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Objectives Biphasic calcium phosphate ( BCP) composed of 10% hydroxyapatite ( HA) and 90% beta-tricalcium phosphate has been developed. Recently, a strontium hydroxyapatite-containing collagen membrane ( Sr) was shown to stimulate early bone formation in rat calvarial defects at 4 weeks postoperatively, as compared with a cross-linked collagen membrane, for guided bone regeneration ( GBR). The objective of this study was to evaluate these novel biomaterials for GBR in relation to a non-cross-linked collagen membrane ( BG) and deproteinized bovine bone mineral ( BO). Materials and methods Twenty New Zealand rabbits were used in this study. Four defects of 7 mm in diameter were created in each rabbit, and three of the defects were treated with BG/ BO, Sr/ BO, and Sr/ BCP. Ten rabbits were sacrificed at 12 and 24 weeks, respectively. Histological and histomorphometric analyses were conducted. Volumetric densities of mineralized new bone ( MNB), bone marrow ( BM), residual grafting material ( RG), and non-mineralized connective tissue ( NCT) were determined for each group. Results After 12 weeks, Sr/ BCP yielded more MNB than BG/ BO and Sr/ BO with no significant difference among the three groups. After 24 weeks, however, Sr/ BCP demonstrated significantly more MNB than BG/ BO and Sr/ BO. Both after 12 and 24 weeks, Sr/ BCP showed significantly less RG than BG/ BO and Sr/ BO. There was a significant increase in MNB in Sr/ BCP from 12 to 24 weeks. Conclusions In defects grafted with BCP, more MNB was formed while less RG remained, than in defects grafted with BO. The Sr membrane was as effective as BG when comparing Sr/ BO with BG/ BO. [ABSTRACT FROM AUTHOR]