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5 results on '"Wynne, Matthew David"'

1. A Non-Healing Lesion on the Anterior Chest of a Patient Receiving Hemodialysis: A Case Study

Author

Wynne, Matthew David and Shah, Manu

Subjects
Basal cell carcinoma -- Case studies -- Diagnosis, Hemodialysis patients -- Case studies, Skin lesions -- Case studies -- Diagnosis, Health
Abstract

Basal cell carcinoma is the most common type of skin cancer, and patients receiving hemodialysis are at increased risk of developing them. This article describes a case of a patient with a basal cell carcinoma in which the diagnosis was delayed due to the lesion masquerading as granulation tissue at the site of a previous tunnelled hemodialysis catheter. Early detection of basal cell carcinomas is important because delayed detection increases the risk of local invasion and the requirement for more complex surgical management. Key Words: Basal cell carcinoma, wound, hemodialysis., An 82-year-old man receiving hemodialysis was referred to Dermatology with a non-healing lesion on his right anterior chest wall. This arose at the precise site of his previous tunnelled hemodialysis [...]

Published
2022
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2. A Retrospective Review of Phototherapy in Children, at a Tertiary Paediatric Unit

Author

Seccombe, Ella, Wynne, Matthew David, Clancy, Cornelius, Godfrey, Keith M, and Fityan, Adam

Subjects
Male, integumentary system, Adolescent, England, Humans, Female, Phototherapy, skin and connective tissue diseases, Child, Skin Diseases, Article, Retrospective Studies
Abstract

PURPOSE: To examine the efficacy, tolerability and safety of phototherapy in children, in whom there is currently a paucity of data. METHOD: Retrospective review of children under 18 years who received narrowband UVB (NB-UVB), broadband UVB (BB-UVB) phototherapy or psoralen with UVA (PUVA) photochemotherapy between 2003-2017 at a tertiary Paediatric dermatology centre in Southampton, UK. RESULTS: 100 children aged 6-17 years were included. The majority of children had psoriasis (74), atopic dermatitis (10) or vitiligo (8), with others having rarer dermatoses. Grade 2 erythema or above occurred in 46% of all included children and 42% (36/86) of those receiving NB-UVB; however, grade 3 and 4 reactions were infrequent and only 3 children stopped treatment due to burning. NB-UVB was particularly effective in those with psoriasis; 55/65 (85%) significantly improved and 72% had not relapsed after 2 years. However, its effectiveness in atopic dermatitis was less convincing; in a small group of children 6/10 (60%) significantly improved, but 66% relapsed within 3 months. CONCLUSIONS: Our analysis demonstrates that NB-UVB is effective in children with psoriasis and vitiligo, with potential to achieve extended periods of remission in psoriasis. Its usefulness in atopic dermatitis is less clear. The long-term safety of NB-UVB in children is still unknown, but it appears to be a well-tolerated treatment and should be considered in children for a variety of inflammatory dermatoses before progressing to immunosuppressive therapies.

Published
2020

3. A retrospective review of phototherapy in children, at a tertiary paediatric dermatology unit

Author

Seccombe, Ella, Department, University Hospital Southampton, Wynne, Matthew David, Clancy, Cornelius, Godfrey, Keith, and Fityan, Adam

Subjects
medicine.medical_specialty, Erythema, Immunology, Narrow band uvb, Dermatology, Vitiligo, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Psoriasis, medicine, Immunology and Allergy, Radiology, Nuclear Medicine and imaging, Paediatric dermatology, skin and connective tissue diseases, Retrospective review, integumentary system, business.industry, General Medicine, Atopic dermatitis, medicine.disease, Tolerability, 030220 oncology & carcinogenesis, medicine.symptom, business
Abstract

Background/Purpose: To examine the efficacy, tolerability and safety of phototherapy in children, in whom there is currently a paucity of data. Materials and Methods: Retrospective review of children under 18 years who received narrowband UVB (NB-UVB), broadband UVB (BB-UVB) phototherapy or psoralen with UVA (PUVA) photochemotherapy between 2003 and 2017 at a tertiary Paediatric dermatology centre in Southampton, UK. Results: 100 children aged 6-17 years were included. The majority of children had psoriasis (74), atopic dermatitis (10) or vitiligo (8), with others having rarer dermatoses. Grade 2 erythema or above occurred in 46% of all included children and 42% (36/86) of those receiving NB-UVB; however, grade 3 and 4 reactions were infrequent and only 3 children stopped treatment due to burning. NB-UVB was particularly effective in those with psoriasis; 55/65 (85%) significantly improved, and 72% had not relapsed after 2 years. However, its effectiveness in atopic dermatitis was less convincing; in a small group of children, 6/10 (60%) significantly improved, but 66% relapsed within 3 months. Conclusions: Our analysis demonstrates that NB-UVB is effective in children with psoriasis and vitiligo, with potential to achieve extended periods of remission in psoriasis. Its usefulness in atopic dermatitis is less clear. The long-term safety of NB-UVB in children is still unknown, but it appears to be a well-tolerated treatment and should be considered in children for a variety of inflammatory dermatoses before progressing to immunosuppressive therapies.

Published
2020

5. A retrospective review of phototherapy in children, at a tertiary paediatric dermatology unit.

Author

Seccombe, Ella, Wynne, Matthew David, Clancy, Cornelius, Godfrey, Keith M., and Fityan, Adam

Subjects
*PHOTOTHERAPY, *DERMATOLOGY, *ATOPIC dermatitis, *SKIN diseases, *IMMUNOSUPPRESSIVE agents
Abstract

Background/Purpose: To examine the efficacy, tolerability and safety of phototherapy in children, in whom there is currently a paucity of data. Materials and Methods: Retrospective review of children under 18 years who received narrowband UVB (NB‐UVB), broadband UVB (BB‐UVB) phototherapy or psoralen with UVA (PUVA) photochemotherapy between 2003 and 2017 at a tertiary Paediatric dermatology centre in Southampton, UK. Results: 100 children aged 6‐17 years were included. The majority of children had psoriasis (74), atopic dermatitis (10) or vitiligo (8), with others having rarer dermatoses. Grade 2 erythema or above occurred in 46% of all included children and 42% (36/86) of those receiving NB‐UVB; however, grade 3 and 4 reactions were infrequent and only 3 children stopped treatment due to burning. NB‐UVB was particularly effective in those with psoriasis; 55/65 (85%) significantly improved, and 72% had not relapsed after 2 years. However, its effectiveness in atopic dermatitis was less convincing; in a small group of children, 6/10 (60%) significantly improved, but 66% relapsed within 3 months. Conclusions: Our analysis demonstrates that NB‐UVB is effective in children with psoriasis and vitiligo, with potential to achieve extended periods of remission in psoriasis. Its usefulness in atopic dermatitis is less clear. The long‐term safety of NB‐UVB in children is still unknown, but it appears to be a well‐tolerated treatment and should be considered in children for a variety of inflammatory dermatoses before progressing to immunosuppressive therapies. [ABSTRACT FROM AUTHOR]

Published
2021
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