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6. Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis

Author

Abboud, Miguel R, Aytac, Sevkiye Selin, Bosse, Franziskus Johannes, Choo, Sharon, Drabko, Katarzyna, Onkologii, Klinika, Elfeky, Reem, El-Ghoneimy, Dalia Helmy, Fadoo, Zehra, Greenwood, Tatiana, Gustafsson, Britt, Hagelberg, Stefan, Hasle, Henrik, Hästbacka, Johanna, Jadrešin, Oleg, Jädersten, Martin, Kaya, Zuhre, Lecumberri, Ranon, Marques, Laura, Mushtaq, Naureen, Naqvi, Ahmed, Neves, João Farela, Nunes, Susana, Paucar, Martin, Payne, Jeanette H., Rascon, Jelena, Ruuska, Terhi Susanna, Saribeyoglu, Ebru Tugrul, Sundin, Mikael C., Svedenkrans, Jenny, Świderska, Natalia, Tedgård, Ulf, Tvedt, Tor Henrik, Ünüvar, Ayşegül, Van Laar, Jan A. M., Weitzman, Sheila, Winiarski, Jacek, Yaseen, Muhamma Zohaib, Yildiz, Mehmet, Zantomio, Daniela, Øra, Ingrid, Øverland, Torstein, Chiang, Samuel C. C., Covill, Laura E., Tesi, Bianca, Campbell, Tessa M., Schlums, Heinrich, Nejati-Zendegani, Jelve, Mördrup, Karina, Wood, Stephanie, Theorell, Jakob, Sekine, Takuya, Al-Herz, Waleed, Akar, Himmet Haluk, Belen, Fatma Burcu, Chan, Mei Yoke, Devecioglu, Omer, Aksu, Tekin, Ifversen, Marianne, Malinowska, Iwona, Sabel, Magnus, Unal, Ekrem, Unal, Sule, Introne, Wendy J., Krzewski, Konrad, Gilmour, Kimberly C., Ehl, Stephan, Ljunggren, Hans-Gustaf, Nordenskjöld, Magnus, Horne, AnnaCarin, Henter, Jan-Inge, Meeths, Marie, and Bryceson, Yenan T.

Published
2024
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16. Estimating Prestressed Concrete Bridge Reliability and Rating Factors Using Bayesian Networks with an Application to a Bridge Made Continuous for Live Load.

Author

Roberts, Jeffery M., Schumacher, Thomas, Groeneveld, Andrew B., Wood, Stephanie G., and Ruiz, Edgardo

Subjects
LIVE loads, PRESTRESSED concrete, BAYESIAN analysis, STRUCTURAL mechanics, CONTINUOUS bridges
Abstract

The bridge inspection process has multiple steps. One obvious element is for inspectors to identify defects in the main components of the structural system and assign condition ratings. These condition ratings are somewhat subjective because they are influenced by the experience of the inspector. In the current work, processes were developed for making inferences on the reliability of prestressed concrete (PC) girders with defects at the girder component level. The Bayesian network (BN) tools constructed in this study use simple structural mechanics to model the capacity of girders. Expert opinion is used to link defects that can be observed during inspections to underlying deterioration mechanisms. By linking these deterioration mechanisms with changes in mechanical properties, inferences on the reliability of a bridge can be made based on visual observation of defects. The BN can then be used to directly determine the rating factor (RF) of individual structural elements. Examples are provided using BNs to evaluate an existing older PC bridge currently behaving as two simply supported spans. The bridge is modeled using two scenarios with the spans acting as simply supported, and then also with the link block (continuity joint) repaired so that the spans are continuous for live load. The spans are considered simply supported for all dead load. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target

Author

Abdelfattah, Nourhan, Kumar, Parveen, Wang, Caiyi, Leu, Jia-Shiun, Flynn, William F., Gao, Ruli, Baskin, David S., Pichumani, Kumar, Ijare, Omkar B., Wood, Stephanie L., Powell, Suzanne Z., Haviland, David L., Parker Kerrigan, Brittany C., Lang, Frederick F., Prabhu, Sujit S., Huntoon, Kristin M., Jiang, Wen, Kim, Betty Y. S., George, Joshy, and Yun, Kyuson

Published
2022
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28. Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis

