940 results on '"Worth, Andrew"'
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2. Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network
3. A matter of trust: Learning lessons about causality will make qAOPs credible
4. Towards a qAOP framework for predictive toxicology - Linking data to decisions
5. Computational modelling and simulation for immunotoxicity prediction induced by skin sensitisers
6. Translatability and transferability of in silico models: Context of use switching to predict the effects of environmental chemicals on the immune system
7. Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures
8. In Silico Models for Predicting Acute Systemic Toxicity
9. Gaining acceptance in next generation PBK modelling approaches for regulatory assessments – An OECD international effort
10. Assessment of the predictive capacity of a physiologically based kinetic model using a read-across approach
11. Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach methodologies
12. Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment
13. The role of validation in establishing the scientific credibility of predictive toxicology approaches intended for regulatory application
14. Optimising testing strategies for classification of human health and environmental hazards – A proof-of-concept study
15. Physiologically based kinetic (PBK) modelling and human biomonitoring data for mixture risk assessment
16. The way forward for assessing the human health safety of cosmetics in the EU - Workshop proceedings
17. Artificial Intelligence for chemical risk assessment
18. LC-quadrupole/Orbitrap high-resolution mass spectrometry enables stable isotope-resolved simultaneous quantification and 13C-isotopic labeling of acyl-coenzyme A thioesters
19. Predictive Modelling of Allergic Responses to Chemical Sensitizers: Distinguishing Skin and Respiratory Reactions
20. Quantitative adverse outcome pathway (qAOP) models for toxicity prediction
21. Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance
22. Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity
23. Development and analysis of an adverse outcome pathway network for human neurotoxicity
24. The virtual cell based assay: Current status and future perspectives
25. Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes
26. Automated workflows for modelling chemical fate, kinetics and toxicity
27. From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling
28. The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data – A case study with caffeine
29. Multiscale modelling approaches for assessing cosmetic ingredients safety
30. The application of molecular modelling in the safety assessment of chemicals: A case study on ligand-dependent PPARγ dysregulation
31. Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop
32. Towards a future regulatory framework for chemicals in the European Union – Chemicals 2.0
33. Methods for Reliability and Uncertainty Assessment and for Applicability Evaluations of Classification- and Regression-Based QSARs
34. Use of QSARs in International Decision-Making Frameworks to Predict Ecologic Effects and Environmental Fate of Chemical Substances
35. Use of QSARs in International Decision-Making Frameworks to Predict Health Effects of Chemical Substances
36. Validation of Computational Methods
37. Integrated Approaches to Testing and Assessment
38. Thresholds of Toxicological Concern for cosmetics-related substances: New database, thresholds, and enrichment of chemical space
39. Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications
40. Quantitative structure-skin permeability relationships
41. Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling
42. Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept
43. Current Developments and Recommendations in Computational Nanotoxicology in View of Regulatory Applications
44. Modeling of Nanomaterials for Safety Assessment: From Regulatory Requirements to Supporting Scientific Theories
45. Types of Toxicity and Applications of Toxicity Testing
46. Involvement of the Organisation for Economic Cooperation and Development
47. The Validation of Alternative Test Methods
48. Integrated Approaches to Testing and Assessment
49. The Role of ECVAM
50. Alternative Toxicity Test Methods
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