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子宫内膜异位症（内异症）是育龄期妇女的常见疾病之一，常导致患者生殖功能及卵巢储备功能降低，因此，在内异症诊治中应注意保护患者的生育力，改善生殖功能。依据患者年龄、内异症病变范围、内异症生育指数、卵巢储备功能及患者意愿等因素综合制定治疗策略；术前做好评估，术后积极备孕或辅助生殖技术；对于无生育需求者，通过药物治疗改善症状，控制病情进展，做好长期管理。对于一些病情严重或复发的内异症患者，可在术前进行生育力保存。.

Since April 2022, severe acute hepatitis of unknown origin in children has spread to 35 countries and regions around the world, and more than 1 010 cases have been reported. Since the severe acute hepatitis of unknown origin involves a wide range of areas and has a high rate, it is critical to identify the etiology and establish effective preventive, diagnostic and therapeutic measures as soon as possible. This study discusses the possible mechanisms and countermeasures of the severe acute hepatitis of unknown origin in children. It speculates that the occurrence of the recent severe acute hepatitis might be related to adenovirus, adeno-associated virus infection, and the COVID-19 epidemic, while the difference in HLA polymorphism among different races might be related to the fact that reported cases were more common in Europe and the United States. Based on the currently available evidence, it can be preliminarily judged that the risk of large-scale outbreak of severe acute hepatitis of unknown origin in children would be low in China, but the persistent awareness and vigilance of the etiology is still needed.2022年4月以来，不明原因儿童严重急性肝炎已蔓延全球35个国家和地区，共计1 010余例病例被相继报道。此次肝炎涉及地域较广且重症率较高，因此尽早锁定病因并建立有效的预防、诊断和治疗措施至关重要。本文讨论了近期不明原因儿童严重急性肝炎的可能病因和发病机制，并推测该病的发生可能与腺病毒、腺相关病毒感染及新型冠状病毒流行有关，而不同种族间HLA多态性的差异则可能与报告病例多见于欧美国家有关。根据目前的相关证据，可初步判定我国大规模暴发不明原因儿童严重急性肝炎的风险较低，但我们仍需提高对该病的认识和警惕，以积极准备应对策略。.

目的 探索慢性髓性白血病（CML）患者外周血样本的存储和运输对实时定量PCR（RQ-PCR）检测BCR-ABL（P210）转录本水平的影响。 方法 采集84例CML患者外周血样本，根据储存时间（0、6、12、24、48和72 h）、温度［室温（18～24 °C）和低温（2～8 °C）］以及振荡条件（振荡时长3、6和12 h）设置不同分组，RQ-PCR法检测不同条件下外周血样本BCR-ABL（P210）转录本水平。本研究将BCR-ABL拷贝数、ABL拷贝数和BCR-ABL（P210）转录本水平等原始数据进行对数转化（log10N）。 结果 ①琼脂糖凝胶电泳结果显示：室温条件下，储存48、72 h的样本RNA出现显著降解；②储存温度方面，总体样本中，室温储存48、72 h的样本BCR-ABL拷贝数检测水平显著低于低温储存的样本（P0.05）；③储存时间方面，与基线的3.35±1.60相比，总体样本的BCR-ABL拷贝数检测结果仅在室温储存储存下48 h（2.93±1.59）和72 h（2.79±1.42）显著下降（P0.05）；④振荡方面，与基线的−0.60±1.37相比，振荡3、6、12 h的样本BCR-ABL（P210）转录本水平检测结果无显著改变（P>0.05）。 结论 样本储存时间、储存温度及运输振荡因素可以影响BCR-ABL、ABL拷贝数的检测结果，但对BCR-ABL（P210）转录本水平定量检测结果无显著影响。

