Search

Your search keyword '"Wulfhekel U"' showing total 88 results
Start Over Author "Wulfhekel U"
88 results on '"Wulfhekel U"'

1. Die Struktur der Leber und Gallenwege

Author

Düllmann, J., Wulfhekel, U., Lierse, W., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

2. Pathologie der Leber und Gallenwege

Author

Denk, H., primary, Dienes, H. P., additional, Düllmann, J., additional, Fischer, H.-P., additional, Klinge, O., additional, Lierse, W., additional, Meyer zum Büschenfelde, K.-H., additional, Pfeifer, U., additional, Preisegger, K. H., additional, Ramadori, G., additional, Tannapfel, A., additional, Wittekind, Ch., additional, Wulfhekel, U., additional, and Zhou, H., additional

Published
2000
Full Text
View/download PDF

24. Physiologie und Pathophysiologie der Leber und Gallenwege

Author

Ramadori, G., Meyer zum Büschenfelde, K.-H., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

26. Cholestase

Author

Klinge, O., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

27. Formvarianten und Fehlbildungen der Leber und Gallenwege

Author

Klinge, O., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

28. Intrahepatische Cholangitis

Author

Klinge, O., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

29. Stoffwechselerkrankungen der Leber

Author

Preisegger, K. H., Denk, H., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

30. Hepatitis

Author

Dienes, H. P., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

31. Tumoren der Gallenblase und Gallengänge

Author

Wittekind, Ch., Tannapfel, A., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

32. Pathologie der Papilla Vateri

Author

Fischer, H.-P., Zhou, H., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

33. Vaskuläre Erkrankungen der Gallenblase und Gallengänge

Author

Wittekind, Ch., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

34. Cholezystitis

Author

Wittekind, Ch., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

35. Extrahepatische Cholangitis

Author

Wittekind, Ch., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

36. Kreislaufstörungen der Leber

Author

Klinge, O., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

37. Besondere Erkrankungen der Gallenblase

Author

Wittekind, Ch., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

39. Motilitätsstörungen von Gallenblase und Gallengängen

Author

Wittekind, Ch., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

40. Metabolische Erkrankungen der Gallenblase

Author

Wittekind, Ch., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

41. Leberfibrose und Leberzirrhose

Author

Pfeifer, U., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

42. Tumoren der Leber

Author

Wittekind, Ch., Tannapfel, A., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

43. Leberveränderungen im Verbund mit anderen Erkrankungen

Author

Dienes, H. P., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

44. Pathologie der transplantierten Leber

Author

Denk, H., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

45. Tumorartige Erkrankungen der Leber

Author

Wittekind, Ch., Tannapfel, A., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

46. Alkoholtoxische Lebererkrankungen

Author

Klinge, O., Seifert, Gerhard, editor, Denk, H., Dienes, H. P., Düllmann, J., Fischer, H.-P., Klinge, O., Lierse, W., Meyer zum Büschenfelde, K.-H., Pfeifer, U., Preisegger, K. H., Ramadori, G., Tannapfel, A., Wittekind, Ch., Wulfhekel, U., and Zhou, H.

Published
2000
Full Text
View/download PDF

47. Nuclear iron deposits in hepatocytes of iron-loaded HFE-knock-out mice: a morphometric and immunocytochemical analysis.

Author

Magens B, Düllmann J, Schümann K, Wulfhekel U, and Nielsen P

Subjects
Animals, Cell Nucleus metabolism, Cell Nucleus pathology, Diet, Hemochromatosis genetics, Hemochromatosis metabolism, Hemochromatosis Protein, Hepatocytes metabolism, Hepatocytes ultrastructure, Immunohistochemistry, Iron administration & dosage, Iron metabolism, Iron Overload metabolism, Mice, Mice, Inbred C57BL, Mice, Knockout, Cell Nucleus chemistry, Hemochromatosis pathology, Hepatocytes chemistry, Histocompatibility Antigens Class I genetics, Iron analysis, Iron Overload pathology, Membrane Proteins genetics
Abstract

Nuclear deposits of stainable iron in hepatocytes are a sign of liver iron overload in mice. Animals with no, partial or total knock-out of the HFE alleles, the deletion of which is responsible for hereditary haemochromatosis, were given different forms of dietary iron to measure nuclear iron deposits which were then related to cytoplasmic iron load. Wild type and heterozygous HFE-knock-out mice kept for 52 weeks on a standard diet showed no such deposits. These were, however, demonstrated in low numbers and with small diameters in homozygous HFE-knock-out mice kept on this diet. Nuclear iron deposits were most abundant in all type of mice fed carbonyl iron (2.5% w/w) for 52 weeks almost irrespective of their genetic background. The diameter of these deposits increased with the genetically conditioned extent of hepatocellular iron overload. Mice that were fed a diet containing TMH-ferrocene for 4 weeks showed amounts of hepatic iron that were comparable to those in the carbonyl iron-fed group but nuclear deposits were small and present in only 0.3% of the hepatocytes. While surrounding karyoplasm was immunostained for H- and L-ferritin, the nuclear iron deposits were not. As the nuclear iron deposits corresponded electron microscopically to aggregated ferritin molecules, they represent a non-immunoreactive form of presumably denatured ferritin.

Published
2005
Full Text
View/download PDF

48. Characteristics of endothelin receptors and intracellular signalling in porcine inner medullary collecting duct cells.

