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1. A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia

Author

Xu, Jason, Chen, Changya, Sussman, Jonathan H., Yoshimura, Satoshi, Vincent, Tiffaney, Pölönen, Petri, Hu, Jianzhong, Bandyopadhyay, Shovik, Elghawy, Omar, Yu, Wenbao, Tumulty, Joseph, Chen, Chia-hui, Li, Elizabeth Y., Diorio, Caroline, Shraim, Rawan, Newman, Haley, Uppuluri, Lahari, Li, Alexander, Chen, Gregory M., Wu, David W., Ding, Yang-yang, Xu, Jessica A., Karanfilovski, Damjan, Lim, Tristan, Hsu, Miles, Thadi, Anusha, Ahn, Kyung Jin, Wu, Chi-Yun, Peng, Jacqueline, Sun, Yusha, Wang, Alice, Mehta, Rushabh, Frank, David, Meyer, Lauren, Loh, Mignon L., Raetz, Elizabeth A., Chen, Zhiguo, Wood, Brent L., Devidas, Meenakshi, Dunsmore, Kimberly P., Winter, Stuart S., Chang, Ti-Cheng, Wu, Gang, Pounds, Stanley B., Zhang, Nancy R., Carroll, William, Hunger, Stephen P., Bernt, Kathrin, Yang, Jun J., Mullighan, Charles G., Tan, Kai, and Teachey, David T.

Published
2024
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2. Low-Grade Glioma Clinical Trials in the United States: A Systematic Review.

Author

Xu, Emily, Patterson, Jonathan, Angione, Angelo, Li, Alexander, Wu, David W., Akca, Ebrar, Elghawy, Omar, Barsouk, Alexander, and Sussman, Jonathan H.

Subjects
RACE, INVESTIGATIONAL therapies, CENTRAL nervous system, CLINICAL trials, AFRICAN Americans
Abstract

Low-grade glioma (LGG) is a malignancy of the central nervous system that is often treatable with surgical resection and chemoradiation. However, despite an initial positive response to standard therapy, most LGG eventually progress to high-grade gliomas which are nearly uniformly fatal. There is a pressing need for more clinical trials and greater clinical trial accessibility to improve the standard of care of LGG to delay or prevent its progression. In this study, we systematically examined the scope and inclusion of clinical trials for LGG based in the United States. This cross-sectional study analyzes trends in trial design and reported demographic data from completed LGG trials registered on ClinicalTrials.gov between 2010 to 2023. Inclusion criteria, investigational therapies, primary outcomes, and preliminary results were compared and summarized. A total of 14 trials with 1067 participants were included in the study. Most of the trials were not exclusive to LGGs and 14% had mutation-specific inclusion criteria. To date, two of the trials have led to new FDA-approved treatments. All trials reported age and sex, while only 57% reported race and 43% reported ethnicity. Individuals identifying as Black or African American and Asian or Pacific Islander were statistically underrepresented. Lastly, we investigated the geographic distributions of trial sites across the United States, which demonstrated several coverage gaps in the Rocky Mountain and Southeast regions. These findings suggest specific areas for improvement in LGG clinical trial reporting and accessibility. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Abstract 3562: Dissecting mechanisms underlying FOXR2-mediated gliomagenesis in diffuse midline gliomas

