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4. Left-ventricular unloading in extracorporeal cardiopulmonary resuscitation due to acute myocardial infarction – A multicenter study

Author

Thevathasan, Tharusan, primary, Kenny, Megan A., additional, Krause, Finn J., additional, Paul, Julia, additional, Wurster, Thomas, additional, Boie, Sebastian D., additional, Friebel, Julian, additional, Knie, Wulf, additional, Girke, Georg, additional, Haghikia, Arash, additional, Reinthaler, Markus, additional, Rauch-Kröhnert, Ursula, additional, Leistner, David M., additional, Sinning, David, additional, Fröhlich, Georg, additional, Heidecker, Bettina, additional, Spillmann, Frank, additional, Praeger, Damaris, additional, Pieske, Burkert, additional, Stangl, Karl, additional, Landmesser, Ulf, additional, Balzer, Felix, additional, and Skurk, Carsten, additional

Published
2023
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7. Case report: Refractory cardiac arrest supported with veno-arterial-venous extracorporeal membrane oxygenation and left-ventricular Impella CP®–Physiological insights and pitfalls of ECMELLA

Author

Thevathasan, Tharusan, primary, Füreder, Lisa, additional, Donker, Dirk W., additional, Nix, Christoph, additional, Wurster, Thomas H., additional, Knie, Wulf, additional, Girke, Georg, additional, Al Harbi, Abdulla S., additional, Landmesser, Ulf, additional, and Skurk, Carsten, additional

Published
2022
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10. Case report: Refractory cardiac arrest supported with veno-arterial-venous extracorporeal membrane oxygenation and left-ventricular Impella CP®–Physiological insights and pitfalls of ECMELLA

Author

Medische Staf Intensive Care, Other research (not in main researchprogram), Thevathasan, Tharusan, Füreder, Lisa, Donker, Dirk W., Nix, Christoph, Wurster, Thomas H., Knie, Wulf, Girke, Georg, Al Harbi, Abdulla S., Landmesser, Ulf, Skurk, Carsten, Medische Staf Intensive Care, Other research (not in main researchprogram), Thevathasan, Tharusan, Füreder, Lisa, Donker, Dirk W., Nix, Christoph, Wurster, Thomas H., Knie, Wulf, Girke, Georg, Al Harbi, Abdulla S., Landmesser, Ulf, and Skurk, Carsten

Published
2022

13. Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization

Author

Wurster, Thomas H, primary, Landmesser, Ulf, additional, Abdelwahed, Youssef S, additional, Skurk, Carsten, additional, Morguet, Andreas, additional, Leistner, David M, additional, Fröhlich, Georg, additional, Haghikia, Arash, additional, Engel, Leif Christopher, additional, Schuster, Andreas, additional, Noutsias, Michel, additional, Schulze, Daniel, additional, Hamm, Bernd, additional, Furth, Christian, additional, Brenner, Winfried, additional, Botnar, Rene M, additional, Bigalke, Boris, additional, and Makowski, Marcus R, additional

Published
2022
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15. Abstract 12405: Treatment With Impella and Veno-Arterial Extracorporeal Membrane Oxygenation During Extracorporeal Cardiopulmonary Resuscitation Improves Survival - A Multicenter Cohort Study

Author

Thevathasan, Tharusan, primary, Kenny, Megan, additional, Boie, Sebastian, additional, Wurster, Thomas, additional, Last, Jana, additional, Kalinowsky, Rene, additional, Landmesser, Ulf, additional, Balzer, Felix, additional, and Skurk, Carsten, additional

Published
2021
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17. The 1975 and 1976 operational zooplankton investigations relative to the Donald C. Cook Nuclear Power Plant, with tests for plant effects (1971-1976) /

Author

Evans, Marlene S., Hawkins, Bethany E., Wurster, Thomas E., University of Michigan. Great Lakes Research Division, University of Michigan (archive.org), Evans, Marlene S., Hawkins, Bethany E., Wurster, Thomas E., and University of Michigan. Great Lakes Research Division

