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Fire disasters pose a significant threat to life and property worldwide, underscoring the urgent necessity for advanced fire prevention technologies. In the field of intelligent fire protection materials, thermoelectric fire-resistant materials have garnered considerable attention due to their high sensitivity and the distinct advantage of not requiring an external power supply. This feature endows them with high responsiveness and energy efficiency in detecting and responding to fire incidents, thereby enhancing overall safety measures. In this study, we develop a series of highly stretchable ionic hydrogels with exceptional thermoelectric properties and flame retardancy for intelligent fire protection applications. Through a simple one-pot photopolymerization process, polyacrylic acid (PAA) and polyethylene glycol (PEO) were combined with sodium dihydrogen phosphate (SDP) to form a robust hydrogen-bonded ionic hydrogel network. The resulting PAA-PEO-SDP ionic hydrogels demonstrated an impressive elongation at break up to 4270% and a very high ionic Seebeck coefficient of 24.7 mV K−1. The incorporation of the phosphorus salt enhanced flame retardancy to reach the UL-94 V-0 rating and significantly increased the oxygen index of encapsulated wood from 27% to 54%. Moreover, as a fire-warning device, it could rapidly generate an output voltage of ca. 50 mV within 1.5 s upon exposure to fire, showcasing potential for autonomous fire prevention systems. This work highlights the synergistic integration of mechanical flexibility, thermoelectric performance, and fire safety in the development of next-generation intelligent materials for fire protection. [ABSTRACT FROM AUTHOR]

Background: Meckel–Gruber syndrome (MKS) is a perinatally lethal, genetically heterogeneous, autosomal recessive condition caused by defective primary cilium formation. So far, the association of TXNDC15‐related MKS has been reported in only five independent families from diverse ethnic origins, including Saudi, Pakistani, Estonian, and Indian. Here, we report a fetus diagnosed with MKS at 12 weeks, exhibiting typical ultrasound findings. Methods: Low‐coverage whole‐genome sequencing was used to identify chromosomal abnormalities. Trio‐base whole exome sequencing (trio‐WES) was performed to investigate the potential pathogenic variants associated with MKS. Preimplantation genetic testing for monogenic disorders (PGT‐M) was applied to prevent the transmission of the pathogenic variant. Results: A novel homozygous pathogenic variant in the TXNDC15 gene was identified through trio‐WES. The application of PGT‐M successfully prevented the transmission of the pathogenic variant and resulted in an ongoing pregnancy. Conclusion: This is the first report of a TXNDC15 variant in the Chinese population and the first PGT case of TXNDC15‐related MKS worldwide. The successful application of PGT‐M in this family provides a potential approach for other monogenic diseases. Our case expands the variant spectrum of TXNDC15 and contributes to the molecular diagnosis and genetic counseling for MKS. This case underscores the importance of appropriate genetic testing methods and accurate genetic counseling in the diagnosis of rare monogenic diseases. [ABSTRACT FROM AUTHOR]

• Conjugation of SN83 of polymer enhanced DOX encapsulation via π-π stacking. • SN38 polymer prodrug enhanced the pharmacokinetics of both SN38 and DOX. • Synergistic action of DOX and SN38 polymer prodrug ensured favorable antitumor effect. • Therapeutic effect of conventional drugs was improved by combination therapy. There are opportunities for improvements to the efficiency and toxicity of widely used cancer chemotherapy agents such as doxorubicin (DOX·HCl) and 7-Ethyl-10-hydroxycamptothecin (SN38). We developed a safe and effective combination therapy by encapsulating DOX into micelles of a zwitterionic polymer prodrug, SN38 conjugate of poly (α-azide caprolactone-co-caprolactone)-b-poly (2-methacryloyloxyethyl phosphorylcholine [P(CL/CL-g-SN38)-b-PMPC)] which was described in our previous work. The polymer prodrug micelles displayed a higher loading capacity of DOX due to the π-π stacking effect between DOX and SN38 in comparison with the micelles self-assembled by prodrug's precursor, poly(α-azide caprolactone-co-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine (P(ACL/CL)-b-PMPC). The DOX loaded prodrug micelles decelerated the release of DOX, and also prolonged its circulation. The micelles showed favorable cellular internalization by 4T1 cells. DOX loaded SN38 prodrug micelles displayed good in vitro anticancer effects owing to the synergistic action of doxorubicin and SN38 and were as effective as DOX·HCl, but with lower toxicity than DOX·HCl. Given the synergetic effects of free drug and polymer prodrug, this nanomedicine may offer a safe and effective drug delivery methodology for conventional drug formations. [ABSTRACT FROM AUTHOR]