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5. Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns

Author

Dreval, Kostiantyn, Hilton, Laura K., Cruz, Manuela, Shaalan, Haya, Ben-Neriah, Susana, Boyle, Merrill, Collinge, Brett, Coyle, Krysta M., Duns, Gerben, Farinha, Pedro, Grande, Bruno M., Meissner, Barbara, Pararajalingam, Prasath, Rushton, Christopher K., Slack, Graham W., Wong, Jasper, Mungall, Andrew J., Marra, Marco A., Connors, Joseph M., Steidl, Christian, Scott, David W., and Morin, Ryan D.

Published
2023
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8. Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma

Author

Thomas, Nicole, Dreval, Kostiantyn, Gerhard, Daniela S., Hilton, Laura K., Abramson, Jeremy S., Ambinder, Richard F., Barta, Stefan, Bartlett, Nancy L., Bethony, Jeffrey, Bhatia, Kishor, Bowen, Jay, Bryan, Anthony C., Cesarman, Ethel, Casper, Corey, Chadburn, Amy, Cruz, Manuela, Dittmer, Dirk P., Dyer, Maureen A., Farinha, Pedro, Gastier-Foster, Julie M., Gerrie, Alina S., Grande, Bruno M., Greiner, Timothy, Griner, Nicholas B., Gross, Thomas G., Harris, Nancy L., Irvin, John D., Jaffe, Elaine S., Henry, David, Huppi, Rebecca, Leal, Fabio E., Lee, Michael S., Martin, Jean Paul, Martin, Marie-Reine, Mbulaiteye, Sam M., Mitsuyasu, Ronald, Morris, Vivian, Mullighan, Charles G., Mungall, Andrew J., Mungall, Karen, Mutyaba, Innocent, Nokta, Mostafa, Namirembe, Constance, Noy, Ariela, Ogwang, Martin D., Omoding, Abraham, Orem, Jackson, Ott, German, Petrello, Hilary, Pittaluga, Stefania, Phelan, James D., Ramos, Juan Carlos, Ratner, Lee, Reynolds, Steven J., Rubinstein, Paul G., Sissolak, Gerhard, Slack, Graham, Soudi, Shaghayegh, Swerdlow, Steven H., Traverse-Glehen, Alexandra, Wilson, Wyndham H., Wong, Jasper, Yarchoan, Robert, ZenKlusen, Jean C., Marra, Marco A., Staudt, Louis M., Scott, David W., and Morin, Ryan D.

Published
2023
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17. Sector-Based Regression Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography

Author

Liu, Keke, primary, You, Qi Sheng, additional, Chen, Aiyin, additional, Choi, Dongseok, additional, White, Elizabeth, additional, Chan, Jonathan C. H., additional, Choy, Bonnie N. K., additional, Shih, Kendrick C., additional, Wong, Jasper K. W., additional, Ng, Alex L. K., additional, Cheung, Janice J. C., additional, Ni, Michael Y., additional, Lai, Jimmy S. M., additional, Leung, Gabriel M., additional, Wong, Ian Y. H., additional, Huang, David, additional, and Tan, Ou, additional

Published
2023
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19. Relapse Timing Is Associated With Distinct Evolutionary Dynamics in Diffuse Large B-Cell Lymphoma

Author

Hilton, Laura K., primary, Ngu, Henry S., additional, Collinge, Brett, additional, Dreval, Kostiantyn, additional, Ben-Neriah, Susana, additional, Rushton, Christopher K., additional, Wong, Jasper C.H., additional, Cruz, Manuela, additional, Roth, Andrew, additional, Boyle, Merrill, additional, Meissner, Barbara, additional, Slack, Graham W., additional, Farinha, Pedro, additional, Craig, Jeffrey W., additional, Gerrie, Alina S., additional, Freeman, Ciara L., additional, Villa, Diego, additional, Rodrigo, Judith A., additional, Song, Kevin, additional, Crump, Michael, additional, Shepherd, Lois, additional, Hay, Annette E., additional, Kuruvilla, John, additional, Savage, Kerry J., additional, Kridel, Robert, additional, Karsan, Aly, additional, Marra, Marco A., additional, Sehn, Laurie H., additional, Steidl, Christian, additional, Morin, Ryan D., additional, and Scott, David W., additional

