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4. Underlying genetic variation in familial frontotemporal dementia: sequencing of 198 patients

Author

Mol, M.O., Rooij, J.G.J. (Jeroen) van, Wong, T.H. (Tsz Hang), Melhem, S. (Shamiram), Verkerk, A., Kievit, A.J.A. (Anneke J.A.), Thornton, A.S. (Andrew), Rademakers, S. (Suzanne), Pottier, C. (Cyril), Donker Kaat, L. (Laura), Seelaar, H. (Harro), Swieten, J.C. (John) van, Dopper, E.G.P. (Elise), Mol, M.O., Rooij, J.G.J. (Jeroen) van, Wong, T.H. (Tsz Hang), Melhem, S. (Shamiram), Verkerk, A., Kievit, A.J.A. (Anneke J.A.), Thornton, A.S. (Andrew), Rademakers, S. (Suzanne), Pottier, C. (Cyril), Donker Kaat, L. (Laura), Seelaar, H. (Harro), Swieten, J.C. (John) van, and Dopper, E.G.P. (Elise)

Abstract

Frontotemporal dementia (FTD) presents with a wide variability in clinical syndromes, genetic etiologies, and underlying pathologies. Despite the discovery of pathogenic variants in several genes, many familial cases remain unsolved. In a large FTD cohort of 198 familial patients, we aimed to determine the types and frequencies of variants in genes related to FTD. Pathogenic or likely pathogenic variants were revealed in 74 (37%) patients, including 4 novel variants. The repeat expansion in C9orf72 was most common (21%), followed by variants in MAPT (6%), GRN (4.5%), and TARDBP (3.5%). Other pathogenic variants were found in VCP, TBK1, PSEN1, and a novel homozygous variant in OPTN. Furthermore, we identified 15 variants of uncertain significance, including a promising variant in TUBA4A and a frameshift in VCP, for which additional research is needed to confirm pathogenicity. The patients without identified genetic cause demonstrated a wide clinical and pathological variety. Our study contributes to the clinical characterization of the genetic subtypes and confirms the value of whole-exome sequencing in identifying novel genetic variants.

Published
2020
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5. Whole Exome Sequencing in Alzheimer’s Disease and Frontotemporal Lobar Degeneration

Author

Wong, T.H. (Tsz Hang) and Wong, T.H. (Tsz Hang)

Abstract

Dementia is a disorder characterized by cognitive impairment and/or behavioral changes that interfere with ability of daily functioning, with Alzheimer’s disease (AD) as the most common form of dementia, and frontotemporal dementia (FTD) as the second most common before age of 65. My thesis focuses on the genetics of these two types of dementia. Using whole exome sequencing (WES), we have attempted to identify the underlying genetics defects in patients with AD and FTD. WES is a technique that investigates genetic information in protein coding regions of DNA. We have identified several mutations in two known AD causing genes (PSEN1 and PSEN2) and a potential new risk factor in EIF2AK3 gene in a few patients with AD. In a subset of FTD patients, we have identified the underlying mutations in VCP and TUBA4A genes. At last, using WES and proteomics we have identified a new mutation in PRKAR1B gene in a rare type of dementia with parkinsonian symptoms. The identification of new genetic defects give us insights in the disease mechanisms involved in AD and FTD. This is important for the development of medication for dementia in the future.

Published
2020

6. MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort

Author

Pellegrini, C. Botta, F. Massi, D. Martorelli, C. Facchetti, F. Gandini, S. Maisonneuve, P. Avril, M.-F. Demenais, F. Bressac-de Paillerets, B. Hoiom, V. Cust, A.E. Anton-Culver, H. Gruber, S.B. Gallagher, R.P. Marrett, L. Zanetti, R. Dwyer, T. Thomas, N.E. Begg, C.B. Berwick, M. Puig, S. Potrony, M. Nagore, E. Ghiorzo, P. Menin, C. Manganoni, A.M. Rodolfo, M. Brugnara, S. Passoni, E. Sekulovic, L.K. Baldini, F. Guida, G. Stratigos, A. Ozdemir, F. Ayala, F. Fernandez-de-Misa, R. Quaglino, P. Ribas, G. Romanini, A. Migliano, E. Stanganelli, I. Kanetsky, P.A. Pizzichetta, M.A. García-Borrón, J.C. Nan, H. Landi, M.T. Little, J. Newton-Bishop, J. Sera, F. Fargnoli, M.C. Raimondi, S. Alaibac, M. Ferrari, A. Valeri, B. Sicher, M. Mangiola, D. Nazzaro, G. Tosti, G. Mazzarol, G. Giudice, G. Ribero, S. Astrua, C. Mazzoni, L. Orlow, I. Mujumdar, U. Hummer, A. Busam, K. Roy, P. Canchola, R. Clas, B. Cotignola, J. Monroe, Y. Armstrong, B. Kricker, A. Litchfield, M. Tucker, P. Stephens, N. Switzer, T. Theis, B. From, L. Chowdhury, N. Vanasse, L. Purdue, M. Northrup, D. Rosso, S. Sacerdote, C. Leighton, N. Gildea, M. Bonner, J. Jeter, J. Klotz, J. Wilcox, H. Weiss, H. Millikan, R. Mattingly, D. Player, J. Tse, C.-K. Rebbeck, T. Walker, A. Panossian, S. Setlow, R. Mohrenweiser, H. Autier, P. Han, J. Caini, S. Hofman, A. Kayser, M. Liu, F. Nijsten, T. Uitterlinden, A.G. Kumar, R. Bishop, T. Elliott, F. Lazovich, D. Polsky, D. Hansson, J. Pastorino, L. Gruis, N.A. Bouwes Bavinck, J.N. Aguilera, P. Badenas, C. Carrera, C. Gimenez-Xavier, P. Malvehy, J. Puig-Butille, J.A. Tell-Marti, G. Blizzard, L. Cochrane, J. Branicki, W. Debniak, T. Morling, N. Johansen, P. Mayne, S. Bale, A. Cartmel, B. Ferrucci, L. Pfeiffer, R. Palmieri, G. Kypreou, K. Bowcock, A. Cornelius, L. Council, M.L. Motokawa, T. Anno, S. Helsing, P. Andresen, P.A. Guida, S. Wong, T.H. IMI Study Group GEM Study Group M-SKIP Study Group

Abstract

Background: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls. Methods: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger. Findings: We analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1·54, 95% CI 1·02–2·33), including when analysis was restricted to patients aged 18 years or younger (1·80, 1·06–3·07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1·60, 95% CI 1·05–2·44; p=0·04) and Asp294His (2·15, 1·05–4·40; p=0·04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants. Interpretation: Our pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies. Funding: SPD-Pilot/Project-Award-2015; AIRC-MFAG-11831. © 2019 Elsevier Ltd

Published
2019

7. Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations

Author

Wong, T.H. (Tsz Hang), Seelaar, H. (Harro), Melhem, S. (Shamiram), Rozemuller, A.J.M. (Annemieke), van Swieten, J.C. (John C.), Wong, T.H. (Tsz Hang), Seelaar, H. (Harro), Melhem, S. (Shamiram), Rozemuller, A.J.M. (Annemieke), and van Swieten, J.C. (John C.)

Abstract

Mutations in presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP) are major genetic causes of early-onset Alzheimer's disease (EOAD). Clinical heterogeneity is frequently observed in patients with PSEN1 and PSEN2 mutations. Using whole exome sequencing, we screened a Dutch cohort of 68 patients with EOAD for rare variants in Mendelian Alzheimer's disease, frontotemporal dementia, and prion disease genes. We identified 3 PSEN1 and 2 PSEN2 variants. Three variants, 1 in PSEN1 (p.H21Profs*2) and both PSEN2 (p.A415S and p.M174I), were novel and absent in control exomes. These novel variants can be classified as probable pathogenic, except for PSEN1 (p.H21Profs*2) in which the pathogenicity is uncertain. The initial clinical symptoms between mutation carriers varied from behavioral problems to memory impairment. Our findings extend the mutation spectrum of EOAD and underline the clinical heterogeneity among PSEN1 and PSEN2 mutation carriers. Screening for Alzheimer's disease–causing genes is indicated in presenile dementia with an overlapping clinical diagnosis.

Published
2019
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8. Hippocampal transcriptome profiling combined with protein-protein interaction analysis elucidates Alzheimer's disease pathways and genes

Author

van Rooij, J.G.J. (Jeroen G.J.), Meeter, L.H.H. (Lieke), Melhem, S. (Shamiram), Nijholt, D.A.T. (Diana A.T.), Wong, T.H. (Tsz Hang), Rozemuller, A.J.M. (Annemieke), Uitterlinden, A.G. (André), van Meurs, J.G. (Joyce G.), van Swieten, J.C. (John C.), van Rooij, J.G.J. (Jeroen G.J.), Meeter, L.H.H. (Lieke), Melhem, S. (Shamiram), Nijholt, D.A.T. (Diana A.T.), Wong, T.H. (Tsz Hang), Rozemuller, A.J.M. (Annemieke), Uitterlinden, A.G. (André), van Meurs, J.G. (Joyce G.), and van Swieten, J.C. (John C.)

