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263 results on '"Wong, Yong Chuan"'

12. Upregulation of twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis

Author

Yuen, Hiu-Fung, Chan, Yuen-Piu, Wong, Michelle Lok-Yee, Kwok, Wei-Kei, Chan, Ka-Kui, Lee, Pin-Yin, Srivastava, Gopesh, Law, Simon Ying-Kit, Wong, Yong-Chuan, Wang, Xianghong, and Chan, Kwok-Wah

Subjects
DNA binding proteins -- Research, Esophageal cancer -- Development and progression, Esophageal cancer -- Complications and side effects, Esophageal cancer -- Research, Neoplastic processes -- Research, Metastasis -- Research, Health
Published
2007

48. Physical activity and risk of prostate and bladder cancer in China: The South and East China case-control study on prostate and bladder cancer

Author

Reulen, Raoul C., de Vogel, Stefan, Zhong, Weide, Zhong, Zhaohui, Xie, Li-Ping, Hu, Zhiquan, Deng, Yilan, Yang, Kai, Liang, Yuxiang, Zeng, Xing, Wong, Yong Chuan, Tam, Po-Chor, Hemelt, Marjolein, Zeegers, Maurice P., RS: CAPHRI - R5 - Optimising Patient Care, and Complexe Genetica

Subjects
Male, lcsh:Medicine, Geographical Locations, Mathematical and Statistical Techniques, Risk Factors, Medicine and Health Sciences, Public and Occupational Health, lcsh:Science, Aged, 80 and over, Prostate Cancer, Prostate Diseases, MEN, Middle Aged, Bladder Cancer, Oncology, Research Design, Physical Sciences, Female, Anatomy, Statistics (Mathematics), Research Article, China, Asia, CARCINOMA, Urology, Research and Analysis Methods, LUNG-CANCER, Exocrine Glands, Diagnostic Medicine, Cancer Detection and Diagnosis, Humans, COHORT, VALIDITY, Statistical Methods, METAANALYSIS, Aged, lcsh:R, Prostatic Neoplasms, Cancers and Neoplasms, Biology and Life Sciences, Physical Activity, Genitourinary Tract Tumors, Urinary Bladder Neoplasms, TAIWAN, Case-Control Studies, People and Places, Prostate Gland, lcsh:Q, Mathematics, Meta-Analysis
Abstract

Background Recent meta-analyses have suggested a modest protective effect of high levels of physical activity on developing both prostate and bladder cancer, but significant heterogeneity between studies included in these meta-analyses existed. To our knowledge, few Chinese studies investigated the association between physical activity and prostate cancer and none between physical activity and bladder cancer. Given the inconsistencies between previous studies and because studies on the relation between physical activity and prostate and bladder cancer in China are scarce, it remains elusive whether there is a relationship between physical activity and prostate and bladder cancer within the Chinese population. Methods We investigated the association between physical activity and risk of developing prostate and bladder cancer within a hospital-based case-control study in the East and South of China among 260 and 438 incident prostate and bladder cancer cases, respectively, and 427 controls. A questionnaire was administered to measure physical activity as metabolic equivalents (METs). Random effects logistic regression was used to calculate odds ratios (ORs) of prostate and bladder cancer for different levels of physical activity and for the specific activities of walking and cycling. Results Increasing overall physical activity was associated with a significant reduction in prostate cancer risk (P-trend = 0.04) with the highest activity tertile level showing a nearly 50% reduction in prostate cancer risk (OR = 0.53, 95% CI: 0.28-0.98). Overall physical activity was not significantly associated with risk of bladder cancer (Ptrend = 0.61), neither were vigorous (P-trend = 0.60) or moderate levels of physical activity (P-trend = 0.21). Walking and cycling were not significantly associated with either prostate (P-trend > = 0.62) or bladder cancer risk (P-trend > = 0.25). Conclusions The findings of this largest ever case-control study in China investigating the relationship between physical activity and prostate and bladder cancer suggest that overall physical activity is associated with a decreased risk of prostate cancer, but not with bladder cancer.

Published
2017

49. Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells

Author

Chiu, Yung-Tuen, Liu, Ji, Tang, Kai Dun, Wong, Yong Chuan, Khanna, Kum, Ling, Patrick, Chiu, Yung-Tuen, Liu, Ji, Tang, Kai Dun, Wong, Yong Chuan, Khanna, Kum, and Ling, Patrick

Abstract

The ATM/ATR DNA damage checkpoint functions in the maintenance of genetic stability and some missense variants of the ATM gene have been shown to confer a moderate increased risk of prostate cancer. However, whether inactivation of this checkpoint contributes directly to prostate specific cancer predisposition is still unknown. Here, we show that exposure of non-malignant prostate epithelial cells (HPr-1AR) to androgen led to activation of the ATM/ATR DNA damage response and induction of cellular senescence. Notably, knockdown of the ATM gene expression in HPr-1AR cells can promote androgen-induced TMPRSS2: ERG rearrangement, a prostate-specific chromosome translocation frequently found in prostate cancer cells. Intriguingly, unlike the non-malignant prostate epithelial cells, the ATM/ATR DNA damage checkpoint appears to be defective in prostate cancer cells, since androgen treatment only induced a partial activation of the DNA damage response. This mechanism appears to preserve androgen induced autophosphorylation of ATM and phosphorylation of H2AX, lesion processing and repair pathway yet restrain ATM/CHK1/CHK2 and p53 signaling pathway. Our findings demonstrate that ATM/ATR inactivation is a crucial step in promoting androgen-induced genomic instability and prostate carcinogenesis.

Published
2012

50. Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population

Author

Lu, Sze Ue, Lee, Terence, Liu, Ji, Lee, Davy Tak Wing, Chiu, Yung-Tuen, Ma, Stephanie, Ng, Irene Oi-Lin, Wong, Yong Chuan, Chan, Franky, Ling, Patrick, Lu, Sze Ue, Lee, Terence, Liu, Ji, Lee, Davy Tak Wing, Chiu, Yung-Tuen, Ma, Stephanie, Ng, Irene Oi-Lin, Wong, Yong Chuan, Chan, Franky, and Ling, Patrick

Abstract

Recent evidence suggested that prostate cancer stem/progenitor cells (CSC) are responsible for cancer initiation as well as disease progression. Unfortunately, conventional therapies are only effective in targeting the more differentiated cancer cells and spare the CSCs. Here, we report that PSP, an active component extracted from the mushroom Turkey tail (also known as Coriolus versicolor), is effective in targeting prostate CSCs. We found that treatment of the prostate cancer cell line PC-3 with PSP led to the down-regulation of CSC markers (CD133 and CD44) in a time and dose-dependent manner. Meanwhile, PSP treatment not only suppressed the ability of PC-3 cells to form prostaspheres under non-adherent culture conditions, but also inhibited their tumorigenicity in vivo, further proving that PSP can suppress prostate CSC properties. To investigate if the anti-CSC effect of PSP may lead to prostate cancer chemoprevention, transgenic mice (TgMAP) that spontaneously develop prostate tumors were orally fed with PSP for 20 weeks. Whereas 100% of the mice that fed with water only developed prostate tumors at the end of experiment, no tumors could be found in any of the mice fed with PSP, suggesting that PSP treatment can completely inhibit prostate tumor formation. Our results not only demonstrated the intriguing anti-CSC effect of PSP, but also revealed, for the first time, the surprising chemopreventive property of oral PSP consumption against prostate cancer.

Published
2011

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