Search

Your search keyword '"Wright, M. J. (Margaret J.)"' showing total 2 results
Start Over Author "Wright, M. J. (Margaret J.)"
2 results on '"Wright, M. J. (Margaret J.)"'

1. Genetic influences on schizophrenia and subcortical brain volumes:large-scale proof of concept

Author

Franke, B. (Barbara), Stein, J. L. (Jason L.), Ripke, S. (Stephan), Anttila, V. (Verneri), Hibar, D. P. (Derrek P.), Hulzen, K. J. (Kimm J. E.), Arias-Vasquez, A. (Alejandro), Smoller, J. W. (Jordan W.), Nichols, T. E. (Thomas E.), Neale, M. C. (Michael C.), McIntosh, A. M. (Andrew M.), Lee, P. (Phil), McMahon, F. J. (Francis J.), Meyer-Lindenberg, A. (Andreas), Mattheisen, M. (Manuel), Andreassen, O. A. (Ole A.), Gruber, O. (Oliver), Sachdev, P. S. (Perminder S.), Roiz-Santiañez, R. (Roberto), Saykin, A. J. (Andrew J.), Ehrlich, S. (Stefan), Mather, K. A. (Karen A.), Turner, J. A. (Jessica A.), Schwarz, E. (Emanuel), Thalamuthu, A. (Anbupalam), Yao, Y. (Yin), Ho, Y. Y. (Yvonne Y. W.), Martin, N. G. (Nicholas G.), Wright, M. J. (Margaret J.), O'Donovan, M. C. (Michael C.), Thompson, P. M. (Paul M.), Neale, B. M. (Benjamin M.), Medland, S. E. (Sarah E.), Sullivan, P. F. (Patrick F.), Franke, B. (Barbara), Stein, J. L. (Jason L.), Ripke, S. (Stephan), Anttila, V. (Verneri), Hibar, D. P. (Derrek P.), Hulzen, K. J. (Kimm J. E.), Arias-Vasquez, A. (Alejandro), Smoller, J. W. (Jordan W.), Nichols, T. E. (Thomas E.), Neale, M. C. (Michael C.), McIntosh, A. M. (Andrew M.), Lee, P. (Phil), McMahon, F. J. (Francis J.), Meyer-Lindenberg, A. (Andreas), Mattheisen, M. (Manuel), Andreassen, O. A. (Ole A.), Gruber, O. (Oliver), Sachdev, P. S. (Perminder S.), Roiz-Santiañez, R. (Roberto), Saykin, A. J. (Andrew J.), Ehrlich, S. (Stefan), Mather, K. A. (Karen A.), Turner, J. A. (Jessica A.), Schwarz, E. (Emanuel), Thalamuthu, A. (Anbupalam), Yao, Y. (Yin), Ho, Y. Y. (Yvonne Y. W.), Martin, N. G. (Nicholas G.), Wright, M. J. (Margaret J.), O'Donovan, M. C. (Michael C.), Thompson, P. M. (Paul M.), Neale, B. M. (Benjamin M.), Medland, S. E. (Sarah E.), and Sullivan, P. F. (Patrick F.)