Abstract

Knowledge about the molecular mechanisms driving Alzheimer's disease (AD) is still limited. To learn more about AD biology, we performed whole transcriptome sequencing on the hippocampus of 20 AD cases and 10 age- and sex-matched cognitively healthy controls. We o

Published
2019
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9. Management of adverse effects of topical PDT

Author

Ibbotson, S.H., primary, Wong, T.H., additional, Morton, C.A., additional, Collier, N.J., additional, Haylett, A., additional, McKenna, K.E., additional, Mallipeddi, R., additional, Moseley, H., additional, Rhodes, L.E., additional, Seukeran, D.C., additional, Ward, K.A., additional, Mohd Mustapa, M.F., additional, and Exton, L.S., additional

Published
2019
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10. 局部 PDT 不良作用的管理

Author

Ibbotson, S.H., primary, Wong, T.H., additional, Morton, C.A., additional, Collier, N.J., additional, Haylett, A., additional, McKenna, K.E., additional, Mallipeddi, R., additional, Moseley, H., additional, Rhodes, L.E., additional, Seukeran, D.C., additional, Ward, K.A., additional, Mohd Mustapa, M.F., additional, and Exton, L.S., additional

Published
2019
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11. Oral versus Intravenous Antibiotics for Bone and Joint Infection

Author

Li, Ho-Kwong, primary, Rombach, Ines, additional, Zambellas, Rhea, additional, Walker, A. Sarah, additional, McNally, Martin A., additional, Atkins, Bridget L., additional, Lipsky, Benjamin A., additional, Hughes, Harriet C., additional, Bose, Deepa, additional, Kümin, Michelle, additional, Scarborough, Claire, additional, Matthews, Philippa C., additional, Brent, Andrew J., additional, Lomas, Jose, additional, Gundle, Roger, additional, Rogers, Mark, additional, Taylor, Adrian, additional, Angus, Brian, additional, Byren, Ivor, additional, Berendt, Anthony R., additional, Warren, Simon, additional, Fitzgerald, Fiona E., additional, Mack, Damien J.F., additional, Hopkins, Susan, additional, Folb, Jonathan, additional, Reynolds, Helen E., additional, Moore, Elinor, additional, Marshall, Jocelyn, additional, Jenkins, Neil, additional, Moran, Christopher E., additional, Woodhouse, Andrew F., additional, Stafford, Samantha, additional, Seaton, R. Andrew, additional, Vallance, Claire, additional, Hemsley, Carolyn J., additional, Bisnauthsing, Karen, additional, Sandoe, Jonathan A.T., additional, Aggarwal, Ila, additional, Ellis, Simon C., additional, Bunn, Deborah J., additional, Sutherland, Rebecca K., additional, Barlow, Gavin, additional, Cooper, Cushla, additional, Geue, Claudia, additional, McMeekin, Nicola, additional, Briggs, Andrew H., additional, Sendi, Parham, additional, Khatamzas, Elham, additional, Wangrangsimakul, Tri, additional, Wong, T.H. Nicholas, additional, Barrett, Lucinda K., additional, Alvand, Abtin, additional, Old, C. Fraser, additional, Bostock, Jennifer, additional, Paul, John, additional, Cooke, Graham, additional, Thwaites, Guy E., additional, Bejon, Philip, additional, and Scarborough, Matthew, additional

Published
2019
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12. British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018

Author

Wong, T.H., primary, Morton, C.A., additional, Collier, N., additional, Haylett, A., additional, Ibbotson, S., additional, McKenna, K.E., additional, Mallipeddi, R., additional, Moseley, H., additional, Seukeran, D.C., additional, Rhodes, L.E., additional, Ward, K.A., additional, Mohd Mustapa, M.F., additional, Exton, L.S., additional, McHenry, P.M., additional, Leslie, T.A., additional, Wakelin, S., additional, Hunasehally, R.Y.P., additional, Cork, M., additional, Johnston, G.A., additional, Worsnop, F.S., additional, Rakvit, P., additional, Salim, A., additional, McDonald, B., additional, Chua, S.L., additional, Buckley, D., additional, Petrof, G., additional, Callachand, N., additional, Flavell, T., additional, and Salad, A.A., additional

Published
2018
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13. Photodynamic therapy for basal cell carcinoma

Author

Collier, N.J., primary, Haylett, A.K., additional, Wong, T.H., additional, Morton, C.A., additional, Ibbotson, S.H., additional, McKenna, K.E., additional, Mallipeddi, R., additional, Moseley, H., additional, Seukeran, D., additional, Ward, K.A., additional, Mohd Mustapa, M.F., additional, Exton, L.S., additional, Green, A.C., additional, and Rhodes, L.E., additional

Published
2018
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16. Conventional and combination topical photodynamic therapy for basal cell carcinoma: systematic review and meta-analysis

Author

Collier, N.J., primary, Haylett, A.K., additional, Wong, T.H., additional, Morton, C.A., additional, Ibbotson, S.H., additional, McKenna, K.E., additional, Mallipeddi, R., additional, Moseley, H., additional, Seukeran, D., additional, Ward, K.A., additional, Mohd Mustapa, M.F., additional, Exton, L.S., additional, Green, A.C., additional, and Rhodes, L.E., additional

Published
2018
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18. Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease

Author

Holstege, H. (Henne), Lee, S.J. (Sven) van der, Hulsman, M. (Marc), Wong, T.H. (Tsz Hang), Rooij, J.G.J. (Jeroen) van, Weiss, M.M. (Marjan M.), Louwersheimer, E. (Eva), Wolters, F.J. (Frank), Amin, N. (Najaf), Uitterlinden, A.G. (André), Hofman, A. (Albert), Ikram, M.A. (Arfan), Swieten, J.C. (John) van, Meijers-Heijboer, E.J. (Hanne), Flier, W.M. (Wiesje) van der, Reinders, M.J. (Marcel), Duijn, C.M. (Cornelia) van, Scheltens, P. (Philip), Holstege, H. (Henne), Lee, S.J. (Sven) van der, Hulsman, M. (Marc), Wong, T.H. (Tsz Hang), Rooij, J.G.J. (Jeroen) van, Weiss, M.M. (Marjan M.), Louwersheimer, E. (Eva), Wolters, F.J. (Frank), Amin, N. (Najaf), Uitterlinden, A.G. (André), Hofman, A. (Albert), Ikram, M.A. (Arfan), Swieten, J.C. (John) van, Meijers-Heijboer, E.J. (Hanne), Flier, W.M. (Wiesje) van der, Reinders, M.J. (Marcel), Duijn, C.M. (Cornelia) van, and Scheltens, P. (Philip)

Abstract

Accumulating evidence suggests that genetic variants in the SORL1 gene are associated with Alzheimer disease (AD), but a strategy to identify which variants are pathogenic is lacking. In a discovery sample of 115 SORL1 variants detected in 1908 Dutch AD cases and controls, we identified the variant characteristics associated with SORL1 variant pathogenicity. Findings were replicated in an independent sample of 103 SORL1 variants detected in 3193 AD cases and controls. In a combined sample of the discovery and replication samples, comprising 181 unique SORL1 variants, we developed a strategy to classify SORL1 variants into five subtypes ranging from pathogenic to benign. We tested this pathogenicity screen in SORL1 variants reported in two independent published studies. SORL1 variant pathogenicity is defined by the Combined Annotation Dependent Depletion (CADD) score and the minor allele frequency (MAF) reported by the Exome Aggregation Consortium (ExAC) database. Variants predicted strongly damaging (CADD score >30), which are extremely rare (ExAC-MAF <1 × 10 '5) increased AD risk by 12-fold (95% CI 4.2-34.3; P=5 × 10 '9). Protein-truncating SORL1 mutations were all unknown to ExAC and occurred exclusively in AD cases. More common SORL1 variants (ExAC-MAF≥1 × 10 '5) were not associated with increased AD risk, even when predicted strongly damaging. Findings were independent of gender and the APOE-I 4 allele. High-risk SORL1 variants were observed in a substantial proportion of the AD cases analyzed (2%). Based on their effect size, we propose to consider high-risk SORL1 variants next to variants in APOE, PSEN1, PSEN2 and APP for personalized risk assessments in clinical practice.

Published
2017
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19. Association of Melanocortin-1 Receptor Variants with Pigmentary Traits in Humans: A Pooled Analysis from the M-Skip Project

Author

Tagliabue, E. Gandini, S. García-Borrón, J.C. Maisonneuve, P. Newton-Bishop, J. Polsky, D. Lazovich, D. Kumar, R. Ghiorzo, P. Ferrucci, L. Gruis, N.A. Puig, S. Kanetsky, P.A. Motokawa, T. Ribas, G. Landi, M.T. Fargnoli, M.C. Wong, T.H. Stratigos, A. Helsing, P. Guida, G. Autier, P. Han, J. Little, J. Sera, F. Raimondi, S. Caini, S. Hofman, A. Kayser, M. Liu, F. Nijsten, T. Uitterlinden, A.G. Scherer, D. Bishop, T. Elliott, F. Nagore, E. Hansson, J. Hoiom, V. Pastorino, L. Bouwes Bavinck, J.N. Aguilera, P. Badenas, C. Carrera, C. Gimenez-Xavier, P. Malvehy, J. Potrony, M. Puig-Butille, J.A. Tell-Marti, G. Dwyer, T. Blizzard, L. Cochrane, J. Fernandez-de-Misa, R. Branicki, W. Debniak, T. Morling, N. Johansen, P. Mayne, S. Bale, A. Cartmel, B. Pfeiffer, R. Palmieri, G. Menin, C. Kypreou, K. Bowcock, A. Cornelius, L. Council, M.L. Anno, S. Andresen, P.A. Guida, S.