Author

Chiang, Samuel C. C., Covill, Laura E., Tesi, Bianca, Campbell, Tessa M., Schlums, Heinrich, Nejati-Zendegani, Jelve, Mördrup, Karina, Wood, Stephanie, Theorell, Jakob, Sekine, Takuya, Al-Herz, Waleed, Akar, Himmet Haluk, Belen, Fatma Burcu, Chan, Mei Yoke, Devecioglu, Omer, Aksu, Tekin, Ifversen, Marianne, Malinowska, Iwona, Sabel, Magnus, Unal, Ekrem, Unal, Sule, Introne, Wendy J., Krzewski, Konrad, Gilmour, Kimberly C., Ehl, Stephan, Abboud, Miguel R, Aytac, Sevkiye Selin, Bosse, Franziskus Johannes, Choo, Sharon, Drabko, Katarzyna, Onkologii, Klinika, Elfeky, Reem, El-Ghoneimy, Dalia Helmy, Fadoo, Zehra, Greenwood, Tatiana, Gustafsson, Britt, Hagelberg, Stefan, Hasle, Henrik, Hästbacka, Johanna, Jadrešin, Oleg, Jädersten, Martin, Kaya, Zuhre, Lecumberri, Ranon, Marques, Laura, Mushtaq, Naureen, Naqvi, Ahmed, Neves, João Farela, Nunes, Susana, Paucar, Martin, Payne, Jeanette H., Rascon, Jelena, Ruuska, Terhi Susanna, Saribeyoglu, Ebru Tugrul, Sundin, Mikael C., Svedenkrans, Jenny, Świderska, Natalia, Tedgård, Ulf, Tvedt, Tor Henrik, Ünüvar, Ayşegül, Van Laar, Jan A. M., Weitzman, Sheila, Winiarski, Jacek, Yaseen, Muhamma Zohaib, Yildiz, Mehmet, Zantomio, Daniela, Øra, Ingrid, Øverland, Torstein, Ljunggren, Hans-Gustaf, Nordenskjöld, Magnus, Horne, AnnaCarin, Henter, Jan-Inge, Meeths, Marie, and Bryceson, Yenan T.

Abstract

•TCR-triggered T-cell and Fc receptor–triggered NK-cell assays are most accurate for diagnosing defective cytotoxic lymphocyte exocytosis.•The standard K562 cell assay has high interindividual variability and is affected by expanded NK-cell subsets and transportation stress.

Published
2024
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29. Report on evaluation of Apartment Towers 1–4 and Parking Garages 1–4 at Camp Walker, Daegu, South Korea

Author

Crane, C., primary, Esquilin-Mangual,, Omar, additional, Foust, Bradley, additional, Groeneveld, Andrew, additional, Heard, William, additional, Hoemann, John, additional, Klaus, Kyle, additional, Morson, Jason, additional, Moser, Robert, additional, Ray, James, additional, Roth, M., additional, Strack, Cody, additional, Walshire, Lucas, additional, Wood, Stephanie, additional, and Woodson, Stanley, additional

Published
2022
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36. Some factors affecting the digestible energy requirements and dry matter intake of mature donkeys and a comparison with normal husbandry practices

Author

Wood, Stephanie Jane, Smith, David, Cuddeford, Derek, Welburn, Susan., Pearson, Anne., and Hovell, Dickon

Subjects
636.085, donkey, nutrition, overfeeding, seasonal changes, dry matter, digestible energy
Abstract

The purpose of this study was to compile practical feeding guidelines for donkeys in the UK. Current guidelines are to feed 0.75 of horse feeding recommendations on a body weight basis. However, the superior digestive efficiency of donkeys, compared to horses, may render the use of horse recommendations inappropriate. The formulation of guidelines specific to donkeys would enable owners to calculate their donkey‟s requirements with greater accuracy and prevent overfeeding. A postal survey, used to gain information on the body condition score of donkeys in the UK, and the husbandry and feeding practices used to manage them, indicated that approximately 24% of donkeys in the UK are overweight. Feeding practices indicated that although owners were aware of their donkey‟s requirement for fibrous forages, the practice of feeding unnecessary concentrates, chaffs and high energy forages, in addition to grazing, was the likely cause of donkeys becoming overweight. The finding that the majority (85 – 90%) of donkeys were kept as non-working companion animals also reduced the need for owners to feed higher energy foods to their donkeys. Results also suggested that owners were unsure of how to adjust their donkey‟s diet to account for seasonal changes in requirements and pasture availability, as most owners‟ adjusted grazing access, and not the feeding of supplementary feeds. From a study of dry matter (DM) and digestible energy (DE) intakes by 20 mature donkeys maintaining weight during each UK season, the maintenance DE requirements of donkeys were calculated. Results showed no effect of sex on DM or DE intake. Season significantly (P<0.001) affected DM and DE intakes, implying increased requirements in winter compared to spring, summer and autumn. Dry matter intakes (DMI) increased from 51g/kg BW0.75 in spring, summer and autumn to 66g/kg BW0.75 in winter. Digestible energy requirements increased from 0.32MJ/kg BW0.75 in spring, summer and autumn to 0.43MJ/kg BW0.75 in winter. Comparison of results with horse recommendations showed considerably reduced requirements by donkeys. Horse recommendations overestimated DE requirements in summer and winter by 82 and 30%, respectively, making horse recommendations unsuitable for calculating donkey energy requirements. Husbandry practices commonly used by owners to manage their donkeys grazing access (grazing time, grazing area, strip grazing), were assessed for their effect on DMI by grazing donkeys in summer and autumn, using n-alkanes. The effect of grazing time was assessed by restricting donkeys to 8, 12 or 23 hours grazing per day. Season significantly affected food intake with donkeys in the 8 and 23 hour grazing groups eating more during summer when pasture availability was greater. Donkeys responded to the poorer quality summer pasture by grazing more intensively but less selectively, increasing the rate at which food was consumed. Grazing time was only influential over grass intake in summer, when pasture was more abundant. Restricting donkeys to 12 hours or less grazing per day significantly (P<0.001) reduced their grass intake compared to that of donkeys with 23 hours access. When grazing sparse pastures (autumn), grazing time did not influence grass intake, indicating an effect of herbage mass on grazing behaviour. Herbage mass was the most influential factor over diet composition (percentage of grass and straw consumed) in a second grazing study assessing the affect of strip grazing and set stocking systems on intake by grazing donkeys during summer and autumn. Herbage mass per donkey was higher in the set stocking system during both seasons, resulting in higher grass intakes. Determining if either grazing system was more effective at regulating grass intake was prevented due to differences in pasture availability between study sites. It is concluded that donkeys have lower DMI and maintenance DE requirements than horses, requiring donkey feeding guidelines to be formulated. Excess body weight in donkeys is caused in part, by the feeding of energy dense feeds in addition to low energy forages. Most owners place little nutritional importance on pasture, despite its potential to provide a large percentage of daily DM, DE and nutrient intake. Therefore nutritional guidelines must include advice on how to manage access to grazing, and how to feed donkeys with access to pasture. Restricting grazing time to 8 hours a day did reduce grass intake by donkeys, but was only effective when grazing abundant pastures. Providing ad libitum straw to grazing donkeys allows them to satisfy their DM and dietary fibre requirements without consuming excess energy.

