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Your search keyword '"Wu, Qiaoyin"' showing total 18 results
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18 results on '"Wu, Qiaoyin"'

1. Clinical targeting of HIV capsid protein with a long-acting small molecule

Author

Link, John O., Rhee, Martin S., Tse, Winston C., Zheng, Jim, Somoza, John R., Rowe, William, Begley, Rebecca, Chiu, Anna, Mulato, Andrew, Hansen, Derek, Singer, Eric, Tsai, Luong K., Bam, Rujuta A., Chou, Chien-Hung, Canales, Eda, Brizgys, Gediminas, Zhang, Jennifer R., Li, Jiayao, Graupe, Michael, Morganelli, Philip, Liu, Qi, Wu, Qiaoyin, Halcomb, Randall L., Saito, Roland D., Schroeder, Scott D., Lazerwith, Scott E., Bondy, Steven, Jin, Debi, Hung, Magdeleine, Novikov, Nikolai, Liu, Xiaohong, Villaseñor, Armando G., Cannizzaro, Carina E., Hu, Eric Y., Anderson, Robert L., Appleby, Todd C., Lu, Bing, Mwangi, Judy, Liclican, Albert, Niedziela-Majka, Anita, Papalia, Giuseppe A., Wong, Melanie H., Leavitt, Stephanie A., Xu, Yili, Koditek, David, Stepan, George J., Yu, Helen, Pagratis, Nikos, Clancy, Sheila, Ahmadyar, Shekeba, Cai, Terrence Z., Sellers, Scott, Wolckenhauer, Scott A., Ling, John, Callebaut, Christian, Margot, Nicolas, Ram, Renee R., Liu, Ya-Pei, Hyland, Rob, Sinclair, Gary I., Ruane, Peter J., Crofoot, Gordon E., McDonald, Cheryl K., Brainard, Diana M., Lad, Latesh, Swaminathan, Swami, Sundquist, Wesley I., Sakowicz, Roman, Chester, Anne E., Lee, William E., Daar, Eric S., Yant, Stephen R., and Cihlar, Tomas

Published
2020
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2. Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873.

Author

Kato, Darryl, Choy, Regina Wai-Yan, Canales, Eda, Dick, Ryan A., Lake, April D., Shapiro, Nathan D., Chin, Elbert, Li, Jiayao, Zhang, Jennifer R., Wu, Qiaoyin, Saito, Roland D., Metobo, Sammy, Aktoudianakis, Evangelos, Schroeder, Scott D., Yang, Zheng-Yu, Glatt, Dylan M., Balsitis, Scott, Gamelin, Lindsay, Yu, Mei, and Cheng, Guofeng

Published
2024
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6. Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease

Author

Michael O'neil Hanrahan Clarke, Jie Xu, Edward Doerffler, Todd Appleby, X. Christopher Sheng, Choung U. Kim, Thomas Butler, John O. Link, William E. Delaney, Mingzhe Ji, Xiaowu Chen, Ruby Cai, Cottell Jeromy J, Hyung-Jung Pyun, Wu Qiaoyin, Aesop Cho, and Rowchanak Pakdaman

Subjects
Models, Molecular, Serine Proteinase Inhibitors, Hepatitis C virus, Hepacivirus, Clinical Biochemistry, Carboxylic Acids, Biological Availability, Pharmaceutical Science, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, biology, Chemistry, Organic Chemistry, Quinoline, virus diseases, Hepatitis C, biology.organism_classification, medicine.disease, Virology, digestive system diseases, Rats, Macaca fascicularis, Caco-2, Quinolines, Molecular Medicine, Caco-2 Cells
Abstract

The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys.

Published
2012

8. Highly potent HCV NS4B inhibitors with activity against multiple genotypes

Author

Zhimin Du, Jianhong Wang, Hyung-Jung Pyun, Wu Qiaoyin, Catalin Sebastian Zonte, Mingzhe Ji, Mish Michael R, Haolun Jin, Phillips Barton W, Huiling Yang, Ruby Cai, Jiayao Li, Joe Saugier, Chris Sheng, Neeraj Tirunagari, William E. Delaney, Anita Niedziela-Majka, and Johnny Lee

Subjects
Magnetic Resonance Spectroscopy, Genotype, Chemistry, Stereochemistry, Drug Discovery, Molecular Medicine, Hepacivirus, Viral Nonstructural Proteins, Mass Spectrometry
Abstract

The exploration of novel inhibitors of the HCV NS4B protein that are based on a 2-oxadiazoloquinoline scaffold is described. Optimization to incorporate activity across genotypes led to a potent new series with broad activity, of which inhibitor 1 displayed the following EC50 values: 1a, 0.08 nM; 1b, 0.10 nM; 2a, 3 nM; 2b, 0.6 nM, 3a, 3.7 nM; 4a, 0.9 nM; 6a, 3.1 nM.

