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11. Wilson Lake site

Author

Miller, K.G., primary, Browning, J.V., additional, Aubry, M.-P., additional, Babila, T., additional, Baluyot, R.D., additional, Esmeray-Senlet, S., additional, Feigenson, M.D., additional, Karakaya, S., additional, Lombardi, C.J., additional, Makarova, M., additional, McCreary, S., additional, McLaughlin, P.P., additional, Monteverde, D.H., additional, Olsson, R.K., additional, Smith, C.T., additional, Sugarman, P.J., additional, and Wright, J.D., additional

Published
2017
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12. Expedition 359 summary

Author

Betzler, C., primary, Eberli, G.P., additional, Alvarez Zarikian, C.A., additional, Alonso-García, M., additional, Bialik, O.M., additional, Blättler, C.L., additional, Guo, J.A., additional, Haffen, S., additional, Horozal, S., additional, Inoue, M., additional, Jovane, L., additional, Kroon, D., additional, Lanci, L., additional, Laya, J.C., additional, Ling Hui Mee, A., additional, Lüdmann, T., additional, Nakakuni, M., additional, Nath, B.N., additional, Niino, K., additional, Petruny, L.M., additional, Pratiwi, S.D., additional, Reijmer, J.J.G., additional, Reolid, J., additional, Slagle, A.L., additional, Sloss, C.R., additional, Su, X., additional, Swart, P.K., additional, Wright, J.D., additional, Yao, Z., additional, and Young, J.R., additional

Published
2017
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19. The Effect of Early Sedation with Dexmedetomidine on Body Temperature in Critically Ill Patients*.

Author

Grayson K.E., Bailey M., Balachandran M., Banneheke P.P., Belletti A., Bellomo R., Naorungroj T., Serpa-Neto A., Wright J.D., Yanase F., Young P.J., Shehabi Y., Grayson K.E., Bailey M., Balachandran M., Banneheke P.P., Belletti A., Bellomo R., Naorungroj T., Serpa-Neto A., Wright J.D., Yanase F., Young P.J., and Shehabi Y.

Abstract

OBJECTIVES: Previous case series reported an association between dexmedetomidine use and hyperthermia. Temperature data have not been systematically reported in previous randomized controlled trials evaluating dexmedetomidine. A causal link between dexmedetomidine administration and elevated temperature has not been demonstrated. DESIGN: Post hoc analysis. SETTING: Four ICUs in Australia and New Zealand. PATIENTS: About 703 mechanically ventilated ICU patients. INTERVENTIONS: Early sedation with dexmedetomidine versus usual care. MEASUREMENTS AND MAIN RESULTS: The primary outcome was mean daily body temperature. Secondary outcomes included the proportions of patients with body temperatures greater than or equal to 38.3degreeC and greater than or equal to 39degreeC, respectively. Outcomes were recorded for 5 days postrandomization in the ICU. The mean daily temperature was not different between the dexmedetomidine (n = 351) and usual care (n = 352) groups (36.84degreeC +/- sd vs 36.78degreeC +/- sd; p = 0.16). Over the first 5 ICU days, more dexmedetomidine group (vs usual care) patients had a temperature greater than or equal to 38.3degreeC (43.3% vs 32.7%, p = 0.004; absolute difference 10.6 percentage points) and greater than or equal to 39.0degreeC (19.4% vs 12.5%, p = 0.013; absolute difference 6.9 percentage points). Results were similar after adjusting for diagnosis, admitting temperature, age, weight, study site, sepsis occurrence, and the time from dexmedetomidine initiation to first hyperthermia recorded. There was a significant dose response relationship with temperature increasing by 0.30degreeC +/-0.08 for every additional 1 mug/kg/hr of dexmedetomidine received p < 0.0002. CONCLUSION(S): Our study suggests potentially important elevations in body temperature are associated with early dexmedetomidine sedation, in adults who are mechanically ventilated in the ICU.Copyright © 2021 Lippincott Williams and Wilkins. All rights reserved.

Published
2021

20. The Effect of Early Sedation With Dexmedetomidine on Body Temperature in Critically Ill Patients.

Author

Wright J.D., Serpa-Neto A., Yanase F., Shehabi Y., Young P.J., Grayson K.E., Bailey M., Balachandran M., Banneheke P.P., Belletti A., Bellomo R., Naorungroj T., Wright J.D., Serpa-Neto A., Yanase F., Shehabi Y., Young P.J., Grayson K.E., Bailey M., Balachandran M., Banneheke P.P., Belletti A., Bellomo R., and Naorungroj T.