Subjects
Donald C. Cook Nuclear Power Plant, Environmental aspects, Michigan, Lake, Nuclear power plants, Zooplankton
Published
1978

18. Imaging coronary plaques using 3D motion-compensated [18F]NaF PET/MR

Author

Mayer, Johannes, primary, Wurster, Thomas-Heinrich, additional, Schaeffter, Tobias, additional, Landmesser, Ulf, additional, Morguet, Andreas, additional, Bigalke, Boris, additional, Hamm, Bernd, additional, Brenner, Winfried, additional, Makowski, Marcus R., additional, and Kolbitsch, Christoph, additional

Published
2021
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20. Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures

Author

Engel, Leif-Christopher, primary, Landmesser, Ulf, additional, Abdelwahed, Youssef S., additional, Jaguszewski, Milosz, additional, Gigengack, Kevin, additional, Wurster, Thomas-Heinrich, additional, Skurk, Carsten, additional, Manes, Costantina, additional, Schuster, Andreas, additional, Noutsias, Michel, additional, Hamm, Bernd, additional, Botnar, Rene M., additional, Makowski, Marcus R., additional, and Bigalke, Boris, additional

Published
2020
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21. Strategy and the new economics of information

Author

Evans, Philip B. and Wurster, Thomas S.

Subjects
Distribution channels -- Forecasts and trends, Newspapers -- Forecasts and trends, Vertical integration -- Forecasts and trends, Information technology -- Appreciation -- Forecasts and trends, Banking industry -- Forecasts and trends, Newspaper publishing -- Forecasts and trends, Industrial suppliers -- Forecasts and trends, Commercial banks -- Forecasts and trends, Product management -- Forecasts and trends, Business, general, Business, Direct market channel, Information technology, Retail/reseller channel, Market trend/market analysis, Banking industry, Appreciation, Forecasts and trends
Abstract

A fundamental shift in the economics of information is under Way -- a shift that is less about any specific new technology than about the fact that a new behavior [...]

Published
1997

22. Impella versus IABP in acute myocardial infarction complicated by cardiogenic shock

Author

Alushi, Brunilda; https://orcid.org/0000-0002-0937-9999, Douedari, Andel, Froehlig, Georg, Knie, Wulf, Wurster, Thomas H, Leistner, David M, Staehli, Barbara-Elisabeth, Mochmann, Hans-Christian, Pieske, Burkert, Landmesser, Ulf, Krackhardt, Florian, Skurk, Carsten, Alushi, Brunilda; https://orcid.org/0000-0002-0937-9999, Douedari, Andel, Froehlig, Georg, Knie, Wulf, Wurster, Thomas H, Leistner, David M, Staehli, Barbara-Elisabeth, Mochmann, Hans-Christian, Pieske, Burkert, Landmesser, Ulf, Krackhardt, Florian, and Skurk, Carsten

Abstract

Objective We investigated the benefit of Impella, a modern percutaneous mechanical support (pMCS) device, versus former standard intra-aortic balloon pump (IABP) in acute myocardial infarction complicated by cardiogenic shock (AMICS). Methods This single-centre, retrospective study included patients with AMICS receiving pMCS with either Impella or IABP. Disease severity at baseline was assessed with the IABP-SHOCK II score. The primary outcome was all-cause mortality at 30 days. Secondary outcomes were parameters of shock severity at the early postimplantation phase. Adjusted Cox proportional hazards models identified independent predictors of the primary outcome. Results Of 116 included patients, 62 (53%) received Impella and 54 (47%) IABP. Despite similar baseline mortality risk (IABP-SHOCK II high-risk score of 18 % vs 20 %; p = 0.76), Impella significantly reduced the inotropic score (p < 0.001), lactate levels (p < 0.001) and SAPS II (p =0.02) and improved left ventricular ejection fraction (p = 0.01). All-cause mortality at 30 days was similar with Impella and IABP (52 % and 67 %, respectively; p = 0.13), but bleeding complications were more frequent in the Impella group (3 vs 4 units of transfused erythrocytes concentrates due to bleeding complications, p = 0.03). Previous cardiopulmonary resuscitation (HR 3.22, 95% CI 1.76 to 5.89; p < 0.01) and an estimated intermediate (HR 2.77, 95% CI 1.42 to 5.40; p < 0.01) and high (HR 4.32 95% CI 2.03 to 9.24; p = 0.01) IABP-SHOCK II score were independent predictors of all-cause mortality. Conclusions In patients with AMICS, haemodynamic support with the Impella device had no significant effect on 30-day mortality as compared with IABP. In these patients, large randomised trials are warranted to ascertain the effect of Impella on the outcome.