Published
2023
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20. Genetic Subdivisions of Follicular Lymphoma Defined by Distinct Coding and non-coding Mutation Patterns

Author

Dreval, Kostiantyn, primary, Hilton, Laura K, additional, Cruz, Manuela, additional, Shaalan, Haya, additional, Ben-Neriah, Susana, additional, Boyle, Merrill, additional, Collinge, Brett J, additional, Coyle, Krysta Mila, additional, Duns, Gerben, additional, Farinha, Pedro, additional, Grande, Bruno, additional, Meissner, Barbara, additional, Pararajalingam, Prasath, additional, Rushton, Christopher K, additional, Slack, Graham W., additional, Wong, Jasper Chun Hei, additional, Mungall, Andrew J, additional, Marra, Marco A, additional, Connors, Joseph M, additional, Steidl, Christian, additional, Scott, David W., additional, and Morin, Ryan D, additional

Published
2023
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23. Relapse timing is associated with distinct evolutionary dynamics in DLBCL

Author

Hilton, Laura K., primary, Ngu, Henry S., additional, Collinge, Brett, additional, Dreval, Kostiantyn, additional, Ben-Neriah, Susana, additional, Rushton, Christopher K., additional, Wong, Jasper C.H., additional, Cruz, Manuela, additional, Roth, Andrew, additional, Boyle, Merrill, additional, Meissner, Barbara, additional, Slack, Graham W., additional, Farinha, Pedro, additional, Craig, Jeffrey W., additional, Gerrie, Alina S., additional, Freeman, Ciara L., additional, Villa, Diego, additional, Crump, Michael, additional, Shepherd, Lois, additional, Hay, Annette E., additional, Kuruvilla, John, additional, Savage, Kerry J., additional, Kridel, Robert, additional, Karsan, Aly, additional, Marra, Marco A., additional, Sehn, Laurie H., additional, Steidl, Christian, additional, Morin, Ryan D., additional, and Scott, David W., additional

Published
2023
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27. Towards a Unified Genetic Classification System for Diffuse Large B-Cell Lymphoma (DLBCL)

Author

Dreval, Kostiantyn, primary, Hilton, Laura K, additional, Coyle, Krysta M., additional, Wong, Jasper, additional, Boyle, Merrill, additional, Collinge, Brett, additional, Cruz, Manuela, additional, Meissner, Barbara, additional, Rushton, Christopher K, additional, Marra, Marco A., additional, Scott, David W., additional, Steidl, Christian, additional, and Morin, Ryan D., additional

Published
2022
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28. Recurrent Copy Number Alterations Contribute to a Unique Genetic Landscape in Relapsed-Refractory DLBCL

Author

Rushton, Christopher K, primary, Rys, Ryan N, additional, Chavez, Elizabeth, additional, Hilton, Laura K, additional, Alcaide, Miguel, additional, Dreval, Kostiantyn, additional, Cheung, Matthew, additional, Cruz, Manuela, additional, Coyle, Krysta M., additional, Meissner, Barbara, additional, Ben-Neriah, Susana, additional, Michaud, Neil R., additional, Daigle, Scott, additional, Davidson, Jordan, additional, Wong, Jasper, additional, Hay, Annette E., additional, Jain, Michael D., additional, Shepherd, Lois E., additional, Marra, Marco A., additional, Kuruvilla, John, additional, Crump, Michael, additional, Mann, Koren Kathleen, additional, Assouline, Sarit, additional, Steidl, Christian, additional, Scott, David W., additional, Johnson, Nathalie A., additional, and Morin, Ryan D., additional

Published
2022
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29. Relapse Timing Is Associated with Distinct Evolutionary Dynamics and Response to Salvage Therapy in DLBCL

