321 results on '"Wong, Y-K"'
Search Results
2. Cultivation of Chlorella vulgaris in Column Photobioreactor for Biomass Production and Lipid Accumulation
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Wong, Y. K., Ho, K. C., Tsang, Y. F., Wang, L., and Yung, K. K. L.
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- 2016
3. An optimal data association method based on the minimum weighted bipartite perfect matching
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Zhang, Xinzheng, Rad, A. B., Huang, Guoquan, and Wong, Y. K.
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- 2016
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4. Integration of Enhanced Adaptive Fuzzy Clustering Algorithm with Probabilistic Technique for Dynamic Map Building
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Ip, Y. L., Rad, A. B., Chow, K. M., Wong, Y. K., Roy, Rajkumar, editor, Köppen, Mario, editor, Ovaska, Seppo, editor, Furuhashi, Takeshi, editor, and Hoffmann, Frank, editor
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- 2002
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5. A Kinetic Examination of the Effects of the Presence of Some Gaseous Fuels and Preignition Reaction Products with Hydrogen on its Autoignition Characteristics in Engines
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Wong, Y. K., Karim, G. A., and Saetre, T. O., editor
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- 1998
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6. Prediction of en-route complications during interfacility transport by outcome predictive scores in ED
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Wong, Y. K., Lui, C. T., Li, K. K., Wong, C. Y., Lee, M. M., Tong, W. L., Ong, K. L., and Tang, S. Y.H.
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- 2016
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7. Garlic intake is an independent predictor of endothelial function in patients with ischemic stroke
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Lau, K. -K., Chan, Y. -H., Wong, Y. -K., Teo, K. -C., Yiu, K. -H., Liu, S., Li, L. S. -W., Shu, X. -O., Ho, S. -L., Chan, K. H., Siu, C. -W., and Tse, Hung Fat
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- 2013
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8. Effect of oral cholecalciferol 2,000 versus 5,000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deficiency
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Diamond, T., Wong, Y. K., and Golombick, T.
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- 2013
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9. On Standard Error for the Line of Mutual Regression
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Wong, Y. K.
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- 1936
10. An Application of Orthogonalization Process to the Theory of Least Squares
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Wong, Y. K.
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- 1935
11. On Non-Negative-Valued Matrices
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Wong, Y. K.
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- 1954
12. Quasi-Inverses Associated with Minkowski-Leontief Matrices
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Wong, Y. K.
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- 1954
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13. On the Elimination of Variables in Multiple Correlation
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Wong, Y. K.
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- 1937
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14. Some Properties of the Proper Values of a Matrix
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Wong, Y. K.
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- 1955
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15. An Inequality for Minkowski Matrices
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Wong, Y. K.
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- 1953
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16. The Distribution of Light Reaching the Ground Vegetation in a Tropical Rain Forest
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Evans, G. C., Whitmore, T. C., and Wong, Y. K.
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- 1960
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17. An Entropy Optimization Strategy for Simultaneous Localization and Mapping
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Liu, Yan, Ren, X. M., Rad, Ahmad B., Zhang, X. Z., and Wong, Y. K.
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- 2010
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18. Visit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarct
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Lau, K. K., Wong, Y. K., Chang, R. S. K., Teo, K. C., Hon, S. F. K., Chan, K. H., Wat, K. L., Cheung, R. T. F., Li, L. S. W., Siu, C. W., Ho, S. L., and Tse, H. F.
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- 2014
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19. Single-centre Initial Experience of Transradial Access for Abdominal Interventional Radiology.
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Lee, M. C., Wong, Y. K., Lee, A. C. W., Fung, H. S., Chiang, J. B., Kwok, C. H., and Chiu, L. F.
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- 2022
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20. A Comparative Study of Three Mapping Methodologies
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Zhang, X. Z., Rad, A. B., Wong, Y. K., Huang, G. Q., Ip, Y. L., and Chow, K. M.
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- 2007
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21. Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial
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Ponikowski, P. Kirwan, B.-A. Anker, S.D. McDonagh, T. Dorobantu, M. Drozdz, J. Fabien, V. Filippatos, G. Göhring, U.M. Keren, A. Khintibidze, I. Kragten, H. Martinez, F.A. Metra, M. Milicic, D. Nicolau, J.C. Ohlsson, M. Parkhomenko, A. Pascual-Figal, D.A. Ruschitzka, F. Sim, D. Skouri, H. van der Meer, P. Lewis, B.S. Comin-Colet, J. von Haehling, S. Cohen-Solal, A. Danchin, N. Doehner, W. Dargie, H.J. Motro, M. Butler, J. Friede, T. Jensen, K.H. Pocock, S. Jankowska, E.A. Azize, G. Fernandez, A. Zapata, G.O. Garcia Pacho, P. Glenny, A. Ferre Pacora, F. Parody, M.L. Bono, J. Beltrano, C. Hershson, A. Vita, N. Luquez, H.A. Cestari, H.G. Fernandez, H. Prado, A. Berli, M. García Durán, R. Thierer, J. Diez, M. Lobo Marquez, L. Borelli, R.R. Hominal, M.Á. Ameri, P. Agostoni, P. Salvioni, A. Fattore, L. Gronda, E. Ghio, S. Turrini, F. Uguccioni, M. Di Biase, M. Piepoli, M. Savonitto, S. Mortara, A. Terrosu, P. Fucili, A. Boriani, G. Midi, P. Passamonti, E. Cosmi, F. van der Meer, P. Van Bergen, P. van de Wetering, M. Al-Windy, N.Y.Y. Tanis, W. Meijs, M. Groutars, R.G.E.J. The, H.K.S. Kietselaer, B. van Kesteren, H.A.M. Beelen, D.P.W. Heymeriks, J. Van de Wal, R. Schaap, J. Emans, M. Westendorp, P. Nierop, P.R. Nijmeijer, R. Manintveld, O.C. Dorobantu, M. Darabantiu, D.A. Zdrenghea, D. Toader, D.M. Petrescu, L. Militaru, C. Crisu, D. Tomescu, M.C. Stanciulescu, G. Rodica Dan, A. Iosipescu, L.C. Serban, D.L. Drozdz, J. Szachniewicz, J. Bronisz, M. Tycińska, A. Wozakowska-Kaplon, B. Mirek-Bryniarska, E. Gruchała, M. Nessler, J. Straburzyńska-Migaj, E. Mizia-Stec, K. Szelemej, R. Gil, R. Gąsior, M. Gotsman, I. Halabi, M. Shochat, M. Shechter, M. Witzling, V. Zukermann, R. Arbel, Y. Flugelman, M. Ben-Gal, T. Zvi, V. Kinany, W. Weinstein, J.M. Atar, S. Goland, S. Milicic, D. Horvat, D. Tušek, S. Udovicic, M. Šutalo, K. Samodol, A. Pesek, K. Artuković, M. Ružić, A. Šikić, J. McDonagh, T. Trevelyan, J. Wong, Y.-K. Gorog, D. Ray, R. Pettit, S. Sharma, S. Kabir, A. Hamdan, H. Tilling, L. Baracioli, L. Nigro Maia, L. Dutra, O. Reis, G. Pimentel Filho, P. Saraiva, J.F. Kormann, A. dos Santos, F.R. Bodanese, L. Almeida, D. Precoma, D. Rassi, S. Costa, F. Kabbani, S. Abdelbaki, K. Abdallah, C. Arnaout, M.S. Azar, R. Chaaban, S. Raed, O. Kiwan, G. Hassouna, B. Bardaji, A. Zamorano, J. del Prado, S. Gonzalez Juanatey, J.R. Ga Bosa Ojeda, F.I. Gomez Bueno, M. Molina, B.D. Sim, D. Yeo, T.J. Loh, S.Y. Soon, D. Ohlsson, M. Smith, J.G. Gerward, S. Khintibidze, I. Lominadze, Z. Chapidze, G. Emukhvari, N. Khabeishvili, G. Chumburidze, V. Paposhvili, K. Shaburishvili, T. Parhomenko, O. Kraiz, I. Koval, O. Zolotaikina, V. Malynovsky, Y. Vakaliuk, I. Rudenko, L. Tseluyko, V. Stanislavchuk, M. AFFIRM-AHF investigators
