Search

Your search keyword '"Wu, Jia-Zhu"' showing total 206 results
Start Over Author "Wu, Jia-Zhu"
206 results on '"Wu, Jia-Zhu"'

31. Dynamic changes in circulating EBV-DNA load during treatment have prognostic values in EBV+ DLBCL-NOS: a Chinese cohort study.

Author

Xing, Tong-Yao, Duan, Zi-Wen, Wang, Wei-Ting, Du, Kai-Xin, Shen, Hao-Rui, Yin, Hua, Wu, Jia-Zhu, Li, Yue, Wang, Li, Li, Jian-Yong, Liang, Jin-Hua, and Xu, Wei

Subjects
CIRCULATING tumor DNA, PROGNOSIS, DIFFUSE large B-cell lymphomas, EPSTEIN-Barr virus diseases, PROGRESSION-free survival, COHORT analysis
Abstract

EBV-positive diffuse large B-cell lymphoma, not otherwise specified (EBV+ DLBCL-NOS), is an EBV-positive clonal B-cell lymphoid proliferation and circulating EBV-DNA is a great indicator for prognosis among EBV associated disease. In this retrospective study, we report 66 EBV+ DLBCL cases among 2137 DLBCL-NOS cases diagnosed from 2013 to 2021 (prevalence of 6.0%). After a median follow-up of 27 months, progression-free survival (PFS) and overall survival (OS) at 2 years were 39.5% ± 6.2% and 53.6% ± 6.4%, respectively. Multivariate analysis showed that only the biomarker of the positivity of post treatment EBV-DNA had a borderline correlation with shorter PFS and OS (PFS: P = 0.053; OS: P = 0.065). Patients were divided into three subgroups according to dynamic changes of EBV-DNA status: EBV-DNA persistently negative group, EBV-DNA persistently positive group, and EBV-DNA transformed from positive to negative group; among the three groups, patients of the persistently positive group had worst PFS and OS (P = 0.0527 and P = 0.0139, respectively). Decline in EBV copies correlated significantly with treatment response as well. In conclusion, circulating EBV-DNA level played a vital role in prognostic and monitoring marker for EBV+ DLBCL-NOS. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

41. Prognostic significance of serum immunoglobulin paraprotein in mucosa‐associated lymphoid tissue (MALT) lymphoma.

Author

Ren, Yi‐Min, Shang, Chun‐Yu, Liang, Jin‐Hua, Yin, Hua, Xia, Yi, Wu, Jia‐Zhu, Wang, Li, Jian‐Yong, Li, Li, Yue, and Xu, Wei

Subjects
LYMPHOID tissue, RECEIVER operating characteristic curves, MUCOSA-associated lymphoid tissue lymphoma, LYMPHOMAS, MALT, WALDENSTROM'S macroglobulinemia
Abstract

Summary: To assess the prognostic significance of immunoglobulin (Ig) paraproteinaemia in mucosa‐associated lymphoid tissue (MALT) lymphoma, 218 patients diagnosed with MALT lymphoma were enrolled in this study. Serum Ig paraprotein was detected in 42 of 218 patients (19.3%), mostly IgM‐K (15, 35.7%), followed by IgM‐L and IgG‐L. Advanced age (p = 0.025), poor Eastern Cooperative Oncology Group performance status (p = 0.014), bone marrow involvement (p = 0.019), B symptoms (p = 0.039), advanced disease stage (III−IV) (p < 0.0001), elevated serum β2‐microglobulin level (p < 0.0001), multiple extranodal sites of involvement (p < 0.0001), nodal involvement (p < 0.0001), systemic therapy (p < 0.0001) and higher MALT‐lymphoma International Prognostic Index (MALT‐IPI) scores (p = 0.001) were significantly associated with the presence of serum Ig paraprotein. Multivariate Cox regression analysis showed that Ig paraproteinaemia was an independent prognostic predictor for inferior progression‐free survival (PFS) and overall survival. A new prognostic index based on MALT‐IPI and Ig paraproteinaemia, as assessed using receiver operating characteristic curves and the area under the curve statistics, showed better discriminative ability than MALT‐IPI in predicting PFS. In conclusion, Ig paraproteinaemia was a promising prognostic predictor for MALT lymphoma. Ig paraproteinaemia together with MALT‐IPI might contribute to optimising therapeutic management in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

50. Dose-adjusted EPOCH regimen as first-line treatment for non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis: a single-arm, open-label, phase II trial

Author

Liang, Jin-Hua, primary, Wang, Li, additional, Zhu, Hua-Yuan, additional, Qian, Jun, additional, Liao, Hui, additional, Wu, Jia-Zhu, additional, Xia, Yi, additional, Wu, Wei, additional, Cao, Lei, additional, Fan, Lei, additional, Li, Jian-Yong, additional, and Xu, Wei, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results