Published
2014

11. Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity

Author

Anthony Casarez, Aesop Cho, William E. Delaney, Choung U. Kim, Mingzhe Ji, Xiaowu Chen, Jie Xu, Edward Doerffler, Rowchanak Pakdaman, Hyung-Jung Pyun, Wu Qiaoyin, Michael O'neil Hanrahan Clarke, Mertzman Michael E, Ruby Cai, Tanisha D. Rowe, and X. Christopher Sheng

Subjects
Swine, Hepatitis C virus, medicine.medical_treatment, Clinical Biochemistry, Cell, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Peptides, Cyclic, chemistry.chemical_compound, Inhibitory Concentration 50, Dogs, Pharmacokinetics, Genotype, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Protease, Molecular Structure, Chemistry, Organic Chemistry, Quinoline, Intracellular Signaling Peptides and Proteins, virus diseases, Virology, Phosphinic Acids, medicine.anatomical_structure, Molecular Medicine, Carrier Proteins, Ns3 4a protease
Abstract

A potent and novel class of phosphinic acid derived product-like inhibitors of the HCV NS3/4A protease was discovered previously. Modification of the phosphinic acid and quinoline heterocycle led to GS-9256 with potent cell-based activity and favorable pharmacokinetic parameters. Based on these attributes, GS-9256 was advanced to human clinical trial as a treatment for chronic infection with genotype 1 HCV.

Published
2011

16. Reversible guest molecule encapsulation in the 3-D framework of a heteropolynuclear luminescent Zn4Eu2cage complexElectronic supplementary information (ESI) available: X-Ray diffraction patterns and experimental. See DOI: 10.1039/b607183jDedicated in Memoriam to Professor Ian O. Rothwell

Author

Yang, Xiaoping, Hahn, Benjamin P., Jones, Richard A., Stevenson, Keith J., Swinnea, J. Steven, and Wu, Qiaoyin

Abstract

Guest molecules of diethyl ether or methanol are reversibly encapsulated in cavities formed by the 3-dimensional supramolecular framework of heteropolynuclear, luminescent [Eu2Zn4L4(OAc)6(NO3)2(OH)2]·2Et2O.

Published
2006
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17. Highly potent HCV NS4B inhibitors with activity against multiple genotypes.

Author

Phillips B, Cai R, Delaney W, Du Z, Ji M, Jin H, Lee J, Li J, Niedziela-Majka A, Mish M, Pyun HJ, Saugier J, Tirunagari N, Wang J, Yang H, Wu Q, Sheng C, and Zonte C

Subjects
Hepacivirus genetics, Magnetic Resonance Spectroscopy, Mass Spectrometry, Genotype, Hepacivirus drug effects, Viral Nonstructural Proteins antagonists & inhibitors
Abstract

The exploration of novel inhibitors of the HCV NS4B protein that are based on a 2-oxadiazoloquinoline scaffold is described. Optimization to incorporate activity across genotypes led to a potent new series with broad activity, of which inhibitor 1 displayed the following EC50 values: 1a, 0.08 nM; 1b, 0.10 nM; 2a, 3 nM; 2b, 0.6 nM, 3a, 3.7 nM; 4a, 0.9 nM; 6a, 3.1 nM.

Published
2014
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18. Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.

Author

Sheng XC, Appleby T, Butler T, Cai R, Chen X, Cho A, Clarke MO, Cottell J, Delaney WE 4th, Doerffler E, Link J, Ji M, Pakdaman R, Pyun HJ, Wu Q, Xu J, and Kim CU

Subjects
Animals, Antiviral Agents pharmacokinetics, Antiviral Agents pharmacology, Biological Availability, Caco-2 Cells, Carboxylic Acids pharmacokinetics, Carboxylic Acids pharmacology, Crystallography, X-Ray, Dogs, Hepacivirus chemistry, Hepacivirus enzymology, Hepatitis C drug therapy, Hepatitis C virology, Humans, Macaca fascicularis, Models, Molecular, Quinolines pharmacokinetics, Quinolines pharmacology, Rats, Serine Proteinase Inhibitors pharmacokinetics, Serine Proteinase Inhibitors pharmacology, Structure-Activity Relationship, Viral Nonstructural Proteins chemistry, Antiviral Agents chemical synthesis, Carboxylic Acids chemical synthesis, Hepacivirus drug effects, Quinolines chemical synthesis, Serine Proteinase Inhibitors chemical synthesis, Viral Nonstructural Proteins antagonists & inhibitors
Abstract

The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Published
2012
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