- Abstract
Background: Intravenous ferric carboxymaltose has been shown to improve symptoms and quality of life in patients with chronic heart failure and iron deficiency. We aimed to evaluate the effect of ferric carboxymaltose, compared with placebo, on outcomes in patients who were stabilised after an episode of acute heart failure. Methods: AFFIRM-AHF was a multicentre, double-blind, randomised trial done at 121 sites in Europe, South America, and Singapore. Eligible patients were aged 18 years or older, were hospitalised for acute heart failure with concomitant iron deficiency (defined as ferritin
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- 2020
22. Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial
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Ponikowski, Piotr, primary, Kirwan, Bridget-Anne, additional, Anker, Stefan D, additional, McDonagh, Theresa, additional, Dorobantu, Maria, additional, Drozdz, Jarosław, additional, Fabien, Vincent, additional, Filippatos, Gerasimos, additional, Göhring, Udo Michael, additional, Keren, Andre, additional, Khintibidze, Irakli, additional, Kragten, Hans, additional, Martinez, Felipe A, additional, Metra, Marco, additional, Milicic, Davor, additional, Nicolau, José C, additional, Ohlsson, Marcus, additional, Parkhomenko, Alexander, additional, Pascual-Figal, Domingo A, additional, Ruschitzka, Frank, additional, Sim, David, additional, Skouri, Hadi, additional, van der Meer, Peter, additional, Lewis, Basil S, additional, Comin-Colet, Josep, additional, von Haehling, Stephan, additional, Cohen-Solal, Alain, additional, Danchin, Nicolas, additional, Doehner, Wolfram, additional, Dargie, Henry J, additional, Motro, Michael, additional, Butler, Javed, additional, Friede, Tim, additional, Jensen, Klaus H, additional, Pocock, Stuart, additional, Jankowska, Ewa A, additional, Azize, G, additional, Fernandez, A, additional, Zapata, GO, additional, Garcia Pacho, P, additional, Glenny, A, additional, Ferre Pacora, F, additional, Parody, ML, additional, Bono, J, additional, Beltrano, C, additional, Hershson, A, additional, Vita, N, additional, Luquez, HA, additional, Cestari, HG, additional, Fernandez, H, additional, Prado, A, additional, Berli, M, additional, García Durán, R, additional, Thierer, J, additional, Diez, M, additional, Lobo Marquez, L, additional, Borelli, RR, additional, Hominal, MÁ, additional, Metra, M, additional, Ameri, P, additional, Agostoni, P, additional, Salvioni, A, additional, Fattore, L, additional, Gronda, E, additional, Ghio, S, additional, Turrini, F, additional, Uguccioni, M, additional, Di Biase, M, additional, Piepoli, M, additional, Savonitto, S, additional, Mortara, A, additional, Terrosu, P, additional, Fucili, A, additional, Boriani, G, additional, Midi, P, additional, Passamonti, E, additional, Cosmi, F, additional, van der Meer, P, additional, Van Bergen, P, additional, van de Wetering, M, additional, Al-Windy, NYY, additional, Tanis, W, additional, Meijs, M, additional, Groutars, RGEJ, additional, The, HKS, additional, Kietselaer, B, additional, van Kesteren, HAM, additional, Beelen, DPW, additional, Heymeriks, J, additional, Van de Wal, R, additional, Schaap, J, additional, Emans, M, additional, Westendorp, P, additional, Nierop, PR, additional, Nijmeijer, R, additional, Manintveld, OC, additional, Dorobantu, M, additional, Darabantiu, DA, additional, Zdrenghea, D, additional, Toader, DM, additional, Petrescu, L, additional, Militaru, C, additional, Crisu, D, additional, Tomescu, MC, additional, Stanciulescu, G, additional, Rodica Dan, A, additional, Iosipescu, LC, additional, Serban, DL, additional, Drozdz, J, additional, Szachniewicz, J, additional, Bronisz, M, additional, Tycińska, A, additional, Wozakowska-Kaplon, B, additional, Mirek-Bryniarska, E, additional, Gruchała, M, additional, Nessler, J, additional, Straburzyńska-Migaj, E, additional, Mizia-Stec, K, additional, Szelemej, R, additional, Gil, R, additional, Gąsior, M, additional, Gotsman, I, additional, Halabi, M, additional, Shochat, M, additional, Shechter, M, additional, Witzling, V, additional, Zukermann, R, additional, Arbel, Y, additional, Flugelman, M, additional, Ben-Gal, T, additional, Zvi, V, additional, Kinany, W, additional, Weinstein, JM, additional, Atar, S, additional, Goland, S, additional, Milicic, D, additional, Horvat, D, additional, Tušek, S, additional, Udovicic, M, additional, Šutalo, K, additional, Samodol, A, additional, Pesek, K, additional, Artuković, M, additional, Ružić, A, additional, Šikić, J, additional, McDonagh, T, additional, Trevelyan, J, additional, Wong, Y-K, additional, Gorog, D, additional, Ray, R, additional, Pettit, S, additional, Sharma, S, additional, Kabir, A, additional, Hamdan, H, additional, Tilling, L, additional, Baracioli, L, additional, Nigro Maia, L, additional, Dutra, O, additional, Reis, G, additional, Pimentel Filho, P, additional, Saraiva, JF, additional, Kormann, A, additional, dos Santos, FR, additional, Bodanese, L, additional, Almeida, D, additional, Precoma, D, additional, Rassi, S, additional, Costa, F, additional, Kabbani, S, additional, Abdelbaki, K, additional, Abdallah, C, additional, Arnaout, MS, additional, Azar, R, additional, Chaaban, S, additional, Raed, O, additional, Kiwan, G, additional, Hassouna, B, additional, Bardaji, A, additional, Zamorano, J, additional, del Prado, S, additional, Gonzalez Juanatey, JR, additional, Ga Bosa Ojeda, FI, additional, Gomez Bueno, M, additional, Molina, BD, additional, Pascual Figal, DA, additional, Sim, D, additional, Yeo, TJ, additional, Loh, SY, additional, Soon, D, additional, Ohlsson, M, additional, Smith, JG, additional, Gerward, S, additional, Khintibidze, I, additional, Lominadze, Z, additional, Chapidze, G, additional, Emukhvari, N, additional, Khabeishvili, G, additional, Chumburidze, V, additional, Paposhvili, K, additional, Shaburishvili, T, additional, Parhomenko, O, additional, Kraiz, I, additional, Koval, O, additional, Zolotaikina, V, additional, Malynovsky, Y, additional, Vakaliuk, I, additional, Rudenko, L, additional, Tseluyko, V, additional, and Stanislavchuk, M, additional
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- 2020
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23. Segment-Based Map Building Using Enhanced Adaptive Fuzzy Clustering Algorithm for Mobile Robot Applications
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Ip, Y. L., Rad, A. B., Chow, K. M., and Wong, Y. K.
