1. The interplay between X-chromosome functional dosage and circadian regulation in females.
- Author
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Moysés-Oliveira, Mariana, Andersen, Monica L., and Tufik, Sergio
- Subjects
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HYPOTHALAMUS physiology , *RESEARCH funding , *SEX distribution , *GENETIC markers , *INSOMNIA , *MENTAL illness , *FISHER exact test , *DESCRIPTIVE statistics , *DISEASE prevalence , *GENE expression , *CHROMOSOMES , *CIRCADIAN rhythms , *SLEEP , *WOMEN'S health , *COMPARATIVE studies , *SLEEP disorders - Abstract
Purpose: Biological factors and mechanisms that drive higher prevalence of insomnia in females are poorly understood. This study focused on the neurological consequences of X-chromosome functional imbalances between sexes. Methods: Benefited from publicly available large-scale genetic, transcriptional and epigenomic data, we curated and contrasted different gene lists: (1) X-liked genes, including assignments for X-chromosome inactivation patterns and disease associations; (2) sleep-associated genes; (3) gene expression markers for the suprachiasmatic nucleus. Results: We show that X-linked markers for the suprachiasmatic nucleus are significantly enriched for clinically relevant genes in the context of rare genetic syndromes and brain waves modulation. Conclusion: Considering female-specific patterns on brain transcriptional programs becomes essential when designing health care strategies for mental and sleep illnesses with sex bias in prevalence. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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