Search

Your search keyword '"Wu, Ming-Shun"' showing total 182 results
Start Over Author "Wu, Ming-Shun"
182 results on '"Wu, Ming-Shun"'

5. Bacteriophage‐cocktail hydrogel dressing to prevent multiple bacterial infections and heal diabetic ulcers in mice.

Author

Shiue, Sheng‐Jie, Wu, Ming‐Shun, Chiang, Yi‐Hsien, and Lin, Hsin‐Yi

Abstract

Bacteriophage (phage) has been reported to reduce the bacterial infection in delayed‐healing wounds and, as a result, aiding in the healing of said wounds. In this study we investigated whether the presence of phage itself could help repair delayed‐healing wounds in diabetic mice. Three strains of phage that target Salmonella enterica, Escherichia coli, and Pseudomonas aeruginosa were used. To prevent the phage liquid from running off the wound, the mixture of phage (phage‐cocktail) was encapsulated in a porous hydrogel dressing made with three‐dimensional printing. The phage‐cocktail dressing was tested for its phage preservation and release efficacy, bacterial reduction, cytotoxicity with 3T3 fibroblast, and performance in repairing a sterile full‐thickness skin wound in diabetic mice. The phage‐cocktail dressing released 1.7%–5.7% of the phages embedded in 24 h, and reduced between 37%–79% of the surface bacteria compared with the blank dressing (p <.05). The phage‐cocktail dressing exhibited no sign of cytotoxicity after 3 days (p <.05). In vivo studies showed that 14 days after incision, the full‐thickness wound treated with a phage‐cocktail dressing had a higher wound healing ratio compared with the blank dressing and control (p <.01). Histological analysis showed that the structure of the skin layers in the group treated with phage‐cocktail dressing was restored in an orderly fashion. Compared with the blank dressing and control, the repaired tissue in the phage‐cocktail dressing group had new capillary vessels and no sign of inflammation in its dermis, and its epidermis had a higher degree of re‐epithelialization (p <.05). The slow‐released phage has demonstrated positive effects in repairing diabetic skin wounds. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Taiwanese consensus recommendations for acute pancreatitis

Author

Liao, Wei-Chih, Tu, Tien-Chien, Lee, Kuei-Chuan, Tseng, Jseng-Hwei, Chen, Ming-Jen, Sun, Cheuk-Kay, Wang, Shang-Yu, Chang, Wei-Kuo, Chang, Pi-Yi, Wu, Ming-Shun, Lin, Tsung-Jung, Lee, Hsiang-Lin, Chen, Jiann-Hwa, Yuan, Kuo-Ching, Liu, Nai-Jen, Wu, Hsing-Chien, Liang, Po-Chin, Wang, Hsiu-Po, Hwang, Tsann-Long, and Lee, Chia-Long

Published
2020
Full Text
View/download PDF

18. Protective effects of statins on the incidence of NAFLD–related decompensated cirrhosis in T2DM.

Author

Wu, Szu‐Yuan, Chen, Wan‐Ming, Chiang, Ming‐Feng, Lo, Hung‐Chieh, Wu, Ming‐Shun, Lee, Ming‐Che, and Soong, Ruey‐Shyang

Subjects
NON-alcoholic fatty liver disease, TYPE 2 diabetes, STATINS (Cardiovascular agents), PROPENSITY score matching, CIRRHOSIS of the liver
Abstract

Background and Aims: Non‐alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and poses a significant threat to patients with type 2 diabetes mellitus (T2DM) and metabolic dysregulation. Statins exert anti‐inflammatory, antioxidative and antithrombotic effects that target mechanisms underlying NAFLD. However, the protective effects of the different doses, intensities and types of statins on the incidence of NAFLD‐related decompensated liver cirrhosis (DLC) in patients with T2DM remain unclear. Methods: This study used the data of patients with T2DM who were non‐HBV and non‐HCV carriers from a national population database to examine the protective effects of statin use on DLC incidence through propensity score matching. The incidence rate (IR) and incidence rate ratios (IRRs) of DLC in patients with T2DM with or without statin use were calculated. Results: A higher cumulative dose and specific types of statins, namely rosuvastatin, pravastatin, atorvastatin, simvastatin and fluvastatin, reduced the risk of DLC in patients with T2DM. Statin use was associated with a significant reduction in the risk of DLC (HR:.65, 95% CI:.61–.70). The optimal daily intensity of statin use with the lowest risk of DLC was.88 defined daily dose (DDD). Conclusions: The results revealed the protective effects of specific types of statins on DLC risk in patients with T2DM and indicated a dose–response relationship. Additional studies are warranted to understand the specific mechanisms of action of different types of statins and their effect on DLC risk in patients with T2DM. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

22. Comparison of endoscopic papillary large‐balloon dilatation with endoscopic sphincterotomy in clearing large common bile duct stones: A systematic review and meta‐analysis of randomized controlled trials

Author

Cheng, Chao‐Ling, primary, Tang, Kung‐Pei, additional, Cheng, Sheng‐Wei, additional, Fang, Hua‐Chen, additional, Shiue, Sheng‐Jie, additional, Suk, Fat‐Moon, additional, Lien, Gi‐Shih, additional, and Wu, Ming‐Shun, additional

Published
2022
Full Text
View/download PDF

40. Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index Than Sorafenib via Zebrafish Drug Screening Platform

Author

Lin, Han-Syuan, primary, Huang, Yi-Luen, additional, Wang, Yi-Rui Stefanie, additional, Hsiao, Eugene, additional, Hsu, Tsu-An, additional, Shiao, Hui-Yi, additional, Jiaang, Weir-Torn, additional, Sampurna, Bonifasius Putera, additional, Lin, Kuan-Hao, additional, Wu, Ming-Shun, additional, Lai, Gi-Ming, additional, and Yuh, Chiou-Hwa, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results