Published
2019

23. Imaging coronary plaques using 3D motion-compensated [18F]NaF PET/MR.

Author

Mayer, Johannes, Wurster, Thomas-Heinrich, Schaeffter, Tobias, Landmesser, Ulf, Morguet, Andreas, Bigalke, Boris, Hamm, Bernd, Brenner, Winfried, Makowski, Marcus R., and Kolbitsch, Christoph

Subjects
*POSITRON emission tomography, *CORONARY artery disease, *MAGNETIC resonance imaging, *RADIOACTIVE tracers, *INTRAVASCULAR ultrasonography, *LUNGS, *FOUR-dimensional imaging
Abstract

Background: Cardiac PET has recently found novel applications in coronary atherosclerosis imaging using [18F]NaF as a radiotracer, highlighting vulnerable plaques. However, the resulting uptakes are relatively small, and cardiac motion and respiration-induced movement of the heart can impair the reconstructed images due to motion blurring and attenuation correction mismatches. This study aimed to apply an MR-based motion compensation framework to [18F]NaF data yielding high-resolution motion-compensated PET and MR images. Methods: Free-breathing 3-dimensional Dixon MR data were acquired, retrospectively binned into multiple respiratory and cardiac motion states, and split into fat and water fraction using a model-based reconstruction framework. From the dynamic MR reconstructions, both a non-rigid cardiorespiratory motion model and a motion-resolved attenuation map were generated and applied to the PET data to improve image quality. The approach was tested in 10 patients and focal tracer hotspots were evaluated concerning their target-to-background ratio, contrast-to-background ratio, and their diameter. Results: MR-based motion models were successfully applied to compensate for physiological motion in both PET and MR. Target-to-background ratios of identified plaques improved by 7 ± 7%, contrast-to-background ratios by 26 ± 38%, and the plaque diameter decreased by −22 ± 18%. MR-based dynamic attenuation correction strongly reduced attenuation correction artefacts and was not affected by stent-related signal voids in the underlying MR reconstructions. Conclusions: The MR-based motion correction framework presented here can improve the target-to-background, contrast-to-background, and width of focal tracer hotspots in the coronary system. The dynamic attenuation correction could effectively mitigate the risk of attenuation correction artefacts in the coronaries at the lung-soft tissue boundary. In combination, this could enable a more reproducible and reliable plaque localisation. [ABSTRACT FROM AUTHOR]

Published
2021
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24. Impella versus IABP in acute myocardial infarction complicated by cardiogenic shock

Author

Alushi, Brunilda, primary, Douedari, Andel, additional, Froehlig, Georg, additional, Knie, Wulf, additional, Wurster, Thomas H, additional, Leistner, David M, additional, Staehli, Barbara-Elisabeth, additional, Mochmann, Hans-Christian, additional, Pieske, Burkert, additional, Landmesser, Ulf, additional, Krackhardt, Florian, additional, and Skurk, Carsten, additional

Published
2019
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25. Novel Approach for In Vivo Detection of Vulnerable Coronary Plaques Using Molecular 3-T CMR Imaging With an Albumin-Binding Probe

Author

Engel, Leif-Christopher, primary, Landmesser, Ulf, additional, Gigengack, Kevin, additional, Wurster, Thomas, additional, Manes, Constantina, additional, Girke, Georg, additional, Jaguszewski, Milosz, additional, Skurk, Carsten, additional, Leistner, David M., additional, Lauten, Alexander, additional, Schuster, Andreas, additional, Hamm, Bernd, additional, Botnar, Rene M., additional, Makowski, Marcus R., additional, and Bigalke, Boris, additional

Published
2019
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26. Noninvasive Imaging of Endothelial Damage in Patients With Different HbA1c Levels: A Proof-of-Concept Study.

