. T. Huang, Z. C. Huang, F. Ji, X. L. Ji, H. Y. Jia, K. Jiang, Z. J. Jiang, C. Jin, D. Kuleshov, K. Levochkin, B. B. Li, C. Li, F. Li, H. B. Li, H. C. Li, H. Y. Li, J. Li, K. Li, W. L. Li, X. Li, X. R. Li, Y. Li, Y. Z. Li, Z. Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, J. S. Liu, J. Y. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. N. Liu, Z. X. Liu, W. J. Long, R. Lu, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, A. Masood, W. Mitthumsiri, T. Montaruli, Y. C. Nan, B. Y. Pang, P. Pattarakijwanich, Z. Y. Pei, M. Y. Qi, D. Ruffolo, V. Rulev, A. Sáiz, L. Shao, O. Shchegolev, X. D. Sheng, J. R. Shi, H. C. Song, Yu. V. Stenkin, V. Stepanov, Q. N. Sun, X. N. Sun, Z. B. Sun, P. H. T. Tam, Z. B. Tang, W. W. Tian, B. D. Wang, C. Wang, H. Wang, H. G. Wang, J. C. Wang, J. S. Wang, L. P. Wang, L. Y. Wang, R. N. Wang, W. Wang, X. G. Wang, X. J. Wang, X. Y. Wang, Y. D. Wang, Y. J. Wang, Y. P. Wang, Z. Wang, Z. H. Wang, Z. X. Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, S. Wu, W. X. Wu, X. F. Wu, S. Q. Xi, J. Xia, J. J. Xia, G. M. Xiang, G. Xiao, H. B. Xiao, G. G. Xin, Y. L. Xin, Y. Xing, D. L. Xu, R. X. Xu, L. Xue, D. H. Yan, C. W. Yang, F. F. Yang, J. Y. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, S. B. Yang, Y. H. Yao, Z. G. Yao, Y. M. Ye, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. D. Zeng, T. X. Zeng, W. Zeng, Z. K. Zeng, M. Zha, X. X. Zhai, B. B. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, J. W. Zhang, L. Zhang, L. X. Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. R. Zhang, S S. Zhang, X. Zhang, X. P. Zhang, Y. Zhang, Y. F. Zhang, Y. L. Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, F. Zheng, Y. Zheng, B. Zhou, H. Zhou, J. N. Zhou, P. Zhou, R. Zhou, X. X. Zhou, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, X. Zuo, and The LHAASO Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The focal plane camera is the core component of the Wide Field-of-view Cherenkov/fluorescence Telescope Array (WFCTA) of the Large High-Altitude Air Shower Observatory (LHAASO). Because of the capability of working under moonlight without aging, silicon photomultipliers (SiPM) have been proven to be not only an alternative but also an improvement to conventional photomultiplier tubes (PMT) in this application. Eighteen SiPM-based cameras with square light funnels have been built for WFCTA. The telescopes have collected more than 100 million cosmic ray events and preliminary results indicate that these cameras are capable of working under moonlight. The characteristics of the light funnels and SiPMs pose challenges (e.g. dynamic range, dark count rate, assembly techniques). In this paper, we present the design features, manufacturing techniques and performances of these cameras. Finally, the test facilities, the test methods and results of SiPMs in the cameras are reported here.

Published
2021
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4. [Pars plana vitrectomy techniques guiding by the pathological anatomy in rhegmatogenous retinal detachment]

Author

X R, Li and Y, Shao

Abstract

Rhegmatogenous retinal detachment (RRD) is a retinal vitreous disease, with increasing incidence in recent years. Pars plana vitrectomy is one of the most common treatments for RRD. To prevent re-detachment after the primary surgery and guarantee the visual outcome of the patients, we highlight the techniques for RRD during the PPV, including the surgical skills to manipulate the breaks, peripheral retina and vitreous base, meanwhile, empathized on the posterior vitreous detachment and posterior vitreous cortex. The aim is to increase the rate of anatomical re-attachment and to improve visual function.孔源性视网膜脱离（RRD）的发病率逐年升高。玻璃体切除术（PPV）是治疗RRD的重要手术方式之一，提高PPV的成功率对于患者视力预后具有重要意义。本述评以玻璃体视网膜组织解剖特点为基础，提出了针对玻璃体视网膜交界面处理RRD的手术技术要点，包括裂孔周围玻璃体，周边部视网膜玻璃体和玻璃体基底部的操作要点以及人工玻璃体后脱离和玻璃体后皮质的处理。旨在通过提高手术技术，降低复发性视网膜脱离的发生率，提升患者术后视功能。.

Published
2022

5. A dynamic range extension system for LHAASO WCDA-1

Author

F. Aharonian, Q. An, null Axikegu, L. X. Bai, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, H. Cai, J. T. Cai, Z. Cao, J. Chang, J. F. Chang, X. C. Chang, B. M. Chen, J. Chen, L. Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, X. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, null Danzengluobu, D. della Volpe, B. D’Ettorre Piazzoli, X. J. Dong, J. H. Fan, Y. Z. Fan, Z. X. Fan, J. Fang, K. Fang, C. F. Feng, L. Feng, S. H. Feng, Y. L. Feng, B. Gao, C. D. Gao, Q. Gao, W. Gao, M. M. Ge, L. S. Geng, G. H. Gong, Q. B. Gou, M. H. Gu, J. G. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, H. H. He, H. N. He, J. C. He, S. L. He, X. B. He, Y. He, M. Heller, Y. K. Hor, C. Hou, X. Hou, H. B. Hu, S. Hu, S. C. Hu, X. J. Hu, D. H. Huang, Q. L. Huang, W. H. Huang, X. T. Huang, Y. Huang, Z. C. Huang, F. Ji, X. L. Ji, H. Y. Jia, K. Jiang, Z. J. Jiang, C. Jin, D. Kuleshov, K. Levochkin, B. B. Li, C. Li, F. Li, H. B. Li, H. C. Li, H. Y. Li, J. Li, K. Li, W. L. Li, X. Li, X. R. Li, Y. Li, Y. Z. Li, Z. Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, J. S. Liu, J. Y. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. N. Liu, Z. X. Liu, W. J. Long, R. Lu, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, A. Masood, W. Mitthumsiri, T. Montaruli, Y. C. Nan, B. Y. Pang, P. Pattarakijwanich, Z. Y. Pei, M. Y. Qi, D. Ruffolo, V. Rulev, A. Sáiz, L. Shao, O. Shchegolev, X. D. Sheng, J. R. Shi, H. C. Song, Yu. V. Stenkin, V. Stepanov, Q. N. Sun, X. N. Sun, Z. B. Sun, P. H. T. Tam, Z. B. Tang, W. W. Tian, B. D. Wang, C. Wang, H. Wang, H. G. Wang, J. C. Wang, J. S. Wang, L. P. Wang, L. Y. Wang, R. N. Wang, W. Wang, X. G. Wang, X. J. Wang, X. Y. Wang, Y. D. Wang, Y. J. Wang, Y. P. Wang, Z. Wang, Z. H. Wang, Z. X. Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, S. Wu, W. X. Wu, X. F. Wu, S. Q. Xi, J. Xia, J. J. Xia, G. M. Xiang, G. Xiao, H. B. Xiao, G. G. Xin, Y. L. Xin, Y. Xing, D. L. Xu, R. X. Xu, L. Xue, D. H. Yan, C. W. Yang, F. F. Yang, J. Y. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, S. B. Yang, Y. H. Yao, Z. G. Yao, Y. M. Ye, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. D. Zeng, T. X. Zeng, W. Zeng, Z. K. Zeng, M. Zha, X. X. Zhai, B. B. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, J. W. Zhang, L. Zhang, L. X. Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. Zhang, Y. F. Zhang, Y. L. Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, F. Zheng, Y. Zheng, B. Zhou, H. Zhou, J. N. Zhou, P. Zhou, R. Zhou, X. X. Zhou, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, and X. Zuo

Subjects
Physics, Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Dynamic range, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Cosmic ray, Extension (predicate logic), Measure (mathematics), Effective nuclear charge, Nuclear physics, Air shower, Nuclear Energy and Engineering, Orders of magnitude (time), Energy (signal processing)
Abstract

The main scientific goal of LHAASO-WCDA is to survey gamma-ray sources with energy from 100 GeV to 30 TeV. To observe high-energy shower events, especially to measure the energy spectrum of cosmic rays from 100 TeV to 10 PeV, a dynamic range extension system (WCDA++) is designed to use a 1.5-inch PMT with a dynamic range of four orders of magnitude for each cell in WCDA-1. The dynamic range is extended by using these PMTs to measure the effective charge density in the core region of air shower events, which is an important parameter for identifying the composition of primary particles. The system has been running for more than one year. In this paper, the details of the design and performance of WCDA++ are presented.

Published
2021

6. [A case of diabetic retinopathy with coagulation factor Ⅷ and Ⅻ deficiency]

Author

M F, Jiao, Z H, Cheng, L, Liu, and X R, Li

Subjects
Male, Plasma, Diabetic Retinopathy, Factor VIII, Laser Coagulation, Vitrectomy, Diabetes Mellitus, Humans, Blood Component Transfusion, Middle Aged
Abstract

The patient was a 48-year-old male with a previous history of diabetes mellitus and hypertension. The patient had persistent bleeding after vitrectomy of the left eye, and the patient was examined for abnormal coagulation factor Ⅷ combined with Ⅻ. This case suggests that we need effective control of blood glucose and blood pressure in patients undergoing vitrectomy in clinical work, and adequate examination of coagulation function. Patients with coagulation factor deficiency should be treated with plasma transfusion to supplement coagulation factors before performing the necessary surgical treatment to prevent severe bleeding.患者男，48岁，既往糖尿病、高血压病史。患者左眼玻璃体切除术后持续出血，检查患者凝血因子Ⅷ合并Ⅻ异常。该病例提示在临床工作中，需要对玻璃体切除手术患者的血糖及血压进行有效控制，详细谨慎检查凝血功能。对有凝血因子缺乏的患者应输注血浆补充凝血因子后再行必要的手术治疗，防止严重的出血情况发生。.

Published
2022

7. Constraints on heavy decaying dark matter from 570 days of LHAASO observations

Author

Zhen, Cao, F, Aharonian, Q, An, Axikegu, L X, Bai, Y X, Bai, Y W, Bao, D, Bastieri, X J, Bi, Y J, Bi, J T, Cai, Zhe, Cao, J, Chang, J F, Chang, E S, Chen, Liang, Chen, Long, Chen, M J, Chen, M L, Chen, Q H, Chen, S H, Chen, S Z, Chen, T L, Chen, Y, Chen, H L, Cheng, N, Cheng, Y D, Cheng, S W, Cui, X H, Cui, Y D, Cui, B, D'Ettorre Piazzoli, B Z, Dai, H L, Dai, Z G, Dai, Danzengluobu, D, Della Volpe, K K, Duan, J H, Fan, Y Z, Fan, Z X, Fan, J, Fang, K, Fang, C F, Feng, L, Feng, S H, Feng, X T, Feng, Y L, Feng, B, Gao, C D, Gao, L Q, Gao, Q, Gao, W, Gao, W K, Gao, M M, Ge, L S, Geng, G H, Gong, Q B, Gou, M H, Gu, F L, Guo, J G, Guo, X L, Guo, Y Q, Guo, Y Y, Guo, Y A, Han, H H, He, H N, He, S L, He, X B, He, Y, He, M, Heller, Y K, Hor, C, Hou, X, Hou, H B, Hu, Q, Hu, S, Hu, S C, Hu, X J, Hu, D H, Huang, W H, Huang, X T, Huang, X Y, Huang, Y, Huang, Z C, Huang, X L, Ji, H Y, Jia, K, Jia, K, Jiang, Z J, Jiang, M, Jin, M M, Kang, T, Ke, D, Kuleshov, K, Levochkin, B B, Li, Cheng, Li, Cong, Li, F, Li, H B, Li, H C, Li, H Y, Li, J, Li, Jian, Li, Jie, Li, K, Li, W L, Li, X R, Li, Xin, Li, Y Z, Li, Zhe, Li, Zhuo, Li, E W, Liang, Y F, Liang, S J, Lin, B, Liu, C, Liu, D, Liu, H, Liu, H D, Liu, J, Liu, J L, Liu, J S, Liu, J Y, Liu, M Y, Liu, R Y, Liu, S M, Liu, W, Liu, Y, Liu, Y N, Liu, W J, Long, R, Lu, Q, Luo, H K, Lv, B Q, Ma, L L, Ma, X H, Ma, J R, Mao, A, Masood, Z, Min, W, Mitthumsiri, Y C, Nan, Z W, Ou, B Y, Pang, P, Pattarakijwanich, Z Y, Pei, M Y, Qi, Y Q, Qi, B Q, Qiao, J J, Qin, D, Ruffolo, A, Sáiz, C Y, Shao, L, Shao, O, Shchegolev, X D, Sheng, J Y, Shi, H C, Song, Yu V, Stenkin, V, Stepanov, Y, Su, Q N, Sun, X N, Sun, Z B, Sun, P H T, Tam, Z B, Tang, W W, Tian, B D, Wang, C, Wang, H, Wang, H G, Wang, J C, Wang, J S, Wang, L P, Wang, L Y, Wang, R, Wang, R N, Wang, W, Wang, X G, Wang, X Y, Wang, Y, Wang, Y D, Wang, Y J, Wang, Y P, Wang, Z H, Wang, Z X, Wang, Zhen, Wang, Zheng, Wang, D M, Wei, J J, Wei, Y J, Wei, T, Wen, C Y, Wu, H R, Wu, S, Wu, X F, Wu, Y S, Wu, S Q, Xi, J, Xia, J J, Xia, G M, Xiang, D X, Xiao, G, Xiao, G G, Xin, Y L, Xin, Y, Xing, Z, Xiong, D L, Xu, R X, Xu, L, Xue, D H, Yan, J Z, Yan, C W, Yang, F F, Yang, H W, Yang, J Y, Yang, L L, Yang, M J, Yang, R Z, Yang, S B, Yang, Y H, Yao, Z G, Yao, Y M, Ye, L Q, Yin, N, Yin, X H, You, Z Y, You, Y H, Yu, Q, Yuan, H, Yue, H D, Zeng, T X, Zeng, W, Zeng, Z K, Zeng, M, Zha, X X, Zhai, B B, Zhang, F, Zhang, H M, Zhang, H Y, Zhang, J L, Zhang, L X, Zhang, Li, Zhang, Lu, Zhang, P F, Zhang, P P, Zhang, R, Zhang, S B, Zhang, S R, Zhang, S S, Zhang, X, Zhang, X P, Zhang, Y F, Zhang, Y L, Zhang, Yi, Zhang, Yong, Zhang, B, Zhao, J, Zhao, L, Zhao, L Z, Zhao, S P, Zhao, F, Zheng, Y, Zheng, B, Zhou, H, Zhou, J N, Zhou, P, Zhou, R, Zhou, X X, Zhou, C G, Zhu, F R, Zhu, H, Zhu, K J, Zhu, X, Zuo, S, Ando, M, Chianese, D F G, Fiorillo, G, Miele, K C Y, Ng, and GRAPPA (ITFA, IoP, FNWI)

