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2. Mask R-CNN Based Object Detection for Intelligent Wireless Power Transfer

Author

Wu, Aozhou, Zhang, Qingqing, Fang, Wen, Deng, Hao, Jiang, Sai, and Liu, Qingwen

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

Resonant Beam Charging (RBC) is a promising multi-Watt and multi-meter wireless power transfer method with safety, mobility and simultaneously-charging capability. However, RBC system operation relies on information availability including power receiver location, class label and the receiver number. Since smartphone is the most widely-used mobile device, we propose a Mask R-CNN based smartphone detection model in the RBC system. Experiments illustrate that our model reduces the smartphone scanning time to one third. Thus, this machine learningdetectionapproachprovidesanintelligentwaytoimprove the user experience in wireless power transfer for mobile and Internet of Things (IoT) devices.

Published
2020

3. Lightweight Mask R-CNN for Long-Range Wireless Power Transfer Systems

Author

Li, Hao, Wu, Aozhou, Fang, Wen, Zhang, Qingqing, Liu, Mingqing, Liu, Qingwen, and Chen, Wei

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Resonant Beam Charging (RBC) is a wireless charging technology which supports multi-watt power transfer over meter-level distance. The features of safety, mobility and simultaneous charging capability enable RBC to charge multiple mobile devices safely at the same time. To detect the devices that need to be charged, a Mask R-CNN based dection model is proposed in previous work. However, considering the constraints of the RBC system, it's not easy to apply Mask R-CNN in lightweight hardware-embedded devices because of its heavy model and huge computation. Thus, we propose a machine learning detection approach which provides a lighter and faster model based on traditional Mask R-CNN. The proposed approach makes the object detection much easier to be transplanted on mobile devices and reduce the burden of hardware computation. By adjusting the structure of the backbone and the head part of Mask R-CNN, we reduce the average detection time from $1.02\mbox{s}$ per image to $0.6132\mbox{s}$, and reduce the model size from $245\mbox{MB}$ to $47.1\mbox{MB}$. The improved model is much more suitable for the application in the RBC system.

Published
2020

4. Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk

Author

Walker, Keenan A, Chen, Jingsha, Zhang, Jingning, Fornage, Myriam, Yang, Yunju, Zhou, Linda, Grams, Morgan E, Tin, Adrienne, Daya, Natalie, Hoogeveen, Ron C, Wu, Aozhou, Sullivan, Kevin J, Ganz, Peter, Zeger, Scott L, Gudmundsson, Elias F, Emilsson, Valur, Launer, Lenore J, Jennings, Lori L, Gudnason, Vilmundur, Chatterjee, Nilanjan, Gottesman, Rebecca F, Mosley, Thomas H, Boerwinkle, Eric, Ballantyne, Christie M, and Coresh, Josef

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Acquired Cognitive Impairment, Neurodegenerative, Prevention, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aging, Clinical Research, Brain Disorders, Biotechnology, Neurosciences, Alzheimer's Disease, Aetiology, 2.1 Biological and endogenous factors, Neurological, Humans, Aged, Proteomics, Alzheimer Disease, Brain, Proteome, Clinical sciences
Abstract

The plasma proteomic changes that precede the onset of dementia could yield insights into disease biology and highlight new biomarkers and avenues for intervention. We quantified 4,877 plasma proteins in nondemented older adults in the Atherosclerosis Risk in Communities cohort and performed a proteome-wide association study of dementia risk over five years (n = 4,110; 428 incident cases). Thirty-eight proteins were associated with incident dementia after Bonferroni correction. Of these, 16 were also associated with late-life dementia risk when measured in plasma collected nearly 20 years earlier, during mid-life. Two-sample Mendelian randomization causally implicated two dementia-associated proteins (SVEP1 and angiostatin) in Alzheimer's disease. SVEP1, an immunologically relevant cellular adhesion protein, was found to be part of larger dementia-associated protein networks, and circulating levels were associated with atrophy in brain regions vulnerable to Alzheimer's pathology. Pathway analyses for the broader set of dementia-associated proteins implicated immune, lipid, metabolic signaling and hemostasis pathways in dementia pathogenesis.

