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242 results on '"Wu, Chanyuan"'

6. A Case Report of Fabry Disease Associated with Dermatomyositis

Author

ZHOU Yi, WU Chanyuan, CHENG Kang′an, and WANG Liang

Subjects
fabry disease, dermatomyositis, autoimmune disease, Medicine
Abstract

Fabry disease is an X-linked lysosomal storage disease, and its pathogenesis is the deficient of α-galactosidase A (α-Gal A) activity caused by GLA mutation, which leads to accumulation of the glycosphingolipid globotriaosylceramide (Gb-3) and other glycosphingolipids in the lysosome of cells, resulting in the dysfunction of relevant tissues and organs. We report the clinical characteristics of a case of Fabry disease with dermatomyositis. The patient, a 61-year-old male, presented with intermittent amaurosis, limb weakness and dyspnea on exertion. Based on the low α-Gal A activity and positive anti-myositis antibodies, diagnosis of Fabry disease with dermatomyositis were confirmed. We reviewed the relevant literature and found that co-existence of Fabry disease and autoimmune diseases was very rare, but it is not rare for patients with Fabry disease to have some autoimmune antibody positive, suggesting that Fabry disease and autoimmune diseases may be related in pathogenesis.

Published
2023
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10. Real-world therapeutic performance of pirfenidone for connective tissue disease-associated interstitial lung diseases.

Author

Yuan, Xueting, Yu, Chen, Liu, Shengyun, Shu, Qiang, Duan, Xinwang, Tang, Lin, Peng, Liying, Zhou, Shuang, Wu, Chanyuan, Zhao, Jiuliang, Xu, Dong, Song, Lan, Huang, Hui, Li, Mengtao, Wang, Yanhong, Wang, Qian, and Zeng, Xiaofeng

Subjects
IDIOPATHIC pulmonary fibrosis, VITAL capacity (Respiration), IMAGE recognition (Computer vision), CONNECTIVE tissue diseases, TREATMENT effectiveness, INTERSTITIAL lung diseases
Abstract

Background: Pirfenidone (PFD) is commonly applied for antifibrotic treatment in patients with idiopathic pulmonary fibrosis but has rarely been studied in cases with connective tissue disease-associated interstitial lung diseases (CTD-ILDs). Objectives: We aimed to examine the efficacy of PFD in patients with CTD-ILD based on real-world data. Design: A retrospective cohort study. Methods: This study assessed the clinical features of CTD-ILD patients with or without a 6-month PFD treatment. A linear mixed effects model was employed to evaluate the effectiveness of PFD in alleviating lung function changes. Differences in response to PFD were analyzed based on CTD subtype, imaging classification, and pattern of pulmonary function at baseline. Results: A total of 289 patients with CTD-ILD were included, with 155 (53.6%) receiving PFD treatment and the remaining constituting the control group. Patients with the usual interstitial pneumonia (UIP) pattern were more likely to receive PFD treatment, and a relatively lower proportion of cases in the PFD group received immunosuppressive therapies compared to the control group (p < 0.05). At the 6-month follow-up, patients in the PFD group demonstrated a more significant improvement in forced vital capacity (FVC) and diffusion capacity for carbon monoxide (DLCO) (ΔFVC%: 2.9% vs 0.45%, p = 0.009; ΔDLCO%: 1.9% vs −1.1%, p = 0.004). In the linear mixed model analysis, there was a statistically significant group-time interaction between FVC% and DLCO% changes over time (FVC%: β = 4.52, p < 0.001; DLCO%: β = 4.13, p = 0.003). Furthermore, subgroup analysis indicated that pirfenidone may have superior therapeutic effects in patients with systemic sclerosis (SSc)-associated ILD, non-UIP pattern, and restrictive pattern of lung function at baseline. Conclusion: This study provided real-world data demonstrating the effectiveness of PFD in terms of lung function improvement in patients with CTD-ILD. [ABSTRACT FROM AUTHOR]

Published
2024
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12. The additional role of anti-nucleosome antibodies in the prediction of renal damage in systemic lupus erythematosus based on CSTAR (XXV)