The current study aimed to investigate the efficacy and safety of carotid endarterectomy combined with endovascular therapy in hybrid operating room for patients with segmental atherosclerotic internal carotid artery occlusion, and share the experience of preoperative screening of patients suitable for vascular reconstruction. A total of 20 patients with internal carotid artery occlusion (ICAO) who were admitted to the Department of Neurosurgery, General Hospital of Tianjin Medical University from May 2018 to May 2020 were collected, and 15 patients met the inclusion criteria. All patients received hybrid surgery. The total success rate of recanalization was 14/15, and only 1 patient developed ICA re-occlusion at 1 year follow up.Therefore, carotid endarterectomy combined with endovascular treatment in hybrid operating room was an alternative treatment for patients with segmental atherosclerotic internal carotid artery occlusion.本研究主要探讨使用复合手术室行颈动脉内膜剥脱术联合血管内治疗对节段性动脉粥样硬化性颈内动脉闭塞患者的疗效，以及总结术前筛选适合接受血管重建的患者的经验。收集2018年5月至2020年5月天津医科大学总医院神经外科连续收治20例动脉粥样硬化性颈内动脉闭塞患者，15例患者符合纳入条件。患者全都接受复合手术治疗，并且血管重建成功率为14/15，术后1年随访时只有1人血管再次闭塞。因此，颈内动脉剥脱术联合血管内治疗的复合手术对于动脉粥样硬化性颈内动脉闭塞患者来说是一种可以选择的治疗方案。.

A series of novel porphyrin ligands and their zinc complexes with twelve long flexible chains have been synthesized and characterized by UV-Vis, IR, and 1H NMR spectra. Liquid-crystal properties of the compounds are studied by differential scanning calorimetry (DSC) and polarizing optical microscopy (POM). Absorption spectra, luminescence spectra and fluorescence lifetime of the products are determined.

Quick and correct prediction of the internal stress and deformation of stainless steel-clad plates on heat treatment is a problem of specific interest. A thermomechanical coupling model based on the engineering elastic-plastic theory is detailed. The discretization method and difference equations used simultaneously provide effective numerical calculations for the model. The generalized finite element model verifies relevant simplification conditions and efficiency of the numerical calculation logic. Heat treatment experiments of clad plates are also designed and presented, and the ability of the model to predict the stress and deformation behavior of the clad plate in the actual heat treatment process is evaluated. The calculation logic of the model is reasonable, and the prediction error of deformation and internal stress of the plate is ~15%. The model exhibits an extremely high computational efficiency and can meet the requirements of on-line analysis for heat treatment processes. Быстрое и точное прогнозирование внутреннего напряжения и кривизны деформации листов, плакированных нержавеющей сталью, при термообработке остается актуальной проблемой в этой области исследования. Рассматривается модель термомеханической связи листа, основанная на инженерной теории упругих и пластических деформаций. Для реализации эффективного численного расчета модели совместно используются метод дискретизации и разностные уравнения. Применение обобщенной конечноэлементной модели позволяет подтвердить соответствующие условия упрощения и рациональность логики численного расчета модели. Планируются и описываются эксперименты по термообработке таких плакированных листов и анализируется способность модели прогнозировать характер напряжения и деформации плакированного листа в реальном процессе термообработки. Логика расчета модели обоснована, при этом погрешность прогнозирования деформации и внутреннего давления листа составляет ~15%. Модель также имеет очень высокую вычислительную эффективность и может удовлетворять требованиям анализа в режиме он-лайн для процессов термообработки. Швидке і точне прогнозування внутрішніх напружень і кривизни деформації листів, плакованих нержавіючої сталлю, при термообробці залишається актуальною проблемою в цій області дослідження. Розглядається модель термомеханічного зв'язку листа, заснованої на інженерної теорії пружних і пластичних деформацій. Для реалізації ефективного чисельного розрахунку моделі спільно використовуються метод дискретизації і різницеві рівняння. Застосування узагальненої скінченноелементної моделі дозволяє підтвердити відповідні умови спрощення і раціональність логіки чисельного розрахунку моделі. Плануються і описуються експерименти по термообробці таких плакованих листів і аналізується здатність моделі прогнозувати характер напружень і деформації плакованного листа в реальному процесі термообробки. Логіка розрахунку моделі обгрунтована, при цьому похибка прогнозування деформації і внутрішнього тиску листа складає ~ 15%. Модель також має дуже високу обчислювальну ефективність і може задовольняти вимогам аналізу в режимі он-лайн для процесів термообробки.