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- 2002
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24. High Silicon Self-Interstitial Diffusivity as Revealed by Lithium Ion Drifting
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Knowlton, W. B., Walton, J. T., Wong, Y. K., Mason, I. A., and Haller, E. E.
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- 1997
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25. Tree species richness in primary and old secondary tropical forest in Singapore
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Turner, I. M., Wong, Y. K., Chew, P. T., and Ibrahim, Ali bin
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- 1997
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26. Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial
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Steg, PG, Szarek, M, Bhatt, DL, Bittner, VA, Bregeault, M-F, Dalby, AJ, Diaz, R, Edelberg, JM, Goodman, SG, Hanotin, C, Harrington, RA, Jukema, JW, Lecorps, G, Mahaffey, KW, Moryusef, A, Ostadal, P, Parkhomenko, A, Pordy, R, Roe, MT, Tricoci, P, Vogel, R, White, HD, Zeiher, AM, Schwartz, GG, Sasiela, WJ, Tamby, J-F, Aylward, PE, Drexel, H, Sinnaeve, P, Dilic, M, Gotcheva, NN, Prieto, J-C, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Poulsen, SH, Viigimaa, M, Nieminen, MS, Danchin, N, Chumburidze, V, Marx, N, Liberopoulos, E, Valdovinos, PCM, Tse, H-F, Kiss, RG, Xavier, D, Zahger, D, Valgimigli, M, Kimura, T, Kim, HS, Kim, S-H, Kedev, S, Erglis, A, Laucevicius, A, Yusoff, K, Lopez, R, Ramos Lopez, GA, Alings, M, Halvorsen, S, Correa Flores, RM, Sy, RG, Budaj, A, Morais, J, Dorobantu, M, Karpov, Y, Ristic, AD, Chua, T, Murin, J, Fras, Z, Tunon, J, De Silva, HA, Hagstrom, E, Muller, C, Chiang, C-E, Sritara, P, Guneri, S, Ray, KK, Moriarty, PM, Chaitman, B, Kelsey, SF, Olsson, AG, Rouleau, J-L, Simoons, ML, Alexander, K, Meloni, C, Rosenson, R, Sijbrands, EJG, Alexander, JH, Armaganijan, L, Bagai, A, Bahit, MC, Brennan, JM, Clifton, S, DeVore, AD, Deloatch, S, Dickey, S, Dombrowski, K, Ducrocq, G, Eapen, Z, Endsley, P, Eppinger, A, Harrison, RW, Hess, CN, Hlatky, MA, Jordan, JD, Knowles, JW, Kolls, BJ, Kong, DF, Leonardi, S, Lillis, L, Maron, DJ, Marcus, J, Mathews, R, Mehta, RH, Mentz, RJ, Moreira, HG, Patel, CB, Pereira, SB, Perkins, L, Povsic, TJ, Puymirat, E, Jones, WS, Shah, BR, Sherwood, MW, Stringfellow, K, Sujjavanich, D, Toma, M, Van Diepen, SFP, Wilson, MD, Yan, AT-K, Lopes, RD, Trotter, C, Schiavi, LB, Garrido, M, Alvarisqueta, AF, Sassone, SA, Bordonava, AP, Alves De Lima, AE, Schmidberg, JM, Duronto, EA, Caruso, OC, Novaretto, LP, Angel Hominal, M, Montana, OR, Caccavo, A, Gomez Vilamajo, OA, Lorenzatti, AJ, Cartasegna, LR, Paterlini, GA, Mackinnon, IJ, Caime, GD, Amuchastegui, M, Salomone, R, Codutti, OR, Jure, HO, Bono, JOE, Hrabar, AD, Vallejos, JA, Ahuad Guerrero, RA, Novoa, F, Patocchi, CA, Zaidman, CJ, Giuliano, ME, Dran, RD, Vico, ML, Carnero, GS, Guzman, PN, Medrano Allende, JC, Garcia Brasca, DF, Bustamante Labarta, MH, Nani, S, Blumberg, EDS, Colombo, HR, Liberman, A, Luciardi, HL, Waisman, GD, Berli, MA, Duran, ROG, Cestari, HG, Luquez, HA, Giordano, JA, Saavedra, SS, Zapata, G, Costamagna, O, Llois, S, Waites, JH, Collins, N, Soward, A, Hii, CLS, Shaw, J, Arstall, MA, Horowitz, J, Rogers, JF, Colquhoun, D, Oqueli Flores, RE, Roberts-Thomson, P, Raffel, O, Lehman, SJ, Aroney, C, Coverdale, SGM, Garrahy, PJ, Starmer, G, Sader, M, Carroll, PA, Dick, R, Zweiker, R, Hoppe, U, Huber, K, Berger, R, Weidinger, F, Faes, D, Hermans, K, Pirenne, B, Leone, A, Hoffer, E, Vrolix, MCM, De Wolf, L, Wollaert, B, Castadot, M, Dujardin, K, Beauloye, C, Vervoort, G, Striekwold, H, Convens, C, Roosen, J, Barbato, E, Claeys, M, Cools, F, Terzic, I, Barakovic, F, Midzic, Z, Pojskic, B, Fazlibegovic, E, Durak-Nalbantic, A, Vulic, D, Muslibegovic, A, Goronja, B, Reis, G, Sousa, L, Nicolau, JC, Giorgeto, FE, Silva, RP, Maia, LN, Rech, R, Rossi, PRF, Cerqueira, MJAG, Duda, N, Kalil, R, Kormann, A, Abrantes, JAM, Pimentel Filho, P, Soggia, AP, De Santos, MON, Neuenschwander, F, Bodanese, LC, Michalaros, YL, Eliaschewitz, FG, Vidotti, MH, Leaes, PE, Botelho, RV, Kaiser, S, Fernandes Manenti, ERF, Precoma, DB, Moura Jorge, JC, Silva, PGMDB, Silveira, JA, Saporito, W, Marin Neto, JA, Feitosa, GS, Ritt, LEF, De Souza, JA, Costa, F, Souza, WKSB, Reis, HJL, Machado, L, Aidar