Published
2021

7. A Matching-adjusted Indirect Comparison of Nivolumab Plus Cabozantinib Versus Pembrolizumab Plus Axitinib in Patients with Advanced Renal Cell Carcinoma

Author

McGregor, Bradley, Geynisman, Daniel M., Burotto, Mauricio, Suárez, Cristina, Bourlon, Maria T., Barata, Pedro C., Gulati, Shuchi, Huo, Stephen, Ejzykowicz, Flavia, Blum, Steven I., Del Tejo, Viviana, Hamilton, Melissa, May, Jessica R., Du, Ella X., Wu, Aozhou, Kral, Pavol, Ivanescu, Cristina, Chin, Andi, Betts, Keith A., Lee, Chung-Han, Choueiri, Toni K., Cella, David, and Porta, Camillo

Published
2023
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11. Association of NTproBNP and cTnI with outpatient sudden cardiac death in hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) study

Author

Kruzan, Rachel M, Herzog, Charles A, Wu, Aozhou, Sang, Yingying, Parekh, Rulan S, Matsushita, Kunihiro, Hwang, Seungyoung, Cheng, Alan, Coresh, Josef, Powe, Neil R, and Shafi, Tariq

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Cardiovascular, Prevention, Kidney Disease, Adult, Biomarkers, Death, Sudden, Cardiac, Female, Follow-Up Studies, Humans, Kidney Failure, Chronic, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Proportional Hazards Models, Prospective Studies, Renal Dialysis, Risk Assessment, Risk Factors, Troponin I, Sudden Cardiac Death, Hemodialysis, NTproBNP, Urology & Nephrology, Clinical sciences, Health services and systems, Nursing
Abstract

BackgroundSudden cardiac death (SCD) is the most common etiology of death in hemodialysis patients but not much is known about its risk factors. The goal of our study was to determine the association and risk prediction of SCD by serum N-terminal prohormone of brain natriuretic peptide (NTproBNP) troponin I (cTnI) in hemodialysis patients.MethodsWe measured NTproBNP and cTnI in 503 hemodialysis patients of a national prospective cohort study. We determined their association with SCD using Cox regression, adjusting for demographics, co-morbidities, and clinical factors and risk prediction using C-statistic and Net Reclassification Improvement (NRI).ResultsPatients' mean age was 58 years and 54 % were male. During follow-up (median 3.5 years), there were 75 outpatient SCD events. In unadjusted and fully-adjusted models, NTproBNP had a significant association with the risk of SCD. Analyzed as a continuous variable, the risk of SCD increased 27 % with each 2-fold increase in NTproBNP (HR, 1.27 per doubling; 95 % CI, 1.13-1.43; p 7,350 pg/mL) compared with the lowest tertile (

Published
2016

19. Associations of Vascular Risk and Amyloid Burden with Subsequent Dementia

Author

Gottesman, Rebecca F., primary, Wu, Aozhou, additional, Coresh, Josef, additional, Knopman, David S., additional, Jack, Clifford R., additional, Rahmim, Arman, additional, Sharrett, A. Richey, additional, Spira, Adam P., additional, Wong, Dean F., additional, Wagenknecht, Lynne E., additional, Hughes, Timothy M., additional, Walker, Keenan A., additional, and Mosley, Thomas H., additional

Published
2022
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20. Comparison of 4‐ or 6‐implant supported immediate full‐arch fixed prostheses: A retrospective cohort study of 217 patients followed up for 3–13 years.

Author

Zhang, Yan, Li, Sha, Di, Ping, Zhang, Yu, Wu, Aozhou, and Lin, Ye

Subjects
COMPLICATIONS of prosthesis, PROSTHETICS, COHORT analysis, IMMEDIATE loading (Dentistry), SMOKING, OLDER patients
Abstract