Author

Tsai, Jessica W., primary, Cejas, Paloma, additional, Coppola, Marissa, additional, Wang, Dayle K., additional, Patel, Smruti, additional, Wu, David W., additional, Arounleut, Phonepasong, additional, Wei, Xin, additional, Zhou, Ningxuan, additional, Syamala, Sudeepa, additional, Dubois, Frank P., additional, Pelton, Kristine, additional, Vogelzang, Jayne, additional, Sousa, Cecilia, additional, Baguette, Audrey, additional, Chen, Xiaolong, additional, Condurat, Alexandra L., additional, Dixon-Clarke, Sarah E., additional, Charles, Annarah, additional, Zhou, Kevin N., additional, Lu, Sophie D., additional, Gonzalez, Elizabeth M., additional, Chacon, Madison S., additional, Digiacomo, Jeromy J., additional, Kumbhani, Rushil, additional, Novikov, Dana, additional, Tsoli, Maria, additional, Ziegler, David S., additional, Dirksen, Uta, additional, Jager, Natalie, additional, Balasubramanian, Gnana Prakash, additional, Kramm, Christof M., additional, Nathrath, Michaela, additional, Bielack, Stefan, additional, Baker, Suzanne J., additional, Zhang, Jinghui, additional, McFarland, James M., additional, Getz, Gad, additional, Aguet, Francois, additional, Jabado, Nada, additional, Witt, Olaf, additional, Pfister, Stefan M., additional, Ligon, Keith L., additional, Hovestadt, Volker, additional, Kleinman, Claudia, additional, Long, Henry, additional, Jones, David T., additional, Bandopadhayay, Pratiti, additional, and Phoenix, Timothy N., additional

Published
2023
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5. Supplementary Table from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Author

Tsai, Jessica W., primary, Cejas, Paloma, primary, Wang, Dayle K., primary, Patel, Smruti, primary, Wu, David W., primary, Arounleut, Phonepasong, primary, Wei, Xin, primary, Zhou, Ningxuan, primary, Syamala, Sudeepa, primary, Dubois, Frank P.B., primary, Crane, Alexander, primary, Pelton, Kristine, primary, Vogelzang, Jayne, primary, Sousa, Cecilia, primary, Baguette, Audrey, primary, Chen, Xiaolong, primary, Condurat, Alexandra L., primary, Dixon-Clarke, Sarah E., primary, Zhou, Kevin N., primary, Lu, Sophie D., primary, Gonzalez, Elizabeth M., primary, Chacon, Madison S., primary, Digiacomo, Jeromy J., primary, Kumbhani, Rushil, primary, Novikov, Dana, primary, Hunter, J'Ya, primary, Tsoli, Maria, primary, Ziegler, David S., primary, Dirksen, Uta, primary, Jager, Natalie, primary, Balasubramanian, Gnana Prakash, primary, Kramm, Christof M., primary, Nathrath, Michaela, primary, Bielack, Stefan, primary, Baker, Suzanne J., primary, Zhang, Jinghui, primary, McFarland, James M., primary, Getz, Gad, primary, Aguet, François, primary, Jabado, Nada, primary, Witt, Olaf, primary, Pfister, Stefan M., primary, Ligon, Keith L., primary, Hovestadt, Volker, primary, Kleinman, Claudia L., primary, Long, Henry, primary, Jones, David T.W., primary, Bandopadhayay, Pratiti, primary, and Phoenix, Timothy N., primary

Published
2023
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6. Supplementary Figure from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Author

Tsai, Jessica W., primary, Cejas, Paloma, primary, Wang, Dayle K., primary, Patel, Smruti, primary, Wu, David W., primary, Arounleut, Phonepasong, primary, Wei, Xin, primary, Zhou, Ningxuan, primary, Syamala, Sudeepa, primary, Dubois, Frank P.B., primary, Crane, Alexander, primary, Pelton, Kristine, primary, Vogelzang, Jayne, primary, Sousa, Cecilia, primary, Baguette, Audrey, primary, Chen, Xiaolong, primary, Condurat, Alexandra L., primary, Dixon-Clarke, Sarah E., primary, Zhou, Kevin N., primary, Lu, Sophie D., primary, Gonzalez, Elizabeth M., primary, Chacon, Madison S., primary, Digiacomo, Jeromy J., primary, Kumbhani, Rushil, primary, Novikov, Dana, primary, Hunter, J'Ya, primary, Tsoli, Maria, primary, Ziegler, David S., primary, Dirksen, Uta, primary, Jager, Natalie, primary, Balasubramanian, Gnana Prakash, primary, Kramm, Christof M., primary, Nathrath, Michaela, primary, Bielack, Stefan, primary, Baker, Suzanne J., primary, Zhang, Jinghui, primary, McFarland, James M., primary, Getz, Gad, primary, Aguet, François, primary, Jabado, Nada, primary, Witt, Olaf, primary, Pfister, Stefan M., primary, Ligon, Keith L., primary, Hovestadt, Volker, primary, Kleinman, Claudia L., primary, Long, Henry, primary, Jones, David T.W., primary, Bandopadhayay, Pratiti, primary, and Phoenix, Timothy N., primary