Ayoub, JC, Todorov, GV, Nikolov, FP, Velcheva, ES, Tzekova, ML, Benov, HO, Petranov, SL, Tumbev, HS, Shehova-Yankova, NS, Markov, DT, Raev, DH, Mollov, MN, Kichukov, KN, Ilieva-Pandeva, KA, Ivanova, R, Mincheva, VM, Lazov, PV, Dimov, BI, Senaratne, M, Stone, J, Kornder, J, Pearce, S, Dion, D, Savard, D, Pesant, Y, Pandey, A, Robinson, S, Gosselin, G, Vizel, S, Hoag, G, Bourgeois, R, Morisset, A, Sabbah, E, Sussex, B, Kouz, S, MacDonald, P, Diaz, A, Michaud, N, Fell, D, Leung, R, Vuurmans, T, Lai, C, Nigro, F, Davies, R, Nogareda, G, Vijayaraghavan, R, Ducas, J, Lepage, S, Mehta, S, Cha, J, Dupuis, R, Fong, P, Rodes-Cabau, J, Fadlallah, H, Cleveland, D, Thao, H, Bata, I, Hameed, A, Pincetti, C, Potthoff, S, Prieto, JC, Acevedo, M, Aguirre, A, Vejar, M, Yanez, M, Araneda, G, Fernandez, M, Perez, L, Varleta, P, Florenzano, F, Huidobro, L, Raffo, CA, Olivares, C, Nahuelpan, L, Montecinos, H, Chen, J, Dong, Y, Huang, W, Wang, J, Huang, S, Yao, Z, Li, X, Cui, L, Lin, W, Sun, Y, Li, J, Zhang, X, Zhu, H, Chen, D, Huang, L, Dong, S, Su, G, Xu, B, Su, X, Cheng, X, Lin, J, Zong, W, Li, H, Feng, Y, Xu, D, Yang, X, Ke, Y, Lin, X, Zhang, Z, Zheng, Z, Luo, Z, Chen, Y, Ding, C, Zheng, Y, Peng, D, Li, Y, Wei, M, Liu, S, Yu, Y, Qu, B, Jiang, W, Zhou, Y, Zhao, X, Yuan, Z, Guo, Y, Xu, X, Shi, X, Ge, J, Fu, G, Bai, F, Fang, W, Shou, X, Lu, Q, Zhang, R, Zhu, J, Xu, Y, Fan, Z, Li, T, Wu, C, Jaramillo, N, Vallejo, GS, Botia, DCL, Lopez, RB, De Salazar, DIM, Bonfanti, AJC, Higuera, JD, Silva, SIB, Lozada, HJG, Arroyo, JAC, Mendoza, JLA, Ruiz, RLF, Jatin, FGM, Herazo, AS, Parada, JC, Triana, MAU, Strozzi, M, Car, S, Milicic, D, Bencic, ML, Pintaric, H, Prvulovic, D, Sikic, J, Persic, V, Mileta, D, Stambuk, K, Zdravko, B, Tomulic, V, Krstulovic, SM, Starcevic, B, Spinar, J, Horak, D, Stasek, J, Alan, D, Machova, V, Linhart, A, Novotny, V, Kaucak, V, Rokyta, R, Naplava, R, Coufal, Z, Adamkova, V, Podpera, I, Zizka, J, Motovska, Z, Marusincova, I, Svab, P, Heinc, P, Kuchar, J, Povolny, P, Matuska, J, Raungaard, B, Clemmensen, P, Bang, LE, May, O, Bottcher, M, Hove, JD, Frost, L, Gislason, G, Larsen, J, Johansen, PB, Hald, F, Jeppesen, J, Nielsen, T, Kristensen, KS, Walichiewicz, PM, Lomholdt, JD, Klausen, IC, Nielsen, PK, Davidsen, F, Videbaek, L, Soots, M, Vahula, V, Hedman, A, Soopold, U, Martsin, K, Kristjan, A, Taskinen, M-R, Porthan, K, Airaksinen, JK, Juonala, M, Kiviniemi, T, Vikman, S, Posio, P, Taurio, J, Huikuri, H, Kaikkonen, K, Coste, P, Ferrari, E, Morel, O, Montalescot, G, Barone-Rochette, G, Mansourati, J, Cottin, Y, Leclercq, F, Belhassane, A, Delarche, N, Boccara, F, Paganelli, F, Clerc, J, Schiele, F, Aboyans, V, Probst, V, Berland, J, Lefevre, T, Citron, B, Khintibidze, I, Shaburishvili, T, Pagava, Z, Ghlonti, R, Lominadze, Z, Khabeishvili, G, Hemetsberger, R, Rauch-Kroehnert, U, Stratmann, M, Appel, K-F, Schmidt, E, Omran, H, Stellbrink, C, Dorsel, T, Lianopoulos, E, Marx, R, Zirlik, A, Schellenberg, D, Heitzer, T, Laufs, U, Gielen, S, Winkelmann, B, Behrens, S, Sydow, K, Simonis, G, Muenzel, T, Werner, N, Leggewie, S, Boecker, D, Braun-Dullaeus, R, Toursarkissian, N, Jeserich, M, Weissbrodt, M, Schaeufele, T, Weil, J, Voeller, H, Waltenberger, J, Natour, M, Schmitt, S, Steiner, S, Heidenreich, L, Gremmler, U, Killat, H, Rieker, W, Patsilinakos, S, Kartalis, A, Manolis, A, Sionis, D, Skoumas, I, Athyros, V, Vardas, P, Parthenakis, F, Alexopoulos, D, Hahalis, G, Lekakis, J, Hatzitolios, A, Ovando, 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BJWM, Bokern, MJJA, Nijmeijer, R, Hersbach, FMRJ, Willems, FF, Gosselink, ATM, Elliott, J, Wilkins, G, Fisher, R, Scott, D, Hart, H, Stewart, R, Harding, S, Ternouth, I, Fisher, N, Aitken, D, Anscombe, R, Davidson, L, Tomala, T, Nygard, O, Sparby, JA, Andersen, K, Gullestad, L, Jortveit, J, Munk, PS, Singsaas, EG, Hurtig, U, Calderon Ticona, JR, Durand Velasquez, JR, Negron Miguel, SA, Sanabria Perez, ES, Carrion Chambilla, JM, Chavez Ayala, CA, Castillo Leon, RP, Vargas Gonzales, RJ, Hernandez Zuniga, JD, Camacho Cosavalente, LA, Bravo Mannucci, JE, Heredia Landeo, J, Llerena Navarro, NC, Roldan Concha, YM, Rodriguez Chavez, V-CE, Anchante Hernandez, HA, Zea Nunez, CA, Mogrovejo Ramos, W, Ferrolino, A, Sy, RAG, Tirador, L, Matiga, G, Coching, RM, Bernan, A, Rogelio, G, Morales, DD, Tan, E, Sulit, DJ, Wlodarczak, A, Jaworska, K, Skonieczny, G, Pawlowicz, L, Wojewod, P, Busz-Papiez, B, Bednarski, J, Goch, A, Staneta, P, Dulak, E, Saminsk, K, Krasowski, W, Sudnik, W, Zurakowski, A, Skorski, M, Lysek, R, Miklaszewicz, B, Kubica, J, Lipko, JA, Kostarska-Srokosz, E, Piepiorka, M, Drzewiecka, A, Sciborski, R, Stasiewski, A, Blicharski, T, Bystryk, L, Szpajer, M, Korol, M, Czerski, T, Mirek-Bryniarska, E, Gniot, J, Lubinski, A, Gorny, J, Franek, E, Raczak, G, Szwed, H, Monteiro, P, Bastos, JM, Pereira, HH, Martins, D, Seixo, F, Mendonca, C, Botelho, A, Minescu, B, Istratoaie, O, Tesloianu, DN, Cristian, G, Podoleanu, CGC, Constantinescu, MCA, Bengus, CM, Militaru, C, Rosu, D, Parepa, IR, Matei, AV, Alexandru, TM, Coman, I, Cioranu, RS, Dimulescu, D, Shvarts, Y, Orlikova, O, Kobalava, Z, Barbarash, OL, Markov, V, Lyamina, N, Gordienko, A, Zrazhevsky, K, Vishnevsky, AY, Gurevich, V, Stryuk, R, Lomakin, NV, Bokarev, I, Shalaev, S, Khaisheva, L, Chizhov, P, Viktorova, I, Osokina, N, Akatova, E, Chumakova, G, Libov, I, Voevoda, MI, Tretyakova, TV, Baranov, E, Shustov, S, Yakushin, S, Gordeev, I, Khasanov, N, Reshetko, O, Sotnikova, T, Molchanova, O, Nikolaev, K, Gapon, L, 