Author

Engel, Leif-Christopher, Landmesser, Ulf, Goehler, Alexander, Gigengack, Kevin, Wurster, Thomas-Heinrich, Manes, Costantina, Girke, Georg, Jaguszewski, Milosz, Skurk, Carsten, Leistner, David M., Lauten, Alexander, Schuster, Andreas, Noutsias, Michel, Hamm, Bernd, Botnar, Rene M., Bigalke, Boris, Makowski, Marcus R., and Wurster, Thomas

Subjects
MAGNETIC resonance angiography, CARDIOGRAPHIC tomography, CORONARY disease, COHERENCE (Optics), CLINICAL indications, CORONARY arteries, MAGNETIC resonance, RESEARCH, CROSS-sectional method, RESEARCH methodology, MAGNETIC resonance imaging, CONTRAST media, EVALUATION research, MEDICAL cooperation, ATHEROSCLEROSIS, ORGANOMETALLIC compounds, CHEMICAL elements, COMPARATIVE studies, CORONARY artery disease, ANGIOGRAPHY
Abstract

The aim of this study was to compare endothelial permeability, which is considered a hallmark of coronary artery disease, between patients with different HbA1c levels using an albumin-binding magnetic resonance (MR) probe. This cross-sectional study included 26 patients with clinical indication for X-ray angiography who were classified into three groups according to HbA1c level (<5.7% [<39 mmol/mol], 5.7-6.4% [39-47 mmol/mol], and ≥6.5% [48 mmol/mol]). Subjects underwent gadofosveset-enhanced coronary magnetic resonance and X-ray angiography including optical coherence within 24 h. Contrast-to-noise ratios (CNRs) were assessed to measure the probe uptake in the coronary wall by coronary segment, excluding those with culprit lesions in X-ray angiography. In the group of patients with HbA1c levels between 5.7 and 6.4%, 0.30 increased normalized CNR values were measured, compared with patients with HbA1c levels <5.7% (0.30 [95% CI 0.04, 0.57]). In patients with HbA1c levels ≥6.5%, we found 0.57 higher normalized CNR values compared with patients with normal HbA1c levels (0.57 [95% CI 0.28, 0.85]) and 0.26 higher CNR values for patients with HbA1c level ≥6.5% compared with patients with HbA1c levels between 5.7 and 6.4% (0.26 [95% CI -0.04, 0.57]). Additionally, late atherosclerotic lesions were more common in patients with high HbA1c levels (HbA1c ≥6.5%, n = 14 [74%]; HbA1c 5.7-6.4%, n = 6 [60%]; and HbA1c <5.7%, n = 10 [53%]). In conclusion, coronary MRI in combination with an albumin-binding MR probe suggests that both patients with intermediate and patients with high HbA1c levels are associated with a higher extent of endothelial damage of the coronary arteries compared with patients with HbA1c levels <5.7%. [ABSTRACT FROM AUTHOR]

Published
2019
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27. Searching for retail strategies

Author

Taylor, David, Mehta, Bobby, and Wurster, Thomas

Subjects
Banking industry -- Technology application, Online transaction processing -- Management, Electronic funds transfer systems -- Usage, Banking, finance and accounting industries, Business
Abstract

Advances in online banking and the immense popularity of the Internet are threatening the retail banking franchise. Many bank CEOs are now aware that the environment for retail banking has grown so intensely competitive that they need to act immediately, as individual banks and as an industry, to secure their organizations' position and ensure continued survival. A growing number of banking institutions are responding to competitive challenges by developing strategies for online payments and online delivery of banking services. By doing so, these banks hope that they will be able to boost the value of their retail franchises and leverage the value of their relationships with their current customers. Four areas relevant to the development of online strategies are examined. These are customer behavior, the economics of delivery, opportunities and options.