Published
2023
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7. Data from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Author

Tsai, Jessica W., primary, Cejas, Paloma, primary, Wang, Dayle K., primary, Patel, Smruti, primary, Wu, David W., primary, Arounleut, Phonepasong, primary, Wei, Xin, primary, Zhou, Ningxuan, primary, Syamala, Sudeepa, primary, Dubois, Frank P.B., primary, Crane, Alexander, primary, Pelton, Kristine, primary, Vogelzang, Jayne, primary, Sousa, Cecilia, primary, Baguette, Audrey, primary, Chen, Xiaolong, primary, Condurat, Alexandra L., primary, Dixon-Clarke, Sarah E., primary, Zhou, Kevin N., primary, Lu, Sophie D., primary, Gonzalez, Elizabeth M., primary, Chacon, Madison S., primary, Digiacomo, Jeromy J., primary, Kumbhani, Rushil, primary, Novikov, Dana, primary, Hunter, J'Ya, primary, Tsoli, Maria, primary, Ziegler, David S., primary, Dirksen, Uta, primary, Jager, Natalie, primary, Balasubramanian, Gnana Prakash, primary, Kramm, Christof M., primary, Nathrath, Michaela, primary, Bielack, Stefan, primary, Baker, Suzanne J., primary, Zhang, Jinghui, primary, McFarland, James M., primary, Getz, Gad, primary, Aguet, François, primary, Jabado, Nada, primary, Witt, Olaf, primary, Pfister, Stefan M., primary, Ligon, Keith L., primary, Hovestadt, Volker, primary, Kleinman, Claudia L., primary, Long, Henry, primary, Jones, David T.W., primary, Bandopadhayay, Pratiti, primary, and Phoenix, Timothy N., primary

Published
2023
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12. FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Author

Tsai, Jessica W., primary, Cejas, Paloma, additional, Wang, Dayle K., additional, Patel, Smruti, additional, Wu, David W., additional, Arounleut, Phonepasong, additional, Wei, Xin, additional, Zhou, Ningxuan, additional, Syamala, Sudeepa, additional, Dubois, Frank P.B., additional, Crane, Alexander, additional, Pelton, Kristine, additional, Vogelzang, Jayne, additional, Sousa, Cecilia, additional, Baguette, Audrey, additional, Chen, Xiaolong, additional, Condurat, Alexandra L., additional, Dixon-Clarke, Sarah E., additional, Zhou, Kevin N., additional, Lu, Sophie D., additional, Gonzalez, Elizabeth M., additional, Chacon, Madison S., additional, Digiacomo, Jeromy J., additional, Kumbhani, Rushil, additional, Novikov, Dana, additional, Hunter, J'Ya, additional, Tsoli, Maria, additional, Ziegler, David S., additional, Dirksen, Uta, additional, Jager, Natalie, additional, Balasubramanian, Gnana Prakash, additional, Kramm, Christof M., additional, Nathrath, Michaela, additional, Bielack, Stefan, additional, Baker, Suzanne J., additional, Zhang, Jinghui, additional, McFarland, James M., additional, Getz, Gad, additional, Aguet, François, additional, Jabado, Nada, additional, Witt, Olaf, additional, Pfister, Stefan M., additional, Ligon, Keith L., additional, Hovestadt, Volker, additional, Kleinman, Claudia L., additional, Long, Henry, additional, Jones, David T.W., additional, Bandopadhayay, Pratiti, additional, and Phoenix, Timothy N., additional