Author

Migas I, Bäcker A, Meyer-Lehnert H, Michel H, Wulfhekel U, and Kramer HJ

Subjects
Animals, Arginine Vasopressin physiology, Calcium metabolism, Cells, Cultured, Cyclic AMP biosynthesis, Dose-Response Relationship, Drug, Endothelins metabolism, Kidney Medulla chemistry, Kidney Medulla cytology, Receptors, Endothelin analysis, Signal Transduction, Swine, Endothelins physiology, Kidney Medulla metabolism, Receptors, Endothelin metabolism
Abstract

In porcine kidneys we investigated the characteristics of endothelin (ET) receptors that are present in papillary tissue but not in glomeruli. Therefore, porcine inner medullary collecting duct (IMCD) cells were separated by Percoll density gradient centrifugation after enzymatic and hypotonic treatment of minced papillary tissue. Studies were performed in fresh cell suspensions and in cells in primary culture. Changes in cytosolic free Ca2+ concentration [Ca2+]i were measured by the use of fura-2. Optimum binding of ET-1 was obtained by incubation for 120 min at 37 degrees C, pH 7.0 when maximal protein content was 40 micrograms. Analysis with the LIGAND program showed an average number of binding sites (Bmax) of 26.0 +/- 30.5 fmol/mg protein and dissociation constant (Kd) of 90.5 +/- 28.6 pmol/L for ET-1 and Bmax of 246.9 fmol/mg protein and Kd of 162.5 pmol/L for ET-3. ET-1, 10(-9) to 10(-6) mol/L, dose dependently raised [Ca2+]i four to tenfold, respectively, from a mean basal level of 41 nmol/L. This rise was significantly attenuated by TMB-8 and by verapamil. Preincubation with Ni2+ almost completely prevented the increment in [Ca2+]i. ET-1 slightly suppressed basal and significantly attenuated arginine vasopressin (AVP)-induced cyclic adenosine monophosphate (cAMP) synthesis. Thus, porcine IMCD cells possess a single class of super high affinity ETB receptors (ETB1). ET-1 raises [Ca2+]i through release from intracellular stores, activation of L-type calcium channels and, probably to a larger extent, through stimulation of other channels, eg, T-type calcium channels or unselective cation channels.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1993
Full Text
View/download PDF

49. Non-transferrin-bound-iron in serum and low-molecular-weight-iron in the liver of dietary iron-loaded rats.

Author

Nielsen P, Düllmann J, Wulfhekel U, and Heinrich HC

Subjects
Animals, Cytosol metabolism, Female, Ferritins metabolism, Ferrous Compounds administration & dosage, Hemosiderin metabolism, Iron blood, Liver ultrastructure, Metallocenes, Microscopy, Electron, Molecular Weight, Organometallic Compounds administration & dosage, Rats, Rats, Wistar, Spectrophotometry, Atomic, Diet, Iron administration & dosage, Iron metabolism, Liver metabolism, Transferrin metabolism
Abstract

1. The feeding of 0.5% (3,5,5-trimethylhexanoyl)ferrocene (TMH-ferrocene) in rats resulted in a severe and progressive liver siderosis (total liver iron, 30 mg/g liver wet weight, after 30 weeks). 2. High concentrations of an iron-rich ferritin (up to 250 mg/l) were detected in serum of heavily iron-loaded rats forming a large fraction of non-transferrin-bound-iron (5000 micrograms/dl in maximum). 3. Ferritin and not haemosiderin was the major iron storage protein in the liver. 4. The total liver iron concentration (from 0.4 to > 30 mg Fe/g wet wt) but not the cytosolic low-molecular-weight-iron fraction (from 0.5 to 2.5 microM) was extremely increased during iron-loading.

Published
1993
Full Text
View/download PDF

50. The diagnostic value of bone marrow iron.

Author

Wulfhekel U and Düllmann J

Subjects
Anemia pathology, Anemia, Sideroblastic diagnosis, Anemia, Sideroblastic pathology, Biomarkers, Blood Transfusion, Hemochromatosis pathology, Humans, Microscopy, Electron, Reference Values, Anemia diagnosis, Bone Marrow ultrastructure, Hemochromatosis diagnosis, Iron analysis, Iron Deficiencies, Macrophages ultrastructure
Abstract

The light and electronmicroscopic representation of non-haemiron in the bone-marrow provides the unique opportunity of extensively evaluating the iron metabolism. In the bone-marrow, macrophages represent the physiological place of iron storage. The iron in the cytoplasma is stored in them in the form of free ferritin molecules and lysomally as aggregated ferritin and/or haemosiderin in siderosomes. In an equal iron balance and unimpaired internal iron exchange only erythroblasts (sideroblasts) and erythrocytes (siderocytes) of the bone-marrow besides macrophages possess siderosomes. In addition to this physiological or orthotopic iron storage a heterotopic iron storage can be observed under pathological conditions, particularly with iron overloading of the organism, in the endothelial cells of sinusoids and plasma cells. In detail, the patterns of iron storage in the bone-marrow are described in the different stages of iron deficiency, disturbance of iron utilization in chronically inflammatory processes or tumour diseases, condition after intravenous iron administration, transfusion siderosis, hereditary haemochromatosis and sideroblastic anaemia.

Published
1990

Catalog

Books, media, physical & digital resources
See catalog results