Published
1996

28. Facing the challenges: online delivery & the information superhighway

Author

Taylor, David, Mehta, Bobby, Wurster, Thomas, Mahan, James S., III, and Winkler, Fred

Subjects
Program trading (Securities) -- Management, Banking industry -- Technology application, Banking, finance and accounting industries, Business
Abstract

Many banks are responding to customer demands by providing interactive delivery of their services to make it easier for their customers to deal with them. This development within the banking industry is a wise decision given that nonbank competitors are increasingly relying on cyberspace to snare their customers. The most popular instrument that these banks are choosing are online services and the Internet which are steadily becoming popular among current and prospective customers. To secure the success of their interactive services, banks should ensure that three elements are in place. Their online service should feature a compelling content that is suitable to the online environment. Moreover, it should provide customers with an easy access to the content and a secure online payment system.

Published
1995

29. Confirmation of nesting in Mexico for four bird species from the Sierra San Pedro Martir, Baja California

Author

Erickson, Richard A. and Wurster, Thomas E.

Subjects
Baja California, Mexico (State) -- Natural history, Bird populations -- Research -- Behavior, Nest building -- Research -- Behavior, Passeriformes -- Behavior -- Research, Biological sciences, Research, Behavior, Natural history
Abstract

We document nesting of Dusky Flycatcher (Empidonax oberholseri), Hermit Thrush (Catharus guttatus), Green-tailed Towhee (Pipilo chlorurus), and Fox Sparrow (Passerella iliaca) in the Sierra San Pedro Martir of northern Baja California. These species are relatively widespread in the mountains of southern California. Additional species recently observed in the Sierra San Pedro Martir in summer remain as unconfirmed breeders in Baja California [Northern Saw-whet Owl (Aegolius acadicus) and Townsend's Solitaire (Myadestes townsendi)] or all of Mexico [Hermit Warbler (Dendroica occidentalis)]. Received 3 March 1997, accepted 3 Oct. 1997., The highlands of the Sierra San Pedro Martir in northern Baja California received scant ornithological coverage prior to completion of the road to the National Observatory in the 1970s. The [...]

Published
1998

30. Noninvasive Imaging of Endothelial Damage in Patients With Different HbA1c Levels: A Proof-of-Concept Study

Author

Engel, Leif-Christopher, primary, Landmesser, Ulf, additional, Goehler, Alexander, additional, Gigengack, Kevin, additional, Wurster, Thomas-Heinrich, additional, Manes, Costantina, additional, Girke, Georg, additional, Jaguszewski, Milosz, additional, Skurk, Carsten, additional, Leistner, David M., additional, Lauten, Alexander, additional, Schuster, Andreas, additional, Noutsias, Michel, additional, Hamm, Bernd, additional, Botnar, Rene M., additional, Bigalke, Boris, additional, and Makowski, Marcus R., additional

Published
2018
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31. click. BOOM

Author

EVANS, PHILIP and WURSTER, THOMAS S.

Subjects
Electronic commerce -- Analysis, Information technology -- Analysis, Management -- Analysis, Business, general, Business, Business, international, Electronic commerce, Information technology, Analysis
Abstract

THE NEXT GENERATION OF E-COMMERCE STRATEGY The value chains that define a business, the supply chains that define an industry, the customer relationships and brands that define a franchise, and [...]

Published
2000

32. Getting Real About Virtual Commerce

Author

Evans, Philip and Wurster, Thomas S.

Subjects
Retail industry -- Management, Electronic commerce -- Management -- Marketing -- Planning, Brand choice -- Marketing, Online services -- Management -- Marketing -- Planning, Distributors (Commerce) -- Management, Home shopping -- Planning -- Marketing, Knowledge management -- Planning, Electronic commerce, Company marketing practices, Cable television/data services, Company business planning, Company business management, Online services, Knowledge management, Business, general, Business
Abstract

A second generation of electronic commerce is emerging, one that will be shaped more by strategy than by experimentation. The battle for competitive advantage will be waged along three dimensions: [...]