Published
2022
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13. Abstract 5730: FOXR2 is an oncogenic driver across adult and pediatric cancers

Author

Tsai, Jessica W., primary, Cejas, Paloma, additional, Wang, Dayle K., additional, Patel, Smruti, additional, Wu, David W., additional, Arounleut, Phonepasong, additional, Wei, Xin, additional, Zhou, Ningxuan, additional, Syamala, Sudeepa, additional, Dubois, Frank P., additional, Pelton, Kristine, additional, Vogelzang, Jayne, additional, Sousa, Cecilia, additional, Baguette, Audrey, additional, Chen, Xiaolong, additional, Condurat, Alexandra L., additional, Dixon-Clarke, Sarah E., additional, Zhou, Kevin N., additional, Lu, Sophie D., additional, Gonzalez, Elizabeth M., additional, Chacon, Madison S., additional, Digiacomo, Jeromy J., additional, Kumbhani, Rushil, additional, Novikov, Dana, additional, Hunter, J'Ya, additional, Tsoli, Maria, additional, Ziegler, David S., additional, Dirksen, Uta, additional, Jager, Natalie, additional, Balasubramanian, Gnana Prakash, additional, Kramm, Christof M., additional, Nathrath, Michaela, additional, Bielack, Stefan, additional, Baker, Suzanne J., additional, Zhang, Jinghui, additional, McFarland, James M., additional, Getz, Gad, additional, Aguet, Francois, additional, Jabado, Nada, additional, Witt, Olaf, additional, Pfister, Stefan M., additional, Ligon, Keith L., additional, Kleinman, Claudia, additional, Long, Henry, additional, Jones, David T., additional, Bandopadhayay, Pratiti, additional, and Phoenix, Timothy N., additional

Published
2022
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14. DIPG-19. FOXR2 is an oncogenic driver across pediatric and adult cancers

Author

Tsai, Jessica W, primary, Cejas, Paloma, additional, Wang, Dayle K, additional, Patel, Smruti, additional, Wu, David W, additional, Arounleut, Phonepasong, additional, Wei, Xin, additional, Zhou, Ningxuan, additional, Syamala, Sudeepa, additional, Dubois, Frank P B, additional, Crane, Alexander, additional, Pelton, Kristine, additional, Vogelzang, Jayne, additional, Sousa, Cecilia, additional, Baguette, Audrey, additional, Chen, Xiaolong, additional, Condurat, Alexandra L, additional, Dixon-Clarke, Sarah E, additional, Zhou, Kevin N, additional, Lu, Sophie D, additional, Gonzalez, Elizabeth M, additional, Chacon, Madison S, additional, Digiacomo, Jeromy J, additional, Kumbhani, Rushil, additional, Novikov, Dana, additional, Hunter, J'Ya, additional, Tsoli, Maria, additional, Ziegler, David S, additional, Dirksen, Uta, additional, Jager, Natalie, additional, Balasubramanian, Gnana Prakash, additional, Kramm, Christof M, additional, Nathrath, Michaela, additional, Bielack, Stefan, additional, Baker, Suzanne J, additional, Zhang, Jinghui, additional, McFarland, James M, additional, Getz, Gad, additional, Aguet, Francois, additional, Jabado, Nada, additional, Witt, Olaf, additional, Pfister, Stefan M, additional, Ligon, Keith L, additional, Kleinman, Claudia L, additional, Long, Henry, additional, Jones, David T W, additional, Bandopadhayay, Pratiti, additional, and Phoenix, Timothy N, additional

Published
2022
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17. Antitrust: TransWeb, LLC v. 3M Innovative Properties Co.

Author

Fischer, Michelle K., Lippetz, Gregory L., Oliver, Geoffrey D., and Wu, David W.