Published
2016

21. MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: A pooled-analysis from the M-SKIP project

Author

Pasquali, E. García-Borrón, J.C. Fargnoli, M.C. Gandini, S. Maisonneuve, P. Bagnardi, V. Specchia, C. Liu, F. Kayser, M. Nijsten, T. Nagore, E. Kumar, R. Hansson, J. Kanetsky, P.A. Ghiorzo, P. Debniak, T. Branicki, W. Gruis, N.A. Han, J. Dwyer, T. Blizzard, L. Landi, M.T. Palmieri, G. Ribas, G. Stratigos, A. Council, M.L. Autier, P. Little, J. Newton-Bishop, J. Sera, F. Raimondi, S. Caini, S. Hofman, A. Uitterlinden, A.G. Scherer, D. Hoiom, V. Pastorino, L. Cochrane, J. Fernandez-De-Misa, R. Morling, N. Johansen, P. Pfeiffer, R. Kypreou, K. Bowcock, A. Cornelius, L. Motokawa, T. Anno, S. Helsing, P. Andresen, P.A. Wong, T.H. M-SKIP Study Group

Abstract

The MC1R gene is a key regulator of skin pigmentation. We aimed to evaluate the association between MC1R variants and the risk of sporadic cutaneous melanoma (CM) within the M-SKIP project, an international pooled-analysis on MC1R, skin cancer and phenotypic characteristics. Data included 5,160 cases and 12,119 controls from 17 studies. We calculated a summary odds ratio (SOR) for the association of each of the nine most studied MC1R variants and of variants combined with CM by using random-effects models. Stratified analysis by phenotypic characteristics were also performed. Melanoma risk increased with presence of any of the main MC1R variants: the SOR for each variant ranged from 1.47 (95%CI: 1.17-1.84) for V60L to 2.74 (1.53-4.89) for D84E. Carriers of any MC1R variant had a 66% higher risk of developing melanoma compared with wildtype subjects (SOR; 95%CI: 1.66; 1.41-1.96) and the risk attributable to MC1R variants was 28%. When taking into account phenotypic characteristics, we found that MC1R-associated melanoma risk increased only for darker-pigmented Caucasians: SOR (95%CI) was 3.14 (2.06-4.80) for subjects with no freckles, no red hair and skin Type III/IV. Our study documents the important role of all the main MC1R variants in sporadic CM and suggests that they have a direct effect on melanoma risk, independently on the phenotypic characteristics of carriers. This is of particular importance for assessing preventive strategies, which may be directed to darker-pigmented Caucasians with MC1R variants as well as to lightly pigmented, fairskinned subjects. © 2014 UICC.

Published
2015

22. British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018.

Author

Wong, T.H., Morton, C.A., Collier, N., Haylett, A., Ibbotson, S., McKenna, K.E., Mallipeddi, R., Moseley, H., Seukeran, D.C., Rhodes, L.E., Ward, K.A., Mohd Mustapa, M.F., and Exton, L.S.

Subjects
*ACTINIC keratosis, *PHOTODYNAMIC therapy, *ROSACEA, *SQUAMOUS cell carcinoma
Abstract

The article offers guidelines for topical photodynamic therapy (PDT) released by the British Association of Dermatologists and British Photodermatology Group. It offers overview of the purpose and scope of the guideline aimed at providing updated evidence-based recommendations for use of PDT. It also notes that the recommendation was developed for implementation in the National Health Service in Great Britain.

Published
2019
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23. Adverse effects of topical photodynamic therapy: a consensus review and approach to management.

Author

Ibbotson, S.H., Wong, T.H., Morton, C.A., Collier, N.J., Haylett, A., McKenna, K.E., Mallipeddi, R., Moseley, H., Rhodes, L.E., Seukeran, D.C., Ward, K.A., Mohd Mustapa, M.F., and Exton, L.S.

Subjects
*PHOTODYNAMIC therapy, *SKIN cancer, *CANCER treatment, *ADVERSE health care events, *THERAPEUTIC complications, *TREATMENT effectiveness
Abstract

Summary: Background: Topical photodynamic therapy (PDT) is widely used to treat superficial nonmelanoma skin cancer and dysplasia, and is generally well tolerated. However, as with all treatments, adverse effects may occur and awareness may facilitate approaches to prevention and management. Objectives: To review the available evidence relating to the adverse effects of topical PDT, to help inform recommendations in updated clinical guidelines produced by the British Association of Dermatologists and British Photodermatology Group, and the efficacy of preventative and therapeutic approaches. Methods: This review summarizes the published evidence related to the adverse effects of topical PDT and attempts to interpret this evidence in the context of patient risk and management. Results: Pain and discomfort during PDT are acute adverse effects, which can be minimized through the use of modified and low‐irradiance PDT regimens and do not therefore usually limit successful treatment delivery. Other adverse effects include the risk of contact allergy to photosensitizer prodrugs, although this is rare but should be kept in mind, particularly for patients who have received multiple PDT treatments to larger areas. There are no other significant documented longer‐term risks and, to date, no evidence of cumulative toxicity or photocarcinogenic risk. Conclusions: Topical PDT is usually well tolerated, reinforcing the utility of this important therapeutic option in dermatology practice. The main acute adverse effect of pain can typically be minimized through preventative approaches of modified PDT regimens. Other adverse effects are uncommon and generally do not limit treatment delivery. What's already known about this topic? Photodynamic therapy (PDT) is widely used in dermatology.Pain is the most well documented adverse effect.Methods of effective pain relief are limited. What does this study add? This review scrutinizes the literature relating to adverse effects of PDT and management approaches.PDT‐induced pain can usually be effectively prevented and managed through adjustments to PDT regimens, such as using lower irradiance light delivery.Phototoxic reactions are to be expected.Other adverse effects are typically uncommon and not limiting. Linked Editorial:Wulf. Br J Dermatol 2019; 180:695–696. Plain language summary available online [ABSTRACT FROM AUTHOR]

Published
2019
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24. Photodissociation spectroscopy of MgO[sub +2].

Author

Chen, J. and Wong, T.H.

Subjects
*SUPEROXIDES, *MAGNESIUM compounds, *PHOTODISSOCIATION
Abstract

Examines the superoxide molecule MgO[sup +,sub 2] using the photodissociation spectroscopy. Nature of MgO[sup +,sub 2]; Analysis of MgO action spectrum; Description of translational energy release.

Published
1998
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25. Scattering state spectroscopy of the reaction Mg*(3s3p [sup 1]P[sub 1]) +....

Author

Wong, T.H. and Freel, C.

Subjects
*SPECTRUM analysis, *SCATTERING (Physics), *MAGNESIUM, *METHANE
Abstract

Presents the scattering state spectroscopy of the reaction between magnesium and methane. Implications for the chemical dynamics of the metal-alkane reaction system; Role of the excitation laser wavelength in product vibrational energy disposal; Independence of the rotational quantum state distribution from laser excitation wavelength.

Published
1998
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26. Photodissociation spectroscopy and dynamics of MgC[sub 2]H[sup +][sub 4].

Author

Chen, J. and Wong, T.H.

Subjects
*COLLISIONS (Physics), *PHOTODISSOCIATION, *SPECTRUM analysis
Abstract

Examines the weakly bound ion-molecule complex by photodissociation spectroscopy. Identification of five molecular absorption bands; Details on the nonadiabatic interactions in chemical dynamics; Implication of photofragment kinetic energy release for the bond dissociation energies.

Published
1998
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28. PLD3 variants in population studies

Author

Lee, S.J. (Sven) van der, Holstege, H. (Henne), Wong, T.H. (Tsz Hang), Jakobsdottir, M. (Margret), Bis, J.C. (Joshua), Chouraki, V. (Vincent), Rooij, J.G.J. (Jeroen) van, Grove, M.L. (Megan), Smith, A.V. (Davey), Amin, N. (Najaf), Choi, S.-H. (Seung-Hoan), Beiser, A. (Alexa), Garcia, M. (Melissa), IJcken, W.F.J. (Wilfred) van, Pijnenburg, Y.A.L. (Yolande), Louwersheimer, E. (Eva), Brouwer, R.W.W. (Rutger), van den hout, M.C.G.N. (Mirjam), Oole, E. (Edwin), Eirkisdottir, G. (Gudny), Levy, D. (Daniel), Rotter, J.I. (Jerome I.), Emilsson, V. (Valur), O'Donnell, C.J. (Christopher), Aspelund, T. (Thor), Uitterlinden, A.G. (André), Launer, L.J. (Lenore), Hofman, A. (Albert), Boerwinkle, E.A. (Eric), Psaty, B.M. (Bruce), DeStefano, A.L. (Anita), Scheltens, P. (Philip), Seshadri, S. (Sudha), Swieten, J.C. (John) van, Gudnason, V. (Vilmundur), Flier, W.M. (Wiesje) van der, Ikram, M.A. (Arfan), Duijn, C.M. (Cornelia) van, Lee, S.J. (Sven) van der, Holstege, H. (Henne), Wong, T.H. (Tsz Hang), Jakobsdottir, M. (Margret), Bis, J.C. (Joshua), Chouraki, V. (Vincent), Rooij, J.G.J. (Jeroen) van, Grove, M.L. (Megan), Smith, A.V. (Davey), Amin, N. (Najaf), Choi, S.-H. (Seung-Hoan), Beiser, A. (Alexa), Garcia, M. (Melissa), IJcken, W.F.J. (Wilfred) van, Pijnenburg, Y.A.L. (Yolande), Louwersheimer, E. (Eva), Brouwer, R.W.W. (Rutger), van den hout, M.C.G.N. (Mirjam), Oole, E. (Edwin), Eirkisdottir, G. (Gudny), Levy, D. (Daniel), Rotter, J.I. (Jerome I.), Emilsson, V. (Valur), O'Donnell, C.J. (Christopher), Aspelund, T. (Thor), Uitterlinden, A.G. (André), Launer, L.J. (Lenore), Hofman, A. (Albert), Boerwinkle, E.A. (Eric), Psaty, B.M. (Bruce), DeStefano, A.L. (Anita), Scheltens, P. (Philip), Seshadri, S. (Sudha), Swieten, J.C. (John) van, Gudnason, V. (Vilmundur), Flier, W.M. (Wiesje) van der, Ikram, M.A. (Arfan), and Duijn, C.M. (Cornelia) van

Published
2015
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29. Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: Study design and methods for pooling results of genetic epidemiological studies

Author

Raimondi, S. Gandini, S. Fargnoli, M.C. Bagnardi, V. Maisonneuve, P. Specchia, C. Kumar, R. Nagore, E. Han, J. Hansson, J. Kanetsky, P.A. Ghiorzo, P. Gruis, N.A. Dwyer, T. Blizzard, L. Fernandez-De-Misa, R. Branicki, W. Debniak, T. Morling, N. Landi, M.T. Palmieri, G. Ribas, G. Stratigos, A. Cornelius, L. Motokawa, T. Anno, S. Helsing, P. Wong, T.H. Autier, P. García-Borrón, J.C. Little, J. Newton-Bishop, J. Sera, F. Liu, F. Kayser, M. Nijsten, T.

