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40 results on '"Wong, Siu Hong Dexter"'

7. An Aggregation-Induced Emission-Based Dual Emitting Nanoprobe for Detecting Intracellular pH and Unravelling Metabolic Variations in Differentiating Lymphocytes

Author

Huang, Yingying, primary, Zhang, Qin, additional, Lam, Ching Ying Katherine, additional, Li, Chuanqi, additional, Yang, Chen, additional, Zhong, Zhiming, additional, Zhang, Ruolin, additional, Yan, Jiaxiang, additional, Chen, Jiareng, additional, Yin, Bohan, additional, Wong, Siu Hong Dexter, additional, and Yang, Mo, additional

Published
2024
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9. Nucleic Acid Armor: Fortifying RNA Therapeutics through Delivery and Targeting Innovations for Immunotherapy.

Author

Jiang, Yi, Jiang, Bolong, Wang, Zhenru, Li, Yuxi, Cheung, James Chung Wai, Yin, Bohan, and Wong, Siu Hong Dexter

Subjects
CYTOCHEMISTRY, GENETIC vectors, CELL receptors, T cells, CLICK chemistry
Abstract

RNA is a promising nucleic acid-based biomolecule for various treatments because of its high efficacy, low toxicity, and the tremendous availability of targeting sequences. Nevertheless, RNA shows instability and has a short half-life in physiological environments such as the bloodstream in the presence of RNAase. Therefore, developing reliable delivery strategies is important for targeting disease sites and maximizing the therapeutic effect of RNA drugs, particularly in the field of immunotherapy. In this mini-review, we highlight two major approaches: (1) delivery vehicles and (2) chemical modifications. Recent advances in delivery vehicles employ nanotechnologies such as lipid-based nanoparticles, viral vectors, and inorganic nanocarriers to precisely target specific cell types to facilitate RNA cellular entry. On the other hand, chemical modification utilizes the alteration of RNA structures via the addition of covalent bonds such as N-acetylgalactosamine or antibodies (antibody–oligonucleotide conjugates) to target specific receptors of cells. The pros and cons of these technologies are enlisted in this review. We aim to review nucleic acid drugs, their delivery systems, targeting strategies, and related chemical modifications. Finally, we express our perspective on the potential combination of RNA-based click chemistry with adoptive cell therapy (e.g., B cells or T cells) to address the issues of short duration and short half-life associated with antibody–oligonucleotide conjugate drugs. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Magnetic-responsive upconversion luminescence resonance energy transfer (LRET) biosensor for ultrasensitive detection of SARS-CoV-2 spike protein

Author

Chen, Jiareng, primary, Ho, Willis Kwun Hei, additional, Yin, Bohan, additional, Zhang, Qin, additional, Li, Chuanqi, additional, Yan, Jiaxiang, additional, Huang, Yingying, additional, Hao, Jianhua, additional, Yi, Changqing, additional, Zhang, Yu, additional, Wong, Siu Hong Dexter, additional, and Yang, Mo, additional

Published
2023
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15. A Multilayered Mesoporous Gold Nanoarchitecture for Ultraeffective Near‐Infrared Light‐Controlled Chemo/Photothermal Therapy for Cancer Guided by SERS Imaging (Small 6/2023)

Author

Yin, Bohan, primary, Ho, Willis Kwun Hei, additional, Xia, Xinyue, additional, Chan, Cecilia Ka Wing, additional, Zhang, Qin, additional, Ng, Yip Ming, additional, Lam, Ching Ying Katherine, additional, Cheung, James Chung Wai, additional, Wang, Jianfang, additional, Yang, Mo, additional, and Wong, Siu Hong Dexter, additional

Published
2023
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18. Smart Skin‐Adhesive Patches: From Design to Biomedical Applications

Author

Wong, Siu Hong Dexter, primary, Deen, G. Roshan, additional, Bates, Jeffrey S., additional, Maiti, Chiranjit, additional, Lam, Ching Ying Katherine, additional, Pachauri, Abhishek, additional, AlAnsari, Renad, additional, Bělský, Petr, additional, Yoon, Jinhwan, additional, and Dodda, Jagan Mohan, additional

Published
2023
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19. An AIEgen/graphene oxide nanocomposite (AIEgen@GO)‐based two‐stage “turn‐on” nucleic acid biosensor for rapid detection of SARS‐CoV‐2 viral sequence

Author

Zhang, Qin, primary, Yin, Bohan, additional, Hao, Jianhua, additional, Ma, Linjie, additional, Huang, Yingying, additional, Shao, Xueying, additional, Li, Chuanqi, additional, Chu, Zhiqin, additional, Yi, Changqing, additional, Wong, Siu Hong Dexter, additional, and Yang, Mo, additional