Purpose: Choosing four or six implants to support immediate full‐arch fixed prostheses (FAFPs) is still controversial worldwide. This study aims to analyze and compare the long‐term results of All‐on‐4 and All‐on‐6. Materials and Methods: This retrospective cohort study enrolled 217 patients rehabilitated with 1222 implants supporting 271 FAFPs, including 202 prostheses supported by 4 implants (All‐on‐4 group) and 69 prostheses supported by 6 implants (All‐on‐6 group), and followed up for 3–13 years. Implant survival, prosthesis survival, complications, and implant marginal bone loss (MBL) were evaluated and compared between two groups. Patient characteristics including age, gender, jaw, opposite dentition condition, smoking habit, bruxism, bone quantity and quality, cantilever length (CL), prosthesis material, and oral hygiene were analyzed to assess their influence on the clinical results of the two groups. Six surgeons and three prosthodontists who performed FAFPs more than 5 years were invited for questionnaires, to assess patient‐ and clinician‐related influences on implant number. Result: In general, All‐on‐4 group indicated no significant difference with All‐on‐6 group in the implant survival (implant‐level: hazard ratio [HR] = 1.0 [95% confidence interval (CI): 0.8–1.2], P = 0.96; prosthesis‐level: HR = 0.8 [95% CI: 0.3–1.8], P = 0.54), prosthesis survival (odds ratio [OR] = 0.8 [95% CI: 0.3–2.8], P = 0.56), biological complications (OR = 0.9 [95% CI: 0.5–1.8], P = 0.78), technical complications of provisional prosthesis (OR = 1.3 [95% CI: 0.7–2.3], P = 0.42), technical complications of definitive prosthesis (OR = 1.1 [95% CI: 0.6–2.2], P = 0.33) and the 1st, 5th, and 10th year MBL (P = 0.65, P = 0.28, P = 0.14). However, for specific covariates, including elderly patients, opposing natural/fixed dentition, smoking, bruxism, long CL, low bone density, and all acrylic provisional prostheses, All‐on‐6 was more predictable in some clinical measurements than All‐on‐4. The implant prosthodontists and the medium‐experienced clinicians showed significant preference for All‐on‐6 (P < 0.05). Conclusion: Based on this study, the long‐term clinical results showed no significant difference between All‐on‐4 and All‐on‐6 groups in general. However, for some specific characteristics, All‐on‐6 seemed to be more predictable in some clinical measurements than All‐on‐4. For the clinicians' decision‐making, medium‐experienced clinicians and the implant prosthodontists showed significant preference for All‐on‐6. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Efficacy outcomes of nivolumab + cabozantinib versus pembrolizumab + axitinib in patients with advanced renal cell carcinoma (aRCC): Matching-adjusted indirect comparison (MAIC).

Author

McGregor, Bradley Alexander, primary, Geynisman, Daniel M., additional, Burotto, Mauricio, additional, Porta, Camillo, additional, Suarez Rodriguez, Cristina, additional, Bourlon, Maria Teresa, additional, Barata, Pedro C., additional, Gulati, Shuchi, additional, Stwalley, Brian, additional, Del Tejo, Viviana, additional, Du, Ella X., additional, Wu, Aozhou, additional, Chin, Andi, additional, Betts, Keith A., additional, Huo, Stephen, additional, and Choueiri, Toni K., additional

Published
2021
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27. Association between Circulating Protein C Levels and Incident Dementia: The Atherosclerosis Risk in Communities Study

Author

Tin, Adrienne, primary, Walker, Keenan A., additional, Bressler, Jan, additional, Windham, B. Gwen, additional, Griswold, Michael, additional, Sullivan, Kevin, additional, Wu, Aozhou, additional, Gottesman, Rebecca, additional, Fornage, Myriam, additional, Coresh, Josef, additional, Sharrett, A. Richey, additional, Folsom, Aaron R., additional, and Mosley, Thomas H., additional

Published
2021
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28. Large‐scale plasma proteomic analysis identifies proteins and biological pathways associated with incident dementia

Author

Walker, Keenan A, primary, Chen, Jingsha, additional, Wu, Aozhou, additional, Tin, Adrienne, additional, Mosley, Thomas H, additional, Fornage, Myriam, additional, Ballantyne, Christie M, additional, Boerwinkle, Eric, additional, Sullivan, Kevin J, additional, Zeger, Scott L, additional, Ganz, Peter, additional, Gottesman, Rebecca F, additional, and Coresh, Josef, additional

Published
2020
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33. Abstract P402: Aortic Stiffness and 5-year Cognitive Decline Among Community-dwelling Older Adults: The Atherosclerosis Risk in Communities Neurocognitive Study (aric-ncs)

Author

Wei, Jingkai, primary, Palta, Priya, additional, Wu, Aozhou, additional, Meyer, Michelle, additional, Sharret, A. Richey, additional, Tanaka, Hirofumi, additional, Knopman, David, additional, Kucharska-newton, Anna, additional, Hughes, Timothy, additional, Matsushita, Kunihiro, additional, Mosley, Thomas, additional, and HEISS, Gerardo M, additional

Published
2020
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34. Abstract P425: Central Aortic Stiffening in Late-life and Odds of Dementia: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)

Author

Palta, Priya, primary, Wei, Jingkai, additional, Wu, Aozhou, additional, Meyer, Michelle, additional, Sharrett, A Richey, additional, Tanaka, Hirofumi, additional, Knopman, David, additional, Kucharska-newton, Anna, additional, Hughes, Timothy, additional, Matsushita, Kunihiro, additional, Mosley, Thomas, additional, and HEISS, Gerardo M, additional

Published
2020
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37. Antihyperglycemic Treatment Patterns for Chronic Kidney Disease and Type 2 Diabetes.

