Search

Your search keyword '"Wu, Kan Xing"' showing total 22 results
Start Over Author "Wu, Kan Xing"
22 results on '"Wu, Kan Xing"'

2. Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease

Author

Tay, Kai Yi, Wu, Kan Xing, Chioh, Florence Wen Jing, Autio, Matias Ilmari, Pek, Nicole Min Qian, Narmada, Balakrishnan Chakrapani, Tan, Sock-Hwee, Low, Adrian Fatt-Hoe, Lian, Michelle Mulan, Chew, Elaine Guo Yan, Lau, Hwee Hui, Kao, Shih Ling, Teo, Adrian Kee Keong, Foo, Jia Nee, Foo, Roger Sik Yin, Heng, Chew Kiat, Chan, Mark Yan Yee, and Cheung, Christine

Published
2022
Full Text
View/download PDF

4. Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype

Author

Tan, Wilson Lek Wen, Anene-Nzelu, Chukwuemeka George, Wong, Eleanor, Lee, Chang Jie Mick, Tan, Hui San, Tang, Sze Jing, Perrin, Arnaud, Wu, Kan Xing, Wenhao, Zheng, Ashburn, Robert John, Pan, Bangfen, Yin, Lee May, Autio, Matias Ilmari, Morley, Michael P., Tam, Wai Leong, Cheung, Christine, Margulies, Kenneth B., Chen, Leilei, Cappola, Thomas P., Loh, Marie, Chambers, John, Prabhakar, Shyam, and Foo, Roger S-Y

Published
2020
Full Text
View/download PDF

5. The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses

Author

Wu, Kan Xing, primary, Yogarajah, Thinesshwary, additional, Choy Loe, Marcus Wing, additional, Kaur, Parveen, additional, Hua Lee, Regina Ching, additional, Mok, Chee Keng, additional, Wong, Yi Hao, additional, Phuektes, Patchara, additional, Yeo, Li Sze, additional, Chow, Vincent T.K., additional, Tan, Yong Wah, additional, and Hann Chu, Justin Jang, additional

Published
2023
Full Text
View/download PDF

6. 292 Discovery and development of t cell receptors for adoptive t cell therapy against solid tumors

Author

Lujan, Juliana Velez, primary, Fields, Hannah, additional, Wu, Kan Xing, additional, Epstein, Natalie, additional, Chioh, Florence, additional, Tan, Nicholas, additional, Carbajo, Daniel, additional, Kulkarni, Neeraja, additional, Gerber, Lorenz, additional, Purwanti, Yovita, additional, Nardin, Alessandra, additional, Fehlings, Michael, additional, Fink, Katja, additional, and Macleod, Dan, additional

Published
2022
Full Text
View/download PDF

8. Endothelial‐immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease

Author

Ng, Chun‐Yi, primary, Lee, Khang Leng, additional, Muthiah, Mark Dhinesh, additional, Wu, Kan Xing, additional, Chioh, Florence Wen Jing, additional, Tan, Konstanze, additional, Soon, Gwyneth Shook Ting, additional, Shabbir, Asim, additional, Loo, Wai Mun, additional, Low, Zun Siong, additional, Chen, Qingfeng, additional, Wahli, Walter, additional, Tan, Nguan Soon, additional, Ng, Huck Hui, additional, Dan, Yock Young, additional, and Cheung, Christine, additional

Published
2022
Full Text
View/download PDF

9. Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease

Author

Tay, Kai Yi, primary, Wu, Kan Xing, additional, Chioh, Florence Wen Jing, additional, Autio, Matias Ilmari, additional, Pek, Nicole Min Qian, additional, Narmada, Balakrishnan Chakrapani, additional, Tan, Sock-Hwee, additional, Low, Adrian Fatt-Hoe, additional, Lian, Michelle Mulan, additional, Chew, Elaine Guo Yan, additional, Lau, Hwee Hui, additional, Kao, Shih Ling, additional, Teo, Adrian Kee Keong, additional, Foo, Jia Nee, additional, Foo, Roger Sik Yin, additional, Heng, Chew Kiat, additional, Chan, Mark Yan Yee, additional, and Cheung, Christine, additional

Published
2022
Full Text
View/download PDF

10. Additional file 1 of Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy

Author

Wu, Kan Xing, Yeo, Natalie Jia Ying, Ng, Chun Yi, Chioh, Florence Wen Jing, Fan, Qiao, Tian, Xianfeng, Yang, Binxia, Narayanan, Gunaseelan, Tay, Hui Min, Hou, Han Wei, Dunn, N. Ray, Su, Xinyi, Cheung, Chui Ming Gemmy, and Cheung, Christine

Subjects
complex mixtures
Abstract

Additional file 1: Figure S1. Extrinsic mediators influence sprouting angiogenesis of BOECs. Figure S2. scRNA-seq data quality checks and cluster marker enrichments. Figure S3. Differential expression in PCV and normal BOECs after heterogeneous flow. Figure S4. Differential expression in PCV and normal BOECs after heterogeneous flow. Table S1. Demographics details of PCV patients and normal individuals. Table S2. HYAL1 validation in clinical samples. Table S3. Key resources used in this study.

