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High thermally conductive polymer composites have garnered significant attention due to their exceptional performance, given the ever-decreasing size of electronic devices and the rise in power densities. Herein, a new three-dimensional (3D) thermal conductivity network structure has been successfully prepared using double fillers of nickel foam (NF) and modified silicon carbide particles (KSiC). The study compared the effect of different filler contents on the thermal conductivity of composites. Compared to conventional composites, those based on 3D filling networks have significantly improved thermal conductivity. The thermal conductivity of the NF/KSiC/PU composite containing 50 [w.sub.t]% KSiC was 1.18 [Wm.sup.-1] [K.sup.-1], exceeding the cumulative thermal conductivity of the NF/PU and KSiC/PU 50 [w.sub.t]% composites, and 637.5% greater than that of neat PU. Meanwhile, the synthesized NF/KSiC/PU composite maintained a high electrical resistivity above [10.sup.12] [ohm]-cm and good mechanical properties. This approach might offer novel solutions for developing high-quality packaging materials for advanced electronic devices with exceptional thermal and mechanical properties. Highlights * Using SiC and NF Constructs a dual filler network. * The dual filler thermal conductivity network can generate synergistic effects. * Improving thermal conductivity compared to original polyurethane. * Maintaining a high electrical resistivity and good mechanical properties. KEYWORDS polyurethane, silicon carbide, thermal conduction network, thermal management material, 1 | INTRODUCTION In recent times, the continual progress of integrated circuits has resulted in increased chip integration levels and power densities. Nevertheless, this has led to heat accumulation, necessitating [...]

In this study, the wild type 6421 and the fruit color mutant E55 of pepper were evaluated for fruit color, pigment contents and quality components at different developmental stages. The results demonstrated that the fruit color of 6421 and E55 changed from green to yellow and then to red, and from green to brown and then to orange, respectively, as the fruit developed from mature green to ripe. For both 6421 and E55, the color parameters a* and C* increased, while hue angle (h) value decreased. Furthermore, chlorophyll (Chl) content declined, whereas carotenoid (Car) content increased. Additionally, the contents of VC, soluble sugar, soluble protein and capsaicin increased, while cellulose content decreased. At the mature green stage, there was no significant difference between 6421 and E55 in five color parameters (L*, a*, b*, C*, and h values), Chl and Car contents or six quality indicators (cellulose, VC, soluble sugar, soluble protein, and capsaicin contents) (P > 0.05). During the color-turning to ripening stages, L*, b* and C* values and VC and soluble sugar contents were significantly higher and soluble protein and cellulose contents were significantly lower in E55 than in 6421 (p 0.05). Correlation analysis showed that for both 6421 and E55, Chl and Car contents were significantly or extremely significantly correlated with each quality parameter except for cellulose content. Among the tested quality indicators, soluble sugar, soluble protein, and capsaicin contents were significantly or extremely significantly positively correlated with each other, while cellulose content was significantly or highly significantly negatively correlated with the other indicators. This study can serve as a theoretical basis for research on the coloration mechanism of peppers as well as for the screening and breeding of high-quality pepper cultivars.

ObjectiveTo determine the effects of Dendrobium nobile Lindl. on the regulation of lipid metabolism based on metabolomics.MethodsTwenty-four rats were randomly divided into the normal control and D. nobile treatment （0.25 g/kg） groups. Rats were intragastrically administered their assigned treatment once every 6 h for 5 d. After the last treatment， the plasma and liver of the animals were collected. Metabolomics were evaluated using UPLC-MS. Principal component analysis （PCA）， cluster analysis， and KEGG pathway analysis were performed to assess the metabolomics data. Compared with the normal control group， different metabolites were identified in the D. nobile treatment group. The expression levels of lipid metabolism-related genes were validated using quantitative real-time PCR.ResultsObvious differences were found between the normal control group and D. nobile treatment group， with significant differences obtained for 1 448 metabolites （P