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), High Energy Physics - Phenomenology, Cosmology and Nongalactic Astrophysics (astro-ph.CO), High Energy Physics - Phenomenology (hep-ph), General Physics and Astronomy, FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The kilometer square array (KM2A) of the large high altitude air shower observatory (LHAASO) aims at surveying the northern γ-ray sky at energies above 10 TeV with unprecedented sensitivity. γ-ray observations have long been one of the most powerful tools for dark matter searches, as, e.g., high-energy γ rays could be produced by the decays of heavy dark matter particles. In this Letter, we present the first dark matter analysis with LHAASO-KM2A, using the first 340 days of data from 1/2-KM2A and 230 days of data from 3/4-KM2A. Several regions of interest are used to search for a signal and account for the residual cosmic-ray background after γ/hadron separation. We find no excess of dark matter signals, and thus place some of the strongest γ-ray constraints on the lifetime of heavy dark matter particles with mass between 105 and 109 GeV. Our results with LHAASO are robust, and have important implications for dark matter interpretations of the diffuse astrophysical high-energy neutrino emission.

Published
2022

8. Association between the Lymphocyte-to-C-Reactive Protein Ratio and Survival Outcomes in Cancer Patients with GLIM-Defined Malnutrition: A Multicenter Study

Author

K.-P. Zhang, X. Zhang, Q. Zhang, G.-T. Ruan, M.-M. Song, H.-L. Xie, H.-Y. Zhang, X.-R. Li, M. Yang, Y.-Y. Liu, Q.-Q. Li, Y.-Z. Ge, X.-Y. Liu, S.-Q. Lin, W. Li, H.-X. Xu, Li Deng, and Han-Ping Shi

Subjects
Inflammation, Male, Nutrition and Dietetics, Malnutrition, Medicine (miscellaneous), Nutritional Status, Globulins, Cohort Studies, Leadership, C-Reactive Protein, Glucose, Nutrition Assessment, Neoplasms, Quality of Life, Humans, Lymphocytes, Prospective Studies, Geriatrics and Gerontology, Biomarkers, Retrospective Studies
Abstract

This study assessed the prognostic value of LCR in patients with cancer-associated malnutrition (CAM). Systemic inflammatory markers, particularly the lymphocyte-to-C-reactive protein ratio (LCR), are related to the survival of patients with CAM. The present retrospective analysis based on a prospective multicenter cohort study, which involved 1,437 hospitalized patients with CAM.The area under the receiver operating characteristic curve (AUC) of ten inflammatory indicators-LCR, advanced lung cancer inflammation index, neutrophil-to-lymphocyte ratio, prognostic nutritional index, modified Glasgow prognostic score, systemic immune-inflammation index, albumin-to-globulin ratio, LCR score, glucose-to-lymphocyte ratio, and platelet-to-lymphocyte ratio-were constructed. Nutritional status, blood markers, and quality of life (QoL) were evaluated within 48 h of admission. The overall survival (OS) was evaluated from September 1 to December 29, 2021.A total of 1,431 cancer patients diagnosed with malnutrition based on the Global Leadership Initiative on Malnutrition (GLIM) criteria. Male patients were 62.8% of all, and the mean age was 60.66 years old. The AUC of LCR was higher than that of other inflammatory markers. The restricted cubic spline (RCS) of the Hazard ratios (HRs) showed an inverse L-shaped relationship with LCR. In addition, patients with low LCR had significantly poorer OS than those with high LCR. The addition of LCR to the model increased the predictive ability of 1-year mortality (AUC increase of 0.036), 3-year mortality (AUC increase of 0.038), and 5-year mortality (AUC increase of 0.031).Assessing the LCR can help the medical staff identify cancer patients with nutritional deficiency at high risk of oncological outcomes and develop individualized therapeutic strategies.

Published
2022

9. [Relationship and coordination between water pollution control and mosquito breeding]

Author

X R, Li and M S, Huang

Subjects
Culicidae, Mosquito Control, Water Pollution, Animals, Water, Mosquito Vectors, Ecosystem
Abstract

Change of water environment is strongly associated with mosquito breeding. Because of long-term effectiveness, low cost and high environmental compatibility, ecological pollution control systems have been widely used in water pollution control projects. However, the potential effects of mosquito breeding are likely to cause expansion of mosquito populations and an increase in the risk of transmission of vector-borne diseases, which may become an urgent problem to be solved during the water environment "post-remediation" period. This review summarizes the physical, chemical and biological factors affecting mosquito breeding caused by water environment changes and analyzes the effects of water pollution control approaches on mosquito breeding and the underlying mechanisms, so as to promote the interdisciplinary connections between water pollution control and vector control, and avoid secondary disasters caused by ecological environment restoration, such as mosquito infestation. This review may provide insights into the use of technology combinations and water pollution control approaches in vector control.

Published
2022

11. [Knobloch syndrome: a case report]

Author

Q Y, Liu, X H, Cui, Z, Li, Y, Shao, D J, Xing, W B, Li, and X R, Li

Subjects
Child, Preschool, Retinal Degeneration, Myopia, Retinal Detachment, Humans, Female, Child, Encephalocele
Abstract

A 5-year-old girl came to the Tianjin Medical University Eye Hospital in May 2021 because of her poor eyesight after birth. The physical examination showed that she had high myopia, esotropia, horizontal tremor, and high myopia retinopathy of both eyes. After inquiring about her medical history, we found that the baby's occipital cystic mass swelled after birth, and CT examination showed that the occipital skull plate defect with meningocele, but without treatment, at present, the occipital mass had subsided by itself. Considering the eye manifestations and skull changes of the child, it may be conformed to Knobloch syndrome, after the detection of V4 by full exon gene, it was found that the child had the compound heterozygous variation of pathogenic gene COL18A1, and Knobloch syndrome was definite, Knobloch syndrome is a rare autosomal recessive hereditary disease with typical features of high myopia, retinal detachment and occipital encephalocele. At present, there is no clear treatment plan, and gene therapy may be an effective treatment for Knobloch syndrome in the future.5岁女童因出生后发现双眼视力差于2021年5月就诊于天津医科大学眼科医院，体检提示：双眼高度近视、双眼内斜视、水平震颤、双眼底高度近视改变，追问病史后发现，患儿出生后头颅枕部囊性肿物膨出，查头颅CT提示：枕部颅板缺损伴脑膜膨出，未作治疗，目前枕部肿物已自行消退。考虑患儿的眼部表现及颅骨改变，可能符合Knobloch综合征，后经全外显子基因检测V4发现，患儿为致病基因COL18A1的复合杂合变异，Knobloch综合征明确，该综合征是一种罕见的常染色体隐性遗传性疾病，典型特征是高度近视、视网膜脱离和枕部脑膨出，目前尚无明确的治疗方案，基因治疗可能是未来应对Knobloch综合征的有效治疗手段。.

Published
2022

12. Ultrahigh-energy photons up to 1.4 petaelectronvolts from 12 γ-ray Galactic sources

Author

Alejandro Sáiz, Y. H. Yao, W. X. Wu, P. P. Zhang, Zhuo Li, R. Liu, Pak-Hin Thomas Tam, H. C. Li, Liang Chen, J. C. Wang, Y. L. Xin, L. Chen, M. J. Chen, Hong-Guang Wang, Y. J. Wei, S. Hu, Junjie Mao, Y. Q. Guo, J. Y. Liu, V. Rulev, P. F. Zhang, L. Xue, H. B. Hu, H. Liu, Rui Zhang, Linbin Yang, C. F. Feng, F. Ji, Xiaofei Zhang, F. Zheng, V. I. Stepanov, Ping Zhou, Q. H. Chen, H. R. Wu, Warit Mitthumsiri, X. C. Chang, Z. K. Zeng, C. D. Gao, Bin Zhou, W. L. Li, S. Z. Chen, M. M. Ge, Lei Zhao, Y. Z. Li, Y. Y. Guo, Y. J. Bi, Zhe Cao, Y. K. Hor, Xuejiao Li, H. D. Liu, S. H. Feng, B. Liu, Y. D. Cheng, Bo Zhang, H. K. Lv, H. M. Zhang, K. Levochkin, Y. J. Wang, L. X. Bai, Jixia Li, T. Montaruli, Duo Yan, Hefan Li, Ying Zhang, Bingshui Gao, Q. An, H. B. Xiao, J. R. Shi, X. D. Sheng, Z. X. Liu, W. H. Huang, M. L. Chen, Jianeng Zhou, Q. Gao, Minghao Qi, W. Zeng, Li-Sheng Geng, J. Chen, B. M. Chen, T. Wen, S. W. Cui, Z. X. Wang, Chiming Jin, S. B. Yang, L. Z. Zhao, C. W. Yang, J. B. Zhao, D.A. Kuleshov, Y. M. Xing, L. P. Wang, E. W. Liang, X. F. Wu, Zhe Li, B. Y. Pang, B. B. Li, X. Zuo, Cong Li, S. Q. Xi, Kun Fang, W. Gao, B. Z. Dai, Z. H. Wang, H. Cai, Jun Liu, Zhen Wang, J. C. He, Houdun Zeng, J. Fang, G. C. Xiao, Y. C. Nan, Z. G. Yao, Z. Y. Pei, Jun-Hui Fan, X. X. Zhou, Q. Yuan, H. B. Li, Shi-Qi Hu, G. G. Xin, J. F. Chang, Xufang Li, Oleg Shchegolev, G. M. Xiang, S. P. Zhao, W. Liu, X. L. Ji, M. J. Yang, H. H. He, R. Lu, Zhengguo Cao, Felix Aharonian, J. W. Zhang, H. C. Song, Yongchun Wang, Yugang Zhang, Wenwu Tian, He Zhang, Bai Yibing, S. L. He, Donglian Xu, Y. L. Feng, Zebo Tang, X. L. Guo, Y. D. Cui, X. J. Dong, Zheng Wang, Jun-Jie Wei, Q. B. Gou, Qizhi Huang, H. N. He, K. J. Zhu, M. Zha, B. D. Wang, Ruizhi Yang, X. N. Sun, Y. P. Wang, Z. C. Huang, H. L. Dai, H. Wang, Xiang Zhang, Xing-Yuan Hou, Yunchao Liu, H. Y. Jia, D. M. Wei, Z. G. Dai, Rong Xu, Fan Yang, A. Masood, F. Y. Li, Xinbo He, Youping Li, X. T. Huang, L. Y. Wang, X. R. Li, J. J. Xia, K. Jiang, Binyu Zhao, X. J. Hu, Yun-Feng Liang, W. Wang, Y. A. Han, J. G. Guo, Yu. V. Stenkin, Lang Shao, J.W. Xia, P. Pattarakijwanich, X. H. You, S.H. Chen, S. R. Zhang, C. Hou, Shuibin Lin, Lu Zhang, L. Feng, Xuelong Wang, S. Wu, X. X. Zhai, Xuliang Chen, C. X. Liu, L. L. Ma, Y. He, Z. X. Fan, Z. Y. You, F. R. Zhu, Y. W. Bao, Qie Sun, Yi Chen, X. G. Wang, Yi Zhang, Xiang-Yu Wang, D. H. Huang, R. Zhou, Hao Zhou, H. Zhu, X. J. Bi, D. della Volpe, Tao Zeng, T. L. Chen, Bin Ma, J. S. Wang, Cunguo Wang, L. X. Zhang, Shujuan Liu, N. Yin, N. Cheng, D. Bastieri, X. H. Cui, Cheng Li, W. J. Long, Shengxue Zhang, Axikegu, Li Zhang, G. H. Gong, Danzengluobu, M. H. Gu, Y. H. Yu, Jie Zhang, Y. Z. Fan, Dong Liu, C. Y. Wu, J. T. Cai, Long Chen, Y. Zheng, L. Q. Yin, Y. M. Ye, J. Y. Yang, B D Ettorre Piazzoli, David Ruffolo, Z. B. Sun, Cheng Guang Zhu, X. H. Ma, M. Heller, K. Li, Z. J. Jiang, J. Liu, Yong Zhang, Minghui Liu, R. N. Wang, and Jinyao Liu

Subjects
Physics, Multidisciplinary, Photon, COSMIC cancer database, Proton, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Electron, Astrophysics, 01 natural sciences, Galaxy, Supernova, Crab Nebula, Pulsar, 0103 physical sciences, 010306 general physics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics
Abstract

The extension of the cosmic-ray spectrum beyond 1 petaelectronvolt (PeV; 1015 electronvolts) indicates the existence of the so-called PeVatrons—cosmic-ray factories that accelerate particles to PeV energies. We need to locate and identify such objects to find the origin of Galactic cosmic rays1. The principal signature of both electron and proton PeVatrons is ultrahigh-energy (exceeding 100 TeV) γ radiation. Evidence of the presence of a proton PeVatron has been found in the Galactic Centre, according to the detection of a hard-spectrum radiation extending to 0.04 PeV (ref. 2). Although γ-rays with energies slightly higher than 0.1 PeV have been reported from a few objects in the Galactic plane3–6, unbiased identification and in-depth exploration of PeVatrons requires detection of γ-rays with energies well above 0.1 PeV. Here we report the detection of more than 530 photons at energies above 100 teraelectronvolts and up to 1.4 PeV from 12 ultrahigh-energy γ-ray sources with a statistical significance greater than seven standard deviations. Despite having several potential counterparts in their proximity, including pulsar wind nebulae, supernova remnants and star-forming regions, the PeVatrons responsible for the ultrahigh-energy γ-rays have not yet been firmly localized and identified (except for the Crab Nebula), leaving open the origin of these extreme accelerators. Observations of γ-rays with energies up to 1.4 PeV find that 12 sources in the Galaxy are PeVatrons, one of which is the Crab Nebula.