Abstract

Background: For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a disease. Pooled-analysis of epidemiological studies has many advantages over meta-analysis, and preliminary results may be obtained faster and with lower costs than with prospective consortia. Design and methods. Based on our experience with the study design of the Melanocortin-1 receptor (MC1R) gene, SKin cancer and Phenotypic characteristics (M-SKIP) project, we describe the most important steps in planning and conducting a pooled-analysis of genetic epidemiological studies. We then present the statistical analysis plan that we are going to apply, giving particular attention to methods of analysis recently proposed to account for between-study heterogeneity and to explore the joint contribution of genetic, phenotypic and environmental factors in the development of a disease. Within the M-SKIP project, data on 10,959 skin cancer cases and 14,785 controls from 31 international investigators were checked for quality and recoded for standardization. We first proposed to fit the aggregated data with random-effects logistic regression models. However, for the M-SKIP project, a two-stage analysis will be preferred to overcome the problem regarding the availability of different study covariates. The joint contribution of MC1R variants and phenotypic characteristics to skin cancer development will be studied via logic regression modeling. Discussion. Methodological guidelines to correctly design and conduct pooled-analyses are needed to facilitate application of such methods, thus providing a better summary of the actual findings on specific fields. © 2012 Raimondi et al.

Published
2012

31. No mutations in hnRNPA1 and hnRNPA2B1 in Dutch patients with amyotrophic lateral sclerosis, frontotemporal dementia, and inclusion body myopathy

Author

Seelen, M., Visser, A.E., Overste, D.J., Kim, H.J., Palud, A., Wong, T.H., Swieten, J.C. van, Scheltens, P., Voermans, N.C., Baas, F., Jong, J.M. de, Kooi, A.J. van der, Visser, M de, Veldink, J.H., Taylor, J.P., Es, M.A. van, Berg, L.H. van den, Seelen, M., Visser, A.E., Overste, D.J., Kim, H.J., Palud, A., Wong, T.H., Swieten, J.C. van, Scheltens, P., Voermans, N.C., Baas, F., Jong, J.M. de, Kooi, A.J. van der, Visser, M de, Veldink, J.H., Taylor, J.P., Es, M.A. van, and Berg, L.H. van den

Abstract

Item does not contain fulltext, Inclusion body myopathy (IBM) associated with Paget disease of the bone, frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), sometimes called IBMPFD/ALS or multi system proteinopathy, is a rare, autosomal dominant disorder characterized by progressive degeneration of muscle, brain, motor neurons, and bone with prominent TDP-43 pathology. Recently, 2 novel genes for multi system proteinopathy were discovered; heterogenous nuclear ribonucleoprotein (hnRNP) A1 and A2B1. Subsequently, a mutation in hnRNPA1 was also identified in a pedigree with autosomal dominant familial ALS. The genetic evidence for ALS and other neurodegenerative diseases is still insufficient. We therefore sequenced the prion-like domain of these genes in 135 familial ALS, 1084 sporadic ALS, 68 familial FTD, 74 sporadic FTD, and 31 sporadic IBM patients in a Dutch population. We did not identify any mutations in these genes in our cohorts. Mutations in hnRNPA1 and hnRNPA2B1 prove to be a rare cause of ALS, FTD, and IBM in the Netherlands.

Published
2014

33. Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project

Author

Raimondi, S. (Susana), Gandini, S. (Sara), Fargnoli, M.C. (Maria Concetta), Bagnardi, V. (Vincenzo), Maisonneuve, P. (Patrick), Specchia, C. (Claudia), Kumar, R. (Rajiv), Nagore, E. (Eduardo), Han, J., Hansson, J. (Johan), Kanetsky, P.A. (Peter A), Ghiorzo, P. (Paola), Gruis, N.A. (Nelleke), Dwyer, T. (Terry), Blizzard, L. (Leigh), Fernandez-De-Misa, R. (Ricardo), Branicki, W. (Wojciech), Debniak, T. (Tadeusz), Morling, N. (Niels), Landi, M.T. (Maria Teresa), Palmieri, D. (Dario), Ribas, G. (Gloria), Stratigos, A. (Alexander), Cornelius, L. (Lynn), Motokawa, T. (Tomonori), Anno, H. (Hirofumi), Helsing, P. (Per), Wong, T.H. (Terence), Autier, P.J.M. (Philippe), García-Borrón, J.C. (José C), Little, J. (Julian), Newton-Bishop, J. (Julia), Sera, J.P. de, Liu, F. (Fan), Kayser, M.H. (Manfred), Nijsten, T.E.C. (Tamar), Raimondi, S. (Susana), Gandini, S. (Sara), Fargnoli, M.C. (Maria Concetta), Bagnardi, V. (Vincenzo), Maisonneuve, P. (Patrick), Specchia, C. (Claudia), Kumar, R. (Rajiv), Nagore, E. (Eduardo), Han, J., Hansson, J. (Johan), Kanetsky, P.A. (Peter A), Ghiorzo, P. (Paola), Gruis, N.A. (Nelleke), Dwyer, T. (Terry), Blizzard, L. (Leigh), Fernandez-De-Misa, R. (Ricardo), Branicki, W. (Wojciech), Debniak, T. (Tadeusz), Morling, N. (Niels), Landi, M.T. (Maria Teresa), Palmieri, D. (Dario), Ribas, G. (Gloria), Stratigos, A. (Alexander), Cornelius, L. (Lynn), Motokawa, T. (Tomonori), Anno, H. (Hirofumi), Helsing, P. (Per), Wong, T.H. (Terence), Autier, P.J.M. (Philippe), García-Borrón, J.C. (José C), Little, J. (Julian), Newton-Bishop, J. (Julia), Sera, J.P. de, Liu, F. (Fan), Kayser, M.H. (Manfred), and Nijsten, T.E.C. (Tamar)

Abstract

Background: For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a disease. Pooled-analysis of epidemiological studies has many advantages over meta-analysis, and preliminary results may be obtained faster and with lower costs than with prospective consortia. Design and methods. Based on our experience with the study design of the Melanocortin-1 receptor (MC1R) gene, SKin cancer and Phenotypic characteristics (M-SKIP) project, we describe the most important steps in planning and conducting a pooled-analysis of genetic epidemiological studies. We then present the statistical analysis plan that we are going to apply, giving particular attention to methods of analysis recently proposed to account for between-study heterogeneity and to explore the joint contribution of genetic, phenotypic and environmental factors in the development of a disease. Within the M-SKIP project, data on 10,959 skin cancer cases and 14,785 controls from 31 international investigators were checked for quality and recoded for standardization. We first proposed to fit the aggregated data with random-effects logistic regression models. However, for the M-SKIP project, a two-stage analysis will be preferred to overcome the problem regarding the availability of different study covariates. The joint contribution of MC1R variants and phenotypic characteristics to skin cancer deve

Published
2012
Full Text
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34. Melanocortin-1receptor, skincancer and phenotypic characteristics (MSKIP) project: study design and methods for pooling results of genetic epidemiological studies.

Author

Raimondi, S., Gandini, S., Fargnoli, M.C., Bagnardi, V., Maissonneuve, P., Specchia, C., Kumar, R., Nagore, E., Han, J., Hansson, J., Kanetsky, P.A., Ghiorzo, P., Gruis, N.A., Dwyer, T., Blizzard, L., Fernandez-de-Misa, R., Brainicki, W., Debniak, T., Landi, M.T., Morling, Niels, Palmieri, G., Ribas, G., Stratigos, A., Cornelius, L., Motokawa, T., Anno, S., Helsing, P., Wong, T.H., Autier, P., Garcia-Borron, J.C., Little, J., Newton-Bishop, J., Liu, F., Kayser, M., Nijsten, T., Raimondi, S., Gandini, S., Fargnoli, M.C., Bagnardi, V., Maissonneuve, P., Specchia, C., Kumar, R., Nagore, E., Han, J., Hansson, J., Kanetsky, P.A., Ghiorzo, P., Gruis, N.A., Dwyer, T., Blizzard, L., Fernandez-de-Misa, R., Brainicki, W., Debniak, T., Landi, M.T., Morling, Niels, Palmieri, G., Ribas, G., Stratigos, A., Cornelius, L., Motokawa, T., Anno, S., Helsing, P., Wong, T.H., Autier, P., Garcia-Borron, J.C., Little, J., Newton-Bishop, J., Liu, F., Kayser, M., and Nijsten, T.