Published
2022
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20. The Effect of the Nanoparticle Shape on T Cell Activation

Author

Oh, Jiwon, primary, Xia, Xingyu, additional, Wong, Wai Ki Ricky, additional, Wong, Siu Hong Dexter, additional, Yuan, Weihao, additional, Wang, Haixing, additional, Lai, Chun Him Nathanael, additional, Tian, Ye, additional, Ho, Yi‐Ping, additional, Zhang, Honglu, additional, Zhang, Yuan, additional, Li, Gang, additional, Lin, Yuan, additional, and Bian, Liming, additional

Published
2022
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24. A CRISPR-Cas12a integrated SERS nanoplatform with chimeric DNA/RNA hairpin guide for ultrasensitive nucleic acid detection

Author

Yin, Bohan, primary, Zhang, Qin, additional, Xia, Xinyue, additional, Li, Chuanqi, additional, Ho, Willis Kwun Hei, additional, Yan, Jiaxiang, additional, Huang, Yingying, additional, Wu, Honglian, additional, Wang, Pui, additional, Yi, Changqing, additional, Hao, Jianhua, additional, Wang, Jianfang, additional, Chen, Honglin, additional, Wong, Siu Hong Dexter, additional, and Yang, Mo, additional

Published
2022
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27. Manipulation of the Nanoscale Presentation of Integrin Ligand Produces Cancer Cells with Enhanced Stemness and Robust Tumorigenicity

Author

Wong, Siu Hong Dexter, primary, Xu, Xiao, additional, Chen, Xi, additional, Xin, Ying, additional, Xu, Limei, additional, Lai, Chun Him Nathanael, additional, Oh, Jiwon, additional, Wong, Wai Ki Ricky, additional, Wang, Xuemei, additional, Han, Shisong, additional, You, Wenxing, additional, Shuai, Xintao, additional, Wong, Nathalie, additional, Tan, Youhua, additional, Duan, Li, additional, and Bian, Liming, additional

Published
2021
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32. Intrapulmonary Cellular-Level Distribution of Inhaled Nanoparticles with Defined Functional Groups and Its Correlations with Protein Corona and Inflammatory Response

Author

Yin, Bohan, primary, Chan, Cecilia Ka Wing, additional, Liu, Shaorui, additional, Hong, Huiling, additional, Wong, Siu Hong Dexter, additional, Lee, Leo Kit Cheung, additional, Ho, Lok Wai Cola, additional, Zhang, Lei, additional, Leung, Ken Cham-Fai, additional, Choi, Paul Cheung-Lung, additional, Bian, Liming, additional, Tian, Xiao Yu, additional, Chan, Man Nin, additional, and Choi, Chung Hang Jonathan, additional

Published
2019
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35. Anisotropic Nanoscale Presentation of Cell Adhesion Ligand Enhances the Recruitment of Diverse Integrins in Adhesion Structures and Mechanosensing‐Dependent Differentiation of Stem Cells

Author

Wong, Siu Hong Dexter, primary, Yin, Bohan, additional, Yang, Boguang, additional, Lin, Sien, additional, Li, Rui, additional, Feng, Qian, additional, Yang, Hongrong, additional, Zhang, Lei, additional, Yang, Zhengmeng, additional, Li, Gang, additional, Choi, Chung Hang Jonathan, additional, and Bian, Liming, additional

Published
2019
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37. Biomimetic Presentation of Cryptic Ligands viaSingle-Chain Nanogels for Synergistic Regulation of Stem Cells

Author

Chen, Xiaoyu, Lai, Nathanael Chun-Him, Wei, Kongchang, Li, Rui, Cui, Miao, Yang, Boguang, Wong, Siu Hong Dexter, Deng, Yingrui, Li, Jiashen, Shuai, Xintao, and Bian, Liming

Abstract

Dynamic controlling the nanoscale presentation of synergistic ligands to stem cells by biomimetic single-chain materials can provide critical insights to understand the molecular crosstalk underlying cells and their extracellular matrix. Here, a stimuli-responsive single-chain macromolecular nanoregulator with conformational dynamics is fabricated based on an advanced scale-up single polymeric chain nanogel (SCNG). Such a carefully designed SCNG is capable of mediating a triggered copresentation of the master and cryptic ligands in a single molecule to elicit the synergistic crosstalk between different intracellular signaling pathways, thereby considerably boosting the bioactivity of the presented ligands. This controllable nanoswitching-on of cell-adhesive ligands’ presentation allows the regulation of cell adhesion and fate from molecular scale. The modular nature of this synthetic macromolecular nanoregulator makes it a versatile nanomaterial platform to assist basic and fundamental studies in a wide array of research topics.