Published
2021

13. Knockdown of FBP1 enhances radiosensitivity in prostate cancer cells by activating autophagy

Author

X R Li, Ke-qin Zhou, Zhuo Yin, Yunliang Gao, and Xiaosu Yang

Subjects
Male, Biochemical recurrence, Cancer Research, Gene knockdown, Oncogene, Prostatectomy, business.industry, medicine.medical_treatment, Prostatic Neoplasms, medicine.disease, Radiation Tolerance, Fructose-Bisphosphatase, Radiation therapy, Prostate cancer, Oncology, DU145, Cell Line, Tumor, Gene Knockdown Techniques, Autophagy, medicine, Cancer research, Humans, Radiosensitivity, Neoplasm Recurrence, Local, business
Abstract

For patients with clinically early-stage localized prostate cancer, radiotherapy is another treatment that can achieve radical treatment in addition to radical prostatectomy. Despite this, there are still a large number of patients with prostate cancer who have a biochemical recurrence after undergoing radiotherapy, or even clinical recurrence, leading to treatment failure. Although the expression of the fructose-1,6-bisphosphatase 1 (FBP1) gene has been found to be absent in various tumors and is associated with a poor prognosis in tumor patients. However, the expression and role of FBP1 in prostate cancer are not clear. The purpose of this study was to investigate the role and mechanism of FBP1 in the radiotherapy resistance of prostate cancer. By analyzing the microarray data of prostate cancer radiotherapy resistant cells and parental cells (GSE53902), we found that FBP1 expression in DU145 radiotherapy resistant cells was significantly higher than in the DU145 parental cells. In addition, we searched for the expression of FBP1 in 492 prostate cancer samples from TCGA and found that its expression in prostate cancer was significantly higher than that in normal tissues. Knockdown of FBP1 expression significantly inhibited the proliferation of prostate cancer cells, promoted DNA damage-mediated apoptosis, and enhanced the sensitivity of prostate cancer cells to radiotherapy. Further mechanism analysis revealed that FBP1 knockdown could activate autophagy mediated by the AMPK-mTOR signaling pathway, while inhibition of the AMPK-mTOR signaling pathway could reverse FBP1 knockdown-mediated autophagy and apoptosis, as well as radiosensitization. In conclusion, this study clarified that FBP1 is an oncogene in prostate cancer, and the main mechanism for knockdown of FBP1 to increase radiosensitivity is to enhance autophagy mediated by the AMPK-mTOR signaling pathway. Therefore, FBP1 may be a potential target for enhancing prostate cancer radiotherapy.

Published
2020

15. [Treatment strategy of proliferative membranes in proliferative diabetic retinopathy based on the recognition of morphology characteristics]

Author

X R, Li and Y, Shao

Subjects
Vitreous Body, Diabetic Retinopathy, Vitrectomy, Diabetes Mellitus, Quality of Life, Humans
Abstract

Diabetic retinopathy is one of the three major microvascular complications of diabetes. Proliferative diabetic retinopathy (PDR) is an important ocular complication that affects the vision and quality of life of patients. Vitrectomy is the most effective treatment option. The characteristic of fibrovascular membranes in PDR varies at different stages of the disease, which requires specific treatment strategy and techniques. In order to improve the clinical diagnosis and treatment of PDR, this article proposes that different treatment methods should be correctly adopted for different types of proliferative membranes on the basis of fully understanding the tissue morphology of these membranes, and more attention should be paid to the treatment of the vitreous body to achieve more effective therapeutic effects.糖尿病视网膜病变是糖尿病三大微血管并发症之一，其中增生型糖尿病视网膜病变（PDR）是影响患者视力和生活质量的重要糖尿病眼部并发症，玻璃体切除手术是目前最为有效的治疗方法。PDR的纤维血管增生膜因病程不同而具有不同特点，处理策略和方法应具有针对性。为了指导临床实践，提高临床PDR的诊疗水平，本文提出应在充分认识增生膜组织形态的基础上，对不同类型增生膜采用不同治疗方法区别对待，并应在治疗中充分重视对玻璃体的处理，以便取得更为有效的治疗效果。

Published
2021

17. Exploring Lorentz Invariance Violation from Ultrahigh-Energy γ Rays Observed by LHAASO

Author

Zhen, Cao, F, Aharonian, Q, An, Axikegu, L X, Bai, Y X, Bai, Y W, Bao, D, Bastieri, X J, Bi, Y J, Bi, H, Cai, J T, Cai, Zhe, Cao, J, Chang, J F, Chang, B M, Chen, E S, Chen, J, Chen, Liang, Chen, Long, Chen, M J, Chen, M L, Chen, Q H, Chen, S H, Chen, S Z, Chen, T L, Chen, X L, Chen, Y, Chen, N, Cheng, Y D, Cheng, S W, Cui, X H, Cui, Y D, Cui, B D'Ettorre, Piazzoli, B Z, Dai, H L, Dai, Z G, Dai, Danzengluobu, D, Della Volpe, X J, Dong, K K, Duan, J H, Fan, Y Z, Fan, Z X, Fan, J, Fang, K, Fang, C F, Feng, L, Feng, S H, Feng, Y L, Feng, B, Gao, C D, Gao, L Q, Gao, Q, Gao, W, Gao, M M, Ge, L S, Geng, G H, Gong, Q B, Gou, M H, Gu, F L, Guo, J G, Guo, X L, Guo, Y Q, Guo, Y Y, Guo, Y A, Han, H H, He, H N, He, J C, He, S L, He, X B, He, Y, He, M, Heller, Y K, Hor, C, Hou, X, Hou, H B, Hu, S, Hu, S C, Hu, X J, Hu, D H, Huang, Q L, Huang, W H, Huang, X T, Huang, X Y, Huang, Z C, Huang, F, Ji, X L, Ji, H Y, Jia, K, Jiang, Z J, Jiang, C, Jin, T, Ke, D, Kuleshov, K, Levochkin, B B, Li, Cheng, Li, Cong, Li, F, Li, H B, Li, H C, Li, H Y, Li, Jian, Li, Jie, Li, K, Li, W L, Li, X R, Li, Xin, Li, Y, Li, Y Z, Li, Zhe, Li, Zhuo, Li, E W, Liang, Y F, Liang, S J, Lin, B, Liu, C, Liu, D, Liu, H, Liu, H D, Liu, J, Liu, J L, Liu, J S, Liu, J Y, Liu, M Y, Liu, R Y, Liu, S M, Liu, W, Liu, Y, Liu, Y N, Liu, Z X, Liu, W J, Long, R, Lu, H K, Lv, B Q, Ma, L L, Ma, X H, Ma, J R, Mao, A, Masood, Z, Min, W, Mitthumsiri, T, Montaruli, Y C, Nan, B Y, Pang, P, Pattarakijwanich, Z Y, Pei, M Y, Qi, Y Q, Qi, B Q, Qiao, J J, Qin, D, Ruffolo, V, Rulev, A, Sáiz, L, Shao, O, Shchegolev, X D, Sheng, J R, Shi, H C, Song, Yu V, Stenkin, V, Stepanov, Y, Su, Q N, Sun, X N, Sun, Z B, Sun, P H T, Tam, Z B, Tang, W W, Tian, B D, Wang, C, Wang, H, Wang, H G, Wang, J C, Wang, J S, Wang, L P, Wang, L Y, Wang, R N, Wang, W, Wang, X G, Wang, X J, Wang, X Y, Wang, Y, Wang, Y D, Wang, Y J, Wang, Y P, Wang, Z H, Wang, Z X, Wang, Zhen, Wang, Zheng, Wang, D M, Wei, J J, Wei, Y J, Wei, T, Wen, C Y, Wu, H R, Wu, S, Wu, W X, Wu, X F, Wu, S Q, Xi, J, Xia, J J, Xia, G M, Xiang, D X, Xiao, G, Xiao, H B, Xiao, G G, Xin, Y L, Xin, Y, Xing, D L, Xu, R X, Xu, L, Xue, D H, Yan, J Z, Yan, C W, Yang, F F, Yang, J Y, Yang, L L, Yang, M J, Yang, R Z, Yang, S B, Yang, Y H, Yao, Z G, Yao, Y M, Ye, L Q, Yin, N, Yin, X H, You, Z Y, You, Y H, Yu, Q, Yuan, H D, Zeng, T X, Zeng, W, Zeng, Z K, Zeng, M, Zha, X X, Zhai, B B, Zhang, H M, Zhang, H Y, Zhang, J L, Zhang, J W, Zhang, L X, Zhang, Li, Zhang, Lu, Zhang, P F, Zhang, P P, Zhang, R, Zhang, S R, Zhang, S S, Zhang, X, Zhang, X P, Zhang, Y F, Zhang, Y L, Zhang, Yi, Zhang, Yong, Zhang, B, Zhao, J, Zhao, L, Zhao, L Z, Zhao, S P, Zhao, F, Zheng, Y, Zheng, B, Zhou, H, Zhou, J N, Zhou, P, Zhou, R, Zhou, X X, Zhou, C G, Zhu, F R, Zhu, H, Zhu, K J, Zhu, and X, Zuo

Subjects
General Physics and Astronomy
Abstract

Recently, the LHAASO Collaboration published the detection of 12 ultrahigh-energy γ-ray sources above 100 TeV, with the highest energy photon reaching 1.4 PeV. The first detection of PeV γ rays from astrophysical sources may provide a very sensitive probe of the effect of the Lorentz invariance violation (LIV), which results in decay of high-energy γ rays in the superluminal scenario and hence a sharp cutoff of the energy spectrum. Two highest energy sources are studied in this work. No signature of the existence of the LIV is found in their energy spectra, and the lower limits on the LIV energy scale are derived. Our results show that the first-order LIV energy scale should be higher than about 10^{5} times the Planck scale M_{Pl} and that the second-order LIV scale is10^{-3}M_{Pl}. Both limits improve by at least one order of magnitude the previous results.

Published
2021

19. [Progress of researches on global prevalence of

Author

F Q, Zhang, P, Wang, X, Feng, Q M, Mi, X F, Mei, Z C, Zhang, X R, Li, and S, Wang

Subjects
Diarrhea, Feces, Gastrointestinal Diseases, Prevalence, Animals, Humans, Blastocystis hominis, Blastocystis Infections
Published
2021

20. [Progress of researches on animal models of

Author

X, Feng, F Q, Zhang, F Y, Xu, X F, Mei, Z C, Zhang, X R, Li, and S, Wang

Subjects
Feces, Virulence, Models, Animal, Animals, Humans, Blastocystis hominis, Blastocystis Infections
Published
2021