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Gonzalez-Juanatey, JR, Fernandez Portales, J, Civeira Murillo, F, Matas Pericas, L, Luis Zamorano, J, De Mora Martin, M, Bruguera Cortada, J, Alonso Martin, JJ, De Berrazueta Fernandez, JR, Diaz Fernandez, JF, Garcia Lledo, JA, Cosin Sales, J, Botas Rodriguez, J, Gusi Tragant, G, Benedicto, A, Gonzalez-Juanatey, C, Camprubi Potau, M, Plaza Perez, I, Moris De La Tassa, C, Loma-Osorio Rincon, P, Balaguer Recena, J, Escudier, JM, Coca Payeras, A, Alonso Orcajo, N, Valdivielso, P, Constantine, G, Haniffa, R, Tissera, N, Amarasekera, S, Fernando, N, Jayawardena, J, Santharaj, W, Ekanayaka, R, Mendis, S, Senaratne, V, Mayurathan, G, Sirisena, T, Rajapaksha, A, Herath, JI, Amarasena, N, Berglund, S, Rasmanis, G, Witt, N, Mourtzinis, G, Nicol, P, Hansen, O, Romeo, S, Jensen, SA, Torstensson, I, Ahremark, U, Sundelin, T, Moccetti, T, Mach, F, Binder, R, Tsai, W-C, Ueng, K-C, Lai, W-T, Liu, M-E, Hwang, J-J, Yin, W-H, Hsieh, I-C, Lin, WH, Kuo, J-Y, Huang, T-Y, Fang, C-Y, Kaewsuwanna, P, Soonfuang, W, Jintapakorn, W, Sukonthasarn, A, Wongpraparut, N, Sastravaha, K, Sansanayudh, N, Kehasukcharoen, W, Piyayotai, D, Chotnoparatpat, P, Camsari, A, Kultursay, H, Mutlu, B, Ersanli, M, Demirtas, M, Kirma, C, Ural, E, Koldas, L, Karpenko, O, Prokhorov, A, Vakaluyk, I, Myshanych, H, Reshotko, D, Batushkin, V, Rudenko, L, Kovalskyi, I, Kushnir, M, Tseluyko, V, Mostovoy, Y, Stanislavchuk, M, Kyiak, Y, Karpenko, Y, Malynovsky, Y, Klantsa, A, Kutniy, O, Amosova, E, Tashchuk, V, Leshchuk, O, Rishko, M, Kopytsya, M, Yagensky, A, Vatutin, M, Bagriy, A, Barna, OM, Ushakov, O, Dzyak, G, Goloborodko, B, Rudenko, A, Zheleznyy, V, Trevelyan, J, Zaman, A, Lee, K, Moriarty, A, Aggarwal, RK, Clifford, P, Wong, Y-K, Iqbal, SMR, Subkovas, E, Braganza, D, Sarkar, D, Storey, R, Griffiths, H, Mcclure, S, Muthusamy, R, Kurian, J, Levy, T, Barr, C, Kadr, H, Gerber, R, Simaitis, A, Soran, H, Mathur, A, Brodison, A, Oliver, R, Mudawi, T, Reynolds, T, Sharman, D, Butler, R, Wilkinson, P, Lip, GYH, Halcox, J, Vardi, G, Baldari, D, Brabham, D, Treasure, C, Dahl, C, Palmer, B, Wiseman, A, Puri, S, Mohart, AE, Ince, C, Flores, E, Wright, S, Cheng, S-C, Rosenberg, M, Rogers, W, Kosinski, E, Forgosh, L, Waltman, J, Khan, M, Shoukfeh, M, Dagher, G, Lieber, I, Kumar, P, East, C, Krichmar, P, White, L, Knickelbine, T, Haldis, T, Gillespie, E, Suh, D, Arif, I, Akhter, F, Carlson, E, D'Urso, M, El-Ahdab, F, Nelson, W, Harris, B, Cohen, S, Carter, L, Sabatino, K, Haddad, T, Malik, A, Rao, S, Mulkay, A, Jovin, I, Klancke, K, Malhotra, V, Devarapalli, SK, Koren, M, Chandna, H, Dodds, G, Janik, M, Moran, J, Sumner, A, Kobayashi, J, Davis, W, Yazdani, S, Pasquini, J, Thakkar, M, Vedere, A, Leimbach, W, Rider, J, Singh, N, Shah, AV, Janosik, D, Pepine, C, Berman, B, Gelormini, J, Daniels, C, Keating, F, Kondo, NI, Shetty, S, Waider, W, Takata, T, Abu-Fadel, M, Shah, V, Aggarwal, R, Izzo, M, Kumar, A, Hattler, B, Link, C, Bortnick, A, Kinzfogl, G, Ghitis, A, Larry, J, Teufel, E, Kuhlman, P, Mclaurin, B, Zhang, W, Thew, S, Abbas, J, White, M, Ranadive, N, Gring, C, Henderson, D, Schuchard, T, Farhat, N, Kline, G, Mahal, S, Whitaker, J, Speirs, S, Andersen, R, Daboul, N, Horwitz, P, Ponce, G, Jafar, Z, Mcgarvey, J, Panchal, V, Voyce, S, Blok, T, Sheldon, W, Azizad, MM, Schmalfuss, C, Picone, M, Herzog, W, Lindsey, J, Nowins, R, Lepor, N, El Shahawy, M, Weintraub, H, Irimpen, A, May, W, Galski, T, Chu, A, Mody, F, Hodes, Z, Rose, G, Fairlamb, J, Lambert, C, Raisinghani, A, Abbate, A, King, M, Carey, C, Gerber, J, Younis, L, Park, HT, Vidovich, M, Knutson, T, Friedman, D, Chaleff, F, Loussararian, A, Rozeman, P, Kimmelstiel, C, Silver, K, Foster, M, Tonnessen, G, Amlani, M, Wali, A, Malozzi, C, Wattanakit, K, O'Donnell, PJ, Singal, D, Jaffrani, N, Banuru, S, Fisher, D, Xenakis, M, Perlmutter, N, Bhagwat, R, Strader, J, Akyea-Djamson, A, Labroo, A, Marais, HJ, Claxton, E, Berk, M, Rossi, P, Joshi, P, Khaira, AS, Kumkumian, G, Lupovitch, S, Purow, J, Welka, S, Hoffman, D, Fischer, S, Soroka, E, Eagerton, D, Pancholy, S, Ray, M, Farrar, M, Pollock, S, French, WJ, Diamantis, S, Gimple, L, Neustel, M, Schwartz, S, Pereira, E, Spriggs, D, Strain, J, Vo, A, Chane, M, Hall, J, Vijay, N, Lotun, K, Lester, FM, Nahhas, A, Pope, T, Nager, P, Vohra, R, Bashir, R, Ahmed, H, Berlowitz, M, Fishberg, R, Barrucco, R, Yang, E, Radin, M, Sporn, D, Eisenberg, S, Landzberg, J, Mcgough, M, Turk, S, Schwartz, M, Sundram, PS, Jain, D, Zainea, M, Bayron, C, Karlsberg, R, Lui, H, Keen, W, Westerhausen, D, Khurana, S, Agarwal, H, Birchem, J, Penny, W, Chang, M, Murphy, S, Schifferdecker, B, Gilbert, JM, Chalavarya, G, Eaton, C, Schmedtje, JF, Christenson, S, Denham, D, Macdonell, A, Gibson, P, Rahman, A, Al