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27 results on '"Wong, Teri Ann S."'

2. Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80–Containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in Both Mice and Non-Human Primates

Author

Preston, Kendall B., Wong, Teri Ann S., Lieberman, Michael M., To, Albert, Lai, Chih-Yun, Granados, Alex, Thomasson, Holly, Misamore, John, Yalley-Ogunro, Jake, Cabus, Mehtap, Andersen, Hanne, Donini, Oreola, Lehrer, Axel T., and Randolph, Theodore W.

Published
2022
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4. A Serological Multiplexed Immunoassay (MIA) Detects Antibody Reactivity to SARS-CoV-2 and Other Viral Pathogens in Liberia and Is Configurable as a Multiplexed Inhibition Test (MINT)

Author

Haun, Brien K., primary, To, Albert, additional, Williams, Caitlin A., additional, Ball, Aquena, additional, Fong, Karalyn, additional, Wong, Teri Ann S., additional, Shobayo, Bode, additional, Teahton, Julius, additional, Ching, Lauren, additional, Kamara, Varney, additional, Tekah, Davidetta M., additional, Humphrey, Peter, additional, Berestecky, John, additional, Nerurkar, Vivek R., additional, and Lehrer, Axel T., additional

Published
2024
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11. A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant

Author

To, Albert, primary, Wong, Teri Ann S., additional, Lieberman, Michael M., additional, Thompson, Karen, additional, Ball, Aquena H., additional, Pessaint, Laurent, additional, Greenhouse, Jack, additional, Daham, Nisrine, additional, Cook, Anthony, additional, Narvaez, Brandon, additional, Flinchbaugh, Zack, additional, Van Ry, Alex, additional, Yalley-Ogunro, Jake, additional, Andersen Elyard, Hanne, additional, Lai, Chih-Yun, additional, Donini, Oreola, additional, and Lehrer, Axel T., additional

Published
2022
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12. Protein Vaccine Induces a Durable, More Broadly Neutralizing Antibody Response in Macaques than Natural Infection with SARS-CoV-2 P.1

Author

To, Albert, primary, Wong, Teri Ann S., additional, Lieberman, Michael M., additional, Thompson, Karen, additional, Pessaint, Laurent, additional, Greenhouse, Jack, additional, Daham, Nisrine, additional, Cook, Anthony, additional, Narvaez, Brandon, additional, Flinchbaugh, Zack, additional, Ry, Alex Van, additional, Yalley-Ogunro, Jake, additional, Elyard, Hanne Andersen, additional, Lai, Chih-Yun, additional, Donini, Oreola, additional, and Lehrer, Axel T., additional

Published
2021
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13. Single-vial filovirus glycoprotein vaccines: Biophysical characteristics and immunogenicity after co-lyophilization with adjuvant

Author

Preston, Kendall B., primary, Wong, Teri Ann S., additional, To, Albert, additional, Tashiro, Taylor E., additional, Lieberman, Michael M., additional, Granados, Alex, additional, Feliciano, Karen, additional, Harrison, John, additional, Yalley-Ogunro, Jake, additional, Elyard, Hanne Andersen, additional, Donini, Oreola, additional, Lehrer, Axel T., additional, and Randolph, Theodore W., additional

Published
2021
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14. Recombinant Protein Filovirus Vaccines Protect Cynomolgus Macaques From Ebola, Sudan, and Marburg Viruses

Author

Lehrer, Axel T., primary, Chuang, Eleanore, additional, Namekar, Madhuri, additional, Williams, Caitlin A., additional, Wong, Teri Ann S., additional, Lieberman, Michael M., additional, Granados, Alex, additional, Misamore, John, additional, Yalley-Ogunro, Jake, additional, Andersen, Hanne, additional, Geisbert, Joan B., additional, Agans, Krystle N., additional, Cross, Robert W., additional, and Geisbert, Thomas W., additional

Published
2021
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16. Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice

Author

Lai, Chih-Yun, primary, To, Albert, additional, Wong, Teri Ann S., additional, Lieberman, Michael M., additional, Clements, David E., additional, Senda, James T., additional, Ball, Aquena H., additional, Pessaint, Laurent, additional, Andersen, Hanne, additional, Donini, Oreola, additional, and Lehrer, Axel T., additional

Published
2021
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17. A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant.

Author

Albert To, Wong, Teri Ann S., Lieberman, Michael M., Thompson, Karen, Ball, Aquena H., Pessaint, Laurent, Greenhouse, Jack, Daham, Nisrine, Cook, Anthony, Narvaez, Brandon, Flinchbaugh, Zack, Van Ry, Alex, Yalley-Ogunro, Jake, Andersen Elyard, Hanne, Chih-Yun Lai, Donini, Oreola, and Lehrer, Axel T.

Published
2022
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20. Serological evidence of Ebola virus exposure in dogs from affected communities in Liberia: A preliminary report

Author

Haun, Brien K., primary, Kamara, Varney, additional, Dweh, Abigail S., additional, Garalde-Machida, Kianalei, additional, Forkay, Saymajunkon S. E., additional, Takaaze, Melissa, additional, Namekar, Madhuri, additional, Wong, Teri Ann S., additional, Bell-Gam Woto, Ayesha E. R., additional, Humphreys, Peter, additional, Weeks, Ophelia I., additional, Fallah, Mosoka P., additional, Berestecky, John M., additional, Nerurkar, Vivek R., additional, and Lehrer, Axel T., additional

Published
2019
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21. A Recombinant Subunit Based Zika Virus Vaccine Is Efficacious in Non-human Primates