Author

Hilton, Laura K, primary, Ngu, Henry S., additional, Collinge, Brett, additional, Dreval, Kostiantyn, additional, Ben-Neriah, Susana, additional, Rushton, Christopher K, additional, Wong, Jasper, additional, Cruz, Manuela, additional, Roth, Andrew, additional, Boyle, Merrill, additional, Meissner, Barbara, additional, Slack, Graham W., additional, Farinha, Pedro, additional, Craig, Jeffrey W., additional, Gerrie, Alina S., additional, Freeman, Ciara L., additional, Villa, Diego, additional, Savage, Kerry J., additional, Sehn, Laurie H., additional, Marra, Marco A., additional, Karsan, Aly, additional, Steidl, Christian, additional, Morin, Ryan D., additional, and Scott, David W., additional

Published
2022
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30. Genetic Determinants of Isolated and Systemic Testicular Diffuse Large B-Cell Lymphoma Highlight a Disease Spectrum

Author

Wong, Jasper, primary, Collinge, Brett, additional, Hilton, Laura K, additional, Ben-Neriah, Susana, additional, Boyle, Merrill, additional, Meissner, Barbara, additional, Mekwunye, Kelly, additional, Slack, Graham W., additional, Farinha, Pedro, additional, Craig, Jeffrey W., additional, Sehn, Laurie H., additional, Villa, Diego, additional, Gerrie, Alina S., additional, Mungall, Andrew J., additional, Steidl, Christian, additional, Cook, James R., additional, Feldman, Andrew L., additional, Rimsza, Lisa M., additional, Savage, Kerry J., additional, Morin, Ryan D., additional, and Scott, David W., additional

Published
2022
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31. Evaluation of Adverse Effects of Topical Glaucoma Medications on Trabeculectomy Outcomes Using the Glaucoma Medications Intensity Index

Author

Wong, Jasper Ka Wai, Leung, Tsz Kin, Lai, Jimmy Shiu-ming, and Chan, Jonathan Cheuk-hung

Subjects
Ophthalmology, genetic structures, Filtration surgery outcome, Glaucoma medications, sense organs, Trabeculectomy outcome, Medication exposure, eye diseases, Treatment intensity, Original Research
Abstract

Introduction Trabeculectomy is commonly performed for glaucoma when medications are unable to control disease progression or have intolerable adverse effects. Previous studies have suggested that a higher number of and/or longer treatment duration with preoperative topical glaucoma medications are associated with a higher risk of trabeculectomy failure, but most of these studies lack quantification of exposure. The aim of this study was to investigate the relationship between preoperative exposure to topical glaucoma medications and trabeculectomy outcome, using a new method for quantifying accumulated exposure. Methods Consecutive patients with primary open-angle glaucoma (POAG) or normal-tension glaucoma (NTG) who underwent primary trabeculectomy between 2013 and 2017 were retrospectively reviewed. The Glaucoma Medications Intensity Index (GMII) was calculated for each eye by multiplying the number of drops per week by duration of use (in years). The relationship between the GMII and postoperative outcome in terms of 1- and 2-year success rates and survival time was analyzed. Results A total of 55 eyes from 40 subjects were analyzed, all with follow-up > 6 months (mean 2.72 ± 1.46 years). The GMII for eyes with successful (n = 41) and failed (n = 14) outcome at last visit was 111.71 ± 78.59 and 167.41 ± 85.04, respectively, and significantly higher in failed eyes (P = 0.03). Univariate regression analysis of age, gender, cup–disc ratio, previous phacoemulsification, diabetes, hypertension, dyslipidemia, preoperative number of glaucoma medications/treatment duration/intraocular pressure (IOP), and GMII showed age and GMII to be possible predictors of treatment failure. On subsequent multivariate analysis, only GMII was correlated with failure (odds ratio 1.021, 95% confidence interval 1.00–1.05; P = 0.05). When GMII ≥ 80, the postoperative survival time was shorter (P = 0.02), the 1-year IOP, number of glaucoma medications, and number of needlings performed were higher (P = 0.03, P