Joundi, T, Conrad, G, Kotha, P, Love, M, Giesler, G, Rubenstein, H, Akright, L, Krawczyk, J, Wells, T, Welker, J, Foster, R, Gilmore, R, Anderson, J, Jacoby, D, Gardner, G, Dandillaya, R, Vora, K, Kostis, J, Hunter, J, Laxson, D, Ball, E, Camp, A, Lopes, R, Egydio, F, Kawakami, A, Oliveira, J, Wozniak, J, Matthews, A, Ratky, C, Valiris, J, Berdan, L, Hepditch, A, Quintero, K, Rorick, T, Westbrook, M, Pascual, A, Rovito, C, Bezault, M, Drouet, E, Simon, T, Alsweiler, C, Luyten, A, Aylward, P, Butters, J, Griffith, L, Shaw, M, Grunberg, L, Islam, S, Bougon, N, Faustino, D, Fontecave, S, Murphy, J, Verrier, M, Agnetti, V, Andersen, D, Badreddine, E, Bekkouche, M, Bouancheau, C, Brigui, I, Brocklehurst, M, Cianciarulo, J, Devaul, D, Domokos, S, Gache, C, Gobillot, C, Guillou, S, Healy, J, Heath, M, Jaiwal, G, Javierre, C, Labeirie, J, Monier, M, Morales, U, Mrabti, A, Mthombeni, B, Okan, B, Smith, L, Sheller, J, Sopena, S, Pellan, V, Benbernou, F, Bengrait, N, Lamoureux, M, Kralova, K, Scemama, M, Bejuit, R, Coulange, A, Berthou, C, Repincay, J, Lorenzato, C, Etienne, A, Gouet, V, Loizeau, V, Normand, M, Ourliac, A, Rondel, C, Adamo, A, Beltran, P, Barraud, P, Dubois-Gache, H, Halle, B, Metwally, L, Mourgues, M, Sotty, M, Vincendet, M, Cotruta, R, Zhu, C, Fournie-Lloret, D, Morrello, C, Perthuis, A, Picault, P, Zobouyan, I, ODYSSEY OUTCOMES Comm, İÜC, Ege Üniversitesi, Rushton-Smith, Sophie, and ODYSSEY OUTCOMES Committees and Investigators
- Subjects
Male ,Cardiac & Cardiovascular Systems ,MONOCLONAL-ANTIBODY ,alirocumab ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ,law.invention ,PCSK9 ,chemistry.chemical_compound ,Randomized controlled trial ,law ,Cardiac and Cardiovascular Systems ,1102 Cardiorespiratory Medicine and Haematology ,Hypercholesterolemia/blood ,Kardiologi ,Hazard ratio ,Middle Aged ,Treatment Outcome ,SAFETY ,Cardiology ,Female ,Drug Therapy, Combination ,Cholesterol, LDL/antagonists & inhibitors ,Cardiology and Cardiovascular Medicine ,Life Sciences & Biomedicine ,REDUCING LIPIDS ,Akutes Koronarsyndrom ,acute coronary syndrome ,cholesterol ,mortality ,PCSK9 protein ,Antibodies, Monoclonal, Humanized/administration & dosage ,medicine.medical_specialty ,Acute coronary syndrome ,Injections, Subcutaneous ,Hypercholesterolemia ,Placebo ,Antibodies, Monoclonal, Humanized ,1117 Public Health and Health Services ,Sterblichkeit ,Double-Blind Method ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,ddc:610 ,Alirocumab ,Aged ,Science & Technology ,Cholesterol ,business.industry ,EVOLOCUMAB ,1103 Clinical Sciences ,Cholesterol, LDL ,medicine.disease ,EFFICACY ,Increased risk ,chemistry ,Peripheral Vascular Disease ,Cardiovascular System & Hematology ,Cardiovascular System & Cardiology ,Acute Coronary Syndrome/blood ,Cholesterin ,Human medicine ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,Follow-Up Studies - Abstract
bastos, jose/0000-0002-9526-3123; Manakshe, Gajendra/0000-0002-4983-4271; Tse, Hung Fat/0000-0002-9578-7808; Gislason, Gunnar H/0000-0002-0548-402X; Taskinen, Marja-Riitta/0000-0002-6229-3588; Racca, Vittorio/0000-0002-4465-3789; Keskin, Kudret/0000-0002-9049-1530; Sherwood, Matthew/0000-0002-4305-5883; Sandhu, Manjinder/0000-0003-2538-2079; Nikolaev, Konstantin/0000-0003-4601-6203; Ersanli, Murat/0000-0003-1847-3087; Raffel, Owen C/0000-0001-5470-7050; Abbate, Antonio/0000-0002-1930-785X; Muenzel, Thomas/0000-0001-5503-4150; Leonardi, Sergio/0000-0002-4800-6132; Chumakova, Galina A/0000-0002-2810-6531; Podoleanu, Cristian/0000-0001-9987-2519; Pereira, Helder/0000-0001-8656-4883; Reshetko, Olga/0000-0003-3107-7636, WOS: 000476768100007, PubMed: 31117810, Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. in a prespecified analysis of 8242 patients eligible for >= 3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P= 100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; P-interaction=0.007). in the alirocumab group, all-cause death declined with achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for >= 3 years, if baseline LDL-C is >= 100 mg/dL, or if achieved LDL-C is low., Sanofi; Regeneron Pharmaceuticals, Inc., The trial was funded by Sanofi and Regeneron Pharmaceuticals, Inc.
