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Slope stability control is crucial for safe and efficient coal mining challenge of stabilizing dip soft rock slope rock slopes, the treatment engineering of inner row tracking pressure side of dip soft rock slope in open-pit mine is proposed based on the analysis of the main controlling factors of slope stability. This study takes the south side of the first mining area of Hesigewula south open-pit coal mine as the engineering background and proposes a synergistic treatment scheme for the slope stability of the stope and inner dump, utilizing the combination of limit equilibrium method and numerical simulation to design the spatial form of the stope slope. This treatment scheme maximizes the safe recovery of the coal resources covered by the slope. The research results indicate that the length of exposed weak layer is the primary controlling factor of the stability in inclined soft rock slopes in open-pit mines. Controlling the tracking distance between the stope and the inner dump is an effective way to improve slope stability. With an increase in tracking distance, the slope damage mode transitions from the cut-layer-sublayer-shear-out sliding with an arc as the side interface and the weak layer as the bottom interface to cut-layer-sublayer sliding with an arc as the side interface and weak layer as the bottom interface, leading to a gradual decrease in slope stability. Moreover, the stability of the inner dump and its composite slope with the stope increases exponentially with an increase in the backfill rock range of the weak layer of the failure floor. The study sets the shallow slope of the south slope of the first mining area of Hesigewula coal mine to be 40 m transportation flat and 15 m security flat, and the deep slope angle of the bottom slope is 29°. When the tracking distance is controlled within 50 m, it can meet the safety requirements. When the weak layer of the inner dump base is destroyed, and the inclined length of the backfill rock is 60 m, it can also meet the safety requirements. The study provides new insights into slope stability control in soft rock open-pit coal mines. [ABSTRACT FROM AUTHOR]

ONOO−, a bioactive molecule, plays a critical role in inflammation-related signaling pathways and pathological mechanisms. Numerous studies have established a direct correlation between elevated ONOO− levels and tumor progression. Therefore, investigating ONOO− levels in inflammation and tumors is of utmost importance. Fluorescence imaging presents a highly sensitive, non-invasive, easily operable, selective, and efficient method for ONOO− detection in situ. In this study, we designed and synthesized a rhodamine-based probe, NRho, which effectively identifies tumors, inflammatory cells, tissues, and organs by detecting ONOO− content. The synthesis process of NRho is simple, yielding a probe with favorable spectral characteristics and rapid response. Our cell imaging analysis has provided novel insights, revealing distinct ONOO− levels among different types of cancer cells, with hepatocellular carcinoma cells exhibiting higher ONOO− content than the others. This observation marks the proposal of such variations in ONOO− levels across cancer cell types. Furthermore, our study has showcased the practicality of our probe in live organ imaging, enabling the identification of tumors from living organs within a brief 5-minute incubation period. Additionally, our findings highlight the rapid detection capability of the probe NRho in various tissue samples, effectively identifying inflammation. This research holds important promise in advancing biomedical research and clinical diagnosis. [ABSTRACT FROM AUTHOR]