21. Extended Very-High-Energy Gamma-Ray Emission Surrounding PSR J0622+3749 Observed by LHAASO-KM2A

Author

F, Aharonian, Q, An, Axikegu, L X, Bai, Y X, Bai, Y W, Bao, D, Bastieri, X J, Bi, Y J, Bi, H, Cai, J T, Cai, Z, Cao, J, Chang, J F, Chang, X C, Chang, B M, Chen, J, Chen, L, Chen, M J, Chen, M L, Chen, Q H, Chen, S H, Chen, S Z, Chen, T L, Chen, X L, Chen, Y, Chen, N, Cheng, Y D, Cheng, S W, Cui, X H, Cui, Y D, Cui, B Z, Dai, H L, Dai, Z G, Dai, Danzengluobu, D, Della Volpe, B, D'Ettorre Piazzoli, X J, Dong, J H, Fan, Y Z, Fan, Z X, Fan, J, Fang, K, Fang, C F, Feng, L, Feng, S H, Feng, Y L, Feng, B, Gao, C D, Gao, Q, Gao, W, Gao, M M, Ge, L S, Geng, G H, Gong, Q B, Gou, M H, Gu, J G, Guo, X L, Guo, Y Q, Guo, Y Y, Guo, Y A, Han, H H, He, H N, He, J C, He, S L, He, X B, He, Y, He, M, Heller, Y K, Hor, C, Hou, X, Hou, H B, Hu, S, Hu, S C, Hu, X J, Hu, D H, Huang, Q L, Huang, W H, Huang, X T, Huang, Z C, Huang, F, Ji, X L, Ji, H Y, Jia, K, Jiang, Z J, Jiang, C, Jin, D, Kuleshov, K, Levochkin, B B, Li, C, Li, F, Li, H B, Li, H C, Li, H Y, Li, J, Li, K, Li, W L, Li, X, Li, X R, Li, Y, Li, Y Z, Li, Z, Li, E W, Liang, Y F, Liang, S J, Lin, B, Liu, C, Liu, D, Liu, H, Liu, H D, Liu, J, Liu, J L, Liu, J S, Liu, J Y, Liu, M Y, Liu, R Y, Liu, S M, Liu, W, Liu, Y N, Liu, Z X, Liu, W J, Long, R, Lu, H K, Lv, B Q, Ma, L L, Ma, X H, Ma, J R, Mao, A, Masood, W, Mitthumsiri, T, Montaruli, Y C, Nan, B Y, Pang, P, Pattarakijwanich, Z Y, Pei, M Y, Qi, D, Ruffolo, V, Rulev, A, Sáiz, L, Shao, O, Shchegolev, X D, Sheng, J R, Shi, H C, Song, Yu V, Stenkin, V, Stepanov, Q N, Sun, X N, Sun, Z B, Sun, P H T, Tam, Z B, Tang, W W, Tian, B D, Wang, C, Wang, H, Wang, H G, Wang, J C, Wang, J S, Wang, L P, Wang, L Y, Wang, R N, Wang, W, Wang, X G, Wang, X J, Wang, X Y, Wang, Y D, Wang, Y J, Wang, Y P, Wang, Z, Wang, Z H, Wang, Z X, Wang, D M, Wei, J J, Wei, Y J, Wei, T, Wen, C Y, Wu, H R, Wu, S, Wu, W X, Wu, X F, Wu, S Q, Xi, J, Xia, J J, Xia, G M, Xiang, G, Xiao, H B, Xiao, G G, Xin, Y L, Xin, Y, Xing, D L, Xu, R X, Xu, L, Xue, D H, Yan, C W, Yang, F F, Yang, J Y, Yang, L L, Yang, M J, Yang, R Z, Yang, S B, Yang, Y H, Yao, Z G, Yao, Y M, Ye, L Q, Yin, N, Yin, X H, You, Z Y, You, Y H, Yu, Q, Yuan, H D, Zeng, T X, Zeng, W, Zeng, Z K, Zeng, M, Zha, X X, Zhai, B B, Zhang, H M, Zhang, H Y, Zhang, J L, Zhang, J W, Zhang, L, Zhang, L X, Zhang, P F, Zhang, P P, Zhang, R, Zhang, S R, Zhang, S S, Zhang, X, Zhang, X P, Zhang, Y, Zhang, Y F, Zhang, Y L, Zhang, B, Zhao, J, Zhao, L, Zhao, L Z, Zhao, S P, Zhao, F, Zheng, Y, Zheng, B, Zhou, H, Zhou, J N, Zhou, P, Zhou, R, Zhou, X X, Zhou, C G, Zhu, F R, Zhu, H, Zhu, K J, Zhu, X, Zuo, and X Y, Huang

Abstract

We report the discovery of an extended very-high-energy (VHE) gamma-ray source around the location of the middle-aged (207.8 kyr) pulsar PSR J0622+3749 with the Large High-Altitude Air Shower Observatory (LHAASO). The source is detected with a significance of 8.2σ for E25 TeV assuming a Gaussian template. The best-fit location is (right ascension, declination) =(95.47°±0.11°,37.92°±0.09°), and the extension is 0.40°±0.07°. The energy spectrum can be described by a power-law spectrum with an index of -2.92±0.17_{stat}±0.02_{sys}. No clear extended multiwavelength counterpart of the LHAASO source has been found from the radio to sub-TeV bands. The LHAASO observations are consistent with the scenario that VHE electrons escaped from the pulsar, diffused in the interstellar medium, and scattered the interstellar radiation field. If interpreted as the pulsar halo scenario, the diffusion coefficient, inferred for electrons with median energies of ∼160 TeV, is consistent with those obtained from the extended halos around Geminga and Monogem and much smaller than that derived from cosmic ray secondaries. The LHAASO discovery of this source thus likely enriches the class of so-called pulsar halos and confirms that high-energy particles generally diffuse very slowly in the disturbed medium around pulsars.

Published
2021

23. Discovery of the Ultra-high energy gamma-ray source LHAASO J2108+5157

Author

Zhen Cao, F. Aharonian, Q. An, null Axikegu, L. X. Bai, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, H. Cai, J. T. Cai, Zhe Cao, J. Chang, J. F. Chang, B. M. Chen, E. S. Chen, J. Chen, Liang Chen, Long Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, X. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, S. W. Cui, X. H. Cui, Y. D. Cui, B. D’Ettorre Piazzoli, B. Z. Dai, H. L. Dai, Z. G. Dai, Dan-Zeng Dan-Zeng-Luo-Bu, D. della Volpe, X. J. Dong, K. K. Duan, J. H. Fan, Y. Z. Fan, Z. X. Fan, J. Fang, K. Fang, C. F. Feng, L. Feng, S. H. Feng, Y. L. Feng, B. Gao, C. D. Gao, L. Q. Gao, Q. Gao, W. Gao, M. M. Ge, L. S. Geng, G. H. Gong, Q. B. Gou, M. H. Gu, F. L. Guo, J. G. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, H. H. He, H. N. He, J. C. He, S. L. He, X. B. He, Y. He, M. Heller, Y. K. Hor, C. Hou, H. B. Hu, S. Hu, S. C. Hu, X. J. Hu, D. H. Huang, Q. L. Huang, W. H. Huang, X. T. Huang, X. Y. Huang, Z. C. Huang, F. Ji, X. L. Ji, H. Y. Jia, K. Jiang, Z. J. Jiang, C. Jin, T. Ke, D. Kuleshov, K. Levochkin, B. B. Li, Cheng Li, Cong Li, F. Li, H. B. Li, H. C. Li, H. Y. Li, J. Li, K. Li, W. L. Li, X. R. Li, Xin Li, Y. Li, Y. Z. Li, Zhe Li, Zhuo Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, J. S. Liu, J. Y. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. Liu, Y. N. Liu, Z. X. Liu, W. J. Long, R. Lu, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, A. Masood, Z. Min, W. Mitthumsiri, T. Montaruli, Y. C. Nan, B. Y. Pang, P. Pattarakijwanich, Z. Y. Pei, M. Y. Qi, Y. Q. Qi, B. Q. Qiao, J. J. Qin, D. Ruffolo, V. Rulev, A. Sáiz, L. Shao, O. Shchegolev, X. D. Sheng, J. Y. Shi, H. C. Song, Yu. V. Stenkin, V. Stepanov, Y. Su, Q. N. Sun, X. N. Sun, Z. B. Sun, P. H. T. Tam, Z. B. Tang, W. W. Tian, B. D. Wang, C. Wang, H. Wang, H. G. Wang, J. C. Wang, J. S. Wang, L. P. Wang, L. Y. Wang, R. N. Wang, W. Wang, X. G. Wang, X. J. Wang, X. Y. Wang, Y. Wang, Y. D. Wang, Y. J. Wang, Y. P. Wang, Z. H. Wang, Z. X. Wang, Zhen Wang, Zheng Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, S. Wu, W. X. Wu, X. F. Wu, S. Q. Xi, J. Xia, J. J. Xia, G. M. Xiang, D. X. Xiao, G. Xiao, H. B. Xiao, G. G. Xin, Y. L. Xin, Y. Xing, D. L. Xu, R. X. Xu, L. Xue, D. H. Yan, J. Z. Yan, C. W. Yang, F. F. Yang, J. Y. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, S. B. Yang, Y. H. Yao, Z. G. Yao, Y. M. Ye, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. D. Zeng, T. X. Zeng, W. Zeng, Z. K. Zeng, M. Zha, X. X. Zhai, B. B. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, J. W. Zhang, L. X. Zhang, Li Zhang, Lu Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. F. Zhang, Y. L. Zhang, Yi Zhang, Yong Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, F. Zheng, Y. Zheng, B. Zhou, H. Zhou, J. N. Zhou, P. Zhou, R. Zhou, X. X. Zhou, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, and X. Zuo

Subjects
Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Molecular cloud, Astrophysics::High Energy Astrophysical Phenomena, Hadron, Gamma ray, Flux, Sigma, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Gamma-ray astronomy, Space and Planetary Science, Energy spectrum, Ultrahigh energy, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report the discovery of a UHE gamma-ray source, LHAASO J2108+5157, by analyzing the LHAASO-KM2A data of 308.33 live days. Significant excess of gamma-ray induced showers is observed in both energy bands of 25-100 TeV and $\gt$100 TeV with 9.5 sigma and 8.5 sigma, respectively. This source is not significantly favored as an extensive source with the angular extension smaller than the point-spread function of KM2A. The measured energy spectrum from 20 to 200 TeV can be approximately described by a power-law function with an index of -2.83$\pm$ 0.18stat. A harder spectrum is demanded at lower energies considering the flux upper limit set by Fermi-LAT observations. The position of the gamma-ray emission is correlated with a giant molecular cloud, which favors a hadronic origin. No obvious counterparts have been found, deeper multiwavelength observations will help to shed new light on this intriguing UHE source., Comment: 12 pages, 7 figures, accepted by ApJL

Published
2021
Full Text
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25. [The dualistic origin and life code of human tumors]

Author

Y P, Zhong, X R, Li, and J S, Liu

Subjects
Neoplasms, Humans
Abstract

肿瘤起源二元论与生命密码是基于胚胎发育学、病理学和分子生物学的人类肿瘤发生的全新理论。从发育生物学角度看，生命延续和启动是一个生命周期，该周期受生殖细胞大小调控。生命延续的必要前提是具备人体最大的细胞——卵细胞，而新生命启动的必要环节是受精卵经历由大变小的卵裂过程进而产生相对小体积的胚胎干细胞，然后进行不同胚层的分化与增殖而诞生新生命。从病理学的角度看，百年来病理学家观察到的肿瘤可归结为两大表型：分化型和未分化型（或分化差型）。前者起源于正常生命周期，受精卵卵裂致胚胎发生、发育过程中分化受阻将产生相应的分化型肿瘤；而后者起源于体细胞在压力因素下形成的老化巨细胞。肿瘤像一个“怪胎”，理论上起源于老化巨细胞的“怪胎”和正常胚胎发生早期过程相似，需经历细胞增大再变小的“卵裂”过程。巨细胞的核内复制和分裂过程与卵裂酷似，但其以出芽、裂解、大爆炸的方式产生的细胞无法像受精卵或胚胎那样正常分化，而是形成未分化肿瘤。细胞大小的变化伴随核质比及倍体的变化，像密码一样，在卵裂或无丝分裂过程中决定了新生命的诞生与肿瘤的发生。肿瘤起源二元论与生命密码阐述了分化型肿瘤与未分化肿瘤的发生机制及其与生命周期的关系，首次将人类肿瘤起源和生命周期统一起来。本文在此概括性介绍该理论，为肿瘤研究乃至治疗提供全新思路和潜在靶点。.

Published
2020

26. [The status and related factors of myopia for children and adolescents aged 5-18 years old in Shaanxi Province in 2018]

Author

Y R, Wang, G H, Zhuang, G, Yang, L R, Wang, M W, Shen, R, Li, N, Li, X R, Li, J, Wei, X L, Wei, and Q, Wu

Subjects
Male, China, Cross-Sectional Studies, Adolescent, Child, Preschool, Myopia, Prevalence, Humans, Female, Child
Abstract

In 2018, the myopia detection rate of children and adolescents aged 5-18 years old in Shaanxi Province was 54.9% (11 060/20 144). The myopia detection rate of girls ［58.6%(5 830/9 949)］ was higher than that of boys ［58.6% (3 416/5 830)］ (2018年陕西省5~18岁儿童青少年近视检出率为54.9%（11 060/20 144），女生近视检出率［58.6%（5 830/9 949）］大于男生［58.6%（3 416/5 830）］（

Published
2020

27. Trichostatin A alleviates the process of breast carcinoma by downregulating LPAR5

Author

Y-Q, Zheng, X, Miao, J, Li, M-F, Hu, Y-S, Zhu, X-R, Li, and Y-J, Zhang

Subjects
Dose-Response Relationship, Drug, Down-Regulation, Mammary Neoplasms, Experimental, Mice, Nude, Breast Neoplasms, Middle Aged, Hydroxamic Acids, Cell Line, Histone Deacetylase Inhibitors, Mice, Cell Movement, Animals, Humans, Female, Receptors, Lysophosphatidic Acid
Abstract

To elucidate the role of histone deacetylase inhibitor Trichostatin A (TSA) in affecting metastasis of breast carcinoma, and its molecular mechanism.LPAR5 levels in breast carcinoma tissues and paracancerous tissues were detected by quantitative real-time polymerase chain reaction (qRT-PCR), and its expression pattern was further verified in breast carcinoma cell lines. The relationship between LPAR5 and prognosis of breast carcinoma patients was analyzed. After TSA induction (100-400 nmol/L) for 6-48 h, the proliferative and migratory abilities of SKBR3 and MDA-MB-231 cells in overexpressing LPAR5 were examined by cell counting kit-8 (CCK-8), transwell and wound healing assay. By constructing a xenograft model in nude mice, the influences of TSA and LPAR5 on in vivo growth of breast carcinoma were examined.LPAR5 was upregulated in breast carcinoma samples. High level of LPAR5 predicted higher rates of lymphatic metastasis and distant metastasis, as well as lower overall survival and progression-free survival in breast carcinoma patients. LPAR5 level was dose-dependently downregulated in TSA-induced SKBR3 and MDA-MB-231 cells. In addition, TSA induction dose-dependently declined proliferative ability, and time-dependently attenuated migratory ability in breast carcinoma cells. In vivo overexpression of LPAR5 in nude mice reversed the inhibitory effect of TSA on breast carcinoma growth.TSA induction can suppress proliferative and migratory abilities in breast carcinoma by downregulating LPAR5.

