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Annotation ambiguity due to inherent data uncertainties such as blurred boundaries in medical scans and different observer expertise and preferences has become a major obstacle for training deep-learning based medical image segmentation models. To address it, the common practice is to gather multiple annotations from different experts, leading to the setting of multi-rater medical image segmentation. Existing works aim to either merge different annotations into the "groundtruth" that is often unattainable in numerous medical contexts, or generate diverse results, or produce personalized results corresponding to individual expert raters. Here, we bring up a more ambitious goal for multi-rater medical image segmentation, i.e., obtaining both diversified and personalized results. Specifically, we propose a two-stage framework named D-Persona (first Diversification and then Personalization). In Stage I, we exploit multiple given annotations to train a Probabilistic U-Net model, with a bound-constrained loss to improve the prediction diversity. In this way, a common latent space is constructed in Stage I, where different latent codes denote diversified expert opinions. Then, in Stage II, we design multiple attention-based projection heads to adaptively query the corresponding expert prompts from the shared latent space, and then perform the personalized medical image segmentation. We evaluated the proposed model on our in-house Nasopharyngeal Carcinoma dataset and the public lung nodule dataset (i.e., LIDC-IDRI). Extensive experiments demonstrated our D-Persona can provide diversified and personalized results at the same time, achieving new SOTA performance for multi-rater medical image segmentation. Our code will be released at https://github.com/ycwu1997/D-Persona., Comment: Accepted by CVPR 2024

Annotation scarcity has become a major obstacle for training powerful deep-learning models for medical image segmentation, restricting their deployment in clinical scenarios. To address it, semi-supervised learning by exploiting abundant unlabeled data is highly desirable to boost the model training. However, most existing works still focus on limited medical tasks and underestimate the potential of learning across diverse tasks and multiple datasets. Therefore, in this paper, we introduce a \textbf{Ver}satile \textbf{Semi}-supervised framework (VerSemi) to point out a new perspective that integrates various tasks into a unified model with a broad label space, to exploit more unlabeled data for semi-supervised medical image segmentation. Specifically, we introduce a dynamic task-prompted design to segment various targets from different datasets. Next, this unified model is used to identify the foreground regions from all labeled data, to capture cross-dataset semantics. Particularly, we create a synthetic task with a cutmix strategy to augment foreground targets within the expanded label space. To effectively utilize unlabeled data, we introduce a consistency constraint. This involves aligning aggregated predictions from various tasks with those from the synthetic task, further guiding the model in accurately segmenting foreground regions during training. We evaluated our VerSemi model on four public benchmarking datasets. Extensive experiments demonstrated that VerSemi can consistently outperform the second-best method by a large margin (e.g., an average 2.69\% Dice gain on four datasets), setting new SOTA performance for semi-supervised medical image segmentation. The code will be released.

New lesion segmentation is essential to estimate the disease progression and therapeutic effects during multiple sclerosis (MS) clinical treatments. However, the expensive data acquisition and expert annotation restrict the feasibility of applying large-scale deep learning models. Since single-time-point samples with all-lesion labels are relatively easy to collect, exploiting them to train deep models is highly desirable to improve new lesion segmentation. Therefore, we proposed a coaction segmentation (CoactSeg) framework to exploit the heterogeneous data (i.e., new-lesion annotated two-time-point data and all-lesion annotated single-time-point data) for new MS lesion segmentation. The CoactSeg model is designed as a unified model, with the same three inputs (the baseline, follow-up, and their longitudinal brain differences) and the same three outputs (the corresponding all-lesion and new-lesion predictions), no matter which type of heterogeneous data is being used. Moreover, a simple and effective relation regularization is proposed to ensure the longitudinal relations among the three outputs to improve the model learning. Extensive experiments demonstrate that utilizing the heterogeneous data and the proposed longitudinal relation constraint can significantly improve the performance for both new-lesion and all-lesion segmentation tasks. Meanwhile, we also introduce an in-house MS-23v1 dataset, including 38 Oceania single-time-point samples with all-lesion labels. Codes and the dataset are released at https://github.com/ycwu1997/CoactSeg., Comment: Accepted by MICCAI 2023 (Early Acceptance)