Background: Neurological detrusor overactivity (NDO) is commonly associated with various neurogenic diseases. Botulinum toxin A (BTX-A) has been proposed as alternatives to traditional treatments. Objective: To summarize the clinical experience of nursing care for the treatment of the Botulinum toxin A (BTX-A) injections due to neurological detrusor overactivity (NDO). Methods: We reviewed the data of 32 inpatients who received BTX-A injections between August 2014 to July 2016. Their mean age was 27.4 years old (range: 19 - 38). They were all on clean intermittent catheterization. All patients presented detrusor overactivity resistant to oral anticholinergic treatment. Results: There were significant difference between outcomes at baseline and week12 for Pdetmax (60.08 cmH2O vs. 28.04 cmH2O, P < 0.001), VFIDC (165.55 ml vs. 276.07, P < 0.001), and urinary incontinence respectively. Prompt psychological counseling and nursing help reduce the patients’ passive psychology, enhance their confidence with good postoperative recovery and symptoms improvement. Conclusions: Patients were satisfied with the treatment and nursing by targeted perioperative nursing.

The study examined the skin histomorphology and biochemistry in mature ovariectomized rats treated and not treated with estrogen. Biochemical parameters (superoxide dismutase, malondialdehyde, and hydroxyproline content) were measured in dorsal skin samples collected in 50 days after surgery. The morphology of dorsal skin was analyzed under a microscope. In ovariectomized rats, the skin levels of superoxide dismutase and hydroxyproline were significantly lower, while the superoxide dismutase content was significantly higher than in shamoperated animals (p0.05). Estrogen therapy significantly increased the levels of superoxide dismutase and hydroxyproline and reduced superoxide dismutase level in ovariectomized rats in comparison with the corresponding parameters in untreated ovariectomized animals (p0.05). Histomorphological analysis of the skin from non-treated ovariectomized rats revealed reduced vascularization and lower density of papillary capillaries in comparison with these parameters in sham-operated controls; estrogen treatment prevented these changes. We concluded that ovariectomized rats can be employed as a model of aging skin in menopause.

An improved partially permeable crack model is put forward to deal with the problem of a single crack embedded in an orthotropic or isotropic material under combined unsymmetric thermal flux and symmetric linear mechanical loading. With the application of the Fourier transform technique (FTT), the thermoelastic field is given in a closed form. Numerical results show combined unsymmetric linear thermal flux, symmetric linear mechanical loading, and dimensionless thermal conductivity, and the coefficient has influences on fracture parameters. For the improved partially permeable crack, the mode II stress intensity factor and the energy release rate might be zero or positive under combined unsymmetric thermal flux and symmetric linear mechanical loading. Therefore, closure of the crack tip region need not be considered under combined unsymmetric thermal flux and symmetric linear mechanical loading when making use of fracture parameters as a criterion.

Long noncoding RNA (lncRNA) is emerging as a vital regulator in various tumors. However, the biological function of ZFPM2-antisense RNA 1 (ZFPM2-AS1) in hepatocellular carcinoma (HCC) remains unclear. The present study aims to explore the function and mechanism of ZFPM2-AS1 in hepatocellular carcinoma progression.The ZFPM2-AS1 expression in HCC cells and tissues was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Effects of ZFPM2-AS1 on tumor cell proliferation and invasion were detected by CCK8 assay or EdU assay or matrigel migration assay and Western blot. The Luciferase reporter assay, RNA pulldown assay, qRT-PCR, and Western blot were performed to explore and confirm the interaction between ZFPM2-AS1 and miR-1226-3p and integrin β1 (ITGB1).ZFPM2-AS1 was overexpressed in HCC tissues and cell lines. High levels of ZFPM2-AS1 were correlated with advanced TNM stage, distant metastasis and a poorer overall survival rate. ZFPM2-AS1 knockdown inhibited cell proliferation and invasion. ZFPM2-AS1 could directly bind to and negatively regulate miR-1226-3p expression. Moreover, ITGB1 was identified as a target gene of miR-1226-3p. ITGB1 was found to be directly negatively regulated by miR-1226-3p and indirectly upregulated by ZFPM2-AS1. Rescue assays demonstrated that ZFPM2-AS1 promotes HCC cell proliferation and invasion through modulating miR-1226/ITGB1 axis.ZFPM2-AS1 promotes cell proliferation and migration by regulating miR-1226-3p/ITGB1 axis in HCC.

Cross-flaws are very common in natural rocks. To date, the understanding of the failure process of rocks with cross-flaws is very limited. In this research, we study the influence of the c...