Published
2020

28. Observation of a Charged Charmoniumlike Structure in e+e−→π+π−J/ψ at s=4.26 GeV

Author

B. J. Liu, G. R. Lu, Z. A. Zhu, D. H. Sun, C. P. Shen, H. S. Chen, G. S. Huang, W. G. Li, Q. P. Ji, Y. F. Wang, Shan Wang, S. H. Zhang, X. Y. Shen, F. Li, T. Hussain, X. Y. Ma, H. Moeini, W. X. Gong, S. Spataro, X. P. Xu, X. T. Liao, F. C. Ma, Xi Chen, M. H. Ye, G. S. Varner, C. Zhu, C. H. Li, Hang Liu, I. Uman, C. Nicholson, R. Baldini Ferroli, H. M. Liu, B. Spruck, E. H. Thorndike, P. Friedel, J. F. Hu, W. B. Yan, M. N. Achasov, J. Min, H. B. Liu, L. Q. Qin, L. Y. Dong, J. F. Qiu, X. Q. Li, M. Greco, Yang Qin, B. Kopf, J. F. Sun, C. Hu, Y. Zeng, S. Pacetti, A. A. Zafar, X. L. Ji, L. Fava, M. Ullrich, Z. J. Xiao, X. N. Li, G. A. Chelkov, Q. Gao, Y. N. Gao, X. Tang, Zhe Sun, Xichao Ruan, S. P. Yu, K. L. He, G. F. Xu, G. F. Cao, Zujian Wang, S. Jin, Zhiqing Liu, Y. X. Xia, Q. A. Malik, D. J. Ambrose, Jie Yu, Y. Zhang, M. G. Zhao, Haiping Peng, M. Z. Wang, K. Y. Liu, K. X. Zhao, J. P. Dai, Tao Luo, J. V. Bennett, J. F. Chang, Z. B. Li, M. Maggiora, Ling Zhao, M. H. Gu, X. K. Zhou, Y. B. Chen, A. Q. Guo, Wei Wu, Xiaofeng Zhu, J. Z. Zhang, Lei Zhao, Z. Y. He, Z. L. Hou, Yang Yang, T. J. Min, K. J. Zhu, B. D. Schaefer, Joong-Won Park, B. X. Yu, S. L. Olsen, C. L. Ma, X. H. Zhao, R. A. Briere, Zhiqiang Liu, Miao He, W. M. Ding, K. Li, E. Prencipe, Y. G. Xie, W. D. Li, M. Qi, X. S. Jiang, J. B. Jiao, W. M. Song, H. Y. Sheng, Fang Liu, K. H. Rashid, S. X. Du, X. Y. Song, G. M. Xu, X. L. Wang, I. Denysenko, Z. G. Wang, Feng Xue, Cui Li, C. Z. Yuan, J. Z. Bai, S. Ma, O. Cakir, N. Wu, J. Q. Zhang, H. Y. Zhang, L. P. Zhou, H. L. Dai, Igor Boyko, H. W. Yu, Krisztian Peters, C. X. Yu, D. Toth, P. L. Wang, X. Zhou, H. J. Lu, J. G. Lu, I. Tapan, S. L. Li, Feng Liu, M. Leyhe, Z. H. Qin, Xiao-Tong Lu, Qi-Wen Lü, Z. P. Mao, Y. T. Liang, S. L. Zang, F. E. Maas, X. Cai, X. R. Li, Ke Wang, T. Hu, B. Y. Zhang, M. L. Chen, Y. H. Yan, C. Geng, J. W. Zhao, D. Cronin-Hennessy, M. Ablikim, Y. C. Zhu, Chuan Liu, G. X. Sun, X. F. Wang, Y. J. Mao, Y. P. Chu, Li Yan, G. F. Chen, B. Q. Wang, W. Ku¨hn, S. J. Chen, H. L. Ma, X. B. Ji, O. Bondarenko, H. P. Cheng, P. Larin, X. H. Mo, L. S. Wang, H. X. Yang, B. Zheng, D. M. Li, Sanfeng Wu, H. Muramatsu, M. Werner, V. V. Bytev, Fenfen An, Xuantong Zhang, R. G. Ping, M. Y. Dong, Y. M. Zhu, T. C. Zhao, X. Liu, F. A. Harris, J. Fang, J. S. Huang, Huihui Liu, Z. Jiao, Fu-Hu Liu, D. H. Zhang, E. Boger, Rui Zhang, T. Held, Y. B. Zhao, Guangming Huang, Z. Wu, Q. M. Ma, M. Pelizaeus, J. P. Liu, M. Bertani, Zhenghao Zhang, Z. A. Liu, C. X. Liu, J. Y. Zhang, K. Moriya, J. G. Messchendorp, Y. P. Guo, Y. H. Zheng, Cong-Feng Qiao, O. Albayrak, Y. X. Yang, Y. Yuan, Zhiqing Zhang, J. H. Zou, L. L. Wang, Qiunan Xu, Chi Zhang, A. Zallo, N. Yu. Muchnoi, T. Guo, Y. S. Zhu, D. X. Lin, O. Fuks, Serkant Ali Cetin, H. Cai, Alexey Zhemchugov, H. M. Hu, Heng-Yun Ye, Y. H. Zhang, M. R. Shepherd, Y. K. Heng, C. S. Ji, S. S. Sun, Y. Ban, P. Weidenkaff, G. Li, Q. Zhao, Y. Z. Sun, Y. J. Mo, Y. Q. Wang, L. L. Jiang, Q. G. Wen, W. Gradl, M. Kavatsyuk, K. Goetzen, J. W. Zhang, Jürgen Becker, Q. Liu, D. Y. Wang, S. Qian, Q. An, Jialun Ping, S. J. Zhao, Xiaocong Ai, I. B. Nikolaev, W. Lai, C. D. Fu, Z. Y. Wang, Gang Zhao, R. E. Mitchell, H. Liang, C. Q. Feng, C. J. Tang, X. Y. Zhang, S. P. Wen, X. S. Qin, X. R. Zhou, Y. P. Lu, B. X. Zhang, Kai Liu, Z. Y. Deng, M. Shao, Y. T. Gu, Z. Ning, X. T. Huang, Y. F. Liang, J. L. Fu, M. Lara, Cheng Li, Xingguo Li, G. Rong, Y. J. Sun, Q. J. Xu, D. P. Jin, Q. J. Li, L. G. Xia, J. C. Chen, Xuanhong Lou, H. B. Li, Y. L. Han, A. G. Denig, C. L. Luo, Nasser Kalantar-Nayestanaki, Dayong Wang, P. L. Liu, S. B. Liu, L. H. Wu, Y. Nefedov, Jianming Bian, C. Morales Morales, A. Sarantsev, D. H. Wei, J. S. Lange, Qun-Yao Wang, Zhiyong Zhang, LiLi Zhang, C. C. Zhang, B. Zhong, L. B. Guo, Lei Li, Ulrich Wiedner, Shou-hua Zhu, M. Kornicer, B. S. Zou, T. Ma, Yanping Huang, J. C. Li, J. Zhuang, M. X. Luo, Jian Wei, Yucheng Huang, D. V. Dedovich, Zhenli Xu, X. L. Luo, Y. H. Guan, G. R. Liao, F. F. Jing, A. Calcaterra, Z. G. Zhao, Q. Ouyang, S. S. Fang, Y. B. Liu, L. Huang, H. H. Zhang, Q. L. Xiu, Z. J. Sun, H. Loehner, HongSheng Zhao, R. Poling, Jianping Zheng, M. Lv, Z. Xue, M. Destefanis, Yao Wang, and Y. Ding

Subjects
Physics, Particle physics, Structure (category theory)
Published
2020

29. Observation of e+e−→γX(3802) at BESIII

Author

F. Li, F. C. Ma, Fang Liu, P. Larin, M. H. Ye, X. L. Ji, Jie Yu, S. P. Yu, C. Dong, L. Y. Dong, J. F. Qiu, C. S. Ji, Q. Ouyang, Yang Qin, L. Fava, Y. X. Xia, X. K. Zhou, T. J. Min, K. J. Zhu, H. Liang, Q. P. Ji, C. B. Zhang, D. X. Lin, Alexey Zhemchugov, H. M. Hu, Q. Liu, J. W. Zhang, S. S. Fang, L. H. Wu, Zhiqing Liu, W. M. Ding, J. M. Bian, T. Johansson, J. F. Chang, H. L. Lu, S. J. Zhao, W. Lai, Y. G. Xie, Y. B. Liu, Q. Gao, Y. N. Gao, P. Wang, Y. Zhang, Y. Ding, Li Zhou, I. Denysenko, G. X. Sun, Li Yan, J. Z. Fan, J. Q. Zhang, Y. L. Han, Xinglong Li, Q. J. Xu, M. Bertani, S. X. Du, L. G. Xia, Z. A. Liu, S. Schumann, Yao Wang, B. Y. Zhang, Y. H. Zheng, A. A. Zafar, G. Li, Y. F. Wang, X. L. Luo, B. J. Liu, J. C. Chen, Xuanhong Lou, Nasser Kalantar-Nayestanaki, Y. H. Guan, Y. X. Yang, K. H. Rashid, X. Cai, X. R. Li, R. Poling, X. H. Mo, L. S. Wang, L. L. Wang, H. Cai, C. D. Fu, Cong-Feng Qiao, O. Albayrak, Y. Ban, P. Weidenkaff, H. W. Yu, C. Q. Feng, H. J. Lu, J. G. Lu, Z. Jiao, Fu-Hu Liu, D. H. Zhang, Y. B. Zhao, W. Shan, J. Dong, C. Morales Morales, J. F. Sun, G. R. Lu, G. A. Chelkov, Kai Liu, M. Y. Dong, Y. T. Liang, S. J. Chen, O. Bondarenko, W. P. Wang, N. Yu. Muchnoi, X. S. Kang, Heng-Yun Ye, Y. H. Zhang, H. B. Liu, Haiping Peng, J. H. Liu, X. R. Chen, Yaquan Fang, T. Hussain, Z. A. Zhu, Z. G. Wang, H. Y. Zhang, G. F. Chen, M. R. Shepherd, M. Werner, W. Gradl, M. Ripka, Z. Y. Deng, Q. Zhao, K. Schoenning, Xingguo Li, B. S. Zou, Y. Zeng, Zhe Sun, Y. Z. Sun, X. Liu, Z. Y. Wang, Y. Q. Wang, S. P. Wen, X. S. Qin, X. R. Zhou, J. L. Fu, Cheng Li, J. H. Zou, O. Fuks, M. Lv, Z. Xue, Ke Wang, D. Y. Wang, I. B. Nikolaev, M. Maggiora, X. Y. Zhou, J. Y. Zhang, J. Min, S. S. Sun, S. Nisar, C. J. Tang, X. Y. Ma, H. Moeini, W. X. Gong, Q. A. Malik, W. C. Yan, S. B. Liu, C. P. Shen, Y. Nefedov, Y. P. Lu, Zhiqiang Liu, Miao He, M. Shao, Y. T. Gu, S. Braun, Ling Zhao, X. K. Chu, Lei Zhao, J. J. Zhang, M. Destefanis, Z. Y. He, Z. L. Hou, B. Kopf, J. Z. Bai, Q. J. Li, Z. H. Wang, B. Spruck, E. H. Thorndike, L. Q. Qin, L. P. Zhou, Fenfen An, Y. K. Heng, Yang Yang, F. E. Maas, Gang Zhao, Y. J. Mo, K. L. He, C. Hu, X. F. Wang, C. F. Redmer, Xiaocong Ai, T. C. Zhao, L. L. Jiang, Z. P. Mao, D. Li, R. E. Mitchell, X. Tang, B. Wang, M. Z. Wang, Q. M. Ma, S. L. Zang, Xiao-Tong Lu, A. Zallo, J. P. Dai, Jinxing Zheng, T. Hu, H. P. Cheng, J. Fang, Tao Li, C. H. Li, Y. B. Chen, D. Xiao, Xiaofeng Zhu, J. Z. Zhang, X. C. Chen, Y. P. Chu, X. L. Kang, A. Sarantsev, B. Kloss, X. Y. Niu, T. Guo, X. B. Ji, M. Qi, D. H. Wei, P. R. Li, J. S. Lange, Q. W. Zhao, W. B. Yan, G. S. Huang, H. L. Ma, X. T. Huang, Y. Yuan, C. Z. Yuan, Y. S. Zhu, Serkant Ali Cetin, D. M. Li, G. Rong, M. G. Zhao, M. N. Achasov, C. Geng, Qun-Yao Wang, S. Pacetti, Q. L. Xiu, Z. Ning, Zhiyong Zhang, M. Pelizaeus, Xuantong Zhang, M. Kavatsyuk, Guangming Huang, Liqing Xu, S. H. Zhang, X. Y. Shen, X. Q. Li, K. Moriya, J. B. Jiao, Z. Wu, Y. P. Guo, Xichao Ruan, Ke Li, M. Greco, R. Baldini Ferroli, N. Wu, Krisztian Peters, Zhiqing Zhang, Z. P. Zhang, M. H. Gu, B. X. Zhang, H. Y. Sheng, C. X. Yu, B. Zheng, R. G. Ping, Zujian Wang, Feng Liu, M. Ablikim, K. Y. Liu, Z. B. Li, X. H. Zhao, S. Qian, Q. An, Jialun Ping, S. L. Olsen, R. A. Briere, X. Y. Zhang, Chi Zhang, X. S. Jiang, M. Lara, Y. J. Sun, X. Zhou, I. Tapan, Y. H. Yan, J. W. Zhao, D. Cronin-Hennessy, Y. C. Zhu, E. Boger, T. Held, D. J. Ambrose, O. Cakir, E. Prencipe, W. D. Li, Cui Li, Shan Wang, G. S. Varner, Magnus Wolke, Y. F. Liang, D. P. Jin, A. Calcaterra, Z. G. Zhao, Dayong Wang, P. L. Liu, Y. J. Mao, H. X. Yang, L. Huang, H. H. Zhang, Andrzej Kupsc, Z. J. Sun, H. Loehner, W. L. Yuan, M. L. Chen, I. Uman, Huihui Liu, J. P. Liu, H. B. Li, A. G. Denig, C. L. Luo, M. Ullrich, Z. J. Xiao, J. G. Messchendorp, C. C. Zhang, B. Zhong, L. B. Guo, H. Muramatsu, Ulrich Wiedner, M. Kornicer, Qiunan Xu, T. Ma, J. C. Li, A. Q. Guo, J. Zhuang, M. X. Luo, Jian Wei, Yucheng Huang, D. V. Dedovich, W. M. Song, M. Leyhe, Z. H. Qin, Chuan Liu, W. G. Li, S. Spataro, X. P. Xu, Lei Li, H. M. Liu, J. F. Hu, G. F. Cao, S. Ma, D. Toth, Tao Luo, J. V. Bennett, B. X. Yu, H. S. Chen, J. S. Huang, C. X. Liu, H. L. Dai, Igor Boyko, G. F. Xu, S. Jin, X. Y. Song, P. L. Wang, K. Goetzen, W. Kuehn, and F. A. Harris