Published
2020
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38. Organic Semiconducting Polymer Nanoparticles for Photoacoustic Labeling and Tracking of Stem Cells in the Second Near-Infrared Window

Author

Yin, Chao, Wen, Guohua, Liu, Chao, Yang, Boguang, Lin, Sien, Huang, Jiawei, Zhao, Pengchao, Wong, Siu Hong Dexter, Zhang, Kunyu, Chen, Xiaoyu, Li, Gang, Jiang, Xiaohua, Huang, Jianping, Pu, Kanyi, Wang, Lidai, and Bian, Liming

Abstract

Photoacoustic (PA) imaging and tracking of stem cells plays an important role in the real-time assessment of cell-based therapies. Nevertheless, the limitations of conventional inorganic PA contrast agents and the narrow range of the excitation wavelength in the first near-infrared (NIR-I) window hamper the applications of PA imaging in living subjects. Herein, we report the design and synthesis of a second near-infrared (NIR-II) absorptive organic semiconducting polymer (OSP)-based nanoprobe (OSPN+) for PA imaging and tracking of stem cells. Comparison studies in biological tissue show that NIR-II light excited PA imaging of the OSPN+has significantly higher signal-to-noise ratio than NIR-I light excited PA imaging, thereby demonstrating the superiority of the OSPN+for deep tissue imaging. With good biocompatibility, appropriate size, and optimized surface property, the OSPN+shows enhanced cellular uptake for highly efficient PA labeling of stem cells. In vivoinvestigations reveal significant NIR-II PA contrast enhancement of the transplanted OSPN+-labeled human mesenchymal stem cells by 40.6- and 21.7-fold in subcutaneous and brain imaging, respectively, compared with unlabeled cases. Our work demonstrates a class of OSP-based nanomaterials for NIR-II PA stem cell imaging to facilitate a better understanding and evaluation of stem cell-based therapies.

Published
2018
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39. Optofluidic chip with directly printed polymer optical waveguide Mach-Zehnder interferometer sensors for label-free biodetection.

Author

Wang H, Chen Z, Li T, Xie H, Yin B, Wong SHD, Shi Y, and Zhang AP

Abstract

Optofluidic devices hold great promise in biomedical diagnostics and testing because of their advantages of miniaturization, high sensitivity, high throughput, and high scalability. However, conventional silicon-based photonic chips suffer from complicated fabrication processes and less flexibility in functionalization, thus hindering their development of cost-effective biomedical diagnostic devices for daily tests and massive applications in responding to public health crises. In this paper, we present an optofluidic chip based on directly printed polymer optical waveguide Mach-Zehnder interferometer (MZI) sensors for label-free biomarker detection. With digital ultraviolet lithography technology, high-sensitivity asymmetric MZI microsensors based on a width-tailored optical waveguide are directly printed and vertically integrated with a microfluidic layer to make an optofluidic chip. Experimental results show that the sensitivity of the directly printed polymer optical waveguide MZI sensor is about 1695.95 nm/RIU. After being modified with capture molecules, i.e., goat anti-human immunoglobulin G (IgG), the polymer optical waveguide MZI sensors can on-chip detect human IgG at the concentration level of 1.78 pM. Such a polymer optical waveguide-based optofluidic chip has the advantages of miniaturization, cost-effectiveness, high sensitivity, and ease in functionalization and thus has great potential in the development of daily available point-of-care diagnostic and testing devices., Competing Interests: There are no conflicts to declare., (© 2024 Optica Publishing Group.)

Published
2024
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40. The Interplay Between Epigenetic Regulation and CD8 + T Cell Differentiation/Exhaustion for T Cell Immunotherapy.

Author

Wong WK, Yin B, Lam CYK, Huang Y, Yan J, Tan Z, and Wong SHD

Abstract

Effective immunotherapy treats cancers by eradicating tumourigenic cells by activated tumour antigen-specific and bystander CD8 + T-cells. However, T-cells can gradually lose cytotoxicity in the tumour microenvironment, known as exhaustion. Recently, DNA methylation, histone modification, and chromatin architecture have provided novel insights into epigenetic regulations of T-cell differentiation/exhaustion, thereby controlling the translational potential of the T-cells. Thus, developing strategies to govern epigenetic switches of T-cells dynamically is critical to maintaining the effector function of antigen-specific T-cells. In this mini-review, we 1) describe the correlation between epigenetic states and T cell phenotypes; 2) discuss the enzymatic factors and intracellular/extracellular microRNA imprinting T-cell epigenomes that drive T-cell exhaustion; 3) highlight recent advances in epigenetic interventions to rescue CD8 + T-cell functions from exhaustion. Finally, we express our perspective that regulating the interplay between epigenetic changes and transcriptional programs provides translational implications of current immunotherapy for cancer treatments., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Wong, Yin, Lam, Huang, Yan, Tan and Wong.)

Published
2022
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