Subjects
Antitrust law -- Evaluation, Costs (Law) -- Laws, regulations and rules, Patent infringement -- Laws, regulations and rules, TransWeb L.L.C. v. 3M Innovative Properties Co. (No. 2014-1646 (Fed. Cir. Feb. 10, 2016)), Government regulation, Antitrust issue, Sherman Act, Clayton Act
Abstract

TransWeb, LLC v. 3M Innovative Properties Co. Antitrust and intellectual property practitioners with an interest in trivia have been known to ask: When is the last time an appellate court [...]

Published
2016

19. Convenience improves composting and recycling rates in high-density residential buildings.

Author

DiGiacomo, Alessandra, Wu, David W.-L., Lenkic, Peter, Fraser, Bud, Zhao, Jiaying, and Kingstone, Alan

Subjects
*SOLID waste, *POLLUTION, *POLLUTION prevention, *WASTE management, *ENVIRONMENTAL policy
Abstract

Increasing volumes of solid waste, implicated in environmental pollution and health problems, are central to the current environmental crisis. In two randomized field experiments, we demonstrate that convenience dramatically boosts recycling and composting rates in multi-family dwellings and university residences. When compost bins were placed on each floor in a multi-family residence, instead of on the ground floor, composting rates increased by 70%, diverting 27 kilograms of compost from the landfill per unit per year. When recycling stations were placed just meters from suites in student residences, instead of in the basement, recycling increased by 147% (container), and 137% (paper), and composting increased by 139%, diverting 23, 22, and 14 kilograms of containers, paper, and compost, respectively, from the landfill per person per year. Simply making recycling and composting convenient can significantly increase waste diversion, and as such this single intervention has important implications for waste management and environmental policy. [ABSTRACT FROM AUTHOR]

Published
2018
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23. Design of a single layer programmable Structured ASIC library

Author

Chau, Thomas C. P., primary, Wu, David W. L., additional, Ai, Yan-Qing, additional, Chan, Brian P. W., additional, Ho, Sam M. H., additional, Lau, Oscar K. L., additional, Yuen, Steve C. L., additional, Pun, Kong-Pang, additional, Choy, Oliver C. S., additional, and Leong, Philip H. W., additional

Published
2010
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28. Case Comment: Missing the Forest for the Trees in Canada (Attorney General) v Bedford.

Author

Wu, David W.-L.

Subjects
*STARE decisis, *CAUSATION (Criminal law), *SEX work, *SEX workers, CANADA. Attorney General
Abstract

This case comment on Canada (Attorney General) v Bedford examines the doctrinal developments of section 7 of the Canadian Charter of Rights and Freedoms. Specifically, Bedford discussed three critical aspects of section 7: 1) the role of stare decisis, 2) the issue of causation, and 3) the substantive principles of procedural fairness analysis. The author identifies access to section 7 as the Supreme Court of Canada's predominant concern in the development of section 7 doctrine in Bedford. Unfortunately, this concern has not made for a necessarily more workable or more coherent doctrine. This paper attempts to show how the doctrinal developments in Bedford, especially those relating to the substantive principles of fundamental justice analysis, may 1) do little to benefit a marginalized claimant's opportunity to succeed, and 2) be inappropriate to resolve the complex systemic issues that section 7 readily attracts. [ABSTRACT FROM AUTHOR]

Published
2014

29. Embedding Environmental Rights in Section 7 of the Canadian Charter: Resolving the Tension Between the Need for Precaution and the Need for Harm.

Author

Wu, David W.-L.

Subjects
ENVIRONMENTAL rights, ENVIRONMENTAL degradation, CONSTITUTIONS, ENVIRONMENTAL protection, WATER shortages, ENVIRONMENTAL law, DAMAGES (Law)
Abstract

The article discusses the embedding of environmental rights in Section 7 of the Canadian Charter of Rights and Freedoms, focusing on Canadian environmental laws, the country's Constitution, and the efforts to resolve the tension between a need for precaution and a need for environmental harm. Environmental protection, a plaintiff's evidentiary burden of proof, and tobacco damages legislation in Canada are mentioned. Environmental degradation, water scarcity, and food security are examined.