Author

Ding, Yufang, primary, Zhou, Yangzhong, additional, Zhao, Jiuliang, additional, Wu, Chanyuan, additional, Zhang, Shangzhu, additional, Jiang, Nan, additional, Qian, Junyan, additional, Zhang, Li, additional, Li, Jing, additional, Xu, Dong, additional, Leng, Xiaomei, additional, Wang, Qian, additional, Tian, Xinping, additional, Li, Mengtao, additional, and Zeng, Xiaofeng, additional

Published
2024
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16. Phenotypic Subgroup Identification in Serologically Active, Clinically Quiescent Systemic Lupus Erythematosus: A Cluster Analysis

Author

Ding, Yufang, primary, Zhou, Yangzhong, additional, Zhan, Feng, additional, Xu, Jian, additional, Duan, Xinwang, additional, Luo, Hui, additional, Zhao, Cheng, additional, Yang, Min, additional, Wu, Rui, additional, Wu, Lijun, additional, Chen, Zhen, additional, Wei, Wei, additional, Huang, Can, additional, Wu, Chanyuan, additional, Zhang, Shangzhu, additional, Jiang, Nan, additional, Xu, Dong, additional, Leng, Xiaomei, additional, Wang, Qian, additional, Tian, Xinping, additional, Li, Mengtao, additional, Zeng, Xiaofeng, additional, and zhao, jiuliang, additional

Published
2024
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20. Patient-reported quality of life and working status outcomes in ambulatory patients with idiopathic inflammatory myopathy.

Author

Peng, Zhao, Wang, Yanhong, Liu, Ning, Zhou, Shuang, Zhao, Jiuliang, Xu, Dong, Li, Mengtao, Wu, Chanyuan, Zeng, Xiaofeng, and Wang, Qian

Subjects
CROSS-sectional method, LABOR productivity, MYOSITIS, RESEARCH funding, OUTPATIENT medical care, SCIENTIFIC observation, QUESTIONNAIRES, LOGISTIC regression analysis, QUALITY of life, HEALTH outcome assessment, CONFIDENCE intervals, PHYSICAL activity
Abstract

Objective To investigate the health-related quality of life (HR-QoL), work productivity and activity impairment and associated factors among patients with idiopathic inflammatory myopathy (IIM). Methods This was an observational, cross-sectional study. The 189 ambulatory patients with IIM were recruited from May 2019 to May 2022. HR-QoL was measured by the European Quality of Life 5-Dimension (EQ-5D) questionnaire. The Work Productivity and Activity Impairment (WPAI) questionnaire was used to evaluate work productivity and activity impairment. The IIM-related parameters were assessed by the 8-item Manual Muscle Test (MMT-8), Myositis Disease Activity Assessment visual analogue scale (MYOACT), Myositis Damage Index (MDI), Disease Activity Score (DAS) and Physician/Patient Global Assessment (PhGA/PtGA). Quantile regression and ordinal logistic regression were performed to identify the factors, considering EQ-5D or WPAI scores as dependent variables, respectively. Results Of the 189 IIM patients enrolled, 60% had DM, 13% had PM and 27% had clinical amyopathic DM. The median EQ-5D score was 1.00 (95% CI 0.73, 1.00), 28% were employed and 45% of overall work was impaired due to health problems. EQ-5D values were positively associated with MMT-8 and negatively with MYOACT, DAS, MDI-global and PhGA/PtGA. For the WPAI, activity impairment was associated with a lower MMT-8 score, older onset age and higher PhGA only in 25th–75th percentile. Increased PtGA was associated with increased activity and overall working productivity impairment in most quantiles (P <0.05). Conclusion Multiple disease characteristics were associated with reduced HR-QoL or working productivity impairment in patients with IIM, especially for PtGA. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Myocardial involvement is not rare in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis/clinically amyopathic dermatomyositis: a retrospective study