Published
2022
Full Text
View/download PDF

11. Endothelial-immune crosstalk contributes to vasculopathy in non-alcoholic fatty liver disease

Author

Ng, Chun-Yi, primary, Lee, Khang Leng, additional, Muthiah, Mark Dhinesh, additional, Wu, Kan Xing, additional, Chioh, Florence, additional, Tan, Konstanze, additional, Soon, Gwyneth, additional, Shabbir, Asim, additional, Loo, Wai Mun, additional, Low, Zun Siong, additional, Chen, Qingfeng, additional, Tan, Nguan Soon, additional, Ng, Huck-Hui, additional, Dan, Yock Young, additional, and Cheung, Christine, additional

Published
2021
Full Text
View/download PDF

12. Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy

Author

Wu, Kan-Xing, primary, Yeo, Natalie Jia Ying, additional, Ng, Chun-Yi, additional, Chioh, Florence Wen Jing, additional, Qiao, Fan, additional, Tian, Xianfeng, additional, Binxia, Yang, additional, Narayanan, Gunaseelan, additional, Tay, Hui-Min, additional, Hou, Han-Wei, additional, Dunn, N Ray, additional, Su, Xinyi, additional, Cheung, Chui Ming Gemmy, additional, and Cheung, Christine, additional

Published
2021
Full Text
View/download PDF

13. Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

Author

Chioh, Florence WJ, primary, Fong, Siew-Wai, additional, Young, Barnaby E, additional, Wu, Kan-Xing, additional, Siau, Anthony, additional, Krishnan, Shuba, additional, Chan, Yi-Hao, additional, Carissimo, Guillaume, additional, Teo, Louis LY, additional, Gao, Fei, additional, Tan, Ru San, additional, Zhong, Liang, additional, Koh, Angela S, additional, Tan, Seow-Yen, additional, Tambyah, Paul A, additional, Renia, Laurent, additional, Ng, Lisa FP, additional, Lye, David C, additional, and Cheung, Christine, additional

Published
2021
Full Text
View/download PDF

14. Author response: Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

Author

Chioh, Florence WJ, primary, Fong, Siew-Wai, additional, Young, Barnaby E, additional, Wu, Kan-Xing, additional, Siau, Anthony, additional, Krishnan, Shuba, additional, Chan, Yi-Hao, additional, Carissimo, Guillaume, additional, Teo, Louis LY, additional, Gao, Fei, additional, Tan, Ru San, additional, Zhong, Liang, additional, Koh, Angela S, additional, Tan, Seow-Yen, additional, Tambyah, Paul A, additional, Renia, Laurent, additional, Ng, Lisa FP, additional, Lye, David C, additional, and Cheung, Christine, additional

Published
2021
Full Text
View/download PDF

16. Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

Author

Chioh, Florence WJ, primary, Fong, Siew-Wai, additional, Young, Barnaby E., additional, Wu, Kan-Xing, additional, Siau, Anthony, additional, Krishnan, Shuba, additional, Chan, Yi-Hao, additional, Teo, Louis LY, additional, Gao, Fei, additional, Tan, Ru San, additional, Zhong, Liang, additional, Koh, Angela S., additional, Tan, Seow-Yen, additional, Tambyah, Paul A., additional, Renia, Laurent, additional, Ng, Lisa FP, additional, Lye, David C, additional, and Cheung, Christine, additional

Published
2020
Full Text
View/download PDF

21. In-depth analysis of human virus-specific CD8+T cells delineates unique phenotypic signatures for T cell specificity prediction

Author

Schmidt, Florian, Fields, Hannah F., Purwanti, Yovita, Milojkovic, Ana, Salim, Syazwani, Wu, Kan Xing, Simoni, Yannick, Vitiello, Antonella, MacLeod, Daniel T., Nardin, Alessandra, Newell, Evan W., Fink, Katja, Wilm, Andreas, and Fehlings, Michael

Abstract

Following viral infection, the human immune system generates CD8+T cell responses to virus antigens that differ in specificity, abundance, and phenotype. A characterization of virus-specific T cell responses allows one to assess infection history and to understand its contribution to protective immunity. Here, we perform in-depth profiling of CD8+T cells binding to CMV-, EBV-, influenza-, and SARS-CoV-2-derived antigens in peripheral blood samples from 114 healthy donors and 55 cancer patients using high-dimensional mass cytometry and single-cell RNA sequencing. We analyze over 500 antigen-specific T cell responses across six different HLA alleles and observed unique phenotypes of T cells specific for antigens from different virus categories. Using machine learning, we extract phenotypic signatures of antigen-specific T cells, predict virus specificity for bulk CD8+T cells, and validate these predictions, suggesting that machine learning can be used to accurately predict antigen specificity from T cell phenotypes.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results