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Your search keyword '"Wu, Lei-Ming"' showing total 18 results
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18 results on '"Wu, Lei-Ming"'

3. Ovarian Tumor Domain‐Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel‐Like Factor 4

Author

Du, Bin‐Bin, primary, Zhang, Jie‐Lei, additional, Kong, Ling‐Yao, additional, Shi, Hui‐Ting, additional, Zhang, Dian‐Hong, additional, Wang, Xing, additional, Yang, Chun‐Lei, additional, Li, Peng‐Cheng, additional, Yao, Rui, additional, Liang, Cui, additional, Wu, Lei‐Ming, additional, and Huang, Zhen, additional

Published
2023
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5. OTUB1 alleviates NASH through inhibition of the TRAF6‐ASK1 signaling pathways

Author

Zhang, Jie‐Lei, primary, Du, Bin‐Bin, additional, Zhang, Dian‐Hong, additional, Li, Huan, additional, Kong, Ling‐Yao, additional, Fan, Guang‐Jian, additional, Li, Ya‐Peng, additional, Li, Peng‐Cheng, additional, Liang, Cui, additional, Wang, Zheng, additional, Yang, Lu‐Lu, additional, Hao, Zheng‐Yang, additional, Wu, Lei‐Ming, additional, Huang, Zhen, additional, Dong, Jian‐Zeng, additional, Zhang, Jin‐Ying, additional, Yao, Rui, additional, Wang, Shou‐Jun, additional, and Zhang, Yan‐Zhou, additional

Published
2021
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7. Effects of chemical fertilizer nitrogen substitution by biogas slurry on yield, quality and growth charac-teristics of winter wheat

Author

WANG Gui-liang, ZHANG Jia-hong, WANG Shou-hong, KOU Xiang-ming, XU Rong, HAN Guang-ming, TANG He-jun, ZHU Ling-yu, BI Jian-hua, and WU Lei-ming

Subjects
lcsh:GE1-350, biogas slurry, chemical fertilizer nitrogen substitution, wheat, growth, quality, heavy metal, food and beverages, lcsh:Agriculture (General), lcsh:S1-972, lcsh:Environmental sciences
Abstract

A field experiment was conducted to study the effects of different ratios of chemical fertilizer nitrogen substitution by biogas slurry on yield, growth characteristics(development progress, plant height dynamic, population dynamic and dry matter accumulation dynamic), quality and heavy metal content of winter wheat. The results showed that winter wheat yield increased significantly(P-2, 18.14% higher than the treatment with total chemical fertilizer nitrogen(Ncf). There were no significant differences between the yields of 100%Nbs and Ncf(P>0.05). The 1000-kernels weight presented a significant declining trend(PPPPP>0.05). The contents of these grain heavy metal of each treatment were lower than the maximum levels of contaminants in foods. When the ratio of chemical fertilizer nitrogen substitution by biogas slurry raised above 50%, because of the prolonged growth duration and the increased basal internode length could lead to lodge and yield reduction, and because of greater use of biogas slurry could lead to the risk of secondary pollution. Therefore, in our preliminary study, in this experiment, the optimal ratio of chemical fertilizer nitrogen substitution by biogas slurry was 50%.

Published
2018

9. Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal–Regulating Kinase 1 Pathways

Author

Huang, Zhen, primary, Wu, Lei‐Ming, additional, Zhang, Jie‐Lei, additional, Sabri, Abdelkarim, additional, Wang, Shou‐Jun, additional, Qin, Gui‐Jun, additional, Guo, Chang‐Qing, additional, Wen, Hong‐Tao, additional, Du, Bin‐Bin, additional, Zhang, Dian‐Hong, additional, Kong, Ling‐Yao, additional, Tian, Xin‐Yu, additional, Yao, Rui, additional, Li, Ya‐Peng, additional, Liang, Cui, additional, Li, Peng‐Cheng, additional, Wang, Zheng, additional, Guo, Jin‐Yan, additional, Li, Ling, additional, Dong, Jian‐Zeng, additional, and Zhang, Yan‐Zhou, additional

Published
2019
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18. Effects of TGF-β signaling blockade on human A549 lung adenocarcinoma cell lines.

Author

Xu CC, Wu LM, Sun W, Zhang N, Chen WS, and Fu XN

Subjects
Adenocarcinoma genetics, Adenocarcinoma pathology, Adenocarcinoma of Lung, Apoptosis, Blotting, Western, Carcinoma, Non-Small-Cell Lung genetics, Cell Line, Tumor, Cell Movement, Cell Proliferation, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Humans, Lung Neoplasms genetics, Lung Neoplasms pathology, Neoplasm Invasiveness, Protein Serine-Threonine Kinases genetics, RNA, Messenger genetics, RNA, Messenger metabolism, RNA, Small Interfering metabolism, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta genetics, Transfection, Tumor Stem Cell Assay, Adenocarcinoma metabolism, Lung Neoplasms metabolism, Protein Serine-Threonine Kinases metabolism, Receptors, Transforming Growth Factor beta metabolism, Signal Transduction, Transforming Growth Factor beta metabolism
Abstract

Transforming growth factor β (TGF-β) is overexpressed in a wide variety of cancer types including lung adenocarcinoma (LAC), and the TGF-β signaling pathway plays an important role in tumor development. To determine whether blockade of the TGF-β signaling pathway can inhibit the malignant biological behavior of LAC, RNA interference (RNAi) technology was used to silence the expression of TGF-β receptor, type II (TGFβRII) in the LAC cell line, A549, and its effects on cell proliferation, invasion and metastasis were examined. Three specific small interfering RNAs (siRNAs) designed for targeting human TGFβRII were transfected into A549 cells. The expression of TGFβRII was detected by Western blot analysis. Cell proliferation was measured by MTT and clonogenic assays. Cell apoptosis was assessed by flow cytometry. The invasion and metastasis of A549 cells were investigated using the wound healing and Matrigel invasion assays. The expression of PI3K, phosphorylated Smad2, Smad4, Akt, Erk1/2, P38 and MMPs was detected by Western blot analysis. The TGFβRII siRNA significantly reduced the expression of TGFβRII in A549 cells. The knockdown of TGFβRII in A549 cells resulted in the suppression of cell proliferation, invasion and metastasis and induced cell apoptosis. In addition to the Smad-dependent pathway, independent pathways including the Erk MAPK, PI3K/Akt and p38 MAPK pathways, as well as the expression of MMPs and VEGF, were inhibited. In conclusion, TGF-β signaling is required for LAC progression. Therefore, the blockade of this signaling pathway by the down-regulation of TGFβRII using SiRNA may provide a potential gene therapy for LAC.

Published
2011
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