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AIM: To explore the application of improved skills in central hole ICL V4c implantation and its clinical efficacy. METHODS: This study included 141 eyes of 72 patients with myopia from September 2015 to August 2016. An implantable contact lens with a central hole(ICL V4c)was inserted by improved surgical skills including single 2.8mm clear corneal incision, no anterior chamber viscoelastics before ICL implantation. The intraocular pressure(IOP)was measured at the early stage within 6h after operation. The visual acuity, diopter, intraocular pressure and corneal endothelial cell density were observed after operation and follow up 2a. RESULTS: ICL V4c was implanted successfully in all patients by this improved skills and fine clinical results were achieved. Elevated IOP is possible at early stage post-operation, especially within 2h after operation. 95.7% had normal IOP 6h after operation. The postoperative IOP was stable within 2a follow-up period. The cumulative corneal endothelial loss rates of 6mo, 1a and 2a were 4.70%, 7.59% and 9.63% respectively. There was no complications such as subcapsular cataract during the 2a follow-up period.CONCLUSION: The improved skills used in our study is safe and feasible.

AIM: To investigate the difference and consistency between iTrace and Pentacam in measuring corneal spherical aberration(SphA)and curvature.METHODS: The corneal spherical aberration and curvature were measured by iTrace and Pentacam in 63 cases(125 eyes)separately, and the SphA, the minimum corneal curvature(K1), maximum corneal curvature(K2)and corneal astigmatism(CA)were recorded respectively. Paired t-test was used for statistical analysis of econometric data, Bland-Altman analysis was used to evaluate the consistency of measurement results(SphA and curvature)measured by iTrace and Pentacam.RESULTS: The measurement result of SphA, K1, K2 and CA were(0.230±0.086)μm,(43.01±2.38)D,(44.08±2.48)D and(1.03±0.57)D measured by iTrace, and(0.247±0.114)μm,(42.88±1.44)D,(43.86±1.51)D and(1.07±0.62)D measured by Pentacam, there was no significant difference of the measurement result of SphA, K1, K2 and CA between iTrace and Pentacam(P>0.05). The difference of SphA, K1, K2 and CA between iTrace and Pentacam was close to 0, the consistency was good because of the narrow 95% confidence interval.CONCLUSION:There is no significant difference of the measurement result between iTrace and Pentacam, the consistency is good, and both can be used as a mutual reference in clinical.

AIM: To observe the efficacy and safety of central hole phakic posterior chamber intraocular lens(ICL V4c)implantation for correction low to moderate myopia.METHODS: Twenty low to moderate myopia patients(forty eyes)who underwent the ICL V4c implantation in our hospital from January 2016 to June 2017 were observed 1wk, 1mo and 1a after operation respectively. Uncorrected visual acuity(UCVA), best corrected visual acuity(BCVA), equivalent spherical mirrors(SE), intraocular pressure, corneal endothelial cell count, ICL-vault, adverse reaction and complication were investigated.RESULTS: Postoperative UCVA and BCVA were significantly higher than that in preoperative group(PPPP>0.05). None of subjects developed cataract, glaucoma and decompensation of corneal endothelium. The degree of postoperative satisfaction was 100%.CONCLUSION: ICL V4c implantation is a safe and effective method for the correction of low to moderate myopia. The visual acuity stabilized 1mo after operation.

AIM: To observe the efficacy and safety of central hole phakic posterior chamber intraocular lens(ICL V4c)implantation for correction high myopia.METHODS: Fifty-eight high myopia patients(116 eyes)who underwent the ICL V4c implantation in our hospital from January 2016 to June 2017 were observed 1wk, 1mo and 1a after operation respectively. Uncorrected visual acuity(UCVA), best corrected visual acuity(BCVA), equivalent spherical mirrors(SE), intraocular pressure(IOP), corneal endothelial cell count, ICL-vault, adverse reaction and complication were investigated.RESULTS: Postoperative UCVA and BCVA were significantly higher than that in preoperative group(PP>0.05). Postoperative SE at all time points were lower than that in preoperative group(PP>0.05). None of subjects developed cataract, glaucoma and decompensation of corneal endothelium. The degree of postoperative satisfaction was 100%.CONCLUSION: ICL V4c implantation is a safe and effective method for correction of high myopia. The visual acuity stabilized 1mo after operation.

AIM: To investigate the clinical effect of intracameral cefuroxime injection on prevention of endophthalmitis following phacoemulsification. METHODS: This was a retrospective clinical study. The clinical records were reviewed for 3112 patients(4210 eyes)with cataract phacoemulsification in our hospital from January 2015 to June 2018; 1810 patients(2250 eyes)without intracameral cefuroxime injection were treated as control group from January 2015 to April 2017; 1302 cases(1960 eyes)with intracameral cefuroxime injection were treated as experimental group from May 2017 to July 2018. Patients in both groups were treated with phacoemulsification and intraocular lens implantation. The follow-up period was 1-8mo and the visual acuity and the infectious endophthalmitis were observed and compared. RESULTS:There were 1 344 eyes with best corrected visual acuity >1.0, 696 eyes with 0.5-0.9, 151 eyes with 0.1-0.4, 59 eyes with P=0.15). All the cases with endophthalmitis were cured. No sever complication was reported with intracameral cefuroxime, corneal endothelium decompensation, retinal toxicity. CONCLUSION: Intracameral cefuroxime injection is safe and effective in prevention of endophthalmitis following phacoemulsification.