Author

Zhou, Shuang, primary, Lai, Jinzhi, additional, Wu, Chanyuan, additional, Liu, Yongtai, additional, Liu, Yingxian, additional, Zhao, Jiuliang, additional, Xu, Dong, additional, Tian, Xinping, additional, Li, Mengtao, additional, Zhao, Yan, additional, Wang, Yining, additional, Wang, Qian, additional, and Zeng, Xiaofeng, additional

Published
2022
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36. Early recognition of catastrophic antiphospholipid syndrome in patients with antiphospholipid syndrome based on a Chinese cohort study

Author

Huang, Can, primary, Zhao, Yuan, additional, Tian, Xinping, additional, Wang, Qian, additional, Hu, Chaojun, additional, Jiang, Nan, additional, Zhou, Shuang, additional, Zhang, Li, additional, Zhou, Jiaxin, additional, Wu, Chanyuan, additional, Li, Jing, additional, Wu, Di, additional, Zhao, Jiuliang, additional, Li, Mengtao, additional, and Zeng, Xiaofeng, additional

Published
2022
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37. Additional file 1 of Clinical characteristics and prognosis of patients with antiphospholipid antibodies based on cluster analysis: an 8-year cohort study

Author

Qi, Wanting, Zhao, Jiuliang, Huang, Can, Jiang, Nan, Li, Jing, Wu, Chanyuan, Zhang, Shangzhu, Hu, Chaojun, Xu, Dong, Wang, Qian, Li, Mengtao, Tian, Xinping, Zhao, Yan, and Zeng, Xiaofeng

Abstract

Additional file 1: Supplementary Figure 1. Number of clusters approved by 26 clustering criteria from “NbClust” package of R software. Supplementary Table 1. Events and event-free Kaplan-Meier survival rate of aPL-positive patients in four clusters from cluster analysis. Supplementary Table 2. Event-free survival rate and 95% confidence interval from Kaplan-Meier survival analysis.

Published
2022
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38. sj-pdf-1-lup-10.1177_09612033211069762 ��� Supplemental Material for Characteristics and risk factors of retinal vasculopathy in antiphospholipid syndrome

Author

Xie, Zhijuan, Li, Hui, Qi, Wanting, Li, Jing, Wu, Chanyuan, Hu, Chaojun, Jiang, Nan, Wang, Qian, Tian, Xinping, Li, Mengtao, Zhao, Jiuliang, Sui, Ruifang, and Zeng, Xiaofeng

Subjects
111702 Aged Health Care, FOS: Health sciences
Abstract

Supplemental Material, sj-pdf-1-lup-10.1177_09612033211069762 for Characteristics and risk factors of retinal vasculopathy in antiphospholipid syndrome by Zhijuan Xie, Hui Li, Wanting Qi, Jing Li, Chanyuan Wu, Chaojun Hu, Nan Jiang, Qian Wang, Xinping Tian, Mengtao Li, Jiuliang Zhao, Ruifang Sui and Xiaofeng Zeng in Lupus

Published
2022
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40. Management of rheumatoid arthritis in China: a study of the implementation of 2019 EULAR recommendations

Author

Jin, Shangyi, primary, Jiang, Nan, additional, Huo, Yuehong, additional, Duan, Xinwang, additional, Fang, Yongfei, additional, Zhao, Cheng, additional, Li, Hongbin, additional, Yang, Min, additional, Huang, Zhirao, additional, Yang, Pingting, additional, Zhang, Hongfeng, additional, Zhan, Feng, additional, Wang, Youlian, additional, Wang, Yanhong, additional, Wu, Chanyuan, additional, Wang, Qian, additional, Hsieh, Evelyn, additional, Li, Mengtao, additional, Tian, Xinping, additional, Zhao, Yan, additional, and Zeng, Xiaofeng, additional

Published
2022
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43. Sirolimus versus tacrolimus for systemic lupus erythematosus treatment: results from a real-world CSTAR cohort study