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- 2019
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27. Antioxidants add protection to a broad-spectrum sunscreen: P2507
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Matsui, Mary, Li, Yuanhong, Chen, Hong-duo, and Wong, Y. K.
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- 2007
28. Increase of MMP-13 expression in multi-stage oral carcinogenesis and epigallocatechin-3-gallate suppress MMP-13 expression
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Chiang, W-C, Wong, Y-K, Lin, S-C, Chang, K-W, and Liu, C-J
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- 2006
29. Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma
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Wong, Y.-K., Chang, K.-W., Cheng, C.-Y., and Liu, C.-J.
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- 2006
30. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
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K., Koren M., Chandna H., Dodds III G., Goraya T., Bengston J., Janik M., Moran J., Sumner A., Kobayashi J., Davis W., Yazdani S., Pasquini J., Thakkar M., Vedere A., Leimbach W., Rider J., Fenton S., Singh N., Shah A. V., Janosik D., Pepine C., Berman B., Gelormini J., Daniels C., Richard K., Keating F., Kondo N. I., Shetty S., Levite H., Waider W., Takata T., Abu-Fadel M., Shah V., Aggarwal R., Izzo M., Kumar A., Hattler B., Do R., Link C., Bortnick A., Kinzfogl III G., Ghitis A., Larry J., Teufel E., Kuhlman P., Mclaurin B., Zhang W., Thew S., Abbas J., White M., Islam O., Subherwal S., Ranadive N., Vakili B., Gring C., Henderson D., Schuchard T., Farhat N., Kline G., Mahal S., Whitaker J., Speirs S., Andersen R., Daboul N., Horwitz P., Zahr F., Ponce G., Jafar Z., Mcgarvey J., Panchal V., Voyce S., Blok T., Sheldon W., Azizad M. M., Schmalfuss C., Picone M., Pederson R., Herzog W., Friedman K., Lindsey J., Nowins R., Timothy E., Leonard P., Lepor N., El Shahawy M., Weintraub H., Irimpen A., Alonso A., May W., Christopher D., Galski T., Chu A., Mody F., Ramin E., Hodes Z., Rossi J., Rose G., Fairlamb J., Lambert C., Raisinghani A., Abbate A., Vetrovec G., King M., Carey C., Gerber J., Younis L., Park H. T., Vidovich M., Knutson T., Friedman D., Chaleff F., Loussararian A., Rozeman P., Kimmelstiel C., Kuvin J., Silver K., Foster M., Tonnessen G., Espinoza A., Amlani M., Wali A., Malozzi C., Jong G. T., Massey C., Wattanakit K., O'Donnell P. J., Singal D., Jaffrani N., Banuru S., Fisher D., Xenakis M., Perlmutter N., Bhagwat R., Strader J., Blonder R., Akyea-Djamson A., Labroo A., Marais H. J., Claxton E., Weiss R., Kathryn R., Berk M., Rossi P., Joshi P., Khera A., Khaira A. S., Kumkumian G., Lupovitch S., Purow J., Welka S., Hoffman D., Fischer S., Soroka E., Eagerton D., Pancholy S., Ray M., Erenrich N., Farrar M., Pollock S., French W. J., Diamantis S., Guy D., Gimple L., Neustel M., Schwartz S., Pereira E., Albert S., Spriggs D., Strain J., Mittal S., Vo A., Chane M., Hall J., Vijay N., Lotun K., Lester F. M., Nahhas A., Pope T., Nager P., Vohra R., Sharma M., Bashir R., Ahmed H., Berlowitz M., Fishberg R., Barrucco R., Yang E., Radin M., Sporn D., Stapleton D., Eisenberg S., Landzberg J., Mcgough M., Turk S., Schwartz M., Sundram P. S., Jain D., Zainea M., Bayron C., Karlsberg R., Dohad S., Lui H., Keen W., Westerhausen D., Khurana S., Agarwal H., Birchem J., Penny W., Chang M., Murphy S., Henry J., Schifferdecker B., Gilbert J. M., Chalavarya G., Eaton C., Schmedtje J. F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. A., and McClanahan M. A.
- Abstract
Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring
- Published
- 2019
31. Improving the positive predictive value of exercise testing in women
- Author
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Wong, Y K, Dawkins, S, Grimes, R, Smith, F, Dawkins, K D, and Simpson, I A
- Published
- 2003
32. Pleomorphic adenoma: A survey of 359 cases in Chinese patients
- Author
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Poon, C. K., Wong, Y. K., Hsiao, Y. L., Chan, M. Y., and Chao, S. Y.