Semi-supervised learning (SSL) has attracted much attention since it reduces the expensive costs of collecting adequate well-labeled training data, especially for deep learning methods. However, traditional SSL is built upon an assumption that labeled and unlabeled data should be from the same distribution \textit{e.g.,} classes and domains. However, in practical scenarios, unlabeled data would be from unseen classes or unseen domains, and it is still challenging to exploit them by existing SSL methods. Therefore, in this paper, we proposed a unified framework to leverage these unseen unlabeled data for open-scenario semi-supervised medical image classification. We first design a novel scoring mechanism, called dual-path outliers estimation, to identify samples from unseen classes. Meanwhile, to extract unseen-domain samples, we then apply an effective variational autoencoder (VAE) pre-training. After that, we conduct domain adaptation to fully exploit the value of the detected unseen-domain samples to boost semi-supervised training. We evaluated our proposed framework on dermatology and ophthalmology tasks. Extensive experiments demonstrate our model can achieve superior classification performance in various medical SSL scenarios. The code implementations are accessible at: https://github.com/PyJulie/USSL4MIC.

Weakly-supervised point cloud segmentation with extremely limited labels is highly desirable to alleviate the expensive costs of collecting densely annotated 3D points. This paper explores applying the consistency regularization that is commonly used in weakly-supervised learning, for its point cloud counterpart with multiple data-specific augmentations, which has not been well studied. We observe that the straightforward way of applying consistency constraints to weakly-supervised point cloud segmentation has two major limitations: noisy pseudo labels due to the conventional confidence-based selection and insufficient consistency constraints due to discarding unreliable pseudo labels. Therefore, we propose a novel Reliability-Adaptive Consistency Network (RAC-Net) to use both prediction confidence and model uncertainty to measure the reliability of pseudo labels and apply consistency training on all unlabeled points while with different consistency constraints for different points based on the reliability of corresponding pseudo labels. Experimental results on the S3DIS and ScanNet-v2 benchmark datasets show that our model achieves superior performance in weakly-supervised point cloud segmentation. The code will be released publicly at https://github.com/wu-zhonghua/RAC-Net.

We present a robust, privacy-preserving visual localization algorithm using event cameras. While event cameras can potentially make robust localization due to high dynamic range and small motion blur, the sensors exhibit large domain gaps making it difficult to directly apply conventional image-based localization algorithms. To mitigate the gap, we propose applying event-to-image conversion prior to localization which leads to stable localization. In the privacy perspective, event cameras capture only a fraction of visual information compared to normal cameras, and thus can naturally hide sensitive visual details. To further enhance the privacy protection in our event-based pipeline, we introduce privacy protection at two levels, namely sensor and network level. Sensor level protection aims at hiding facial details with lightweight filtering while network level protection targets hiding the entire user's view in private scene applications using a novel neural network inference pipeline. Both levels of protection involve light-weight computation and incur only a small performance loss. We thus project our method to serve as a building block for practical location-based services using event cameras. The code and dataset will be made public through the following link: https://github.com/82magnolia/event_localization.

Flash illumination is widely used in imaging under low-light environments. However, illumination intensity falls off with propagation distance quadratically, which poses significant challenges for flash imaging at a long distance. We propose a new flash technique, named ``patterned flash'', for flash imaging at a long distance. Patterned flash concentrates optical power into a dot array. Compared with the conventional uniform flash where the signal is overwhelmed by the noise everywhere, patterned flash provides stronger signals at sparsely distributed points across the field of view to ensure the signals at those points stand out from the sensor noise. This enables post-processing to resolve important objects and details. Additionally, the patterned flash projects texture onto the scene, which can be treated as a structured light system for depth perception. Given the novel system, we develop a joint image reconstruction and depth estimation algorithm with a convolutional neural network. We build a hardware prototype and test the proposed flash technique on various scenes. The experimental results demonstrate that our patterned flash has significantly better performance at long distances in low-light environments.