Published
2021

32. Regression-Based Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography

Author

Liu, Keke, primary, Tan, Ou, additional, You, Qi Sheng, additional, Chen, Aiyin, additional, Chan, Jonathan C. H., additional, Choy, Bonnie N. K., additional, Shih, Kendrick C., additional, Wong, Jasper K. W., additional, Ng, Alex L. K., additional, Cheung, Janice J. C., additional, Ni, Michael Y., additional, Lai, Jimmy S. M., additional, Leung, Gabriel M., additional, Liu, Liang, additional, Huang, David, additional, and Wong, Ian Y. H., additional

Published
2022
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33. Abstract A12: Pervasive hypermutation of super-enhancer regions dysregulates oncogene expression in diffuse large B-cell lymphoma

Author

Bal, Elodie, primary, Kumar, Rahul, additional, Hadigol, Mohammad, additional, Holmes, Antony B., additional, Hilton, Laura K., additional, Loh, Jui Wan, additional, Dreval, Kostiantyn, additional, Wong, Jasper, additional, Vlasevska, Sofija, additional, Corinaldesi, Clarissa, additional, Soni, Rajesh Kumar Soni, additional, Basso, Katia, additional, Morin, Ryan D., additional, Khiabanian, Hossein, additional, Pasqualucci, Laura, additional, and Dalla-Favera, Riccardo, additional

Published
2022
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39. Engineering Outreach: A Successful Initiative with Gifted Students in Science and Technology in Hong Kong

Author

Chan, Yuen-Yan, Hui, Diane, Dickinson, Anthony R., Chu, Dennis, Cheng, David Ki-Wai, Cheung, Edward, Ki, Wing-Hung, Lau, Wing-Hong, Wong, Jasper, Lo, Edward W. C., and Luk, Kwai-Man

Abstract

The primary goal of engineering outreach is to attract prospective students to engineering education and the engineering profession. Gifted students, especially those identified as possessing unusually high abilities in science and technology, are especially promising students to attract to careers in engineering. It is critical to cultivate these students' interests and develop their potential for engineering while encouraging them to pursue engineering studies beyond K-12 education. This article presents examples of the successful learning outcomes of an ongoing University-based Electronics Technology Project Study (UETPS) program, a joint endeavor between the IEEE Hong Kong Section, the Education Bureau of the Hong Kong SAR Government, and the Hong Kong Academy of Gifted Education (HKAGE). The UETPS program promotes electrical, electronic, and computer engineering education in Hong Kong and is aimed particularly at gifted students as well as their parents, teachers, and schools. Project applicants underwent formal identification procedures by the Gifted Education Section of the HKSAR Education Bureau and were identified as being gifted in the area of science and technology. Selected participants then participated in one-year research projects in electronics and computer engineering under the guidance of university professors in their respective engineering departments. This program addresses an urgent need of the engineering education sector by reaching out to highly talented K-12 students and their surrounding communities. According to the evaluation results, the UETPS program has significantly enhanced the participating students' interest in engineering as a career choice and encouraged them to pursue undergraduate studies in engineering. This article also discusses lessons learned and proposes strategies for future potential implementers. (Contains 3 tables and 5 figures.)

Published
2010
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41. An Open-Source Toolkit That Powers the Genome-Wide Analysis of Mature B-Cell Lymphomas (GAMBL) Project

Author

Dreval, Kostiantyn, Grande, Bruno, Winata, Helena, Wong, Jasper, Sethi, Lakshay, Rushton, Christopher, Pararajalingam, Prasath, Arthur, Sarah, Chong, Lauren C., Collinge, Brett, Coyle, Krysta, Cruz, Manuela, Hung, Stacy, Soudi, Shaghayegh, Thomas, Nicole, Steidl, Christian, Scott, David, Morin, Ryan, and Hilton, Laura

