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Abnormal wear of stitch wires due to interference poses a serious threat to railway safety. To avoid this scenario, the concept of the dynamic envelope of the stitch wire was proposed, accompanied by an interference check method. A multi-node beam model of the stitch wire was established using the finite element method, employed to simulate the pantograph and catenary system, and validated by field test. The dynamic behaviour of the stitch wire was studied, and the concept of dynamic envelope was introduced. Moreover, factors affecting this envelope were analysed, and an interference check method was proposed. Results demonstrate that, the vibration of the stitch wire mainly occurs in the vertical direction and intensifies with increasing speed. Its vertical vibration increases from 70 mm to 137 mm as the train speed goes from 300 km/h to 400 km/h. Cantilever assembly errors and dropper installation issues are the main causes for the abnormal wear of stitch wires. A 100 mm assembly error reduces the clearance from 67 mm to 14 mm, while a 2 m dropper installation error eliminates the clearance entirely. This study provides valuable insights for enhancing the safety of catenary system. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Cone Beam Computed Tomography (CBCT) was used to observe and describe the distribution of canalis sinuosus (CS) in the Chinese population and the location of CS in the maxillary alveolar bone, so as to help oral surgeons evaluate the intraoperative risk and prognosis before maxillary surgery and reduce the complications caused by the injury of this structure in anterior surgery. PATIENTS AND METHODS: CBCT images of 600 patients admitted from 2021 to 2022 were collected to observe the anatomical structure of CS in the maxillary region. The following parameters were recorded: age, sex, number of CS, left and right distribution of CS, CS diameter, and location. Statistical analysis was performed on all of the collected data. RESULTS: The discovery rate of CS in this study was 59.75%, and it is commonly found in the lateral incisor area (64.82%). No significant difference can be found in the presence and number of CS in different gender and age groups (p>0.05). CONCLUSIONS: The use of high-resolution CBCT before implantation is of irreplaceable significance in the diagnosis and analysis of CS, which is conducive to reducing implantation complications and failure rate. The incidence of CS was independent of age or sex, while the location of CS was statistically significant. [ABSTRACT FROM AUTHOR]

Stitch wire is the key component in high-speed railway catenary. During the construction and operation of the catenary, tension changes can lead to fracture of the stitch wire. This study proposed a simulation method considering the structure and stress distribution of stitch wire to reveal the effect of tension changes on the fatigue life. Dynamic simulation model at a speed of 300 km/h was constructed to obtain the vibration load. A refined model of stitch wire was used to simulate the contact between the structures. Finally, the fatigue life of stitch wire was calculated when the tension changes by analysing the stress distribution under vibration. Results demonstrate that the lifting effect of the pantograph during operation causes vertical vibrations of stitch wire, and the stress concentration position is located at the connection with its clamp. As the tension increases form 2.0 kN to 5.0 kN, the range of vibration angle at the clamp decreases from 2.73° to 1.33°, and fatigue life increases from 1.36 x 106 to 8.76 x 106. The proposed method provides an accurate approach to simulate the load and fatigue life of stitch wire under real working conditions. [ABSTRACT FROM AUTHOR]

Improvement in the field emission properties of α-Fe2O3 nanoflakes is observed after high energy X-ray irradiation from synchrotron radiation. Field emission threshold field of α-Fe2O3 nanoflakes is found to decrease from 10.1 to 7.8 MV/m after X-ray irradiation with the dose of 9.0 × 1014 phs/cm2. Electrical measurement reveals that the potential barrier at the back contact between the α-Fe2O3 layer and the iron substrate changes after X-ray irradiation. The observed threshold field decrease is well explained by the changes in potential barrier at the back contact of α-Fe2O3 nanoflakes, which indicates the back contact plays an important role in controlling the field emission properties of α-Fe2O3 nanoflakes. Our study shows that the α-Fe2O3 nanoflakes are a promising material for the application as field emitter under X-ray environment. [ABSTRACT FROM AUTHOR]

Genome‐wide transcriptional studies have demonstrated that tens of thousands of long non‐coding RNAs (lncRNA) genes are expressed in the central nervous system (CNS) and that they exhibit tissue‐ and cell‐type specificity. Their regulated and dynamic expression and their co‐expression with protein‐coding gene neighbours have led to the study of the functions of lncRNAs in CNS development and disorders. In this review, we describe the general characteristics, localization and classification of lncRNAs. We also elucidate the examples of the molecular mechanisms of nuclear and cytoplasmic lncRNA actions in the CNS and discuss common experimental approaches used to identify and unveil the functions of lncRNAs. Additionally, we provide examples of lncRNA studies of cell differentiation and CNS disorders including CNS injuries and neurodegenerative diseases. Finally, we review novel lncRNA‐based therapies. Overall, this review highlights the important biological roles of lncRNAs in CNS functions and disorders. [ABSTRACT FROM AUTHOR]