Weakly supervised point cloud segmentation, i.e. semantically segmenting a point cloud with only a few labeled points in the whole 3D scene, is highly desirable due to the heavy burden of collecting abundant dense annotations for the model training. However, existing methods remain challenging to accurately segment 3D point clouds since limited annotated data may lead to insufficient guidance for label propagation to unlabeled data. Considering the smoothness-based methods have achieved promising progress, in this paper, we advocate applying the consistency constraint under various perturbations to effectively regularize unlabeled 3D points. Specifically, we propose a novel DAT (\textbf{D}ual \textbf{A}daptive \textbf{T}ransformations) model for weakly supervised point cloud segmentation, where the dual adaptive transformations are performed via an adversarial strategy at both point-level and region-level, aiming at enforcing the local and structural smoothness constraints on 3D point clouds. We evaluate our proposed DAT model with two popular backbones on the large-scale S3DIS and ScanNet-V2 datasets. Extensive experiments demonstrate that our model can effectively leverage the unlabeled 3D points and achieve significant performance gains on both datasets, setting new state-of-the-art performance for weakly supervised point cloud segmentation., Comment: ECCV 2022

Structured light (SL) systems acquire high-fidelity 3D geometry with active illumination projection. Conventional systems exhibit challenges when working in environments with strong ambient illumination, global illumination and cross-device interference. This paper proposes a general-purposed technique to improve the robustness of SL by projecting redundant optical signals in addition to the native SL patterns. In this way, projected signals become more distinguishable from errors. Thus the geometry information can be more easily recovered using simple signal processing and the ``coding gain" in performance is obtained. We propose three applications using our redundancy codes: (1) Self error-correction for SL imaging under strong ambient light, (2) Error detection for adaptive reconstruction under global illumination, and (3) Interference filtering with device-specific projection sequence encoding, especially for event camera-based SL and light curtain devices. We systematically analyze the design rules and signal processing algorithms in these applications. Corresponding hardware prototypes are built for evaluations on real-world complex scenes. Experimental results on the synthetic and real data demonstrate the significant performance improvements in SL systems with our redundancy codes.

Most of the medical tasks naturally exhibit a long-tailed distribution due to the complex patient-level conditions and the existence of rare diseases. Existing long-tailed learning methods usually treat each class equally to re-balance the long-tailed distribution. However, considering that some challenging classes may present diverse intra-class distributions, re-balancing all classes equally may lead to a significant performance drop. To address this, in this paper, we propose a curriculum learning-based framework called Flexible Sampling for the long-tailed skin lesion classification task. Specifically, we initially sample a subset of training data as anchor points based on the individual class prototypes. Then, these anchor points are used to pre-train an inference model to evaluate the per-class learning difficulty. Finally, we use a curriculum sampling module to dynamically query new samples from the rest training samples with the learning difficulty-aware sampling probability. We evaluated our model against several state-of-the-art methods on the ISIC dataset. The results with two long-tailed settings have demonstrated the superiority of our proposed training strategy, which achieves a new benchmark for long-tailed skin lesion classification.

Semi-supervised segmentation remains challenging in medical imaging since the amount of annotated medical data is often scarce and there are many blurred pixels near the adhesive edges or in the low-contrast regions. To address the issues, we advocate to firstly constrain the consistency of pixels with and without strong perturbations to apply a sufficient smoothness constraint and further encourage the class-level separation to exploit the low-entropy regularization for the model training. Particularly, in this paper, we propose the SS-Net for semi-supervised medical image segmentation tasks, via exploring the pixel-level smoothness and inter-class separation at the same time. The pixel-level smoothness forces the model to generate invariant results under adversarial perturbations. Meanwhile, the inter-class separation encourages individual class features should approach their corresponding high-quality prototypes, in order to make each class distribution compact and separate different classes. We evaluated our SS-Net against five recent methods on the public LA and ACDC datasets. Extensive experimental results under two semi-supervised settings demonstrate the superiority of our proposed SS-Net model, achieving new state-of-the-art (SOTA) performance on both datasets. The code is available at https://github.com/ycwu1997/SS-Net., Comment: Accepted by MICCAI 2022