Abstract

Introduction: Genome- and transcriptome-wide analyses continue to enhance our understanding of the molecular pathogenesis of cancer. In lymphomas, this has enabled the identification of hundreds of recurrently mutated genes, highlighting genetic heterogeneity and relationships both within and among clinical entities. While the growing availability of lymphoma genomic data sets can be leveraged to integrate genomic analyses into diagnostic testing and clinical trials, the ability to rapidly process genomic data sets in a reproducible manner serves as a barrier to this goal. To this end, we developed a suite of tools Lymphoid Cancer Research modules (LCR-modules) to facilitate the discovery of novel drivers and molecular features in lymphoma cancers and perform quantitative comparisons between disease entities. We demonstrate here how this toolkit enabled a meta-analysis of lymphoma genomic data involving genome-wide profiles of 3330 patients. Methods: We assembled a collection of whole genome, whole exome, and RNA sequencing data from a combination of controlled-access repositories and ongoing projects at BC Cancer. The scope of genomic analysis of mature B-cell lymphomas (GAMBL) project includes cell lines and patient tumors from all common mature B cell neoplasms, comprising a total of 4612 samples from 3330 patients. To facilitate the project, we developed a suite of open-source and custom bioinformatics tools (https://github.com/LCR-BCCRC/lcr-modules) that leverages the Snakemake workflow management system and includes lymphoma-centric modules for the discovery and annotation of common mutation types, analysis of B-cell receptor repertoires and discovery of novel aSHM targets and relevant non-coding mutations, and RNA-seq analysis with batch correction and normalization. Individual modules are configured to create an automated, scalable, and reproducible workflow that runs each step as dictated by the availability of new data. The cohort-level integrative analysis and comparisons across entities are handled by our custom R package GAMBLR, which facilitates open-ended data analysis and custom visualizations. Results: Simple somatic mutations (SSM) were detected using a workflow that utilizes four algorithms to identify high-confidence variants with validated default thresholds for filtering of germline variants and common FFPE-associated artifacts, allowing for processing of samples without matched normal tissue. This automated and reproducible workflow facilitated the discovery of novel genes significantly mutated across lymphomas and broadened our understanding of the scope of aberrant somatic hypermutation (aSHM) and other non-coding mutations. Specifically, HNRNPU, STAT3, TFAP4, RRAGC were found to be mutated at relatively low frequencies, and their presence is a distinct feature of certain lymphomas or novel genetic subgroups within lymphoma types (Figure 1A). The aSHM analysis and discovery of novel hypermutated regions is handled by a custom tool Rainstorm. As a result, we were able to detect sites preferentially hypermutated in a single entity, such as the transcription start site of BACH2, mutated at lower rates than the other common target sites but significantly more in BL compared to other entities (Figure 1B). Combining aSHM at target sites discovered using our toolkit with other genetic features allowed us to explore and establish novel genetic subgroups within Burkitt lymphoma and follicular lymphoma. SV analysis can be conducted using Manta, GRIDSS, and JaBbA modules with downstream processing in GAMBLR. In B-cell lymphomas, the most common SVs identified using the automated workflow were targeting MYC, BCL2, and CCND1. Unsurprisingly, the most common translocation partner among B-cell lymphomas was the immunoglobulin heavy chain, but the novel BCL6-FOXP1, CD274-BACH2, BCL6-RHOH translocations in DLBCLs and MYC-BCL6 translocations in BLs were identified, among others (Figure 1C). Conclusions: We present here the modularized workflow for scalable and automated analysis of genomic and transcriptomic data and demonstrate that it can be successfully deployed across thousands of tumour samples for the discovery of known and novel lymphoma biology. This represents an important advancement in reproducibility that will facilitate clinical translation of genomic discoveries.

