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Regional two-dimensional (2D) echocardiographic amplitude patterns, or image texture, may be of diagnostic importance. Echocardiographic image texture is due in part to acoustic speckle, a complex pattern of interference of reflections from many small scatterers in tissue. The regional speckle pattern appears to be altered in several disorders associated with abnormalities in myocardial structure but also may be altered by a variety of characteristics of the scanning instrument. We hypothesized that quantitative measures of regional 2D echocardiographic image texture would vary as a function of position in range and azimuth within the field of view, even when imaging a uniform ensemble of scatterers. We tested this hypothesis by imaging a tissue-equivalent phantom with two phased-array scanners and two different methods of digitization. We analyzed the texture in several regions of interest separated in range and azimuth and found significant differences in quantitative texture measures as a function of position of the region of interest in the sector field of view (p values .006 to .0001 by multivariate analysis of variance). We found significant regional variability in texture with both scanners and both methods of digitization. We conclude that regional quantitative image texture in 2D echocardiograms varies as a function of range and azimuth, even when imaging a uniform ensemble of scatterers. This variability is related to several physical and instrument-related phenomena and precludes interpreting all regional texture alterations as indicating tissue structural abnormalities.