Published
2020

30. Observation of a Charged Charmoniumlike Structure Zc(4020) and Search for the Zc(3900) in e+e−→π+π−hc

Author

H. B. Li, H. J. Lu, J. G. Lu, A. G. Denig, C. L. Luo, M. Werner, Y. Ding, C. C. Zhang, A. Q. Guo, B. Zhong, L. B. Guo, X. Liu, B. J. Liu, W. M. Song, Lei Li, M. Maggiora, Ling Zhao, P. L. Wang, X. L. Luo, F. E. Maas, T. Hu, Ulrich Wiedner, G. R. Lu, K. Goetzen, W. Kuehn, Y. P. Guo, Z. G. Wang, Lei Zhao, Z. Y. He, Z. L. Hou, M. Kornicer, T. Ma, M. Leyhe, Z. H. Qin, Yang Yang, Chuan Liu, T. Guo, Serkant Ali Cetin, H. Y. Zhang, Kai Liu, W. G. Li, Z. A. Zhu, S. Spataro, X. P. Xu, S. Schumann, G. F. Chen, H. M. Liu, X. L. Ji, S. P. Yu, J. F. Hu, G. F. Cao, Yao Wang, Y. H. Guan, Z. H. Wang, S. L. Olsen, J. Y. Zhang, Guangming Huang, S. B. Liu, Xichao Ruan, B. Spruck, R. A. Briere, E. H. Thorndike, Y. J. Mao, H. X. Yang, Yang Qin, Y. Nefedov, Huihui Liu, J. P. Liu, C. P. Shen, Z. Wu, G. Li, J. G. Messchendorp, A. Calcaterra, Z. G. Zhao, L. Q. Qin, M. H. Gu, X. S. Jiang, Qiunan Xu, C. F. Redmer, X. H. Mo, L. S. Wang, H. Y. Sheng, P. Friedel, D. Li, M. H. Ye, C. Z. Yuan, C. D. Fu, L. Huang, H. H. Zhang, C. Q. Feng, Y. X. Xia, J. P. Dai, S. Ma, S. Qian, Q. An, Jialun Ping, Y. K. Heng, X. R. Chen, Z. J. Sun, H. Loehner, C. X. Yu, O. Cakir, D. Toth, Y. G. Xie, Y. N. Gao, S. X. Du, Y. Zhang, Z. Y. Deng, X. Y. Zhang, A. Zallo, X. T. Huang, M. Lara, X. K. Zhou, G. Rong, Wei Wu, L. L. Wang, H. Cai, Tao Luo, Y. J. Sun, J. V. Bennett, B. Wang, J. C. Li, J. Zhuang, G. R. Liao, M. Kavatsyuk, Y. X. Yang, B. Zheng, R. G. Ping, Sanfeng Wu, Xingguo Li, X. Q. Li, Shan Wang, M. G. Zhao, M. Greco, M. X. Luo, Jian Wei, Yucheng Huang, J. S. Huang, F. A. Harris, C. Geng, D. V. Dedovich, Q. Liu, Z. A. Liu, B. X. Yu, L. H. Wu, J. B. Jiao, G. S. Huang, Y. F. Liang, C. X. Liu, D. P. Jin, J. Z. Bai, M. R. Shepherd, B. X. Zhang, F. F. Jing, Y. Z. Yang, Q. Zhao, Y. Z. Sun, L. Y. Dong, S. L. Zang, Y. Ban, P. Weidenkaff, G. S. Varner, Zhenli Xu, B. S. Zou, J. M. Bian, S. J. Zhao, Y. H. Zheng, Dayong Wang, W. Lai, Q. Ouyang, P. L. Liu, Y. P. Chu, K. Y. Liu, Z. B. Li, S. P. Wen, J. Q. Zhang, Feng Liu, G. F. Xu, Cong-Feng Qiao, O. Albayrak, S. S. Fang, Gang Zhao, L. G. Xia, X. B. Ji, N. Yu. Muchnoi, H. S. Chen, Q. P. Ji, W. M. Ding, C. S. Ji, A. A. Zafar, C. Hu, X. S. Qin, X. R. Zhou, J. L. Fu, S. Jin, X. L. Wang, Cheng Li, X. Tang, H. L. Dai, Igor Boyko, M. Ablikim, F. Li, Q. J. Xu, F. C. Ma, H. Liang, Xiao-Tong Lu, Y. B. Liu, Heng-Yun Ye, Y. H. Zhang, I. B. Nikolaev, Y. F. Wang, G. A. Chelkov, K. H. Rashid, M. Shao, Y. T. Gu, J. C. Chen, C. B. Zhang, Xuanhong Lou, D. X. Lin, Nasser Kalantar-Nayestanaki, Q. G. Wen, W. L. Yuan, H. L. Ma, Alexey Zhemchugov, H. M. Hu, D. M. Li, Q. J. Li, H. W. Yu, Y. T. Liang, Jie Yu, M. L. Chen, X. K. Chu, X. Y. Song, S. H. Zhang, X. Y. Shen, Ke Wang, H. Muramatsu, T. Hussain, C. Morales Morales, X. Y. Ma, H. Moeini, W. X. Gong, Z. Y. Wang, S. J. Chen, O. Bondarenko, M. Pelizaeus, A. Sarantsev, D. H. Wei, P. R. Li, V. V. Bytev, T. J. Min, K. J. Zhu, J. S. Lange, Fenfen An, I. Uman, Xuantong Zhang, T. C. Zhao, K. Moriya, J. W. Zhang, Zhenghao Zhang, Q. A. Malik, Qun-Yao Wang, W. C. Yan, Q. L. Xiu, Zhiyong Zhang, LiLi Zhang, Zhiqiang Liu, Miao He, C. H. Li, Y. L. Han, R. Baldini Ferroli, S. Braun, R. Poling, J. F. Qiu, Jianping Zheng, L. Fava, L. P. Zhou, X. N. Li, M. Lv, Haiping Peng, Z. Xue, Z. P. Mao, M. Destefanis, P. Larin, H. P. Cheng, J. Fang, N. Wu, Krisztian Peters, X. F. Wang, Q. M. Ma, K. Li, Fang Liu, B. Kloss, I. Denysenko, Y. Yuan, B. Y. Zhang, Y. S. Zhu, W. B. Yan, M. N. Achasov, S. Pacetti, M. Y. Dong, H. B. Liu, J. H. Zou, O. Fuks, S. S. Sun, Jürgen Becker, R. E. Mitchell, L. L. Jiang, Zhiqing Liu, Y. B. Zhao, J. F. Chang, W. Shan, Y. Q. Wang, S. Nisar, X. Cai, X. R. Li, C. J. Tang, Y. P. Lu, Z. Ning, M. Bertani, Z. P. Zhang, J. W. Park, Zujian Wang, W. Gradl, M. Ripka, X. H. Zhao, Chi Zhang, D. Y. Wang, M. Qi, G. X. Sun, Li Yan, Z. Jiao, Fu-Hu Liu, D. H. Zhang, J. Min, B. Kopf, N. Li, K. L. He, M. Z. Wang, J. F. Sun, Y. Zeng, Zhe Sun, Y. B. Chen, Xiaofeng Zhu, J. Z. Zhang, X. Zhou, I. Tapan, Y. H. Yan, J. W. Zhao, D. Cronin-Hennessy, Y. C. Zhu, E. Boger, T. Held, D. J. Ambrose, E. Prencipe, W. D. Li, Cui Li, M. Ullrich, and Z. J. Xiao

Subjects
Physics, Structure (category theory), Atomic physics, Zc(3900)
Published
2020

31. Relationship between Wound Age and Serum Marker Metabolites of Rats Skin Incised Wound

Author

T, Tian, X R, Li, H J, Zhai, X D, Zhang, M, Li, and M, Liu

Subjects
Rats, Sprague-Dawley, Animals, Metabolomics, Biomarkers, Gas Chromatography-Mass Spectrometry, Rats, Skin
Abstract

Objective To observe the metabolomics changes of serum after skin incision of rats and to determine the wound age of skin incision. Methods A rat skin incision model was established, 21 SD rats were divided into 1 h, 2 h, 4 h, 8 h, 16 h, 24 h after skin incision groups and the control group, then blood was taken from rats in the experimental groups at the corresponding time points after injury, and taken from the control group directly. Gas chromatography-mass spectrometry （GC-MS） technology was used to detect serum metabolites and screen marker metabolites, then orthogonal partial least square-discriminant analysis （OPLS-DA） model was used to establish a regression model for the relationship between marker metabolite content and wound age to determine wound age of skin. Results GC-MS was used to detect the serum collected, and 21 marker metabolites were obtained through initial screening, and 4 marker metabolites were further analyzed and screened using multivariate statistical analysis methods. There was no correspondence between the change rule of the serum content and wound age, therefore it cannot be used directly to determine wound age. OPLS model could be used to obtain regression models of the content and wound age of 21 marker metabolites and 4 marker metabolites, both of which can determine wound age, but the prediction accuracy of the regression model of 21 marker metabolites was significantly higher. Conclusion Using metabolomics to establish a regression model of the metabolite content and wound age has the potential to be applied to skin incision wound age determination.大鼠皮肤切创损伤时间与血清标志代谢物的关系.目的 观察大鼠皮肤切创后血清代谢组学变化情况，推断皮肤切创的损伤时间。 方法 建立大鼠皮肤切创模型，将21只SD大鼠分为切创后1、2、4、8、16、24 h组和对照组，实验组大鼠于伤后相应时间点取血，对照组直接取血。使用气相色谱-质谱联用（gas chromatography-mass spectrometry，GC-MS）技术检测血清代谢物并筛选标志代谢物，采用正交偏最小二乘-判别分析（orthogonal partial least square-discriminant analysis，OPLS-DA）模式建立标志代谢物含量与损伤时间关系的回归模型，对皮肤切创损伤时间进行推断。 结果 使用GC-MS对所取血清进行检测，初筛得到21种标志代谢物，使用多元统计分析筛选出4种标志代谢物，其含量的变化规律与损伤时间之间无对应关系，不能直接用于损伤时间推断。使用OPLS模式可得到21种标志代谢物和4种标志代谢物的含量与损伤时间的回归模型，两者均可对损伤时间进行推断，但21种标志代谢物的回归模型预测准确性明显更高。 结论 利用代谢组学方法建立代谢物含量与损伤时间的回归模型，有望应用于皮肤切创的损伤时间推断。.法医病理学；代谢组学；创伤和损伤；代谢物；损伤时间推断；回归模型；大鼠.

Published
2020

32. [The treatment proposal for the patients with breast diseases in the central epidemic area of 2019 coronavirus disease]

Author

L, Zhao, L, Zhang, J W, Liu, Z F, Yang, W Z, Shen, and X R, Li

Subjects
Coronavirus, Betacoronavirus, Breast Diseases, China, Cross Infection, Infection Control, Infectious Disease Transmission, Patient-to-Professional, SARS-CoV-2, Pneumonia, Viral, COVID-19, Humans, Coronavirus Infections, Pandemics
Abstract

Currently, the epidemic of 2019 coronavirus disease (COVID-19) is still ongoing. Its characteristics include high contagiousness, herd susceptibility and clinical phenotype diversity, which have a severe influence on people's daily life and rountine therapy for other diseases. Breast dieases are clinical common diseases. In the central epidemic area of COVID-19, the clinical specialists of breast diseases should consider all of the following factors comprehensively: the prevention of COVID-19, the diagnosis and treatment of breast diseases and the accessibility of medical resources. Besides, we should select the appropriate therapy and optimize treatment process so as to prevent the propagation and cross infection of COVID-19 as well as manage the breast diseases without delay. Therefore, we carried out some management proposals of the patients with breast diseases in the central epidemic area during the epidemic of COVID-19 on the basis of conventional treatment guidelines and clinical experiences. The suggestions and corrections from colleagues will be welcomed.新型冠状病毒肺炎传染力强，人群易感性高，临床表现多样化，严重影响了群众正常的工作和生活，也影响了其他疾病的正常诊疗。乳腺疾病是临床常见病、多发病。在疫情严重地区，乳腺专科医师需要全面考虑疫情防控、疾病诊疗和医疗资源可及性等因素，合理选择诊疗方案，优化诊治流程；既避免新型冠状病毒肺炎的传播和交叉感染，也不延误疾病诊治。为此，我们依据相关诊疗规范和指南，结合实际工作经验，就疫情严重地区乳腺疾病诊疗问题提出有关策略建议。.