Published
2022
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42. Genetic Subgroups Inform on Pathobiology in Adult and Pediatric Burkitt Lymphoma

Author

Thomas, Nicole, primary, Dreval, Kostiantyn, additional, Gerhard, Daniela S., additional, Hilton, Laura K., additional, Abramson, Jeremy S., additional, Bartlett, Nancy L., additional, Bethony, Jeffrey, additional, Bowen, Jay, additional, Bryan, Anthony C., additional, Casper, Corey, additional, Cruz, Manuela, additional, Dyer, Maureen A., additional, Farinha, Pedro, additional, Gastier-Foster, Julie M., additional, Gerrie, Alina S., additional, Grande, Bruno M., additional, Greiner, Timothy, additional, Griner, Nicholas B., additional, Gross, Thomas G., additional, Harris, Nancy L., additional, Irvin, John D., additional, Jaffe, Elaine S., additional, Leal, Fabio E., additional, Martin, Jean Paul, additional, Martin, Marie-Reine, additional, Mbulaiteye, Sam M., additional, Mullighan, Charles G., additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Namirembe, Constance, additional, Noy, Ariela, additional, Ogwang, Martin D., additional, Orem, Jackson, additional, Ott, German, additional, Petrello, Hilary, additional, Reynolds, Steven J., additional, Slack, Graham, additional, Soudi, Shaghayegh, additional, Swerdlow, Steven H., additional, Traverse-Glehen, Alexandra, additional, Wilson, Wyndham H., additional, Wong, Jasper, additional, Marra, Marco A., additional, Staudt, Louis M., additional, Scott, David W., additional, and Morin, Ryan D., additional

Published
2021
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43. Novel Genetic Subgroups Inform on Shared Pathobiology within Adult and Pediatric Burkitt Lymphoma

Author

Thomas, Nicole, primary, Dreval, Kostiantyn, additional, Gerhard, Daniela S., additional, Hilton, Laura K, additional, Abramson, Jeremy S., additional, Bartlett, Nancy L., additional, Bethony, Jeffrey, additional, Bowen, Jay, additional, Bryan, Anthony, additional, Casper, Corey, additional, Cruz, Manuela, additional, Dyer, Maureen, additional, Gastier-Foster, Julie M, additional, Gerrie, Alina S., additional, Grande, Bruno M., additional, Greiner, Timothy C., additional, Griner, Nicholas B., additional, Gross, Thomas G., additional, Harris, Nancy Lee, additional, Irvin, John D., additional, Jaffe, Elaine S., additional, Leal, Fabio, additional, Martin, Jean Paul, additional, Martin, Marie-Reine, additional, Mbulaiteye, Sam M., additional, Mullighan, Charles G., additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Namirembe, Constance, additional, Noy, Ariela, additional, Ogwang, Martin, additional, Orem, Jackson, additional, Ott, German, additional, Petrello, Hilary, additional, Reynolds, Steven, additional, Soudi, Shaghayegh, additional, Swerdlow, Steven H., additional, Traverse-Glehen, Alexandra, additional, Wilson, Wyndham H., additional, Wong, Jasper, additional, Marra, Marco A., additional, Staudt, Louis M., additional, Scott, David W., additional, and Morin, Ryan D, additional

Published
2021
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44. Elucidating the Importance and Regulation of Key Enhancers for Human MEIS1 Expression

Author

Yang, Xining, primary, Xiang, Ping, additional, Escano, Leo, additional, Dhillon, Ishpreet, additional, Schneider, Edith, additional, Clemans-Gibbon, Jack, additional, Wei, Wei, additional, Wong, Jasper, additional, Wang, Simon Xufeng, additional, Morin, Gregg, additional, Hoodless, Pamela A, additional, Hirst, Martin, additional, Karsan, Aly, additional, Kuchenbauer, Florian, additional, Humphries, R. Keith, additional, and Rouhi, Arefeh, additional

Published
2021
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45. An Open-Source Toolkit That Powers the Genome-Wide Analysis of Mature B-Cell Lymphomas (GAMBL) Project

Author

Dreval, Kostiantyn, primary, Grande, Bruno M., additional, Winata, Helena, additional, Wong, Jasper, additional, Sethi, Lakshay, additional, Rushton, Christopher K., additional, Pararajalingam, Prasath, additional, Arthur, Sarah E., additional, Chong, Lauren C., additional, Collinge, Brett, additional, Coyle, Krysta M., additional, Cruz, Manuela, additional, Hung, Stacy, additional, Soudi, Shaghayegh, additional, Thomas, Nicole, additional, Steidl, Christian, additional, Scott, David W., additional, Morin, Ryan D, additional, and Hilton, Laura K, additional

