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Alcohol dehydrogenase iron containing 1 (ADHFE1) encodes a hydroxyacid-oxoacid transhydrogenase participating in multiple biological processes. The role of ADHFE1 in cancer has not been fully uncovered. Herein, we performed data analysis to investigate the expression of ADHFE1 and the underlying regulatory mechanisms, its relationship with cancer patients’ survival, and the relevant pathways in cancer. A range of recognized, web-available databases and bioinformatics tools were used in this in silico study. We found that ADHFE1 was frequently downregulated and hypermethylated in various cancer cell lines and tissue samples. High expression of ADHFE1 was positively associated with favorable patient prognosis in breast, colon, and gastric cancers. Pathway analysis revealed its potential role in cancer-related biological processes, including energy metabolism, DNA replication, and cell cycle regulation. AHDFE1 mRNA expression and DNA methylation can potentially be used as diagnostic markers in cancer and might be of great value in predicting the survival of patients with cancer.

In order to seek a better inhibitor to suppress the explosion of lycopodium powder, this paper used Hartmann experimental system and 20 L spherical explosion experimental system to conduct the flame propagation and explosion pressure suppression experiments of lycopodium powder explosion, respectively, to study the suppression effect of lycopodium powder explosion under the conditions of adding different proportions of montmorillonite powder and hydroxy modified montmorillonite powder, combined with the FTIR curves before and after the explosion of lycopodium powder as well as the reaction involving it and inhibitors, the inhibition mechanism of montmorillonite powder and hydroxy- montmorillonite powder on the explosion of lycopodium powder was analyzed. The experimental results show that: with the increase of the addition ratio of the two inhibitor powder, the flame brightness becomes darker, the flame propagation speed gradually decreases, and the maximum explosion pressure and the maximum explosion pressure change rate gradually decreases. By the analysis of inhibition mechanism: montmorillonite powder blocks and absorbs thermal radiation and has basically no chemical inhibition effect whose inhibition effect is relatively weak; hydroxy-montmorillonite powder in addition to the basic physical inhibition with montmorillonite powder, but also decomposition at high temperatures to generate a large number of hydroxyl radicals, the radicals generated can make the reaction of the explosion in the reverse direction, and nearly can block the explosion chain reaction continues, playing a key role in chemical inhibition. Research results show that: montmorillonite powder and hydroxyl modified montmorillonite powder on lycopodium powder explosion have a certain inhibition effect, and modified hydroxyl montmorillonite powder than montmorillonite powder on the lycopodium powder explosion inhibition effect is better. [ABSTRACT FROM AUTHOR]

Localized surface plasmon resonance (LSPR) is attractive to fabricate visible (VIS) and near‐infrared (NIR) dual‐band electrochromic materials. However, the introduction of the LSPR effect in the available dual‐band electrochromic materials can only be manifested to the spectral enhancement in the NIR region, and difficult issues of electrochromic materials such as low coloration efficiency and unsatisfactory long‐term cycling durability still remain. Here, a dual‐band electrochromic thin film consisting of a 2D ordered macroporous (2DOM) Au LSPR layer and a poly(3,4‐(2,2‐dimethylpropylenedioxy)thiophene) (PProDot‐Me2) electrochromic layer is presented, where LSPR and electrochromism interact in a complementary fashion. The 2DOM Au exhibits LSPR effect at wavelengths of 550 and 1700 nm, leading to a unique electrochromic performance improvement of the film in both of the VIS and NIR spectral regions. Large optical modulation, rapid switching speed, high coloration efficiency, and long‐term durability are achieved due to the collective effect of the near‐field enhancement of the 2DOM Au and the reduced bandgap of PProDot‐Me2. These advantages can be well retained in the dual‐band electrochromic device using the 2DOM Au/PProDot‐Me2 films as the electrochromic layers. This work provides new ideas for designing LSPR‐based devices, especially dual‐band electrochromic materials and devices, both experimentally and theoretically. [ABSTRACT FROM AUTHOR]