S100 proteins conduce to tumorigenesis and metastasis in a variety of ways, facilitating a local inflammatory environment for development and progression of tumors. However, the expression patterns and the precise roles of the S100 family members contributing to tumorigenesis and the progression of acute myeloid leukemia (AML) remain to be elucidated.Herein, the expression of S100 transcripts was analyzed in various tumor types in comparison to the normal controls using the ONCOMINE database, along with the corresponding expression profiles in the different subtypes of AML as retrieved from The Cancer Genome Atlas (TCGA) database. We used the Gene Expression Profiling Interactive Analysis (GEPIA) database to investigate the prognostic values of S100 mRNA expression in AML.Our results indicated that high expression of S100A4 mRNA was associated with poor overall survival (OS) (p=0.026), while that of S100P was correlated with a favorable OS in AML patients (p=0.028). Other members of the S100 family did not show any correlation to the survival. Moreover, the correlation between the expression levels of S100A4 and S100P and the clinical characteristics and methylation of AML patients was investigated. The results demonstrated that the promoter methylation level of S100A4 (p=0.002) and S100P (p=0.029) was higher in 61-80-years-old group as compared to the other age groups.Taken together, it can be deduced that S100A4 and S100P might be novel biomarkers and crucial prognostic factors for AML.

Objective To construct a polymerase chain reaction-capillary electrophoresis （PCR-CE） detection method using绿藻目的 利用绿藻法医病理学；法医遗传学；溺水；聚合酶链反应；毛细管电泳；蓝藻；绿藻；

Background Twenty-five percent of pediatric patients with inflammatory bowel disease (IBD) are diagnosed between the age of 16 and 18 years. They represent a unique challenge associated with the short follow-up time between diagnosis and transition to adult care. Aims The primary aim was to compare the current practices related to the transitional process in adolescents diagnosed before 16 years (early-adolescence (EA)) or after 16 years (late-adolescence (LA)). The secondary aim was to investigate clinical factors associated with age at transfer. Methods Patients diagnosed between 2013 and 2015, at the IBD clinic of CHU Sainte-Justine were included in the study. The date of transfer to adult care was defined as the date of the last visit in the pediatric unit. The factors associated with transition process and transfer included: disease type, disease severity at diagnosis and last pediatric visit, age at diagnosis, treatment group, disease burden (hospitalizations/relapses) and disease education. Results We included 144 patients (77 males; median (interquartile range (IQR) age at diagnosis 15.2(14.3–16.2) years; Crohn’s disease (N=98), ulcerative colitis (N=31) and IBD-unclassified (N=15). The median (IQR) duration of pediatric follow-up was 3.6 (2.7–4.1) years in the EA group as compared to 1.4 (1.0–1.8) yrs in the LA group; P< 0.01. While most of the patients completed the transition at a median (IQR) age of 18.0 (17.9–18.3) years, 15 % of patients were transferred at an older age (18.5 to 20 years). Overall, 75.7% were in remission, 13.9% with mild disease activity and 10.4% with moderate activity at the last pediatric visit. Patients with moderate activity at last pediatric visit tend to be transferred at an older age as compared to patients in remission or mild activity. The median (IQR) age were respectively 18.4 (18.2–19.1), 18.0 (17.9–18.1), 18.0 (17.9–18.3) years; P=0.024. There was a modest correlation between age at diagnosis and age at transfer (R = 0.22; P = 0.0068). Patients were transferred to adult gastroenterologists in academic hospitals (50.8%) or non-academic hospitals (43.1%). However, the disease activity at transfer was not associated with the adult care setting (academic vs non-academic). The number of relapses and hospitalizations during pediatric care were associated with older age at transfer: (> 18.5 yrs vs < 18.5 years): median(IQR) of 0.8(0.4–1.4) vs 0.3 (0.-0.6) for relapses; P=0.009 and 0.4 (0.0–1.1) vs 0.3 (0.0–0.7) for hospitalizations; P=0.009. Conclusions Pediatric IBD diagnosed at late adolescence tend to have more active disease and older age at transfer. Therefore, efforts to design a structured transitional care program are needed in order to improve transition outcomes for IBD patients with a special focus for subjects diagnosed in late adolescence. Funding Agencies CAG