Published
2012

36. Letter to the Editor

Author

Lee, Vincent Y.W., primary, Kwok, Alvin K.H., additional, Wong, T.H., additional, and Lam, Dennis S.C., additional

Published
2003
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43. 光动力疗法治疗基底细胞癌.

Author

Collier, N.J., Haylett, A.K., Wong, T.H., Morton, C.A., Ibbotson, S.H., McKenna, K.E., Mallipeddi, R., Moseley, H., Seukeran, D., Ward, K.A., Mohd Mustapa, M.F., Exton, L.S., Green, A.C., and Rhodes, L.E.

Abstract

Copyright of British Journal of Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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47. Photoredox Organocatalysis for the Enantioselective Synthesis of 1,7-Dicarbonyl Compounds

Author

Thomas Hin-Fung Wong, Dengke Ma, Riccardo Di Sanza, Paolo Melchiorre, Wong T.H., Ma D., Di Sanza R., and Melchiorre P.

Subjects
Organic Chemistry, Physical and Theoretical Chemistry, asymmetric catalysis, organocatalysis, photoredox catalysis, radicals, Biochemistry
Abstract

We describe an asymmetric organocatalytic method to synthesize 1,7-dicarbonyl compounds containing a β-stereocenter. The chemistry relies on the formation of γ-keto radicals, generated upon oxidative ring opening of cyclobutanols mastered by an organic photoredox catalyst. These nonstabilized primary radicals are stereoselectively intercepted by an iminium ion intermediate, formed upon activation of aliphatic and aromatic enals by a chiral secondary amine catalyst. This organocatalytic photoredox method served to prepare scaffolds found in natural products and drug molecules.