Published
2021
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46. The Genomic Landscape of Plasmablastic Lymphoma (PBL) - an L.L.M.P.P. Project

Author

Wong, Jasper, primary, Collinge, Brett, additional, Hilton, Laura K, additional, Ben-Neriah, Susana, additional, Slack, Graham W., additional, Farinha, Pedro, additional, Cook, James R., additional, Salaverria, Itziar, additional, Campo, Elías, additional, Ott, German, additional, Rosenwald, Andreas, additional, Amador, Catalina, additional, Jaffe, Elaine S., additional, Greiner, Timothy C., additional, Raess, Philipp, additional, Song, Joo Y., additional, Inghirami, Giorgio, additional, Weisenburger, Dennis D., additional, Chan, Wing (John) C., additional, Holte, Harald, additional, Beiske, Klaus, additional, Fu, Kai, additional, Delabie, Jan, additional, Pittaluga, Stefania, additional, Feldman, Andrew L., additional, Savage, Kerry J., additional, Mungall, Andrew J., additional, Steidl, Christian, additional, Rimsza, Lisa M., additional, Morin, Ryan D, additional, and Scott, David W., additional

Published
2021
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47. Optic disc and peripapillary vessel density measured with optical coherence tomography angiography and its associations in Chinese adults: a large population-based study.

Author

Ming Ming Zhu, Choy, Bonnie N. K., Qi Sheng You, Hung Chan, Jonathan Cheuk, Ng, Alex L. K., Shih, Kendrick, Jing Chee Cheung, Janice, Ka Wai Wong, Jasper, Shum, Jennifer, Ni, Michael Y., Shiu-Ming Lai, Jimmy, Leung, Gabriel M., and Wong, Ian Y.

Abstract

Purpose To investigate the optic disc and peripapillary vessel density, as well as its ocular and systemic associations, in healthy eyes among adult Chinese population. Methods A population-based cross-sectional eye survey was conducted on Chinese adults residing in Hong Kong. 1891 eyes from 1891 participants who completed 4.5×4.5 mm optical coherence tomography angiography scans were recruited. Among the 1891 eyes, 404 were excluded due to low scan quality, optic disc or retinal disorders and non-Chinese ethnicity. The vessel densities (VDs) at nerve fibre layer plexus (NFLP) at both optic disc and peripapillary were collected for analysis. Multiple linear regression analysis was performed to determine the ocular and systemic associations of NFLP VD. Results The study included 1487 participants (men: 41.2%) with a mean age of 48.8±15.4 years. The mean NFLP VD of the whole en face image, inside disc and peripapillary region was 53.8%, 42.7% and 60.3%, respectively. In the multivariable model, decreased NFLP VDs were significantly associated with older age, male gender, longer axial length (AL) and lower Signal Strength Index. Conclusions This large population-based cross-sectional study provided quantitative data of optic disc and peripapillary NFLP VD which may serve as a normative reference for clinical use. Apart from age, gender and AL, the scan signal strength also should be taken into consideration during the assessment of NFLP VD. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Optic disc and peripapillary vessel density measured with optical coherence tomography angiography and its associations in Chinese adults: a large population-based study

Author

Zhu, Ming Ming, primary, Choy, Bonnie N K, additional, You, Qi Sheng, additional, Chan, Jonathan Cheuk Hung, additional, Ng, Alex L K, additional, Shih, Kendrick, additional, Cheung, Janice Jing Chee, additional, Wong, Jasper Ka Wai, additional, Shum, Jennifer, additional, Ni, Michael Y, additional, Lai, Jimmy Shiu-Ming, additional, Leung, Gabriel M, additional, and Wong, Ian Y, additional

Published
2021
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