Object proposal generation is an important and fundamental task in computer vision. In this paper, we propose ProposalCLIP, a method towards unsupervised open-category object proposal generation. Unlike previous works which require a large number of bounding box annotations and/or can only generate proposals for limited object categories, our ProposalCLIP is able to predict proposals for a large variety of object categories without annotations, by exploiting CLIP (contrastive language-image pre-training) cues. Firstly, we analyze CLIP for unsupervised open-category proposal generation and design an objectness score based on our empirical analysis on proposal selection. Secondly, a graph-based merging module is proposed to solve the limitations of CLIP cues and merge fragmented proposals. Finally, we present a proposal regression module that extracts pseudo labels based on CLIP cues and trains a lightweight network to further refine proposals. Extensive experiments on PASCAL VOC, COCO and Visual Genome datasets show that our ProposalCLIP can better generate proposals than previous state-of-the-art methods. Our ProposalCLIP also shows benefits for downstream tasks, such as unsupervised object detection., Comment: 10 pages, 5 figures

Visual content creation has spurred a soaring interest given its applications in mobile photography and AR / VR. Style transfer and single-image 3D photography as two representative tasks have so far evolved independently. In this paper, we make a connection between the two, and address the challenging task of 3D photo stylization - generating stylized novel views from a single image given an arbitrary style. Our key intuition is that style transfer and view synthesis have to be jointly modeled for this task. To this end, we propose a deep model that learns geometry-aware content features for stylization from a point cloud representation of the scene, resulting in high-quality stylized images that are consistent across views. Further, we introduce a novel training protocol to enable the learning using only 2D images. We demonstrate the superiority of our method via extensive qualitative and quantitative studies, and showcase key applications of our method in light of the growing demand for 3D content creation from 2D image assets., Comment: Project page: http://pages.cs.wisc.edu/~fmu/style3d/

In this paper, we propose a novel mutual consistency network (MC-Net+) to effectively exploit the unlabeled data for semi-supervised medical image segmentation. The MC-Net+ model is motivated by the observation that deep models trained with limited annotations are prone to output highly uncertain and easily mis-classified predictions in the ambiguous regions (e.g., adhesive edges or thin branches) for medical image segmentation. Leveraging these challenging samples can make the semi-supervised segmentation model training more effective. Therefore, our proposed MC-Net+ model consists of two new designs. First, the model contains one shared encoder and multiple slightly different decoders (i.e., using different up-sampling strategies). The statistical discrepancy of multiple decoders' outputs is computed to denote the model's uncertainty, which indicates the unlabeled hard regions. Second, we apply a novel mutual consistency constraint between one decoder's probability output and other decoders' soft pseudo labels. In this way, we minimize the discrepancy of multiple outputs (i.e., the model uncertainty) during training and force the model to generate invariant results in such challenging regions, aiming at regularizing the model training. We compared the segmentation results of our MC-Net+ model with five state-of-the-art semi-supervised approaches on three public medical datasets. Extension experiments with two standard semi-supervised settings demonstrate the superior performance of our model over other methods, which sets a new state of the art for semi-supervised medical image segmentation. Our code is released publicly at https://github.com/ycwu1997/MC-Net., Comment: Accepted by Medical Image Analysis