Published
2022

48. Diversity and ethics in trauma and acute care surgery teams: results from an international survey

Author

Cobianchi L., Dal Mas F., Massaro M., Biffl W., Catena F., Coccolini F., Dionigi B., Dionigi P., Di Saverio S., Fugazzola P., Kluger Y., Leppaniemi A., Moore E. E., Sartelli M., Velmahos G., Woltz S., Angelos P., Ansaloni L., Abdelmalik A., Abebe N. S., Abu-Zidan F. M., Adam Y. A. Y., Adamou H., Agrusa A., Akin E., Alexandrino H., Ali S. M., Almeida P. M., Amico F., Ammendola M., Andreuccetti J., Aparicio-Sanchez D., Ardito A., Argenio G., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bagnoli C., Bains L., Balalis D., Baldini E., Baraket O., Barone M., Barreras J. A., Bellanova G., Biancuzzi H., Bignell M. B., Bini R., Bissacco D., Boati P., Bottari A., Bouliaris K., Brillantino A., Buonomo L. A., Buscemi S., Calu V., Campo Dall'Orto R., Campostrini S., Carvas J. M., Casoni Pattacini G., Celentano V., Ceresoli M., Chirica M., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colak E., Conti L., Dantas Costa S., D'Acapito F., Damaskos D., Das K., Davies R. J., De Beaux A. C., De Simone B., Demetrashvili Z., Demetriades A. K., Denicolai S., Di Buono G., Di Carlo I., Diaconescu B., Dibra R., Dios-Barbeito S., Dogjani A., Domanin M., D'Oria M., Duran Munoz-Cruzado V., East B., Ekwen G. T., Elbaih A. H., Escalera-Antezana J. P., Esposito G., Farre R., Ferrario di Tor Vajana A., Cordeiro Fonseca V., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Gachabayov M., Garcia Vazquez A. A., Ghannam W. M., Gioco R., Giraudo G., Giuffrida M., Giulii Capponi M., Gomes C. A., Teixeira Gonsaga R. A., Gonullu E., Goosen J., Goranovic T., Griffiths E. A., Haidar M. G., Hamid H. K. S., Harddastle T. C., Healey A. J., Hecker M., Hernandez Garcia E. F., Huaman E. C., Hutan M., Ioannidis O., Isik A., Ismail A. M. H., Ismail N., Jang J. Y., Kaafarani H. M. A., Kalipershad S. N. R., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Kavalakat A. J., Kechagias A., Kenig J., Khan J. S., Khokha V., Klappenbach R., Kobe Y., Kong V., Korkolis D., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Licari L., Litvin A., Loftus T. J., Lohsiriwat V., Lopes Moreira C. C., Lostoridis E., Luna A. T., Luppi D., Machain G. M., Maegele M., Maggiore D., Maier R. V., Manangi M., Manetti A., Mantoglu B., Mariani F., Marinis A., Sbalcheiro Mariot E. A., Marseglia G. R., Martellucci J., Martines G., Martinez Perez A., Mascagni P., Massalou D., Melo R. B., Miceli L., Mingoli A., Mishra T. S., Mohamedahmed A. Y. Y., Mohan R., Morales-Garcia D., Mustafa S. M. S., Naimzada M. D., Negoi I., Nguyen C., Nidaw M. K., Nigri G., Ogundipe H. D., Oliveri C., Olmi S., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papis D., Pararas N., Pata F., Paterson-Brown S., Pavone G., Pecchini F., Pellino G., Pelloni M., Peloso A., Perea del Pozo E., Goncalves Pereira R., Monteiro Pereira B., Lizarazu Perez A., Perrone G., Pesce A., Petracca G., Piccoli M., Piccolo D., Picetti E., Pikoulis E., Pintar T., Pirozzolo G., Podda M., Previtali P., Privitera F., Punzo C., Quiodettis M. A., Qvist N., Rahim R., Reinisch-Liese A., Rodriguez-Luna M. R., Roizblatt D., Roscio F. P. M., Rossi S., Ruta F., Sakakushev B. E., Salamea J. C., Sall I., Sammartano F., Sanchez Arteaga A., Sanchez-Cordero S., Sasia D., Sawyer R. G., Seretis C., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Simoes R. L., Siribumrungwong B., Slavchev M., Solaini L., Soldini G., Soreide K., Spada F., Stahel P., Sydorchuk L., Sydorchuk R., Syed A. M., Tallon-Aguilar L., Tan J. H., Tan E., Tarasconi A., Tartaglia D., Tartaglia N., Taylor J., Tebala G. D., Teuben M., Tolonen M., Tomasicchio G., Triantafyllou T., Trigiante G., Turrado-Rodriguez V., Tutino R., Uccelli M., Ugarte-Sierra B., Ukkonen M., Vassiliu P. G., Verde J. M., Veroux M., Vilallonga R., Visconti D., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Wong T. H., Xenaki S., Yu B., Yule S., Zakaria A. D., Zambrano D. A., Zese M., Cobianchi, L, Dal Mas, F, Massaro, M, Biffl, W, Catena, F, Coccolini, F, Dionigi, B, Dionigi, P, Di Saverio, S, Fugazzola, P, Kluger, Y, Leppaniemi, A, Moore, E, Sartelli, M, Velmahos, G, Woltz, S, Angelos, P, Ansaloni, L, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Agrusa, A, Akin, E, Alexandrino, H, Ali, S, Almeida, P, Amico, F, Ammendola, M, Andreuccetti, J, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bagnoli, C, Bains, L, Balalis, D, Baldini, E, Baraket, O, Barone, M, Barreras, J, Bellanova, G, Biancuzzi, H, Bignell, M, Bini, R, Bissacco, D, Boati, P, Bottari, A, Bouliaris, K, Brillantino, A, Buonomo, L, Buscemi, S, Calu, V, Campo Dall'Orto, R, Campostrini, S, Carvas, J, Casoni Pattacini, G, Celentano, V, Ceresoli, M, Chirica, M, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colak, E, Conti, L, Dantas Costa, S, D'Acapito, F, Damaskos, D, Das, K, Davies, R, De Beaux, A, De Simone, B, Demetrashvili, Z, Demetriades, A, Denicolai, S, Di Buono, G, Di Carlo, I, Diaconescu, B, Dibra, R, Dios-Barbeito, S, Dogjani, A, Domanin, M, D'Oria, M, Duran Munoz-Cruzado, V, East, B, Ekwen, G, Elbaih, A, Escalera-Antezana, J, Esposito, G, Farre, R, Ferrario di Tor Vajana, A, Cordeiro Fonseca, V, Forfori, F, Fortuna, L, Fradelos, E, Fraga, G, Fransvea, P, Gachabayov, M, Garcia Vazquez, A, Ghannam, W, Gioco, R, Giraudo, G, Giuffrida, M, Giulii Capponi, M, Gomes, C, Teixeira Gonsaga, R, Gonullu, E, Goosen, J, Goranovic, T, Griffiths, E, Haidar, M, Hamid, H, Harddastle, T, Healey, A, Hecker, M, Hernandez Garcia, E, Huaman, E, Hutan, M, Ioannidis, O, Isik, A, Ismail, A, Ismail, N, Jang, J, Kaafarani, H, Kalipershad, S, Kaplan, L, Kara, Y, Karamagioli, E, Karamarkovia, A, Kavalakat, A, Kechagias, A, Kenig, J, Khan, J, Khokha, V, Klappenbach, R, Kobe, Y, Kong, V, Korkolis, D, Kurihara, H, Kuriyama, A, Landaluce-Olavarria, A, Licari, L, Litvin, A, Loftus, T, Lohsiriwat, V, Lopes Moreira, C, Lostoridis, E, Luna, A, Luppi, D, Machain, G, Maegele, M, Maggiore, D, Maier, R, Manangi, M, Manetti, A, Mantoglu, B, Mariani, F, Marinis, A, Sbalcheiro Mariot, E, Marseglia, G, Martellucci, J, Martines, G, Martinez Perez, A, Mascagni, P, Massalou, D, Melo, R, Miceli, L, Mingoli, A, Mishra, T, Mohamedahmed, A, Mohan, R, Morales-Garcia, D, Mustafa, S, Naimzada, M, Negoi, I, Nguyen, C, Nidaw, M, Nigri, G, Ogundipe, H, Oliveri, C, Olmi, S, Pagani, L, Palomba, G, Pantalone, D, Panyko, A, Paolillo, C, Papis, D, Pararas, N, Pata, F, Paterson-Brown, S, Pavone, G, Pecchini, F, Pellino, G, Pelloni, M, Peloso, A, Perea del Pozo, E, Goncalves Pereira, R, Monteiro Pereira, B, Lizarazu Perez, A, Perrone, G, Pesce, A, Petracca, G, Piccoli, M, Piccolo, D, Picetti, E, Pikoulis, E, Pintar, T, Pirozzolo, G, Podda, M, Previtali, P, Privitera, F, Punzo, C, Quiodettis, M, Qvist, N, Rahim, R, Reinisch-Liese, A, Rodriguez-Luna, M, Roizblatt, D, Roscio, F, Rossi, S, Ruta, F, Sakakushev, B, Salamea, J, Sall, I, Sammartano, F, Sanchez Arteaga, A, Sanchez-Cordero, S, Sasia, D, Sawyer, R, Seretis, C, Serradilla-Martin, M, Shelat, V, Shlyapnikov, S, Simoes, R, Siribumrungwong, B, Slavchev, M, Solaini, L, Soldini, G, Soreide, K, Spada, F, Stahel, P, Sydorchuk, L, Sydorchuk, R, Syed, A, Tallon-Aguilar, L, Tan, J, Tan, E, Tarasconi, A, Tartaglia, D, Tartaglia, N, Taylor, J, Tebala, G, Teuben, M, Tolonen, M, Tomasicchio, G, Triantafyllou, T, Trigiante, G, Turrado-Rodriguez, V, Tutino, R, Uccelli, M, Ugarte-Sierra, B, Ukkonen, M, Vassiliu, P, Verde, J, Veroux, M, Vilallonga, R, Visconti, D, Waledziak, M, Wannatoop, T, Widmer, L, Wilson, M, Wong, T, Xenaki, S, Yu, B, Yule, S, Zakaria, A, Zambrano, D, Zese, M, Cobianchi L., Dal Mas F., Massaro M., Biffl W., Catena F., Coccolini F., Dionigi B., Dionigi P., Di Saverio S., Fugazzola P., Kluger Y., Leppaniemi A., Moore E.E., Sartelli M., Velmahos G., Woltz S., Angelos P., Ansaloni L., Abdelmalik A., Abebe N.S., Abu-Zidan F.M., Adam Y.A.Y., Adamou H., Agrusa A., Akin E., Alexandrino H., Ali S.M., Almeida P.M., Amico F., Ammendola M., Andreuccetti J., Aparicio-Sanchez D., Ardito A., Argenio G., Askevold I.H., Atanasov B.T., Augustin G., Awad S.S., Bagnoli C., Bains L., Balalis D., Baldini E., Baraket O., Barone M., Barreras J.A., Bellanova G., Biancuzzi H., Bignell M.B., Bini R., Bissacco D., Boati P., Bottari A., Bouliaris K., Brillantino A., Buonomo L.A., Buscemi S., Calu V., Campo Dall'Orto R., Campostrini S., Carvas J.M., Casoni Pattacini G., Celentano V., Ceresoli M., Chirica M., Cianci P., Cillara N., Cimbanassi S., Cioffi S.P.B., Colak E., Conti L., Dantas Costa S., D'Acapito F., Damaskos D., Das K., Davies R.J., De Beaux A.C., De Simone B., Demetrashvili Z., Demetriades A.K., Denicolai S., Di Buono G., Di Carlo I., Diaconescu B., Dibra R., Dios-Barbeito S., Dogjani A., Domanin M., D'Oria M., Duran Munoz-Cruzado V., East B., Ekwen G.T., Elbaih A.H., Escalera-Antezana J.P., Esposito G., Farre R., Ferrario di Tor Vajana A., Cordeiro Fonseca V., Forfori F., Fortuna L., Fradelos E., Fraga G.P., Fransvea P., Gachabayov M., Garcia Vazquez A.A., Ghannam W.M., Gioco R., Giraudo G., Giuffrida M., Giulii Capponi M., Gomes C.A., Teixeira Gonsaga R.A., Gonullu E., Goosen J., Goranovic T., Griffiths E.A., Haidar M.G., Hamid H.K.S., Harddastle T.C., Healey A.J., Hecker M., Hernandez Garcia E.F., Huaman E.C., Hutan M., Ioannidis O., Isik A., Ismail A.M.H., Ismail N., Jang J.Y., Kaafarani H.M.A., Kalipershad S.N.R., Kaplan L.J., Kara Y., Karamagioli E., Karamarkovia A., Kavalakat A.J., Kechagias A., Kenig J., Khan J.S., Khokha V., Klappenbach R., Kobe Y., Kong V., Korkolis D., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Licari L., Litvin A., Loftus T.J., Lohsiriwat V., Lopes Moreira C.C., Lostoridis E., Luna A.T., Luppi D., Machain G.M., Maegele M., Maggiore D., Maier R.V., Manangi M., Manetti A., Mantoglu B., Mariani F., Marinis A., Sbalcheiro Mariot E.A., Marseglia G.R., Martellucci J., Martines G., Martinez Perez A., Mascagni P., Massalou D., Melo R.B., Miceli L., Mingoli A., Mishra T.S., Mohamedahmed A.Y.Y., Mohan R., Morales-Garcia D., Mustafa S.M.S., Naimzada M.D., Negoi I., Nguyen C., Nidaw M.K., Nigri G., Ogundipe H.D., Oliveri C., Olmi S., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papis D., Pararas N., Pata F., Paterson-Brown S., Pavone G., Pecchini F., Pellino G., Pelloni M., Peloso A., Perea del Pozo E., Goncalves Pereira R., Monteiro Pereira B., Lizarazu Perez A., Perrone G., Pesce A., Petracca G., Piccoli M., Piccolo D., Picetti E., Pikoulis E., Pintar T., Pirozzolo G., Podda M., Previtali P., Privitera F., Punzo C., Quiodettis M.A., Qvist N., Rahim R., Reinisch-Liese A., Rodriguez-Luna M.R., Roizblatt D., Roscio F.P.M., Rossi S., Ruta F., Sakakushev B.E., Salamea J.C., Sall I., Sammartano F., Sanchez Arteaga A., Sanchez-Cordero S., Sasia D., Sawyer R.G., Seretis C., Serradilla-Martin M., Shelat V.G., Shlyapnikov S., Simoes R.L., Siribumrungwong B., Slavchev M., Solaini L., Soldini G., Soreide K., Spada F., Stahel P., Sydorchuk L., Sydorchuk R., Syed A.M., Tallon-Aguilar L., Tan J.H., Tan E., Tarasconi A., Tartaglia D., Tartaglia N., Taylor J., Tebala G.D., Teuben M., Tolonen M., Tomasicchio G., Triantafyllou T., Trigiante G., Turrado-Rodriguez V., Tutino R., Uccelli M., Ugarte-Sierra B., Ukkonen M., Vassiliu P.G., Verde J.M., Veroux M., Vilallonga R., Visconti D., Waledziak M., Wannatoop T., Widmer L.W., Wilson M.S.J., Wong T.H., Xenaki S., Yu B., Yule S., Zakaria A.D., Zambrano D.A., Zese M., HUS Abdominal Center, II kirurgian klinikka, and Helsinki University Hospital Area

Subjects
Ethics, Patient Care Team, Diversity, Acute care surgery, 3126 Surgery, anesthesiology, intensive care, radiology, Trauma surgery, Settore SECS-P/10 - Organizzazione Aziendale, Settore MED/18 - Chirurgia Generale, Settore SECS-P/07 - Economia Aziendale, Surveys and Questionnaires, Emergency Medicine, Humans, Surveys and Questionnaire, Surgery, Team dynamics, Ethic, Team dynamic, Human
Abstract

Background Investigating the context of trauma and acute care surgery, the article aims at understanding the factors that can enhance some ethical aspects, namely the importance of patient consent, the perceptiveness of the ethical role of the trauma leader, and the perceived importance of ethics as an educational subject. Methods The article employs an international questionnaire promoted by the World Society of Emergency Surgery. Results Through the analysis of 402 fully filled questionnaires by surgeons from 72 different countries, the three main ethical topics are investigated through the lens of gender, membership of an academic or non-academic institution, an official trauma team, and a diverse group. In general terms, results highlight greater attention paid by surgeons belonging to academic institutions, official trauma teams, and diverse groups. Conclusions Our results underline that some organizational factors (e.g., the fact that the team belongs to a university context or is more diverse) might lead to the development of a higher sensibility on ethical matters. Embracing cultural diversity forces trauma teams to deal with different mindsets. Organizations should, therefore, consider those elements in defining their organizational procedures. Level of evidence Trauma and acute care teams work under tremendous pressure and complex circumstances, with their members needing to make ethical decisions quickly. The international survey allowed to shed light on how team assembly decisions might represent an opportunity to coordinate team member actions and increase performance.