Author

Medina, Liana O., primary, To, Albert, additional, Lieberman, Michael M., additional, Wong, Teri Ann S., additional, Namekar, Madhuri, additional, Nakano, Eileen, additional, Andersen, Hanne, additional, Yalley-Ogunro, Jake, additional, Greenhouse, Jack, additional, Higgs, Stephen, additional, Huang, Yan-Jang S., additional, Vanlandingham, Dana L., additional, Horton, Jaime S., additional, Clements, David E., additional, and Lehrer, Axel T., additional

Published
2018
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22. Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice

Author

To, Albert, primary, Medina, Liana O., additional, Mfuh, Kenji O., additional, Lieberman, Michael M., additional, Wong, Teri Ann S., additional, Namekar, Madhuri, additional, Nakano, Eileen, additional, Lai, Chih-Yun, additional, Kumar, Mukesh, additional, Nerurkar, Vivek R., additional, and Lehrer, Axel T., additional

Published
2018
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24. Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4.

Author

Chih-Yun Lai, Strange, Daniel P., Wong, Teri Ann S., Lehrer, Axel T., and Verma, Saguna

Subjects
GLYCOPROTEIN analysis, EBOLA virus
Abstract

Ebola virus (EBOV), a member of the Filoviridae family, causes the most severe form of viral hemorrhagic fever. Although no FDA licensed vaccine or treatment against Ebola virus disease (EVD) is currently available, Ebola virus glycoprotein (GP) is the major antigen used in all candidate Ebola vaccines. Recent reports of protection as quickly as within 6 days of administration of the rVSV-based vaccine expressing EBOV GP before robust humoral responses were generated suggests that the innate immune responses elicited early after vaccination may contribute to the protection. However, the innate immune responses induced by EBOV GP in the absence of viral vectors or adjuvants have not been fully characterized in vivo. Our recent studies demonstrated that immunization with highly purified recombinant GP in the absence of adjuvants induced a robust IgG response and partial protection against EBOV infection suggesting that GP alone can induce protective immunity. In this study we investigated the early immune response to purified EBOV GP alone in vitro and in vivo. We show that GP was efficiently internalized by antigen presenting cells and subsequently induced production of key inflammatory cytokines. In vivo, immunization of mice with EBOV GP triggered the production of key Th1 and Th2 innate immune cytokines and chemokines, which directly governed the recruitment of CD11b+ macrophages and CD11c+ dendritic cells to the draining lymph nodes (DLNs). Pre-treatment of mice with a TLR4 antagonist inhibited GP-induced cytokine production and recruitment of immune cells to the DLN. EBOV GP also upregulated the expression of costimulatory molecules in bone marrow derived macrophages suggesting its ability to enhance APC stimulatory capacity, which is critical for the induction of effective antigen-specific adaptive immunity. Collectively, these results provide the first in vivo evidence that early innate immune responses to EBOV GP are mediated via the TLR4 pathway and are able to modulate the innate-adaptive interface. These mechanistic insights into the adjuvant-like property of EBOV GP may help to develop a better understanding of how optimal prophylactic efficacy of EBOV vaccines can be achieved as well as further explore the potential post-exposure use of vaccines to prevent filoviral disease. [ABSTRACT FROM AUTHOR]

Published
2017
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26. A Microsphere Immunoassay for the Quantitative Detection of Antigens in Cell Culture Supernatant.

Author

Mayerlen LI, Wong TAS, and Lehrer AT

Subjects
Animals, Immunoassay methods, Marburgvirus immunology, Marburgvirus isolation & purification, Drosophila, Cell Culture Techniques methods, Cell Line, Enzyme-Linked Immunosorbent Assay methods, Microspheres, Antigens, Viral immunology, Antigens, Viral analysis
Abstract

Quantitative immunoassays, such as the traditional enzyme-linked immunosorbent assay (ELISA), are used to determine concentrations of an antigen in a matrix of unknown antigen concentration. Magnetic immunoassays, such as the Luminex xMAP technology, allow for the simultaneous detection of multiple analytes and offer heightened sensitivity, specificity, low sample volume requirements, and high-throughput capabilities. Here, we describe a quantitative immunoassay using the Luminex MAGPIX® System to determine the antigen concentration from liquid samples with unknown concentrations. In detail, we describe a newly developed assay for determining production yields of Drosophila S2-produced Marburg virus (MARV) glycoprotein in insect-cell-culture-derived supernatant. The potential applications of this assay could extend to the quantification of viral antigens in fluids derived from both in vitro and in vivo models infected with live MARV, thereby providing additional applications for virological research., (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2024
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27. Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice.

Author

Lai CY, To A, Wong TAS, Lieberman MM, Clements DE, Senda JT, Ball AH, Pessaint L, Andersen H, Donini O, and Lehrer AT

Abstract

The speed at which several COVID-19 vaccines went from conception to receiving FDA and EMA approval for emergency use is an achievement unrivaled in the history of vaccine development. Mass vaccination efforts using the highly effective vaccines are currently underway to generate sufficient herd immunity and reduce transmission of the SARS-CoV-2 virus. Despite the most advanced vaccine technology, global recipient coverage, especially in resource-poor areas remains a challenge as genetic drift in naïve population pockets threatens overall vaccine efficacy. In this study, we described the production of insect-cell expressed SARS-CoV-2 spike protein ectodomain and examined its immunogenicity in mice. We demonstrated that, when formulated with CoVaccine HT™adjuvant, an oil-in-water nanoemulsion compatible with lyophilization, our vaccine candidates elicit a broad-spectrum IgG response, high neutralizing antibody titers, and a robust, antigen-specific IFN-γ secreting response from immune splenocytes in outbred mice. Our findings lay the foundation for the development of a dry-thermostabilized vaccine that is deployable without refrigeration.

Published
2021
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