Background The burden associated with the management of pediatric patients with inflammatory bowel disease (IBD) has been rising over the past years as the incidence of IBD is increasing in children. In addition, the widespread use of biologics and a treat-to-target approach also contributes to the increase of healthcare utilization. Aims The purpose of this study was to assess the health care services utilization and the associated factors in a prospective cohort of children diagnosed with IBD in Quebec. Methods Patients diagnosed from 2013 to 2015 and followed up until the transfer to adult care were identified in our IBD database. Data on IBD related services and treatments: imaging procedures, hospitalizations and outpatient visits, medications from diagnosis to transition was extracted. We analyzed the healthcare utilization according to the baseline disease severity (pediatric Crohn’s disease activity index (PCDAI) or pediatric ulcerative colitis activity index (PUCAI)) at diagnosis, and according to exposition to intravenous biologics. Results A total of 144 patients were included in the study [(77 males), Crohn’s disease (98), Ulcerative Colitis (31) and IBD-unclassified (15); median (interquartile(IQR)) age at diagnosis 15.2(14.3–16.3)]. The median(IQR) duration of follow up at the IBD clinic was 2.9 (1.8–3.9) years. The median (min-max) number of imaging procedures varied largely: esophagogastroduodenoscopy 1(0–2), Colonoscopy 1(1–6), abdominal ultrasound 1(0–13), abdominal MRI 1(0–4), tomodensitometry 0(0–2), Bone densitometry 1(0–5). Patients had various follow-up encounters (median (min-max)): outpatient visits 9 (1–28), IBD nurses phone follow-up 4(0–33). A total of 64.6% of patients had at least one hospitalization [median(min-max) number 1(0–10); median duration 4(0–150 days)] and 35.41% had at least one emergency room visit. Baseline disease severity did not predict the disease burden: the mean number of encounters was 3.0 /year in the moderate/severe group as compared to 2.5/year in the mild group; P= 0.61. Among the, 63.5% of patients exposed to an intravenous biologic (Infliximab or Vedolizumab), those exposed earlier ( Conclusions Adolescents with IBD have several encounters between the diagnosis and transition to adult care. Disease severity at diagnosis was not related to a higher level of health services utilization during follow-up. However, treatment with intravenous biologics was associated with a high health service utilization and school missing during follow-up. Funding Agencies None

Main text A key comparison of the standards for absorbed dose to water of the National Institute of Metrology (NIM), China, and the Bureau International des Poids et Mesures (BIPM) was carried out in the 60Co radiation beam of the BIPM in December 2021. The comparison result, based on the calibration coefficients for four transfer standards and evaluated as a ratio of the NIM and the BIPM standards for absorbed dose to water, is 1.0027 with a combined standard uncertainty of 3.6 parts in 103. The results are analysed and presented in terms of degrees of equivalence, suitable for entry in the BIPM key comparison database. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

To uncover the role of UPF1 in alleviating the progression of glioma via targeting long non-coding RNA (lncRNA) CYTOR and underlying mechanism.A total of 30 glioma tissues surgically resected from glioma patients and 30 brain tissues were collected from brain trauma patients undergoing craniotomy during the same period. Relative levels of UPF1 and CYTOR in collected tissues were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Correlation between levels of UPF1 and CYTOR in glioma tissues was assessed, and the regulatory effects of UPF1/CYTOR on proliferative and invasive abilities in U87 and LN229 cells were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) and transwell assay, respectively. In addition, the interaction between UPF1 and CYTOR was explored by RIP (RNA-Binding Protein Immunoprecipitation) assay. Through Actinomycin D treatment in U87 and LN229 cells, RNA stability of CYTOR influenced by UPF1 was determined. Finally, rescue experiments were conducted to ascertain the involvement of CYTOR in UPF1-regulated progression of glioma.UPF1 was downregulated in glioma tissues and cells. A lower level of UPF1 was observed in glioma tissues in the more advanced stage with a larger tumor size. Besides, the overexpression of UPF1 markedly suppressed proliferation and invasion abilities of U87 and LN229 cells, and CYTOR was upregulated in glioma tissues and cells, which was negatively correlated with UPF1 level. Moreover, the overexpression of UPF1 decreased the half-life of CYTOR in glioma cells. Furthermore, the RIP assay confirmed the interaction between UPF1 and CYTOR. Rescue experiments finally confirmed that the overexpression of CYTOR partially reversed the inhibitory effects of UPF1 on proliferation and invasion abilities in glioma.UPF1 is down-regulated in glioma and alleviates the progression of glioma via targeting CYTOR.