Abstract

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

Published
2017

2. Hair cortisol in twins:heritability and genetic overlap with psychological variables and stress-system genes

Author

Rietschel, L. (Liz), Streit, F. (Fabian), Zhu, G. (Gu), McAlone, K. (Kerrie), Frank, J. (Josef), Couvy-Duchesne, B. (Baptiste), Witt, S. H. (Stephanie H.), Binz, T. M. (Tina M.), McGrath, J. (John), Hickie, I. B. (Ian B.), Hansel, N. K. (Narelle K.), Wright, M. J. (Margaret J.), Gillespie, N. A. (Nathan A.), Forstner, A. J. (Andreas J.), Schulze, T. G. (Thomas G.), Wüst, S. (Stefan), Nöthen, M. M. (Markus M.), Baumgartner, M. R. (Markus R.), Walker, B. R. (Brian R.), Crawford, A. A. (Andrew A.), Colodro-Conde, L. (Lucía), Medland, S. E. (Sarah E.), Martin, N. G. (Nicholas G.), Rietschel, M. (Marcella), Rietschel, L. (Liz), Streit, F. (Fabian), Zhu, G. (Gu), McAlone, K. (Kerrie), Frank, J. (Josef), Couvy-Duchesne, B. (Baptiste), Witt, S. H. (Stephanie H.), Binz, T. M. (Tina M.), McGrath, J. (John), Hickie, I. B. (Ian B.), Hansel, N. K. (Narelle K.), Wright, M. J. (Margaret J.), Gillespie, N. A. (Nathan A.), Forstner, A. J. (Andreas J.), Schulze, T. G. (Thomas G.), Wüst, S. (Stefan), Nöthen, M. M. (Markus M.), Baumgartner, M. R. (Markus R.), Walker, B. R. (Brian R.), Crawford, A. A. (Andrew A.), Colodro-Conde, L. (Lucía), Medland, S. E. (Sarah E.), Martin, N. G. (Nicholas G.), and Rietschel, M. (Marcella)

Abstract

Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables., Consortia CORtisolNETwork (CORNET) Consortium Jennifer L. Bolton21 Caroline Hayward23 Nese Direk24,25 Anna Anderson21 Jennifer Huffman23 James F. Wilson26 Harry Campbell26 Igor Rudan26 Alan Wright23 Nicholas Hastie23 Sarah H. Wild26 Fleur P. Velders24 Albert Hofman24 Andre G. Uitterlinden24,27 Jari Lahti28 Katri Räikkönen28 Eero Kajantie29 Elisabeth Widen30 Aarno Palotie30,31 Johan G. Eriksson29,32,33,34,35 Marika Kaakinen36 Marjo-Riitta Järvelin36,37,38,39 Nicholas J. Timpson40 George Davey Smith40 Susan M. Ring41 David M. Evans40 Beate St Pourcain41 Toshiko Tanaka42 Yuri Milaneschi42,43 Stefania Bandinelli44 Luigi Ferrucci42 Pim van der Harst45,46,47 Judith GM Rosmalen48 Stephen JL Bakker49 Niek Verweij45 Robin PF Dullaart49 Anubha Mahajan50 Cecilia M. Lindgren50 Andrew Morris50 Lars Lind51 Erik Ingelsson51 Laura N. Anderson52 Craig E. Pennell53 Stephen J. Lye52 Stephen G. Matthews54 Joel Eriksson55 Dan Mellstrom55 Claes Ohlsson55 Jackie F. Price26 Mark WJ Strachan21 Rebecca M. Reynolds21 Henning Tiemeier24,56,57 Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) Stephan Ripke58,59,60 Manuel Mattheisen61,62,63 Abdel Abdellaoui64 Mark J. Adams65 Esben Agerbo66,8,67 Tracy M. Air68 Till FM Andlauer69,70 Silviu-Alin Bacanu71 Marie Bækvad-Hansen67,72 Aartjan TF Beekman43 David A. Bennett73 Klaus Berger74 Tim B. Bigdeli71,11 Jonas Bybjerg-Grauholm67,72 Enda M. Byrne5 Na Cai75 Enrique Castelao76 Toni-Kim Clarke65 Jonathan RI Coleman77 Converge Consortium78 Nick Craddock79 Udo Dannlowski80,81 Gareth Davies82 Gail Davies83 Eco. J. C. de Geus64,84 Philip De Jager85 Ian J. Deary83 Franziska Degenhardt12,13 Erin C. Dunn86,87,88 Erik A. Ehli82 Thalia C. Eley77 Valentina Escott-Price89 Tõnu Esko58,90,91,92 Hilary K. Finucane93,94 Michael Gill95 Scott D. Gordon96 Jakob Grove61,62,67,97 Lynsey S. Hall65,98 Thomas F. Hansen99,100 Christine Søholm Hansen67,72 Thomas F. Hansen101 Andrew C. Heath102 Anjali K. Henders5 Stefan Herms12,13,15 Per Hoffman

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results