Conventional stereo suffers from a fundamental trade-off between imaging volume and signal-to-noise ratio (SNR) -- due to the conflicting impact of aperture size on both these variables. Inspired by the extended depth of field cameras, we propose a novel end-to-end learning-based technique to overcome this limitation, by introducing a phase mask at the aperture plane of the cameras in a stereo imaging system. The phase mask creates a depth-dependent point spread function, allowing us to recover sharp image texture and stereo correspondence over a significantly extended depth of field (EDOF) than conventional stereo. The phase mask pattern, the EDOF image reconstruction, and the stereo disparity estimation are all trained together using an end-to-end learned deep neural network. We perform theoretical analysis and characterization of the proposed approach and show a 6x increase in volume that can be imaged in simulation. We also build an experimental prototype and validate the approach using real-world results acquired using this prototype system., Comment: Accepted to CVPR 2021 as an oral presentation

Semi-supervised learning has attracted great attention in the field of machine learning, especially for medical image segmentation tasks, since it alleviates the heavy burden of collecting abundant densely annotated data for training. However, most of existing methods underestimate the importance of challenging regions (e.g. small branches or blurred edges) during training. We believe that these unlabeled regions may contain more crucial information to minimize the uncertainty prediction for the model and should be emphasized in the training process. Therefore, in this paper, we propose a novel Mutual Consistency Network (MC-Net) for semi-supervised left atrium segmentation from 3D MR images. Particularly, our MC-Net consists of one encoder and two slightly different decoders, and the prediction discrepancies of two decoders are transformed as an unsupervised loss by our designed cycled pseudo label scheme to encourage mutual consistency. Such mutual consistency encourages the two decoders to have consistent and low-entropy predictions and enables the model to gradually capture generalized features from these unlabeled challenging regions. We evaluate our MC-Net on the public Left Atrium (LA) database and it obtains impressive performance gains by exploiting the unlabeled data effectively. Our MC-Net outperforms six recent semi-supervised methods for left atrium segmentation, and sets the new state-of-the-art performance on the LA database., Comment: Accepted by MICCAI 2021

When a camera is pointed at a strong light source, the resulting photograph may contain lens flare artifacts. Flares appear in a wide variety of patterns (halos, streaks, color bleeding, haze, etc.) and this diversity in appearance makes flare removal challenging. Existing analytical solutions make strong assumptions about the artifact's geometry or brightness, and therefore only work well on a small subset of flares. Machine learning techniques have shown success in removing other types of artifacts, like reflections, but have not been widely applied to flare removal due to the lack of training data. To solve this problem, we explicitly model the optical causes of flare either empirically or using wave optics, and generate semi-synthetic pairs of flare-corrupted and clean images. This enables us to train neural networks to remove lens flare for the first time. Experiments show our data synthesis approach is critical for accurate flare removal, and that models trained with our technique generalize well to real lens flares across different scenes, lighting conditions, and cameras., Comment: A new version paper is uploaded

Analyzing the morphological attributes of blood vessels plays a critical role in the computer-aided diagnosis of many cardiovascular and ophthalmologic diseases. Although being extensively studied, segmentation of blood vessels, particularly thin vessels and capillaries, remains challenging mainly due to the lack of an effective interaction between local and global features. In this paper, we propose a novel deep learning model called PC-Net to segment retinal vessels and major arteries in 2D fundus image and 3D computed tomography angiography (CTA) scans, respectively. In PC-Net, the pyramid squeeze-and-excitation (PSE) module introduces spatial information to each convolutional block, boosting its ability to extract more effective multi-scale features, and the coarse-to-fine (CF) module replaces the conventional decoder to enhance the details of thin vessels and process hard-to-classify pixels again. We evaluated our PC-Net on the Digital Retinal Images for Vessel Extraction (DRIVE) database and an in-house 3D major artery (3MA) database against several recent methods. Our results not only demonstrate the effectiveness of the proposed PSE module and CF module, but also suggest that our proposed PC-Net sets new state of the art in the segmentation of retinal vessels (AUC: 98.31%) and major arteries (AUC: 98.35%) on both databases, respectively.