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Byline: Hai-En. Wu, Tie-Nan. Li, Chun-Lin. Jin, Yong-Bin. Liu Sir, The co-occurrence of neurofibromatosis type 1 (NF-1), Becker's nevus (BN), and nevus of Ota is expected to be very rare. [...]

We reported a case of cystic acne occurring after 20% GAP in a patient with hyperandrogenism, treated successfully by topical 5-aminolevulinic acid photodynamic therapy (ALA-PDT), pulsed dye laser (PDL), and oral antiandrogen drugs. Keywords: acne; ALA-PDT; complication; glycolic acid peel; hyperandrogenism EN acne ALA-PDT complication glycolic acid peel hyperandrogenism 184 187 4 03/23/22 20220301 NES 220301 ACKNOWLEDGMENTS The patient mentioned in this manuscript has given written informed consent for publication of her case details. ALA-PDT and pulsed dye laser combined with oral antiandrogen drug in the treatment of cystic acne in a patient with hyperandrogenism. [Extracted from the article]

Objective: To investigate the therapeutic effects and mechanisms of curcumin treatment on hepatic fibrosis., Methods: A model of hepatic fibrosis was established using carbon tetrachloride intraperitoneal injections in rats. Curcumin was administered to one group of the model rats (curcumin group) and the other rats were used as controls (control group). Serum levels of ALT, AST, HA, LN, PCIII, and NO were measured, and Hyp, MDA, and SOD in liver tissues were measured. Liver tissue slides were stained with HE and Masson staining to study the pathological changes in the livers. Grades of hepatic fibrosis were evaluated according to a semiquantitative scoring system., Results: In the curcumin group, serum levels of ALT, AST, NO, HA, LN, PCIII, MDA, and Hyp, were (218.50+/-48.89) U/L, (376.60+/-79.13) U/L, (47.96+/-6.53) micromol/L, (289.96+/-60.43) mg/L, (107.35+/-27.24) mg/L, (148.95+/-28.63) microg/L, (236.10+/-30.54) nmol/g, (478.40+/-75.74) microg/g and all were lower than those of the control group (693.75+/-117.57) U/L, (892.50+/-105.69) U/L, (70.95+/-10.23) micromol/L, (468.22+/-93.45) mg/L, (346.44+/-75.08) mg/L, (279.82+/-54.00) microg/L, (402.25+/-39.16) nmol/g, and (752.50+/-77.62) microg/g. The differences were significant. In the curcumin group, the level of SOD (90.39+/-21.23) in the liver tissues was significantly higher than that of the control group (46.52+/-20.01). The hepatic fibrosis scores in the curcumin group were significantly lower than those of the control group. These effects were dose-dependent., Conclusions: Curcumin reduces rat hepatic fibrosis. Anti-peroxidation and regulation of collagen metabolism in liver tissues may be involved in the therapeutic effectiveness of curcumin on hepatic fibrosis.