Published
2022

49. Team dynamics in emergency surgery teams: results from a first international survey

Author

Cobianchi L., Dal Mas F., Massaro M., Fugazzola P., Coccolini F., Kluger Y., Leppaniemi A., Moore E. E., Sartelli M., Angelos P., Ansaloni L., Abdelmalik A., Abebe N. S., Abu-Zidan F. M., Adam Y. A. Y., Adamou H., Agrusa A., Akin E., Alexandrino H., Ali S. M., Almeida P. M., Amico F., Ammendola M., Andreuccetti J., Aparicio-Sanchez D., Ardito A., Argenio G., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bagnoli C., Bains L., Balalis D., Baldini E., Baraket O., Barone M., Barreras J. A., Bellanova G., Biancuzzi H., Bignell M. B., Bini R., Bissacco D., Boati P., Bottari A., Bouliaris K., Brillantino A., Buonomo L. A., Buscemi S., Calu V., Campo Dall'Orto R., Carvas J. M., Casoni Pattacini G., Catena F., Celentano V., Ceresoli M., Chirica M., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colak E., Conti L., Dantas Costa S., D'acapito F., Damaskos D., Das K., Davies R. J., De Beaux A. C., De Simone B., Demetrashvili Z., Demetriades A. K., Denicolai S., Di Buono G., Di Carlo I., Di Saverio S., Diaconescu B., Dibra R., Dios-Barbeito S., Dogjani A., Domanin M., D'Oria M., Duran Munoz-Cruzado V., East B., Ekwen G. T., Elbaih A. H., Escalera-Antezana J. P., Esposito G., Farre R., Ferrario di Tor Vajana A., Cordeiro Fonseca V., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Gachabayov M., Garcia Vazquez A., Ghannam W. M., Gioco R., Giraudo G., Giuffrida M., Giulii Capponi M., Gomes C. A., Teixeira Gonsaga R. A., Gonullu E., Goosen J., Goranovic T., Griffiths E. A., Haidar M. G., Hamid H. K. S., Harddastle T. C., Hecker M., Hernandez Garcia E. F., Cancio Huaman E., Hutan M., Ioannidis O., Isik A., Ismail A. M. H., Ismail N., Jang J. Y., Kalipershad S. N. R., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Kavalakat A. J., Kechagias A., Kenig J., Khan J. S., Khokha V., Klappenbach R. F., Klappenbach R., Kobe Y., Kong V., Korkolis D., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Licari L., Litvin A., Lohsiriwat V., Lopes Moreira C. C., Lostoridis E., Tovar Luna A., Luppi D., Machain G. M., Maegele M., Maggiore D., Maier R. V., Manangi M., Manetti A., Mantoglu B., Mariani F., Marinis A., Sbalcheiro Mariot E. A., Martines G., Martinez Perez A., Mascagni P., Massalou D., Bessa Melo R., Miceli L., Mingoli A., Mishra T. S., Mohamedahmed A. Y. Y., Mohan R., Morales-Garcia D., Mustafa S. M. S., Naimzada M. D., Negoi I., Nidaw M. K., Nigri G., Ogundipe H. D., Oliveri C., Olmi S., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papis D., Pararas N., Pata F., Pavone G., Pecchini F., Pellino G., Pelloni M., Peloso A., Perea Del Pozo E., Goncalves Pereira R., Monteiro Pereira B., Lizarazu Perez A., Perrone G., Pesce A., Petracca G., Piccoli M., Picetti E., Pikoulis E., Pintar T., Pirozzolo G., Podda M., Previtali P., Privitera F., Punzo C., Quiodettis M. A., Qvist N., Rahim R., Reinisch-Liese A., Rodriguez-Luna M. R., Roizblatt D., Roscio F. P. M., Rossi S., Sakakushev B. E., Salamea J. C., Sall I., Sammartano F., Sanchez Arteaga A., Sanchez-Cordero S., Sasia D., Sawyer R. G., Seretis C., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Lages Simoes R., Siribumrungwong B., Slavchev M., Solaini L., Soldini G., Soreide K., Sydorchuk L., Sydorchuk R., Syed A. M., Tallon-Aguilar L., Tan J. H., Tarasconi A., Tartaglia D., Tartaglia N., Taylor J., Tebala G. D., Teuben M., Tolonen M., Tomasicchio G., Triantafyllou T., Trigiante G., Turrado-Rodriguez V., Tutino R., Uccelli M., Ugarte-Sierra B., Ukkonen M., Vassiliu P. G., Verde J. M., Veroux M., Vilallonga R., Visconti D., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Wong T. H., Xenaki S., Yu B., Zakaria A. D., Zambrano D. A., Zese M., Cobianchi, L., Dal Mas, F., Massaro, M., Fugazzola, P., Coccolini, F., Kluger, Y., Leppaniemi, A., Moore, E. E., Sartelli, M., Angelos, P., Ansaloni, L., Abdelmalik, A., Abebe, N. S., Abu-Zidan, F. M., Adam, Y. A. Y., Adamou, H., Agrusa, A., Akin, E., Alexandrino, H., Ali, S. M., Almeida, P. M., Amico, F., Ammendola, M., Andreuccetti, J., Aparicio-Sanchez, D., Ardito, A., Argenio, G., Askevold, I. H., Atanasov, B. T., Augustin, G., Awad, S. S., Bagnoli, C., Bains, L., Balalis, D., Baldini, E., Baraket, O., Barone, M., Barreras, J. A., Bellanova, G., Biancuzzi, H., Bignell, M. B., Bini, R., Bissacco, D., Boati, P., Bottari, A., Bouliaris, K., Brillantino, A., Buonomo, L. A., Buscemi, S., Calu, V., Campo Dall'Orto, R., Carvas, J. M., Casoni Pattacini, G., Catena, F., Celentano, V., Ceresoli, M., Chirica, M., Cianci, P., Cillara, N., Cimbanassi, S., Cioffi, S. P. B., Colak, E., Conti, L., Dantas Costa, S., D'Acapito, F., Damaskos, D., Das, K., Davies, R. J., De Beaux, A. C., De Simone, B., Demetrashvili, Z., Demetriades, A. K., Denicolai, S., Di Buono, G., Di Carlo, I., Di Saverio, S., Diaconescu, B., Dibra, R., Dios-Barbeito, S., Dogjani, A., Domanin, M., D'Oria, M., Duran Munoz-Cruzado, V., East, B., Ekwen, G. T., Elbaih, A. H., Escalera-Antezana, J. P., Esposito, G., Farre, R., Ferrario di Tor Vajana, A., Cordeiro Fonseca, V., Forfori, F., Fortuna, L., Fradelos, E., Fraga, G. P., Fransvea, P., Gachabayov, M., Garcia Vazquez, A., Ghannam, W. M., Gioco, R., Giraudo, G., Giuffrida, M., Giulii Capponi, M., Gomes, C. A., Teixeira Gonsaga, R. A., Gonullu, E., Goosen, J., Goranovic, T., Griffiths, E. A., Haidar, M. G., Hamid, H. K. S., Harddastle, T. C., Hecker, M., Hernandez Garcia, E. F., Cancio Huaman, E., Hutan, M., Ioannidis, O., Isik, A., Ismail, A. M. H., Ismail, N., Jang, J. Y., Kalipershad, S. N. R., Kaplan, L. J., Kara, Y., Karamagioli, E., Karamarkovia, A., Kavalakat, A. J., Kechagias, A., Kenig, J., Khan, J. S., Khokha, V., Klappenbach, R. F., Klappenbach, R., Kobe, Y., Kong, V., Korkolis, D., Kurihara, H., Kuriyama, A., Landaluce-Olavarria, A., Licari, L., Litvin, A., Lohsiriwat, V., Lopes Moreira, C. C., Lostoridis, E., Tovar Luna, A., Luppi, D., Machain, G. M., Maegele, M., Maggiore, D., Maier, R. V., Manangi, M., Manetti, A., Mantoglu, B., Mariani, F., Marinis, A., Sbalcheiro Mariot, E. A., Martines, G., Martinez Perez, A., Mascagni, P., Massalou, D., Bessa Melo, R., Miceli, L., Mingoli, A., Mishra, T. S., Mohamedahmed, A. Y. Y., Mohan, R., Morales-Garcia, D., Mustafa, S. M. S., Naimzada, M. D., Negoi, I., Nidaw, M. K., Nigri, G., Ogundipe, H. D., Oliveri, C., Olmi, S., Pagani, L., Palomba, G., Pantalone, D., Panyko, A., Paolillo, C., Papis, D., Pararas, N., Pata, F., Pavone, G., Pecchini, F., Pellino, G., Pelloni, M., Peloso, A., Perea Del Pozo, E., Goncalves Pereira, R., Monteiro Pereira, B., Lizarazu Perez, A., Perrone, G., Pesce, A., Petracca, G., Piccoli, M., Picetti, E., Pikoulis, E., Pintar, T., Pirozzolo, G., Podda, M., Previtali, P., Privitera, F., Punzo, C., Quiodettis, M. A., Qvist, N., Rahim, R., Reinisch-Liese, A., Rodriguez-Luna, M. R., Roizblatt, D., Roscio, F. P. M., Rossi, S., Sakakushev, B. E., Salamea, J. C., Sall, I., Sammartano, F., Sanchez Arteaga, A., Sanchez-Cordero, S., Sasia, D., Sawyer, R. G., Seretis, C., Serradilla-Martin, M., Shelat, V. G., Shlyapnikov, S., Lages Simoes, R., Siribumrungwong, B., Slavchev, M., Solaini, L., Soldini, G., Soreide, K., Sydorchuk, L., Sydorchuk, R., Syed, A. M., Tallon-Aguilar, L., Tan, J. H., Tarasconi, A., Tartaglia, D., Tartaglia, N., Taylor, J., Tebala, G. D., Teuben, M., Tolonen, M., Tomasicchio, G., Triantafyllou, T., Trigiante, G., Turrado-Rodriguez, V., Tutino, R., Uccelli, M., Ugarte-Sierra, B., Ukkonen, M., Vassiliu, P. G., Verde, J. M., Veroux, M., Vilallonga, R., Visconti, D., Waledziak, M., Wannatoop, T., Widmer, L. W., Wilson, M. S. J., Wong, T. H., Xenaki, S., Yu, B., Zakaria, A. D., Zambrano, D. A., Zese, M., Cobianchi L., Dal Mas F., Massaro M., Fugazzola P., Coccolini F., Kluger Y., Leppaniemi A., Moore E.E., Sartelli M., Angelos P., Ansaloni L., Abdelmalik A., Abebe N.S., Abu-Zidan F.M., Adam Y.A.Y., Adamou H., Agrusa A., Akin E., Alexandrino H., Ali S.M., Almeida P.M., Amico F., Ammendola M., Andreuccetti J., Aparicio-Sanchez D., Ardito A., Argenio G., Askevold I.H., Atanasov B.T., Augustin G., Awad S.S., Bagnoli C., Bains L., Balalis D., Baldini E., Baraket O., Barone M., Barreras J.A., Bellanova G., Biancuzzi H., Bignell M.B., Bini R., Bissacco D., Boati P., Bottari A., Bouliaris K., Brillantino A., Buonomo L.A., Buscemi S., Calu V., Campo Dall'Orto R., Carvas J.M., Casoni Pattacini G., Catena F., Celentano V., Ceresoli M., Chirica M., Cianci P., Cillara N., Cimbanassi S., Cioffi S.P.B., Colak E., Conti L., Dantas Costa S., D'acapito F., Damaskos D., Das K., Davies R.J., De Beaux A.C., De Simone B., Demetrashvili Z., Demetriades A.K., Denicolai S., Di Buono G., Di Carlo I., Di Saverio S., Diaconescu B., Dibra R., Dios-Barbeito S., Dogjani A., Domanin M., D'Oria M., Duran Munoz-Cruzado V., East B., Ekwen G.T., Elbaih A.H., Escalera-Antezana J.P., Esposito G., Farre R., Ferrario di Tor Vajana A., Cordeiro Fonseca V., Forfori F., Fortuna L., Fradelos E., Fraga G.P., Fransvea P., Gachabayov M., Garcia Vazquez A., Ghannam W.M., Gioco R., Giraudo G., Giuffrida M., Giulii Capponi M., Gomes C.A., Teixeira Gonsaga R.A., Gonullu E., Goosen J., Goranovic T., Griffiths E.A., Haidar M.G., Hamid H.K.S., Harddastle T.C., Hecker M., Hernandez Garcia E.F., Cancio Huaman E., Hutan M., Ioannidis O., Isik A., Ismail A.M.H., Ismail N., Jang J.Y., Kalipershad S.N.R., Kaplan L.J., Kara Y., Karamagioli E., Karamarkovia A., Kavalakat A.J., Kechagias A., Kenig J., Khan J.S., Khokha V., Klappenbach R.F., Klappenbach R., Kobe Y., Kong V., Korkolis D., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Licari L., Litvin A., Lohsiriwat V., Lopes Moreira C.C., Lostoridis E., Tovar Luna A., Luppi D., Machain G.M., Maegele M., Maggiore D., Maier R.V., Manangi M., Manetti A., Mantoglu B., Mariani F., Marinis A., Sbalcheiro Mariot E.A., Martines G., Martinez Perez A., Mascagni P., Massalou D., Bessa Melo R., Miceli L., Mingoli A., Mishra T.S., Mohamedahmed A.Y.Y., Mohan R., Morales-Garcia D., Mustafa S.M.S., Naimzada M.D., Negoi I., Nidaw M.K., Nigri G., Ogundipe H.D., Oliveri C., Olmi S., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papis D., Pararas N., Pata F., Pavone G., Pecchini F., Pellino G., Pelloni M., Peloso A., Perea Del Pozo E., Goncalves Pereira R., Monteiro Pereira B., Lizarazu Perez A., Perrone G., Pesce A., Petracca G., Piccoli M., Picetti E., Pikoulis E., Pintar T., Pirozzolo G., Podda M., Previtali P., Privitera F., Punzo C., Quiodettis M.A., Qvist N., Rahim R., Reinisch-Liese A., Rodriguez-Luna M.R., Roizblatt D., Roscio F.P.M., Rossi S., Sakakushev B.E., Salamea J.C., Sall I., Sammartano F., Sanchez Arteaga A., Sanchez-Cordero S., Sasia D., Sawyer R.G., Seretis C., Serradilla-Martin M., Shelat V.G., Shlyapnikov S., Lages Simoes R., Siribumrungwong B., Slavchev M., Solaini L., Soldini G., Soreide K., Sydorchuk L., Sydorchuk R., Syed A.M., Tallon-Aguilar L., Tan J.H., Tarasconi A., Tartaglia D., Tartaglia N., Taylor J., Tebala G.D., Teuben M., Tolonen M., Tomasicchio G., Triantafyllou T., Trigiante G., Turrado-Rodriguez V., Tutino R., Uccelli M., Ugarte-Sierra B., Ukkonen M., Vassiliu P.G., Verde J.M., Veroux M., Vilallonga R., Visconti D., Waledziak M., Wannatoop T., Widmer L.W., Wilson M.S.J., Wong T.H., Xenaki S., Yu B., Zakaria A.D., Zambrano D.A., Zese M., Cobianchi, L, Dal Mas, F, Massaro, M, Fugazzola, P, Coccolini, F, Kluger, Y, Leppaniemi, A, Moore, E, Sartelli, M, Angelos, P, Ansaloni, L, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Agrusa, A, Akin, E, Alexandrino, H, Ali, S, Almeida, P, Amico, F, Ammendola, M, Andreuccetti, J, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bagnoli, C, Bains, L, Balalis, D, Baldini, E, Baraket, O, Barone, M, Barreras, J, Bellanova, G, Biancuzzi, H, Bignell, M, Bini, R, Bissacco, D, Boati, P, Bottari, A, Bouliaris, K, Brillantino, A, Buonomo, L, Buscemi, S, Calu, V, Campo Dall'Orto, R, Carvas, J, Casoni Pattacini, G, Catena, F, Celentano, V, Ceresoli, M, Chirica, M, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colak, E, Conti, L, Dantas Costa, S, D'Acapito, F, Damaskos, D, Das, K, Davies, R, De Beaux, A, De Simone, B, Demetrashvili, Z, Demetriades, A, Denicolai, S, Di Buono, G, Di Carlo, I, Di Saverio, S, Diaconescu, B, Dibra, R, Dios-Barbeito, S, Dogjani, A, Domanin, M, D'Oria, M, Duran Munoz-Cruzado, V, East, B, Ekwen, G, Elbaih, A, Escalera-Antezana, J, Esposito, G, Farre, R, Ferrario di Tor Vajana, A, Cordeiro Fonseca, V, Forfori, F, Fortuna, L, Fradelos, E, Fraga, G, Fransvea, P, Gachabayov, M, Garcia Vazquez, A, Ghannam, W, Gioco, R, Giraudo, G, Giuffrida, M, Giulii Capponi, M, 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Subjects
RD1-811, media_common.quotation_subject, education, Trauma leaders, Context (language use), Knowledge translation, Trauma leader, Trauma teams, Knowledge translation, Team dynamics, Non-technical skills, Trauma leaders, Settore SECS-P/07 - Economia Aziendale, Multidisciplinary approach, Surveys and Questionnaires, Health care, Medicine, Humans, Non-technical skill, knowledge translation, non-technical skills, team dynamics, trauma leaders, trauma teams, humans, surveys and questionnaires, patient care team, Function (engineering), Trauma teams, Non-technical skills, media_common, Patient Care Team, Medical education, Teamwork, RC86-88.9, business.industry, Team dynamics, Correction, Medical emergencies. Critical care. Intensive care. First aid, Checklist, Emergency Medicine, Surgery, The Internet, Team dynamic, business, Trauma team, Research Article
Abstract