Abstract

OBJECTIVES: Previous case series reported an association between dexmedetomidine use and hyperthermia. Temperature data have not been systematically reported in previous randomized controlled trials evaluating dexmedetomidine. A causal link between dexmedetomidine administration and elevated temperature has not been demonstrated. DESIGN: Post hoc analysis. SETTING: Four ICUs in Australia and New Zealand. PATIENTS: About 703 mechanically ventilated ICU patients. INTERVENTIONS: Early sedation with dexmedetomidine versus usual care. MEASUREMENTS AND MAIN RESULTS: The primary outcome was mean daily body temperature. Secondary outcomes included the proportions of patients with body temperatures greater than or equal to 38.3degreeC and greater than or equal to 39degreeC, respectively. Outcomes were recorded for 5 days postrandomization in the ICU. The mean daily temperature was not different between the dexmedetomidine (n = 351) and usual care (n = 352) groups (36.84degreeC +/- SD vs 36.78degreeC +/- SD; p = 0.16). Over the first 5 ICU days, more dexmedetomidine group (vs usual care) patients had a temperature greater than or equal to 38.3degreeC (43.3% vs 32.7%, p = 0.004; absolute difference 10.6 percentage points) and greater than or equal to 39.0degreeC (19.4% vs 12.5%, p = 0.013; absolute difference 6.9 percentage points). Results were similar after adjusting for diagnosis, admitting temperature, age, weight, study site, sepsis occurrence, and the time from dexmedetomidine initiation to first hyperthermia recorded. There was a significant dose response relationship with temperature increasing by 0.30degreeC +/-0.08 for every additional 1 mug/kg/hr of dexmedetomidine received p < 0.0002. CONCLUSION(S): Our study suggests potentially important elevations in body temperature are associated with early dexmedetomidine sedation, in adults who are mechanically ventilated in the ICU.

Published
2021

22. Study of particle trajectories, residence times and flow behavior in kneading discs of intermeshing co-rotating twin-screw extruders

Author

Bravo, V.L., Hrymak, A.N., and Wright, J.D.

Subjects
Polymers -- Research, Engineering and manufacturing industries, Science and technology, Research
Abstract

A three-dimensional finite element model was implemented for the solution of mass and momentum conservation equations in the kneading disc section of an intermeshing co-rotating twin-screw extruder. The polymer melt was modeled with a Carreau constitutive equation. The particle tracking technique was used to obtain residence times and analyze distributive mixing for different length to diameter ratios (L/D) of kneading discs. Previous studies from Kalyon et al. (1) and Cheng and Manas-Zloczower (2) have shown that the mixing performance of intermeshing co-rotating twin-screw extruders is highly dependent on the combination of screw configuration and operating conditions. The complexity of the geometry and the transient character of the flow demand powerful computational tools to characterize the flow and to develop a prediction tool for the analysis of relative performance between different configurations. Difficulties arise in the particle tracking technique because of the time discretization and the presence of moving boundaries. Results show the importance of particle history on the evaluation of the relative performance of different configurations of kneading blocks and suggest a reevaluation of the use of average flow characteristics for the analysis of mixing. Results also confirm the importance of an accurate description of the geometry and clearances in order to obtain information about relative mixing performance. Polym. Eng. Sci. 44:779-793, 2004., INTRODUCTION The problem of polymer mixing involves the aspects of fluid dynamics and rheology. Mixing is usually obtained through a combination of mechanical motion of the mixing device and the [...]

Published
2004

38. Minimally invasive hysterectomy rates and surgical outcomes in uterine cancer: A Society of Gynecologic Oncology clinical outcomes registry analysis

Author

Fader, A. Nickles, primary, Dewdney, S.B., additional, Wright, J.D., additional, Wethington, S.L., additional, Huang, Y., additional, Grendys, E.C., additional, Wilkinson-Ryan, I., additional, Timmins, P.F., additional, Rocconi, R.P., additional, Clark, R., additional, Huh, W., additional, Kim, K.H., additional, Rimel, B.J., additional, Lachance, J.A., additional, Straughn, J.M., additional, Jimenez, E.A., additional, Cohn, D.E., additional, Pearl, M.L., additional, Powell, M.A., additional, and Dowdy, S.C., additional

Published
2020
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