Published
1999

39. Green Fluorescent Protein (GFP) color reporter gene visualizes parvovirus B19 Non-structural Segment 1 (NS1) transfected endothelial modification

Author

Wurster, Thomas Heinrich, Pölzelbauer, Catharina, Schönberger, Tanja, Paul, Angela, Seizer, Peter, Stellos, Konstantinos L., Schuster, Andreas, Botnar, Rene Michael, Gawaz, Meinrad Paul, Bigalke, Boris, Wurster, Thomas Heinrich, Pölzelbauer, Catharina, Schönberger, Tanja, Paul, Angela, Seizer, Peter, Stellos, Konstantinos L., Schuster, Andreas, Botnar, Rene Michael, Gawaz, Meinrad Paul, and Bigalke, Boris

Abstract

Background: Human Parvovirus B19 (PVB19) has been associated with myocarditis putative due to endothelial infection. Whether PVB19 infects endothelial cells and causes a modification of endothelial function and inflammation and, thus, disturbance of microcirculation has not been elucidated and could not be visualized so far. Methods and Findings: To examine the PVB19-induced endothelial modification, we used green fluorescent protein (GFP) color reporter gene in the non-structural segment 1 (NS1) of PVB19. NS1-GFP-PVB19 or GFP plasmid as control were transfected in an endothelial-like cell line (ECV304). The endothelial surface expression of intercellular-adhesion molecule-1 (CD54/ICAM-1) and extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) were evaluated by flow cytometry after NS-1-GFP or control-GFP transfection. To evaluate platelet adhesion on NS-1 transfected ECs, we performed a dynamic adhesion assay (flow chamber). NS-1 transfection causes endothelial activation and enhanced expression of ICAM-1 (CD54: mean±standard deviation: NS1-GFP vs. control-GFP: 85.3±11.2 vs. 61.6±8.1; P<0.05) and induces endothelial expression of EMMPRIN/CD147 (CD147: mean±SEM: NS1-GFP vs. control-GFP: 114±15.3 vs. 80±0.91; P<0.05) compared to control-GFP transfected cells. Dynamic adhesion assays showed that adhesion of platelets is significantly enhanced on NS1 transfected ECs when compared to control-GFP (P<0.05). The transfection of ECs was verified simultaneously through flow cytometry, immunofluorescence microscopy and polymerase chain reaction (PCR) analysis. Conclusions: GFP color reporter gene shows transfection of ECs and may help to visualize NS1-PVB19 induced endothelial activation and platelet adhesion as well as an enhanced monocyte adhesion directly, providing in vitro evidence of possible microcirculatory dysfunction in PVB19-induced myocarditis and, thus, myocardial tissue damage.

Published
2012

40. Positron Emission Tomography/Computed Tomographic and Magnetic Resonance Imaging in a Murine Model of Progressive Atherosclerosis Using64Cu-Labeled Glycoprotein VI-Fc

Author

Bigalke, Boris, primary, Phinikaridou, Alkystis, additional, Andia, Marcelo E., additional, Cooper, Margaret S., additional, Schuster, Andreas, additional, Schönberger, Tanja, additional, Griessinger, Christoph M., additional, Wurster, Thomas, additional, Onthank, David, additional, Ungerer, Martin, additional, Gawaz, Meinrad, additional, Nagel, Eike, additional, and Botnar, Rene M., additional

Published
2013
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43. Copeptin as a prognostic factor for major adverse cardiovascular events in patients with coronary artery disease

Author

von Haehling, Stephan, primary, Papassotiriou, Jana, additional, Morgenthaler, Nils G., additional, Hartmann, Oliver, additional, Doehner, Wolfram, additional, Stellos, Konstantinos, additional, Wurster, Thomas, additional, Schuster, Andreas, additional, Nagel, Eike, additional, Gawaz, Meinrad, additional, and Bigalke, Boris, additional

Published
2012
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44. Mid-regional pro-atrial natriuretic peptide as a prognostic marker for all-cause mortality in patients with symptomatic coronary artery disease