Published
2020

34. Prevalence and genetic features of hepatitis E virus in swine, in Gansu, China

Author

Y. S. Liu, Qiuwei Pan, X. Lan, Y. N. Wang, J. H. Zhou, X. R. Li, and Gastroenterology & Hepatology

Subjects
0301 basic medicine, China, Genotype, Swine, Prevalence, Biology, medicine.disease_cause, Feces, Open Reading Frames, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Hepatitis E virus, Virology, Genetic variation, medicine, Animals, ORFS, Phylogeny, Swine Diseases, Genetics, Genetic diversity, Genetic Variation, General Medicine, Hepatitis E, medicine.disease, 030104 developmental biology, Infectious Diseases, Codon usage bias
Abstract

The prevalence of hepatitis E virus (HEV) in domestic swine threats the public health, due to the risk of zoonotic transmission. In this study, we investigated the prevalence and genetic features of HEV in swine, in Gansu, which is geographically an important province in China. 377 fecal samples were collected from pig farms in Gansu province of China and tested for HEV RNA by RT-PCR. The prevalence rate is about 23% in pig farms of Gansu province. By RT-nPCR, 5' and 3' RACE methods, a whole genome with 7,284 nt in length, termed as swCH189, was obtained and investigated by nucleotide, codon and amino acid usage analyses. Phylogenetic tree analysis classified swCH189 strain into genotype 4e. Although this subtype has never been reported in the local population, genotype 4 is known as zoonotic and more pathogenic than other genotypes. According to the synonymous codon usage patterns of the three open reading frames (ORFs) of swCH189, compositional constraint mainly influences usage patterns of synonymous codons with A-end, while natural selections dominate in usage patterns of synonymous codons with G, C and U-ends. Genetic diversities of each ORFs, in respect to codon and amino acid usage patterns, are closely related to other members of genotype 4 in general, but with distinct features. Thus, the prevalence rate and the genetic features of HEV determined by this study are important for the prevention of zoonotic transmission of HEV from swine to human in this region as well as in China.

Published
2018

35. Characterization of bactericidal efficiency, cell selectivity, and mechanism of short interspecific hybrid peptides

Author

X. Y. Xu, Zhongyu Li, Yinfeng Lv, J L Wang, X. R. Li, Na Dong, and A. S. Shan

Subjects
0301 basic medicine, Cell Membrane Permeability, Erythrocytes, Nematoda, Swine, 030106 microbiology, Clinical Biochemistry, Antimicrobial peptides, Peptide, Microbial Sensitivity Tests, Biochemistry, Flow cytometry, 03 medical and health sciences, Cathelicidins, Gram-Negative Bacteria, medicine, Animals, Humans, Amino Acid Sequence, chemistry.chemical_classification, medicine.diagnostic_test, biology, Circular Dichroism, Organic Chemistry, medicine.disease, biology.organism_classification, Antimicrobial, Hemolysis, Anti-Bacterial Agents, Rats, 030104 developmental biology, Membrane, chemistry, Drug Design, Indolicidin, Peptides, Bacteria, Antimicrobial Cationic Peptides
Abstract

Facing rising global antibiotics resistance, physical membrane-damaging antimicrobial peptides (AMPs) represent promising antimicrobial agents. Various strategies to design effective hybrid peptides offer many advantages in overcoming the adverse effects of natural AMPs. In this study, hybrid peptides from different species were investigated, and three hybrid antimicrobial peptides, LI, LN, and LC, were designed by combining the typical fragment of human cathelicidin-derived LL37 with either indolicidin, pig nematode cecropin P1 (CP-1) or rat neutrophil peptide-1 (NP-1). In an aqueous solution, all hybrid peptides had an unordered conformation. In simulated membrane conditions, the hybrid peptide LI displayed more β-turn and β-hairpin structures, whereas LN and LC folded into α-helix structures. The three interspecific hybrid peptides LI, LN, and LC exhibited different levels of antimicrobial activity against Gram-positive and Gram-negative bacteria. LI demonstrated the highest antimicrobial activity and cell selectivity. The results of the swimming motility indicated that LI repressed bacterial motility in a concentration-dependent method. Endotoxin binding assay demonstrated that hybrid peptide LI conserved the binding ability to LPS (polyanionic lipopolysaccharides) of its parental peptides. Fluorescence assays, flow cytometry, and SEM further revealed that hybrid peptide LI acted through different bacteriostatic mechanisms than LL37 and indolicidin and that LI killed bacterial cells via membrane damage. In summary, this study demonstrated that hybrid peptide LI produced by interspecific hybrid synthesis possessed strong cell selectivity and is a promising therapeutic candidate for drug-resistant bacteria infection.

Published
2017

36. Observation of New Resonant Structures inγγ→ωϕ,ϕϕ, andωω

Author

Z. Q. Liu, C. P. Shen, C. Z. Yuan, T. Iijima, I. Adachi, H. Aihara, D. M. Asner, V. Aulchenko, T. Aushev, A. M. Bakich, K. Belous, V. Bhardwaj, B. Bhuyan, M. Bischofberger, A. Bondar, A. Bozek, M. Bračko, T. E. Browder, M.-C. Chang, P. Chang, A. Chen, P. Chen, B. G. Cheon, R. Chistov, I.-S. Cho, K. Cho, S.-K. Choi, Y. Choi, J. Dalseno, Z. Doležal, Z. Drásal, S. Eidelman, D. Epifanov, J. E. Fast, V. Gaur, N. Gabyshev, A. Garmash, Y. M. Goh, J. Haba, K. Hayasaka, H. Hayashii, Y. Horii, Y. Hoshi, W.-S. Hou, Y. B. Hsiung, H. J. Hyun, K. Inami, A. Ishikawa, R. Itoh, M. Iwabuchi, Y. Iwasaki, T. Iwashita, T. Julius, J. H. Kang, T. Kawasaki, C. Kiesling, H. J. Kim, H. O. Kim, J. B. Kim, K. T. Kim, M. J. Kim, Y. J. Kim, B. R. Ko, S. Koblitz, P. Kodyš, S. Korpar, P. Križan, P. Krokovny, T. Kumita, A. Kuzmin, Y.-J. Kwon, J. S. Lange, S.-H. Lee, J. Li, X. R. Li, Y. Li, J. Libby, C. Liu, D. Liventsev, R. Louvot, D. Matvienko, S. McOnie, K. Miyabayashi, H. Miyata, Y. Miyazaki, R. Mizuk, G. B. Mohanty, A. Moll, T. Mori, N. Muramatsu, R. Mussa, Y. Nagasaka, E. Nakano, M. Nakao, H. Nakazawa, C. Ng, S. Nishida, K. Nishimura, O. Nitoh, T. Nozaki, S. Ogawa, T. Ohshima, S. Okuno, S. L. Olsen, Y. Onuki, P. Pakhlov, G. Pakhlova, C. W. Park, H. K. Park, T. K. Pedlar, R. Pestotnik, M. Petrič, L. E. Piilonen, M. Ritter, M. Röhrken, S. Ryu, H. Sahoo, K. Sakai, Y. Sakai, T. Sanuki, Y. Sato, O. Schneider, C. Schwanda, R. Seidl, K. Senyo, M. E. Sevior, M. Shapkin, V. Shebalin, T.-A. Shibata, J.-G. Shiu, B. Shwartz, A. Sibidanov, F. Simon, P. Smerkol, Y.-S. Sohn, A. Sokolov, E. Solovieva, S. Stanič, M. Starič, T. Sumiyoshi, G. Tatishvili, Y. Teramoto, M. Uchida, S. Uehara, T. Uglov, Y. Unno, S. Uno, P. Urquijo, G. Varner, A. Vinokurova, V. Vorobyev, C. H. Wang, P. Wang, X. L. Wang, M. Watanabe, Y. Watanabe, K. M. Williams, E. Won, Y. Yamashita, Y. Yusa, C. C. Zhang, Z. P. Zhang, V. Zhilich, and V. Zhulanov

Published
2012
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37. Clinical analysis of 95 cases with ovarian pregnancy

Author

Lili Shan, X Y Dai, Z H Wang, X R Li, Xiao T, and Aiwen Le

Subjects
Abdominal pain, Pregnancy, medicine.medical_specialty, medicine.diagnostic_test, Ectopic pregnancy, business.industry, Obstetrics and Gynecology, Abortion, medicine.disease, Surgery, Menopause, Reproductive Medicine, medicine, Ovarian pregnancy, Vaginal bleeding, medicine.symptom, Laparoscopy, business
Abstract

Background Ovarian pregnancy (OP) is a rare ectopic pregnancy, in which it is very difficult to achieve preoperative diagnosis. Ovarian blood supply in OP increases which will lead to intra-abdominal bleeding, hazarding women's lives. Surgical exploration should be conducted once cases of OP are suspected. Objective To investigate clinical characteristics, diagnosis, and therapy of OP. Materials and methods A retrospective study was conducted in 95 patients with OP admitted to the present hospital from January 2005 to June 2014. Results OP accounted for 1.79% of ectopic pregnancy over the same period, of which 68.4% had a history of artificial abortion, 6.3% was treated with intrauterine contraceptive device (IUD), 87.4% had abdominal pain, 84.2% had a history of menopause, and 51.6% had vaginal bleeding. All patients had no preoperative diagnosis and underwent laparoscopic wedge resection of ovary or lesionectomy and were all were cured. Conclusion Since the cause of OP is still unknown and it has no typical clinical manifestations, the present authors adopt blood P-hCG combined with B-ultrasound to improve the preoperative diagnosis. They prefer laparoscopic wedge resection of ovary or lesionectomy, which induce higher rate of intrauterine pregnancy and lower rates of ectopic pregnancy and infertility in re-pregnancy after surgery.

Published
2016

38. [Pleural amoebic empyema: a case report]

Author

X Q, Han, M Y, Zhang, Y, Wu, J W, Wang, C L, Yu, Q B, Li, L, Yuan, X R, Li, and A Y, Dong

Subjects
Humans, Empyema, Pleural
Abstract

In this paper, a case of pleural amoebic empyema and its diagnosis and treatment were reported.

Published
2019

41. Research on Minimum Schedulable Power Optimization of CCHP System

Author

J. M. Liu, K. Zhang, and X. R. Li

Subjects
Electrical load, business.industry, Computer science, 020209 energy, 020208 electrical & electronic engineering, Scheduling (production processes), 02 engineering and technology, Automotive engineering, Power optimization, Power (physics), 0202 electrical engineering, electronic engineering, information engineering, Gas engine, Energy supply, Microgrid, Electricity, business
Abstract

In this paper, a dynamic optimal setting method of schedulable minimum power for combined cooling, heating and power (CCHP) system is proposed, which aims at maximizing the energy utilization of gas engine in CCHP microgrid. Firstly, according to the short-term energy supply demand of cold/heat/electricity load under isolated grid, a hierarchical scheduling strategy is developed for the CCHP microgrid. Based on the dispatching strategy, the method of setting the minimum dispatching power of the CCHP microgrid is improved. The minimum dispatching power of the CCHP microgrid is dynamically adjusted according to the energy supply situation in different periods to ensure that the gas engine always operates in the most efficient state, making full use of the energy of the gas engine to supply electric load, while maximizing the output of cold/heat energy. Through the example analysis, the method proposed in this paper realizes the maximum utilization of electric/cold/heat of gas engine, and verifies the effectiveness of the method.

Published
2019

43. Geometrical reconstruction of fluorescence events observed by the LHAASO experiment *

Author

F. Aharonian, Q. An, null Axikegu, L. X. Bai, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, H. Cai, J. T. Cai, Z. Cao, J. Chang, J. F. Chang, X. C. Chang, B. M. Chen, J. Chen, L. Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, X. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, null Danzengluobu, D. della Volpe, B. D'Ettorre Piazzoli, X. J. Dong, J. H. Fan, Y. Z. Fan, Z. X. Fan, J. Fang, K. Fang, C. F. Feng, L. Feng, S. H. Feng, Y. L. Feng, B. Gao, C. D. Gao, Q. Gao, W. Gao, M. M. Ge, L. S. Geng, G. H. Gong, Q. B. Gou, M. H. Gu, J. G. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, H. H. He, H. N. He, J. C. He, S. L. He, X. B. He, Y. He, M. Heller, Y. K. Hor, C. Hou, X. Hou, H. B. Hu, S. Hu, S. C. Hu, X. J. Hu, D. H. Huang, Q. L. Huang, W. H. Huang, X. T. Huang, Z. C. Huang, F. Ji, X. L. Ji, H. Y. Jia, K. Jiang, Z. J. Jiang, C. Jin, D. Kuleshov, K. Levochkin, B. B. Li, C. Li, F. Li, H. B. Li, H. C. Li, H. Y. Li, J. Li, K. Li, W. L. Li, X. Li, X. R. Li, Y. Li, Y. Z. Li, Z. Li, E. W. Liang, Y. F. Liang, S.J. Lin, B. Liu, C. Liu, D. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, J. S. Liu, J. Y. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. N. Liu, Z. X. Liu, W. J. Long, R. Lu, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, A. Masood, W. Mitthumsiri, T. Montaruli, Y. C. Nan, B. Y. Pang, P. Pattarakijwanich, Z. Y. Pei, M. Y. Qi, D. Ruffolo, V. Rulev, A. Sáiz, L. Shao, O. Shchegolev, X. D. Sheng, J. R. Shi, H. C. Song, Yu.V. Stenkin, V. Stepanov, Q. N. Sun, X. N. Sun, Z. B. Sun, P. H. T. Tam, Z. B. Tang, W. W. Tian, B. D. Wang, C. Wang, H. Wang, H. G. Wang, J. C. Wang, J. S. Wang, L. P. Wang, L. Y. Wang, R. N. Wang, W. Wang, X. G. Wang, X. J. Wang, X. Y. Wang, Y. D. Wang, Y. J. Wang, Y. P. Wang, Z. Wang, Z. H. Wang, Z. X. Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, S. Wu, W. X. Wu, X. F. Wu, S. Q. Xi, J. Xia, J. J. Xia, G. M. Xiang, G. Xiao, H. B. Xiao, G. G. Xin, Y. L. Xin, Y. Xing, D. L. Xu, R. X. Xu, L. Xue, D. H. Yan, C. W. Yang, F. F. Yang, J. Y. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, S. B. Yang, Y. H. Yao, Z. G. Yao, Y. M. Ye, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. D. Zeng, T. X. Zeng, W. Zeng, Z. K. Zeng, M. Zha, X. X. Zhai, B. B. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, J. W. Zhang, L. Zhang, L. X. Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. Zhang, Y. F. Zhang, Y. L. Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, F. Zheng, Y. Zheng, B. Zhou, H. Zhou, J. N. Zhou, P. Zhou, R. Zhou, X. X. Zhou, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, and X. Zuo

