262 results on '"Wsól, Vladimír"'
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2. Selective inhibition of aldo-keto reductase 1C3: a novel mechanism involved in midostaurin and daunorubicin synergism
3. Interactions of antileukemic drugs with daunorubicin reductases: could reductases affect the clinical efficacy of daunorubicin chemoregimens?
4. Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile
5. Bruton’s Tyrosine Kinase Inhibitor Zanubrutinib Effectively Modulates Cancer Resistance by Inhibiting Anthracycline Metabolism and Efflux
6. Deeper Insight into the Reducing Biotransformation of Bupropion in the Human Liver
7. Human dehydrogenase/reductase (SDR family) member 8 (DHRS8): a description and evaluation of its biochemical properties
8. Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2′-hydroxybenzanilides, their thioxo analogues and benzoxazoles
9. Isocitrate Dehydrogenase 2 Inhibitor Enasidenib Synergizes Daunorubicin Cytotoxicity by Targeting Aldo-Keto Reductase 1c3 and Atp-Binding Cassette Transporters
10. Carbonyl reduction of warfarin: Identification and characterization of human warfarin reductases
11. Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin
12. Variations in the chemical profile and biological activities of licorice (Glycyrrhiza glabra L.), as influenced by harvest times
13. Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3
14. Bruton’s Tyrosine Kinase Inhibitors Ibrutinib and Acalabrutinib Counteract Anthracycline Resistance in Cancer Cells Expressing AKR1C3
15. Liquid chromatography–tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes
16. Selective inhibition of aldo-keto reductase 1C3: a novel mechanism involved in midostaurin and daunorubicin synergism
17. The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes
18. HPLC—radiometric determination of quinlukast in biological fluids
19. Initial characterization of human DHRS1 (SDR19C1), a member of the short-chain dehydrogenase/reductase superfamily
20. Central composite design as a powerful optimisation technique for enantioresolution of the rac-11-dihydrooracin—the principal metabolite of the potential cytostatic drug oracin
21. Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment
22. Metabolic pathways of flobufen — a new antirheumatic and antiarthritic drug. Interspecies comparison
23. Reductive metabolism of tiaprofenic acid by the human liver and recombinant carbonyl reducing enzymes
24. Design, Synthesis, and Biological Evaluation of Isothiosemicarbazones with Antimycobacterial Activity
25. AKR1C3 Inhibitory Potency of Naturally-occurring Amaryllidaceae Alkaloids of Different Structural Types
26. In vitro metabolism of fenofibric acid by carbonyl reducing enzymes
27. Human DHRS7, promising enzyme in metabolism of steroids and retinoids?
28. Human dehydrogenase/reductase (SDR family) member 8 (DHRS8): a description and evaluation of its biochemical properties
29. Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3)
30. Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier
31. The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man
32. Synthesis and Biological Activity of Quaternary Ammonium Salt-Type Agents Containing Cholesterol and Terpenes
33. Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells
34. Carbonyl reduction pathways in drug metabolism
35. Efficient isolation of carbonyl‐reducing enzymes using affinity approach with anticancer drug oracin as a specific ligand
36. S-Nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity
37. Variations in the chemical profile and biological activities of licorice (Glycyrrhiza glabra L.), as influenced by harvest times
38. Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase
39. Expression of human carbonyl reductase 3 (CBR3; SDR21C2) is inducible by pro-inflammatory stimuli
40. Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily
41. Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase
42. AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids
43. Liquid chromatographic–electrospray mass spectrometric determination (LC–ESI-MS) of phase II metabolites of flobufen in rat liver microsomes—Chiral discrimination
44. Coordination Compounds Based on 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic Acid
45. Metabolite profile of sibutramine in human urine: a liquid chromatography-electrospray ionization mass spectrometric study
46. Hydantoins and Thiohydantoins Derived from 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
47. Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes
48. The Phase I Biotransformation of the Potential Antileukotrienic Drug Quinlukast in Rat Microsomes and Hepatocytes
49. Stereospecific reduction of the original anticancer drug oracin in rat extrahepatic tissues
50. Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes
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