Suitable fuel reduction treatments are needed in the Colville National Forest, Washington, to reduce the risk of severe wildfire. This study aimed to identify high-risk erosion hillslopes following wildfire to aid in forest fuel reduction planning and to evaluate the effects of fuel treatments on the watershed hydrological response. The specific objectives were (1) to assess the soil burn severity associated with wildfires and use that information to identify critical hillslopes for forest fuel treatments, and (2) to evaluate the potential changes in water yield and peak flows from pre-treatment (undisturbed forest) to post-treatment (thinning and prescribed burn) conditions, in the East Deer Creek Watershed (EDCW), a subwatershed of the Colville National Forest. Assessments were made using a modeling approach for hypothetical wildfire and fuel treatment scenarios. FlamMap, a fire behavior model, was used to predict the spatial distribution of wildfire intensity for a hypothetical event under current vegetation conditions. WEPP simulations were subsequently completed to obtain sediment and water yields based on fire intensity and topography. WEPP erosion estimations following a simulated wildfire showed hillslope sediment yield varying from 0 to 49.4 Mg ha-1 year-1 from the 777 hillslopes, which were ranked in descending order of sediment yield to identify critical hillslopes for fuel treatments. The WEPP model calibrated for a nearby gauged watershed was then applied to the EDCW for pre-treatment and post-treatment conditions. At the watershed scale, the increase in water yield from pre-treatment to post-treatment conditions ranged from 0.7% to 5.6% on hillslopes delivering 10% to 50% of the predicted post-fire sediment. Simulated water balance components at the treated hillslopes showed substantial changes. Surface runoff, subsurface lateral flow, and deep percolation increased 150% (5 mm), 50% (9 mm), and 40% (41 mm), respectively, whereas evapotranspiration (ET) decreased 23% (124 mm). The relative differences between pre- and post-harvest peak flows showed no clear trends as treatment area increased. The results suggest that thinning and prescribed burns to treated hillslopes in the EDCW may lead to an increase in water yield and significant alterations in hydrological processes. [ABSTRACT FROM AUTHOR]

The Water Erosion Prediction Project (WEPP) model was originally developed for hillslope and small watershed applications. Recent improvements to WEPP have led to enhanced computations for deep percolation, subsurface lateral flow, and frozen soil. In addition, the incorporation of channel routing has made the WEPP model well suited for large watersheds with perennial flows. However, WEPP is still limited in modeling forested watersheds where groundwater baseflow is substantial. The objectives of this study were to (1) incorporate nonlinear algorithms into WEPP (v2012.8) for estimating groundwater baseflow, (2) auto-calibrate the current and modified WEPP model using a model-independent parameter estimation tool, and (3) evaluate and compare the performance of the current version of WEPP without baseflow (WEPP-Cur) and the modified WEPP model with baseflow (WEPP-Mod) in simulating the hydrology of a snow-dominated watershed in the U.S. Pacific Northwest. A subwatershed of the Upper Cedar River Watershed in western Washington State was chosen for WEPP application and assessment. Simulations were conducted for two periods: 1997-2003 to calibrate the model and 2004-2011 to assess the model performance. The WEPP-Cur simulations resulted in Nash-Sutcliffe efficiency (NSE) and deviation of runoff volume (Dv) values of 0.55 and 24%, respectively, for the calibration period, and 0.60 and 21%, respectively, for the assessment period. The WEPP-Mod simulated streamflow showed improved agreement with observed streamflow, with NSE and Dv values of 0.76 and 6%, respectively, for the calibration period, and 0.74 and 2%, respectively, for the assessment period. The WEPP-Mod model reproduced hydrograph recessions during the low-flow periods and the general trend of the hydrographs, demonstrating its applicability to a watershed where groundwater baseflow was significant. The incorporation of a baseflow component into WEPP will help forest managers to assess the alterations in hydrological processes and water yield for their forest management practices. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Dysfunctional metabolisms have contributed towards ischemia-reperfusion (I/R) injury. However, the role of remote ischemic preconditioning (RIP) in I/R injury is not well known. The present study showed alleviated I/R injury in kidneys treated with RIP. MATERIALS AND METHODS: We utilized GC/MS-based metabolomics to characterize the variation of metabolomes. RESULTS: Metabolic category using differential metabolites showed the lower percentage of amino acids in I/R group in comparison to RIP+I/R group, confirming the importance of amino acid metabolism in RIP-treated rat kidney. Further, pathway enrichment analysis showed alanine, aspartate and glutamate metabolism to be involved in the beneficial effects of RIP during renal I/R injury. Furthermore, another crucial enrichment pathway is biosynthesis of unsaturated fatty acids. Other vital metabolites detected in independent component analysis (ICA) analysis were d-glucose, lactic acid and cholesterol. The variation tendency of above-mentioned metabolites was overall consistent with the protective nature of RIP. CONCLUSIONS: These findings elicited a viewpoint that metabolic strategy affected by RIP are linked to underlying mechanisms of RIP and highlighted the importance of metabolic strategy against I/R injury. [ABSTRACT FROM AUTHOR]