Objective To evaluate the effect of intraoperative multimodal analgesia on the early postoperative quality of recovery in end-stage head and neck cancer patients undergoing open gastrostomy surgery. Methods This was a prospective, parallel, randomized controlled study. The research subjects were end-stage head and neck cancer patients who underwent elective open gastrostomy at Beijing Tongren Hospital affiliated to Capital Medical University from November 2022 to May 2023. The patients were randomly divided into local anesthesia group and multimodal analgesia group at a 1∶1 ratio. For local anesthesia group, 0.25% ropivacaine 20-30 mL was administered for local infiltration anesthesia. For multimodal analgesia group, the anesthesia method was nerve block + intravenous analgesia: ultrasound-guided left transverse abdominis plane block (0.25% ropivacaine 0.3 mL/kg)+bilateral rectus abdominis sheath block (0.25% ropivacaine 0.3 mL/kg per side)+intravenous injection of oxycodone 0.1 mg/kg, flurbiprofen 1 mg/kg, and dexamethasone 0.2 mg/kg. The primary outcome measure was the quality of requirements-15 (QoR-15) score at postoperative 24 h, while the secondary outcome measures were the QoR-15 score at postoperative 48 h, the numerical rating scale (NRS) and Bruggemann comfort scale (BCS) scores at different time points after the surgery, the first time of rescue analgesia, the first time of off-bed activity and intestinal exhaust, as well as the incidences of adverse reactions within postoperative 48 h. Results A total of 46 patients with end-stage head and neck cancer who underwent open gastrostomy and met the inclusion and exclusion criteria were ultimately enrolled, with 23 patients in multimodal analgesia group and 23 patients in local anesthesia group. There was no statistically significant difference in preoperative QoR-15 scores between the two groups (P > 0.05). Multimodal analgesia group had higher QoR-15 scores at 24 h postoperatively[(81.77±8.91) vs. (71.46±7.61), P < 0.05] and 48 h postoperatively[(86.26±7.92) vs. (80.13±6.98), P < 0.05], and the difference in QoR-15 scores at 24 h postoperatively was clinically significant. Compared with local anesthesia group, at 6 h and 24 h after surgery, the multimodal analgesia group showed a decrease in NRS scores at rest and during exercise, while the comfort BCS score increased (all P < 0.05). Multimodal analgesia group also had a delayed time for the first rescue analgesia, a reduced incidence of rescue analgesia within 48 h after surgery, an earlier time for first postoperative off-bed activity and intestinal exhaust (all P < 0.05). The incidence of adverse reactions in multimodal analgesia group and local anesthesia group was 8.70% and 13.04%, respectively, but the difference was not statistically significant (P > 0.05). Conclusion Intraoperative multimodal analgesia can effectively alleviate postoperative pain, increase the comfortable degree, shorten the first time of postoperative off-bed activity and intestinal exhaust, and accordingly improve the quality of early postoperative recovery in patients undergoing open gastrostomy.

Objective Preoperative frailty in elderly patients with colorectal cancer was evaluated using six frailty assessment tools, frailty phenotype (FP), frailty scale (FRAIL), clinical frailty scale (CFS), Tilburg frailty index (TFI), Edmonton frailty scale (EFS) and Groningen frailty index (GFI). The predictive levels of each scale for short-term adverse outcomes after surgery were compared. Methods A total of 290 elderly patients undergoing laparoscopic radical resection of colorectal cancer in Cancer Hospital Affiliated of Guangxi Medical University from June 2021 to February 2023 were selected as the study subjects. FP, FRAIL, CFS, TFI, EFS, and GFI were used to assess the patient ‘s frailty status. Baseline data and postoperative disability, complications, prolonged hospital stay, and increased treatment costs were collected. The predictive levels of 6 scales for short-term adverse outcomes after surgery were evaluated by receiver operating characteristic (ROC) curves. Results The evaluation of FP, FRAIL, CFS, TFI, EFS and GFI showed that the frailty rate was 41.3%, 29.6%, 38.6%, 65.5%, 37.9% and 38.6%, respectively. There was a statistically significant difference in the detection rates of the six attenuation tools (χ2=88.510, P＜0.01). The maximum AUC for postoperative disability and increased treatment costs were 0.814 and 0.661 predicted by FP. The maximum AUC for postoperative complications and prolonged hospital stay were 0.741 and 0.754 predicted by FRAIL. Conclusion Different frailty tools have significant differences in the detection rate of frailty, with poor consistency; Based on the characteristics and advantages of the tool, taking into account both time and cost, FRAIL is the best predictor of short-term adverse outcomes after surgery.

This study proposes to investigate the failure characteristics and load-bearing performance of external prestressed composite reinforced concrete beams by conducting a three-point loading test on 12 full FRP reinforced concrete beams. These external prestressed concrete beams were reinforced with carbon fiber reinforced polymer(CFRP), while the stress reinforcement and stirrup were made of glass fiber reinforced polymer(GFRP). Specifically, the study compares the impact of prestress level, shear span ratio, and concrete type on the bearing capacity of GFRP reinforced concrete beams. derives an expression for flexural bearing capacity to account for the effect of stress increment of prestressed tendons, and is verified by experimental results. The test results indicate that the failure of non-prestressed FRP reinforced concrete beams is primarily governed by deformation, whereas applying prestress can shift the failure mode from deformation control to bearing capacity control. The mid-span deflection of the concrete beam is directly proportional to the increase in prestress. The bearing capacity of FRP beams decreases with an increase in shear span ratio, with particularly significant effect on cracking load. The effect of concrete type on the cracking load of prestressed beams surpasses its impact on the ultimate load, while it exerts minimal influence on cracking and ultimate load of non-prestressed beams. The calculated results for the bearing capacity of prestressed FRP reinforced concrete beams derived in this study align well with the measured values.