Subjects
Physics, Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Detector, Resolution (electron density), Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, Cosmic ray, 01 natural sciences, Fluorescence, law.invention, Telescope, Optics, law, 0103 physical sciences, Trajectory, Range (statistics), 010306 general physics, business, Instrumentation, Cherenkov radiation
Abstract

The LHAASO-WFCTA experiment, which aims to observe cosmic rays in the sub-EeV range using the fluorescence technique, uses a new generation of high-performance telescopes. To ensure that the experiment has excellent detection capability associated with the measurement of the energy spectrum, the primary composition of cosmic rays, and so on, an accurate geometrical reconstruction of air-shower events is fundamental. This paper describes the development and testing of geometrical reconstruction for stereo viewed events using the WFCTA (Wide Field of view Cherenkov/Fluorescence Telescope Array) detectors. Two approaches, which take full advantage of the WFCTA detectors, are investigated. One is the stereo-angular method, which uses the pointing of triggered SiPMs in the shower trajectory, and the other is the stereo-timing method, which uses the triggering time of the fired SiPMs. The results show that both methods have good geometrical resolution; the resolution of the stereo-timing method is slightly better than the stereo-angular method because the resolution of the latter is slightly limited by the shower track length.

Published
2021

44. Observation of the Crab Nebula with LHAASO-KM2A − a performance study *

Author

F. Aharonian, Q. An, 克古 Axikegu, L. X. Bai, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, H. Cai, J. T. Cai, Z. Cao, J. Chang, J. F. Chang, X. C. Chang, B. M. Chen, J. Chen, L. Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, X. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, 罗布 Danzengluobu, D. della Volpe, B. D'Ettorre Piazzoli, X. J. Dong, J. H. Fan, Y. Z. Fan, Z. X. Fan, J. Fang, K. Fang, C. F. Feng, L. Feng, S. H. Feng, Y. L. Feng, B. Gao, C. D. Gao, Q. Gao, W. Gao, M. M. Ge, L. S. Geng, G. H. Gong, Q. B. Gou, M. H. Gu, J. G. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, H. H. He, H. N. He, J. C. He, S. L. He, X. B. He, Y. He, M. Heller, Y. K. Hor, C. Hou, X. Hou, H. B. Hu, S. Hu, S. C. Hu, X. J. Hu, D. H. Huang, Q. L. Huang, W. H. Huang, X. T. Huang, Z. C. Huang, F. Ji, X. L. Ji, H. Y. Jia, K. Jiang, Z. J. Jiang, C. Jin, D. Kuleshov, K. Levochkin, B. B. Li, C. Li, F. Li, H. B. Li, H. C. Li, H. Y. Li, J. Li, K. Li, W. L. Li, X. Li, X. R. Li, Y. Li, Y. Z. Li, Z. Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, J. S. Liu, J. Y. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. N. Liu, Z. X. Liu, W. J. Long, R. Lu, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, A. Masood, W. Mitthumsiri, T. Montaruli, Y. C. Nan, B. Y. Pang, P. Pattarakijwanich, Z. Y. Pei, M. Y. Qi, D. Ruffolo, V. Rulev, A. Sáiz, L. Shao, O. Shchegolev, X. D. Sheng, J. R. Shi, H. C. Song, Yu. V. Stenkin, V. Stepanov, Q. N. Sun, X. N. Sun, Z. B. Sun, P. H. T. Tam, Z. B. Tang, W. W. Tian, B. D. Wang, C. Wang, H. Wang, H. G. Wang, J. C. Wang, J. S. Wang, L. P. Wang, L. Y. Wang, R. N. Wang, W. Wang, X. G. Wang, X. J. Wang, X. Y. Wang, Y. D. Wang, Y. J. Wang, Y. P. Wang, Z. Wang, Z. H. Wang, Z. X. Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, S. Wu, W. X. Wu, X. F. Wu, S. Q. Xi, J. Xia, J. J. Xia, G. M. Xiang, G. Xiao, H. B. Xiao, G. G. Xin, Y. L. Xin, Y. Xing, D. L. Xu, R. X. Xu, L. Xue, D. H. Yan, C. W. Yang, F. F. Yang, J. Y. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, S. B. Yang, Y. H. Yao, Z. G. Yao, Y. M. Ye, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. D. Zeng, T. X. Zeng, W. Zeng, Z. K. Zeng, M. Zha, X. X. Zhai, B. B. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, J. W. Zhang, L. Zhang, L. X. Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. Zhang, Y. F. Zhang, Y. L. Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, F. Zheng, Y. Zheng, B. Zhou, H. Zhou, J. N. Zhou, P. Zhou, R. Zhou, X. X. Zhou, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, and X. Zuo

Subjects
Physics, Nuclear and High Energy Physics, High energy, 010308 nuclear & particles physics, Cosmic distance ladder, Astronomy and Astrophysics, Astrophysics, 01 natural sciences, Crab Nebula, 0103 physical sciences, Energy spectrum, 010306 general physics, Instrumentation, Energy (signal processing)
Abstract

A sub-array of the Large High Altitude Air Shower Observatory (LHAASO), KM2A is mainly designed to observe a large fraction of the northern sky to hunt for γ-ray sources at energies above 10 TeV. Even though the detector construction is still underway, half of the KM2A array has been operating stably since the end of 2019. In this paper, we present the KM2A data analysis pipeline and the first observation of the Crab Nebula, a standard candle in very high energy γ-ray astronomy. We detect γ-ray signals from the Crab Nebula in both energy ranges of 10 100 TeV and 100 TeV with high significance, by analyzing the KM2A data of 136 live days between December 2019 and May 2020. With the observations, we test the detector performance, including angular resolution, pointing accuracy and cosmic-ray background rejection power. The energy spectrum of the Crab Nebula in the energy range 10-250 TeV fits well with a single power-law function dN/dE = (1.13 0.05 0.08 ) 10 (E/20 TeV) cm s TeV . It is consistent with previous measurements by other experiments. This opens a new window of γ-ray astronomy above 0.1 PeV through which new ultrahigh-energy γ-ray phenomena, such as cosmic PeVatrons, might be discovered.

Published
2021

45. Research on automatic aerodynamic optimization for a SUV based on RBF model

Author

L L Wu, X L Ma, X R Li, X B Bu, and Y Fu

Subjects
History, Drag coefficient, business.industry, Computer science, Automotive industry, Aerodynamics, Computer Science Applications, Education, Software, Design objective, Control theory, Drag, Windshield, business, Reduction (mathematics)
Abstract

Considering the continuous shortening of automobile R & D cycle, mathematical methods have been more used in automotive aerodynamic optimization design for their capability to fit the law and calculate the optimal results. In this paper, the deformation software, fluid analysis software and optimization software are connected to build an automatic aerodynamics optimization platform of automotive shape. Based on the RBF model, the automatic aerodynamic optimization for a SUV is completed with the front windshield angle, rear windshield angle, engine cover angle, approach angle and departure angle as design parameters and the drag coefficient as design objective. The drag coefficient of the optimal model is 9.40% lower than that of the initial model, and remarkable drag reduction effect is achieved.

Published
2020

46. Research on tire model parameter identification strategy based on CDTire/3D

Author

F. L. Gao, X. B. Bu, X. R. Li, N. Zhan, and Y. Wu

Subjects
History, Identification (information), Model parameter, Computer science, Data mining, computer.software_genre, computer, Computer Science Applications, Education
Abstract

High accuracy tire modeling is essential to study the automotive fatigue-durability, handling-stability, and NVH performance in the virtual proving ground. Compared with other tire models, CDTire/3D can be directly used in multi-body dynamics simulation, and its linearized version can be adopted in road noise analysis. In consideration of its high generality for cost saving, CDTire/3D has an extensive engineering application prospective in the automotive industry. It is the critical technique to accomplish high-efficiency and high-precision CDTire/3D modeling by investigating the mechanical mechanism of tire and the influence of parameters on all test conditions, based on which a parameter identification strategy is conducted in this paper. The effectiveness of the strategy is verified by a tire modeling case.

Published
2020

47. Bandgap calculation of shock-resistant metamaterials and evaluation of shockwave resistance

Author

Y. W. Ma, Zh G. Wang, X. R. Li, and G. H. Wang

Subjects
Physics::Fluid Dynamics, History, Materials science, business.industry, Band gap, Physics::Optics, Optoelectronics, Metamaterial, business, Computer Science Applications, Education, Shock (mechanics)
Abstract

Theoretical bandgap calculation and numerical simulations were carried out in order to evaluate the shockwave resistance of the structures made of metamaterials, specifically in real applications. Assuming that the microstructures of the shockwave-resistant metamaterials are the same as that of the phononic crystals, a bandgap calculation model was constructed based on the wave function and the Bloch theory. Besides, the bandgap calculations of certain specific structures were carried out. Using the Abaqus dynamic simulation analysis software, the shockwave resistance of specific metamaterial structures and ordinary steel plates were compared and analyzed in terms of their response to stress and displacement. Consequently, the shockwave resistance and the results of bandgap calculations of the metamaterials were verified. The results showed that the bandgap model, constructed for the metamaterials, is highly accurate and the metamaterials with the structures of photonic crystal were found to be more resistant to shockwave. This investigation can provide a theoretical reference for future structural designs of shockwave-resistant metamaterials.

Published
2020

49. Suppressing stathmin-l can inhibit chkl protein expression and reduce the invasion and tumorigenicity of cervical cancer cells

Author

Sh F, Kong, T, Lv, X, Sun, H, Yuan, J Y, Zhong, X R, Li, and S Zh, Dai

Subjects
Carcinogenesis, Genetic Vectors, Uterine Cervical Neoplasms, Mice, SCID, Mice, HEK293 Cells, Cell Movement, Lymphatic Metastasis, Checkpoint Kinase 1, Animals, Humans, Stathmin, Female, Neoplasm Invasiveness, RNA, Small Interfering, Neoplasm Transplantation, Cell Proliferation, HeLa Cells
Abstract

The purpose of this study was to evaluate the effects of stathmin-l on chkl protein expression in cervical cancer cells and the influ- ences on the cells' invasion and tumorigenicity. Suppressed stathmin-l expression in Hela cells and C33A cells by lentiviral vector were utilized. Real time PCR and Western blot were used to examine the expression of chkl. Cell proliferation and invasion were stud- ied using MTT assays and transwell migration assays.The differences of tumorigenicity in vivo were explored using xenograft experi- ments. In addition, stathmin-l expressions in 24 cervical cancer patients were studied without regional lymph nodes metastasis and 16 metastatic patients by immunohistochemistry assays and real time PCR. This study found downregulating stathmin-l reduced chkl ex- pressions and the proliferation and invasion in cervical cancer cells and reduced the tumorigenicity of tumor cells.

Published
2018

50. Clinical analysis of 95 cases with ovarian pregnancy

Author

A W, Le, Z H, Wang, L, Shan, X Y, Dai, T H, Xiao, and X R, Li

Subjects
Adult, Ovary, Abortion, Induced, Hemorrhage, Pregnancy, Ovarian, Young Adult, Pregnancy, Risk Factors, Humans, Chorionic Gonadotropin, beta Subunit, Human, Female, Laparoscopy, Uterine Hemorrhage, Intrauterine Devices, Retrospective Studies, Ultrasonography
Abstract

Ovarian pregnancy (OP) is a rare ectopic pregnancy, in which it is very difficult to achieve preoperative diagnosis. Ovarian blood supply in OP increases which will lead to intra-abdominal bleeding, hazarding women's lives. Surgical exploration should be conducted once cases of OP are suspected.To investigate clinical characteristics, diagnosis, and therapy of OP.A retrospective study was conducted in 95 patients with OP admitted to the present hospital from January 2005 to June 2014.OP accounted for 1.79% of ectopic pregnancy over the same period, of which 68.4% had a history of artificial abortion, 6.3% was treated with intrauterine contraceptive device (IUD), 87.4% had abdominal pain, 84.2% had a history of menopause, and 51.6% had vaginal bleeding. All patients had no preoperative diagnosis and underwent laparoscopic wedge resection of ovary or lesionectomy and were all were cured.Since the cause of OP is still unknown and it has no typical clinical manifestations, the present authors adopt blood P-hCG combined with B-ultrasound to improve the preoperative diagnosis. They prefer laparoscopic wedge resection of ovary or lesionectomy, which induce higher rate of intrauterine pregnancy and lower rates of ectopic pregnancy and infertility in re-pregnancy after surgery.

Published
2018

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