Author

von Haehling, Stephan, primary, Papassotiriou, Jana, additional, Hartmann, Oliver, additional, Doehner, Wolfram, additional, Stellos, Konstantinos, additional, Geisler, Tobias, additional, Wurster, Thomas, additional, Schuster, Andreas, additional, Botnar, Rene M., additional, Gawaz, Meinrad, additional, and Bigalke, Boris, additional

Published
2012
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47. Green Fluorescent Protein (GFP) Color Reporter Gene Visualizes Parvovirus B19 Non-Structural Segment 1 (NS1) Transfected Endothelial Modification

Author

Wurster, Thomas, primary, Pölzelbauer, Catharina, additional, Schönberger, Tanja, additional, Paul, Angela, additional, Seizer, Peter, additional, Stellos, Konstantinos, additional, Schuster, Andreas, additional, Botnar, Rene M., additional, Gawaz, Meinrad, additional, and Bigalke, Boris, additional

Published
2012
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49. Retail banking & the information superhighway

Author

Taylor, David, Mehta, Bobby, and Wurster, Thomas

Subjects
Banking industry -- Information management, Internet -- Evaluation, Banking, finance and accounting industries, Business
Abstract

The information superhighway presents new opportunities and challenges to the banking industry. Bank executives, realizing the potential of the information technology, are therefore taking steps to take advantage of the superhighway although they are hampered by the fact that it is still evolving, making it difficult to determine the most appropriate move to make. These executives are also aware of competition from the non-bank sector which is greatly aided by the superhighway. Entities such as Microsoft, America Online and telephone companies are threatening to become major challengers of the banking industry and have the technological facility to realize this potential. Nevertheless, bank executives are confident that their incumbency will help them retain their dominant hold of the market for a long time. Nevertheless, this should not give them a false sense of security and find ways to fortify their leadership.

Published
1995

50. Plasma levels of soluble glycoprotein VI (sGPVI) are associated with ischemic stroke.

Author

Wurster, Thomas, Poetz, Oliver, Stellos, Konstantinos, Kremmer, Elisabeth, Melms, Arthur, Schuster, Andreas, Nagel, Eike, Joos, Thomas, Gawaz, Meinrad, and Bigalke, Boris

Abstract

Platelet collagen receptor glycoprotein VI (pGPVI) is elevated in patients with acute coronary syndrome (ACS) and ischemic stroke. Recently, we developed a novel bead-based sandwich immunoassay to determine soluble GPVI (sGPVI), which has been validated in ACS patients. This study aimed to evaluate the plasma levels of sGPVI and pGPVI expression in patients with suspected stroke. We consecutively evaluated 176 patients, who were admitted to the stroke unit. Surface expression of pGPVI was determined by flow cytometry, sGPVI concentrations were determined using our sandwich immunoassay. Unlike patients with TIA, patients with stroke showed significantly decreased plasma levels of sGPVI compared to patients with non-ischemic (NI) events (TIA: mean [µg/L] ± standard deviation): 6.1 ± 2.1 vs. NI: 8 ± 4; p = 0.192; stroke: 5.9 ± 2.3 vs. NI; p = 0.013), whereas for pGPVI, patients with TIA and ischemic stroke revealed a significantly increased platelet surface expression compared to NI patients (TIA: mean fluorescence intensity [MFI] ± standard deviation): 20.9 ± 5.4 vs. NI: 17.6 ± 5.2; p = 0.021; stroke: 20.3 ± 6.2 vs. NI; p = 0.016). Using logistic regression analysis, both sGPVI (p = 0.002) and pGPVI (p = 0.012) are independently associated with ischemic stroke compared to other laboratory markers. To predict the individual risk for ischemic stroke using the plasma levels of sGPVI, receiver operating characteristic (ROC) analysis determined an optimal cutoff value of sGPVI at 6.5 µg/l, thus, patients with decreased plasma levels (<6.5 µg/l) have a 1.5-fold adjusted odds ratio (95%confidence interval, 1.4-2.7). Lower plasma levels of sGPVI are associated with the slightly elevated risk of stroke and may be a promising novel biomarker. [ABSTRACT FROM AUTHOR]

Published
2013
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