Published
2010

40. Seals and the Marine Ecosystem: Attitudes, Ecological Benefits/Risks and Lethal Management Views.

Author

Jackman, Jennifer L., Vaske, Jerry J., Dowling-Guyer, Seana, Bratton, Rachel, Bogomolni, Andrea, and Wood, Stephanie A.

Subjects
WHITE shark, MAMMAL conservation, MARINE resources conservation, MARINE mammals, MARINE ecology, ATTITUDE (Psychology)
Abstract

Under the Marine Mammal Protection Act of 1972, seals have recolonized historic ranges along the New England coast after near extirpation from bounty hunting in the 19th and 20th centuries. On Cape Cod, Massachusetts, concerns that rebounding seal populations damage fisheries and draw great white sharks have led some to call for a seal cull. Surveys on Cape Cod found strong opposition to lethal management among residents and tourists, and neutrality, on average, among commercial fishers. For all three samples, lethal management support was substantially explained by general attitudes toward seals and partially mediated by specific ecological benefits and risks associated with seals. Positive attitudes toward seals and perceived ecosystem benefits reduced support for lethal management among residents, tourists and commercial fishers. Negative attitudes and perceived ecological risks of seals increased lethal management support. These findings suggest communication of the ecological benefits of species can enhance continued marine mammal conservation. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Abstract 5871: Pan-cancer myeloid cell analysis at the single cell level reveals the influence of distinct organ sites in myeloid cell phenotypes and support targeting S100A4 to reverse immune suppression

Author

Abdelfattah, Nourhan, primary, Kumar, Parveen, additional, Wang, Caiyi, additional, Leu, Jia-Shiun, additional, Baskin, David, additional, Flynn, William, additional, Gao, Ruli, additional, Pichumani, Kumar, additional, Ijare, Omkar, additional, Wood, Stephanie, additional, Powell, Suzanne, additional, Haviland, David, additional, Kerrigan, Brittany Parker, additional, Lang, Frederick, additional, Prabhu, Sujit, additional, Huntoon, Kristin, additional, Jiang, Wen, additional, Kim, Betty, additional, George, Joshy, additional, and Yun, Kyuson, additional

Published
2023
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47. The Relationship Between Secondary Teachers’ Self-efficacy Subscales of Student Engagement, Instructional Practices, and Classroom Management, and Attitudes About the Inclusive Setting

Author

Wood, Stephanie Marie and Wood, Stephanie Marie

Abstract

The purpose of this quantitative correlation study is to determine if there is a relationship between in-service secondary teachers’ self-efficacy regarding student engagement, instructional practices, and classroom management and their attitudes toward the inclusive setting. Secondary teachers’ self-efficacy is imperative to student engagement, instructional practices, and classroom management in an inclusive setting. The study surveys 67 in-service middle and high school level general education teachers from a single, rural school district in eastern Pennsylvania. Data were collected using two surveys which are the long form of Teachers’ Sense of Efficacy Scale and The Scale of Teacher’s Attitudes towards Inclusive Classroom. Data were collected anonymously through Survey Monkey. A Pearson product-moment correlation was used to analyze the data. The results revealed a statistically significant positive correlation at a very large effect size between student engagement and attitudes toward inclusion, instructional practices and attitude toward inclusion, and classroom management and attitudes toward inclusion.

Published
2023

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