Background Emergency surgery represents a unique context. Trauma teams are often multidisciplinary and need to operate under extreme stress and time constraints, sometimes with no awareness of the trauma’s causes or the patient’s personal and clinical information. In this perspective, the dynamics of how trauma teams function is fundamental to ensuring the best performance and outcomes. Methods An online survey was conducted among the World Society of Emergency Surgery members in early 2021. 402 fully filled questionnaires on the topics of knowledge translation dynamics and tools, non-technical skills, and difficulties in teamwork were collected. Data were analyzed using the software R, and reported following the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Results Findings highlight how several surgeons are still unsure about the meaning and potential of knowledge translation and its mechanisms. Tools like training, clinical guidelines, and non-technical skills are recognized and used in clinical practice. Others, like patients’ and stakeholders’ engagement, are hardly implemented, despite their increasing importance in the modern healthcare scenario. Several difficulties in working as a team are described, including the lack of time, communication, training, trust, and ego. Discussion Scientific societies should take the lead in offering training and support about the abovementioned topics. Dedicated educational initiatives, practical cases and experiences, workshops and symposia may allow mitigating the difficulties highlighted by the survey’s participants, boosting the performance of emergency teams. Additional investigation of the survey results and its characteristics may lead to more further specific suggestions and potential solutions.

Published
2021

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