Published
2014

32. Looking while eating: The importance of social context to social attention.

Author

Wu, David W. -L., Bischof, Walter F., and Kingstone, Alan

Subjects
*SOCIAL interaction, *SOCIAL norms, *DYADS, *SOCIAL contact, *SOCIAL exchange
Abstract

Recent studies have found that participants consistently look less at social stimuli in live situations than expected from conventional laboratory experiments, raising questions as to the cause for this discrepancy and concerns about the validity of typical studies. We tested the possibility that it is the consequences of a potential social interaction that dictates one's looking behaviour. By placing participants in a situation where the social consequences of interacting are congruent with social norms (sharing a meal), we find an increased preference for participants to look at each other. Dyads who were particularly interactive also looked more at the other person than dyads who did not interact. Recent landmark studies have shown that in real world settings people avoid looking at strangers, but we show that in a situation with a different social context the opposite holds true. [ABSTRACT FROM AUTHOR]

Published
2013
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33. Compelled Expression and the Charter.

Author

Elliot, Robin and Wu, David W.-L.

Subjects
FREEDOM of expression lawsuits, JURISPRUDENCE, TOBACCO products, TOBACCO laws
Abstract

The article focuses on state actions that compels people to engage in expressive activities in which they do not wish to engage and the section 2(b) of the Canadian Charter of Rights and Freedoms. It discusses the Supreme Court of Canada's decision in case Slaight Communications Inc v. Davidson that addressed right to freedom of expression under section 2(b) of the Charter and issues relating to the constitutionality of provisions of the Tobacco Products Control Act.

Published
2015

34. Antitrust.

Author

Fischer, Michelle K., Lippetz, Gregory L., Oliver, Geoffrey D., and Wu, David W.

Subjects
*INTELLECTUAL property lawsuits, *ANTITRUST lawsuits, *PATENT suits, *LEGAL judgments, *LAWYERS' fees, *ACTIONS & defenses (Law)
Abstract

The article discusses a court case that focuses on the antitrust and intellectual property concerns between TransWeb LLC and 3M Innovative Properties Co. Topics covered include the details of the alleged infringement complaint filed by TransWeb and the decision of the Federal Circuit court over the case. Also mentioned is the impact of the case on the antitrust attorney fees of 3M.

Published
2016

35. Temporal dynamics of eye movements are related to differences in scene complexity and clutter.

Author

Wu DW, Anderson NC, Bischof WF, and Kingstone A

Subjects
Fractals, Humans, Eye Movements physiology, Fixation, Ocular physiology, Pattern Recognition, Visual physiology
Abstract

Recent research has begun to explore not just the spatial distribution of eye fixations but also the temporal dynamics of how we look at the world. In this investigation, we assess how scene characteristics contribute to these fixation dynamics. In a free-viewing task, participants viewed three scene types: fractal, landscape, and social scenes. We used a relatively new method, recurrence quantification analysis (RQA), to quantify eye movement dynamics. RQA revealed that eye movement dynamics were dependent on the scene type viewed. To understand the underlying cause for these differences we applied a technique known as fractal analysis and discovered that complexity and clutter are two scene characteristics that affect fixation dynamics, but only in scenes with meaningful content. Critically, scene primitives-revealed by saliency analysis-had no impact on performance. In addition, we explored how RQA differs from the first half of the trial to the second half, as well as the potential to investigate the precision of fixation targeting by changing RQA radius values. Collectively, our results suggest that eye movement dynamics result from top-down viewing strategies that vary according to the meaning of a scene and its associated visual complexity and clutter., (© 2014 ARVO.)

Published
2014
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