Author

Jiang, Nan, primary, Li, Mengtao, additional, Zhang, Hongfeng, additional, Duan, Xinwang, additional, Li, Xiaofeng, additional, Fang, Yongfei, additional, Li, Hongbin, additional, Yang, Pingting, additional, Luo, Hui, additional, Wang, Yanhong, additional, Peng, Liying, additional, Zhao, Jiuliang, additional, Wu, Chanyuan, additional, Wang, Qian, additional, Tian, Xinping, additional, Zhao, Yan, additional, and Zeng, Xiaofeng, additional

Published
2022
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44. Clinical Characteristics and Prognosis of Patients With Antiphospholipid Antibodies Based on Cluster Analysis: An 8-Year Cohort Study

Author

Qi, Wanting, primary, Zhao, Jiuliang, additional, Huang, Can, additional, Jiang, Nan, additional, Li, Jing, additional, Wu, Chanyuan, additional, Zhang, Shangzhu, additional, Hu, Chaojun, additional, Xu, Dong, additional, Wang, Qian, additional, Li, Mengtao, additional, Tian, Xinping, additional, Zhao, Yan, additional, and Zeng, Xiaofeng, additional

Published
2021
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46. Clinical characteristics of immunoglobulin G4–related disease: a prospective study of 118 Chinese patients

Author

Lin, Wei, Lu, Sha, Chen, Hua, Wu, Qingjun, Fei, Yunyun, Li, Mengtao, Zhang, Xuan, Tian, Xinping, Zheng, Wenjie, Leng, Xiaomei, Xu, Dong, Wang, Qian, Shen, Min, Wang, Li, Li, Jing, Wu, Di, Zhao, Lidan, Wu, Chanyuan, Yang, Yunjiao, Peng, Linyi, Zhou, Jiaxin, Wang, Yu, Sha, Yue, Huang, Xiaoming, Jiao, Yang, Zeng, Xuejun, Shi, Qun, Li, Ping, Zhang, Shulan, Hu, Chaojun, Deng, Chuiwen, Li, Yongzhe, Zhang, Shangzhu, Liu, Jinjing, Su, Jinmei, Hou, Yong, Jiang, Ying, You, Xin, Zhang, Haiting, Yan, Linyi, Zhang, Wen, Zhao, Yan, Zeng, Xiaofeng, Zhang, Fengchun, and Lipsky, Peter E.

Published
2015
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47. Clinical Characteristics and Prognoses of Patients With Systemic Lupus Erythematosus Hospitalized for Pulmonary Infections

Author

Yang, Yanli, primary, Jiang, Hui, additional, Wang, Chuhan, additional, Jiang, Nan, additional, Wu, Chanyuan, additional, Zhang, Shangzhu, additional, Jiang, Wei, additional, Peng, Jinmin, additional, Weng, Li, additional, Zhao, Jiuliang, additional, Wang, Qian, additional, Li, Mengtao, additional, Du, Bin, additional, Zhao, Yan, additional, and Zeng, Xiaofeng, additional

Published
2021
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48. Diagnosis and treatment directions and research frontiers of systemic lupus erythematosus

Author

JIANG, Nan, primary, BAI, Wei, additional, ZHAO, JiuLiang, additional, ZHANG, ShangZhu, additional, WU, ChanYuan, additional, WANG, Li, additional, ZHAO, LiDan, additional, LI, Jing, additional, HU, ChaoJun, additional, WANG, Qian, additional, XU, Dong, additional, LENG, XiaoMei, additional, ZHANG, Wen, additional, LI, MengTao, additional, TIAN, XinPing, additional, and ZENG, XiaoFeng, additional

Published
2021
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50. Comment on: The diagnostic value of sST2 for myocardial fibrosis in idiopathic inflammatory myopathies in subclinical stage of cardiac involvement.

Author

Zhang, Lixi, Peng, Liying, Zhou, Shuang, Wu, Chanyuan, Wang, Qian, and Li, Mengtao

Subjects
PREDICTIVE tests, MYOSITIS, CARDIOMYOPATHIES, ENZYME-linked immunosorbent assay, EDEMA, MAGNETIC resonance imaging, FIBROSIS, EXTRACELLULAR space, MEMBRANE proteins, CELL receptors, BIOMARKERS, BLOOD, DISEASE complications
Published
2024
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