Author

Betts, Keith A., Oberprieler, Nikolaus G., Wu, Aozhou, James, Glen, Beeman, Scott, Gay, Alain, Xuanhao He, Jingyi Chen, and Vizcaya, David

Subjects
*GLUCAGON-like peptide-1 agonists, *RISK assessment, *GLYCOSYLATED hemoglobin, *CREATININE, *RESEARCH funding, *DISEASE management, *HYPOGLYCEMIC agents, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *SEVERITY of illness index, *SYMPTOMS, *CHRONIC kidney failure, *LONGITUDINAL method, *TYPE 2 diabetes, *MEDICAL records, *ACQUISITION of data, *ELECTRONIC health records, *SODIUM-glucose cotransporter 2 inhibitors, *PHYSICIAN practice patterns, *COMPARATIVE studies, *ALBUMINS, *DATA analysis software, *DRUG prescribing, *COMORBIDITY, *DISEASE risk factors, *DISEASE complications, CHRONIC kidney failure complications
Abstract

OBJECTIVE: Patients with type 2 diabetes (T2D) are at high risk for developing chronic kidney disease (CKD). The onset of incident CKD may complicate glycemic control among these patients. This study aimed to characterize antihyperglycemic medication use after incident CKD onset among patients with T2D to inform disease management. STUDY DESIGN: Retrospective cohort study. METHODS: Patients with incident CKD and prior T2D were identified from the Optum electronic health records database between March 2013 and September 2021. Patterns of antihyperglycemic use were assessed during the 1-year baseline period and after incident CKD diagnosis and described by baseline hemoglobin A1C (HbA1C) level (controlled [< 7%] vs elevated [≥ 7%]) and CKD severity. RESULTS: The study consisted of 262,395 patients, of whom 51% had elevated HbA1C. After CKD onset, 23.9% of patients initiated new antihyperglycemics within 1 year. Patients with elevated HbA1C had shorter time to new treatment initiation compared with those with controlled HbA1C (median, 28.7 vs 83.7 months). Patients with elevated urine albumin-to-creatinine ratio (uACR) had shorter median time to new treatment initiation (39.9-42.4 months) than those with normal uACR (59.8 months). Less than 7% of patients with stage 3 CKD and even smaller percentages of patients with higher stages of CKD utilized glucagon-like peptide1 receptor agonists and sodium-glucose cotransporter 2 inhibitors. CONCLUSIONS: Treatment of T2D was considerably heterogenous by HbA1C level and CKD severity in patients with incident CKD. Current agents may not sufficiently fulfill the unmet need of T2D management in patients with CKD. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Association of Midlife to Late-Life Blood Pressure Patterns With Incident Dementia

Author

Walker, Keenan A., primary, Sharrett, A. Richey, additional, Wu, Aozhou, additional, Schneider, Andrea L. C., additional, Albert, Marilyn, additional, Lutsey, Pamela L., additional, Bandeen-Roche, Karen, additional, Coresh, Josef, additional, Gross, Alden L., additional, Windham, B. Gwen, additional, Knopman, David S., additional, Power, Melinda C., additional, Rawlings, Andreea M., additional, Mosley, Thomas H., additional, and Gottesman, Rebecca F., additional

Published
2019
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40. Association of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment

Author

Wu, Aozhou, primary, Sharrett, A. Richey, additional, Gottesman, Rebecca F., additional, Power, Melinda C., additional, Mosley, Thomas H., additional, Jack, Clifford R., additional, Knopman, David S., additional, Windham, B. Gwen, additional, Gross, Alden L., additional, and Coresh, Josef, additional

Published
2019
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42. Abstract P018: Smoking and Cognitive Decline at Older Age: Using Surveillance and Imputation to Deal With Differential Mortality

Author

Wu, Aozhou, primary, Sharrett, A. R, additional, Deal, Jennifer A, additional, Bandeen-Roche, Karen, additional, Rawlings, Andreea, additional, Power, Melinda C, additional, Gross, Alden L, additional, Couper, David, additional, Griswold, Michael, additional, Mosley, Thomas, additional, Gottesman, Rebecca F, additional, and Coresh, Josef, additional

Published
2019
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45. Neural correlates of domain-specific cognitive decline

Author

Schneider, Andrea L.C., primary, Senjem, Matthew L., additional, Wu, Aozhou, additional, Gross, Alden, additional, Knopman, David S., additional, Gunter, Jeffrey L., additional, Schwarz, Christopher G., additional, Mosley, Thomas H., additional, Gottesman, Rebecca F., additional, Sharrett, A. Richey, additional, and Jack, Clifford R., additional

Published
2019
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