Increasing evidence has suggested that microRNAs (miRNAs) may function as positive regulators at the post-transcriptional level. A search for associations between miRNAs and diseases is crucial for understanding the pathogenesis. Various publicly available databases have been constructed to store meaningful information on a large number of miRNA molecules. In this study, to resolve the limitation that individual sources of miRNA target data tend to be incomplete and noisy, we propose a network-based computational method called self-weighting for integrating multiple data sources. A bipartite phenotype-miRNA network (BPMN) incorporates known disease-miRNA interactions as well as the similarities between disease phenotypes and functional similarities of miRNAs. Random walk with restart algorithm was deployed on the bipartite network to predict novel disease-miRNA associations. In leave-one-out cross-validation experiments, our technique achieves an AUC of 0.801 when evaluating against known disease-related miRNAs from HMDD. Systematic prioritization of miRNAs for 11 common diseases obtained an average AUC of 0.765. Additionally, a case study on colon cancer uncovered a number of potential miRNA candidates as biomarkers of this disease.

We aimed to explore the real experience of patients after liver transplantation in the intensive care unit (ICU).Objective sampling method was used to select patients transferred to the ICU in 10 hospitals in Zhuhai from May 2018 to August 2020. Patients need liver transplantation due to advanced liver cancer and decompensated cirrhosis. The eligibility criteria of patients mainly included liver transplant patients who were clear-minded and willing to participate in the study and had stayed in ICU. Phenomenological research methods and in-depth interviews were used in this qualitative study.The results showed that the true experience of patients after liver transplantation during ICU stay was summarized into four themes. The strengths of our qualitative research are that we can find the trend from a phenomenon through interviews and other methods to provide a directional foundation for future quantitative research. Its limitations are that it requires a lot of manpower and time, and its objectivity and universality are limited.Hospitalization experience in the ICU may lead to many negative experiences for liver transplant patients. Nurses should fully understand and pay attention to the psychological changes in patients. Nurses should take effective targeted measures to reduce or eliminate patients' fear of ICU stay and promote rehabilitation.

Background Twenty-five per cent of paediatric patients with inflammatory bowel disease (IBD) are diagnosed between the age of 16 and 18 years. They represent a unique challenge associated with the short follow-up time between diagnosis and transition to adult care. Methods The primary aim was to compare the current transitional process in adolescents diagnosed before 16 years (early-adolescence (EA)) or after 16 years (late-adolescence (LA)). The secondary aim was to investigate clinical factors associated with age at transfer. Patients diagnosed between 2013 and 2015, at the IBD clinic of CHU Sainte-Justine and followed up to the transfer to adult care were included in the study. The date of transfer to adult care was defined as the date of the last visit in the paediatric unit. The factors associated with the transition process and transfer included: disease type, disease severity at diagnosis and last paediatric visit, age at diagnosis, treatment group, disease burden (hospitalisations/relapses) and disease education. Results We included 144 patients (77 males; median (interquartile range (IQR) age at diagnosis 15.2 (14.3–16.2) years; CD (n = 98), UC (n = 31) and IBD-U (n = 15). The median (IQR) duration of paediatric follow-up was 3.6(2.7–4.1) years in the EA group when compared with 1.4 (1.0–1.8) years in the LA group; p < 0.01. While most of the patients completed the transition at a median (IQR) age of 18.0(17.9–18.3) years, 15 % of patients were transferred at an older age (18.5 to 20 years). Overall, 75.7% were in remission, 13.9% with mild disease activity and 10.4% with moderate activity at the last paediatric visit. Patients with moderate activity at last paediatric visit tend to be transferred at an older age as compared with patients in remission or mild activity. The median (IQR) age were, respectively, 18.4(18.2–19.1), 18.0(17.9–18.1), 18.0(17.9–18.3) years; p =0.024. There was a modest correlation between age at diagnosis and age at transfer (R = 0.22; p = 0.0068). Patients were transferred to adult gastroenterologists in academic hospitals (50.8%) or non-academic hospitals (43.1%). However, the disease activity at transfer was not associated with the adult care setting (academic vs. non-academic). The number of relapses and hospitalisations during paediatric care were associated with older age at transfer: (> 18.5 years vs. < 18.5 years): median(IQR) 0.8(0.4–1.4) vs. 0.3(0.−0.6) for relapses; p = 0.009 and 0.4(0.0–1.1) vs. 0.3(0.0–0.7) for hospitalisations; p = 0.009. Conclusion Paediatric IBD diagnosed at late adolescence tend to have more active disease and older age at transfer. Therefore, efforts to design a structured transitional care program are needed in order to improve transition outcomes for IBD patients with a special focus for subjects diagnosed in late adolescence.