- Published
- 2001
33. GENDER DIFFERENCES IN SYMPTOMS, EXERCISE TEST RESULTS AND TREATMENT IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY
- Author
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Wong, Y K, Rodwell, A, Dawkins, S, Livesey, S A, and Simpson, I A
- Published
- 2000
34. ORAL SQUAMOUS CELL CARCINOMA IN CENTRAL TAIWAN: A RETROSPECTIVE STUDY
- Author
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Poon, C K, Huang, W J, Wong, Y K, Hsiao, Y L, Chan, M Y, and Chao, S Y
- Published
- 2000
35. Chlamydia pneumoniae and atherosclerosis
- Author
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Wong, Y-K, Gallagher, P J, and Ward, M E
- Published
- 1999
36. The species specificity of the microimmunofluorescence antibody test and comparisons with a time resolved fluoroscopic immunoassay for measuring IgG antibodies against Chlamydia pneumoniae
- Author
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Wong, Y K, Sueur, J M, Fall, C H D, Orfila, J, and Ward, M E
- Published
- 1999
37. Lithium-ion drifting: Application to the study of point defects in floating-zone silicon
- Author
-
Walton, J. T, Wong, Y. K, and Zulehner, W
- Subjects
Solid-State Physics - Abstract
The use of lithium-ion (Li(+)) drifting to study the properties of point defects in p-type Floating-Zone (FZ) silicon crystals is reported. The Li(+) drift technique is used to detect the presence of vacancy-related defects (D defects) in certain p-type FZ silicon crystals. SUPREM-IV modeling suggests that the silicon point defect diffusivities are considerably higher than those commonly accepted, but are in reasonable agreement with values recently proposed. These results demonstrate the utility of Li(+) drifting in the study of silicon point defect properties in p-type FZ crystals. Finally, a straightforward measurement of the Li(+) compensation depth is shown to yield estimates of the vacancy-related defect concentration in p-type FZ crystals.
- Published
- 1997
38. Variable Temperature Performance of a Si(Li) Detector Stack
- Author
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Hubbard, G. Scott, McMurray, Robert E., Jr, Keller, R. G, Wercinski, P. F, Walton, J. T, and Wong, Y. K
- Subjects
Instrumentation And Photography - Abstract
New experimental data is presented which displays 137Cs resolution of both single Si(Li) devices and a detector stack 2 cm in height as a function of temperature (85 K greater than or equal to T greater than or equal to 245 K). We also discuss variations in photopeak shape which indicate that detector charge collection may be temperature dependent over the range of interest.
- Published
- 1994
- Full Text
- View/download PDF
39. Deep neural network for marine water quality classification with the consideration of coastal current circulation effect
- Author
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Chu, Carlin C.F., primary, Yuen, S. C., additional, and Wong, Y. K., additional
- Published
- 2017
- Full Text
- View/download PDF
40. A Study of Linear Economic Systems
- Author
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Wong, Y. K. and Morgenstern, Oskar
- Published
- 1957
41. Breast-Milk Jaundice And Oral Contraceptives
- Author
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Wong, Y. K. and Wood, B. S. B.
- Published
- 1971
42. Breast-Milk Jaundice And The Pill
- Author
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Wood, B. S. B. and Wong, Y. K.
- Published
- 1972
43. Applications of digital PCR in precision medicine
- Author
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Wong, Y. K., primary, Tsang, H. F., additional, Xue, V. W., additional, Chan, C. M., additional, Au, T. C., additional, Cho, W. C., additional, Chan, L. W., additional, and Wong, S. C., additional
- Published
- 2017
- Full Text
- View/download PDF
44. Cardiopulmonary Resuscitation—From the Patient'S Perspective
- Author
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Wee, S., primary, Chang, Z. Y., additional, Lau, Y. H., additional, Wong, Y. K. Y., additional, and Ong, C. Y. M., additional
- Published
- 2017
- Full Text
- View/download PDF
45. Enhancement of Chlorella vulgaris harvesting via the electro-coagulation-flotation (ECF) method
- Author
-
Wong, Y. K., primary, Ho, Y. H., additional, Leung, H. M., additional, Ho, K. C., additional, Yau, Y. H., additional, and Yung, K. K. L., additional
- Published
- 2016
- Full Text
- View/download PDF
46. Proper interpretation of photoconductive decay transients in semiconductors having finite surface recombination velocity.
- Author
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Derhacobian, N., Walton, J. T., Luke, P. N., Wong, Y. K., and Rossington, C. S.
- Subjects
SEMICONDUCTORS ,SOLID state electronics ,RECOMBINATION in semiconductors - Abstract
Discusses the influence of finite surface recombination velocity on the proper interpretation of photoconductive decay (PCD) transients in semiconductors. Consideration of the limitations of simple analytical equations which relate the observed effective lifetime to the material parameters; Proposed methods to extract information from PCD experiments; Conclusion.
- Published
- 1994
- Full Text
- View/download PDF
47. Direct Self-Control of Induction Motor Based on Neural Network
- Author
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Shi, K. L., Chan, T. F., Wong, Y. K., and Ho, S. L.
- Subjects
Control equipment -- Technology application ,Neural networks -- Usage ,Induction electric motors -- Design and construction ,Process control -- Research ,Electrical engineering -- Research ,Business ,Computers ,Electronics ,Electronics and electrical industries ,MatLab (Statistical/mathematical software) -- Usage ,Simulink 2.0 (Statistical/mathematical software) -- Usage - Abstract
This paper presents an artificial-neural-network-based direct-self-control (ANN-DSC) scheme for an inverter-fed three-phase induction motor. In order to cope with the complex calculations required in direct self control (DSC), the proposed artificial-neural-network (ANN) system employs the individual training strategy with fixed-weight and supervised models. A computer simulation program is developed using Matlab/Simulink together with the Neural Network Toolbox. The simulated results obtained demonstrate the feasibility of ANN-DSC. Compared with the classical digital-signal-processor-based DSC, the proposed ANN-based scheme incurs much shorter execution times and, hence, the errors caused by control time delays are minimized. Index Terms--Direct self control, induction motor drive, Matlab/Simulink, neural networks.
- Published
- 2001
48. Monitoring and assessment of heavy metal contamination in a constructed wetland in Shaoguan (Guangdong Province, China): bioaccumulation of Pb, Zn, Cu and Cd in aquatic and terrestrial components
- Author
-
Leung, H. M., primary, Duzgoren-Aydin, N. S., additional, Au, C. K., additional, Krupanidhi, S., additional, Fung, K. Y., additional, Cheung, K. C., additional, Wong, Y. K., additional, Peng, X. L., additional, Ye, Z. H., additional, Yung, K. K. L., additional, and Tsui, M. T. K., additional
- Published
- 2016
- Full Text
- View/download PDF
49. An optimal data association method based on the minimum weighted bipartite perfect matching
- Author
-
Zhang, Xinzheng, primary, Rad, A. B., additional, Huang, Guoquan, additional, and Wong, Y. K., additional
- Published
- 2015
- Full Text
- View/download PDF
50. Effective Method for Autonomous Simultaneous Localization and Map Building in Unknown Indoor Environments
- Author
-
Rad, A. B., Wong, Y. K., and Ip, Y. L.
- Subjects
Technology & Engineering / Automation - Abstract
Effective Method for Autonomous Simultaneous Localization and Map Building in Unknown Indoor Environments
- Published
- 2007
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