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5. Mapping sex and gender differences in falls among older adults: A scoping review.

Author

Sebastiani, Crista, Wong, Jamie Yee Xin, Litt, Amandeep, Loewen, Julia, Reece, Karly, Conlin, Nicole, Dunand, Tessa, Montero Odasso, Manuel, D'Amore, Cassandra, Saunders, Stephanie, and Beauchamp, Marla

Subjects
*RISK assessment, *MEDICAL information storage & retrieval systems, *SEX distribution, *CINAHL database, *DESCRIPTIVE statistics, *DISEASE prevalence, *SYSTEMATIC reviews, *MEDLINE, *LITERATURE reviews, *ACCIDENTAL falls, *PSYCHOLOGY information storage & retrieval systems, *OLD age
Abstract

Background: There is growing recognition of the importance of sex and gender differences within falls literature, but the characterization of such literature is uncertain. The aim of this scoping review was to (1) map the nature and extent of falls literature examining sex or gender differences among older adults, and (2) identify gaps and opportunities for further research and practice. Methods: We used a scoping review methodology. Eligible studies included participants with a mean age of ≥60 years and study aims specifying falls and either sex or gender concepts. MEDLINE, Embase, CINAHL, Ageline, and Psychinfo databases were searched from inception to March 2, 2022. Records were screened and charted by six independent reviewers. Descriptive and narrative reports were generated. Results: A total of 15,266 records were screened and 74 studies were included. Most studies reported on sex and gender differences in fall risk factors (n = 52, 70%), incidence/prevalence (n = 26, 35%), fall consequences (n = 22, 30%), and fall characteristics (n = 15, 20%). The majority of studies (n = 70, 95%) found significant sex or gender differences in relation to falls, with 39 (53%) identifying significant sex differences and 31 (42%) identifying significant gender differences. However, only three (4%) studies defined sex or gender concepts and only nine (12%) studies used sex or gender terms appropriately. Fifty‐six (76%) studies had more female participants than males. Four (5%) were intervention studies. Studies did not report falls in line with guidelines nor use common fall definitions. Conclusion: Sex and gender differences are commonly reported in falls literature. It is critical for future research to use sex and gender terms appropriately and include similar sample sizes across all genders and sexes. In addition, there is a need to examine more gender‐diverse populations and to develop interventions to prevent falls that address sex and gender differences among older adults. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Mapping sex and gender differences in falls among older adults: a scoping review protocol

Author

Sebastiani, Crista, Wong, Jamie, Loewen, Julia, Litt, Amandeep, Reece, Karly, Conlin, Nicole, Dunand, Tessa, Odasso, Manuel, D'Amore, Cassandra, Saunders, Stephanie, and Beauchamp, Marla

Subjects
Rehabilitation and Therapy, Medicine and Health Sciences
Abstract

Objective: The objective of this scoping review is to map the nature, extent, and types of literature examining sex and gender differences in falls among older adults. We will also identify gaps that exist in the current literature and opportunities for further research. Introduction: Due to the high prevalence and impact of falls on the aging population in Canada, there is a need to identify subgroups of individuals at greater risk of falls to allow for more targeted fall prevention interventions. In particular, a growing body of literature has examined differences in sex and gender among those who have fallen or those who are at risk of falling. However, there is currently a lack of literature within falls research that defines and operationalizes sex and gender terms, limiting the interpretability of health outcomes and how outcomes differ between males and females and individuals with different gender characteristics. A scoping review has been deemed appropriate due to the broad nature of this topic to focus on and inform future research. Inclusion: Studies must include individuals 60 years or older and discuss concepts related to falls and sex or gender to be eligible for inclusion. Studies will be included if the mean age of participants is 60 years or over. Methods: MEDLINE, Embase, CINAHL, Ageline, and Psychinfo databases will be searched from inception to March 2, 2022. Following the removal of duplicate studies, titles and abstracts will be screened and selected according to predefined inclusion criteria by two or more reviewers. The selected full texts will also be screened and reasons for exclusion will be reported. Data will be extracted from included studies by two or more independent reviewers according to the Participant, Concept and Context Framework. Information regarding the aims of this review will be extracted and presented in a tabular format accompanied by a narrative summary.

Published
2022
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18. Su1121: PHARMACOLOGIC INHIBITION OF INTEGRIN α4β7 BY SMALL MOLECULE INHIBITOR ARRESTS B LYMPHOCYTE TRAFFICKING TO MURINE GUT-ASSOCIATED LYMPHOID TISSUES

Author

Redhu, Naresh S., primary, Sang, Allison, additional, Lee, Dooyoung, additional, Dhang, Fyonn, additional, Rowe, Michael, additional, Yadav, Vinod, additional, Hussain, Ali, additional, Harrison, Bryce, additional, Mangada, Maloy, additional, Gelais, Sarah St., additional, Troast, Dawn, additional, Zhong, Cheng, additional, Ge, Xiaomei, additional, Sun, Lili, additional, Wang, Wei, additional, Cui, Dan, additional, Bursavich, Matthew, additional, Lippa, Blaise, additional, Rogers, Bruce N., additional, Ray, Adrian S., additional, and Wong, Jamie, additional

Published
2022
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19. The development of a gut-specific immune response to an oral antigen is dependent on α4β7 mediated lymphocyte trafficking

Author

Sang, Allison L, primary, Redhu, Naresh S, additional, Lee, Dooyoung, additional, Dhang, Fyonn, additional, Bonesteel, Raegan, additional, St. Gelais, Sarah, additional, Zhong, Cheng, additional, Cui, Dan, additional, Harrison, Bryce, additional, Troast, Dawn, additional, Bursavich, Matthew G, additional, Lippa, Blaise, additional, Rogers, Bruce N, additional, Ray, Adrian S, additional, and Wong, Jamie, additional

Published
2022
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20. 1142 INTEGRIN INHIBITION REDUCES PROFIBROTIC RESPONSES IN CROHN'S DISEASE (CD) HUMAN INTESTINAL MYOFIBROBLASTS IN VITRO AND AMELIORATES EXPERIMENTAL INTESTINAL FIBROSIS IN VIVO - A POTENTIAL NOVEL APPROACH TO CD STRICTURE THERAPY

Author

Mukherjee, Pranab K., Czarnecki, Doug, Chandra, Jyotsna, Hu, Shaomin, Nguyen, Quang Tam, Liu, Weiwei, Massey, William J., Wang, Yan, Wong, Jamie, Liu, Min, West, Gail A., Banerjee, Suhanti, Goren, Idan, and Rieder, Florian

Published
2024
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22. “Let’s Go, Baby Forklift!”: Fandom Governance and the Political Power of Cuteness in China

Author

Massachusetts Institute of Technology. Anthropology Program, Wong, Jamie, Lee, Crystal, Long, Vesper Keyi, Wu, Di, Jones, Graham M, Massachusetts Institute of Technology. Anthropology Program, Wong, Jamie, Lee, Crystal, Long, Vesper Keyi, Wu, Di, and Jones, Graham M

Abstract

This article describes how the Chinese state borrows from the culture of celebrity fandom to implement a novel strategy of governing that we term “fandom governance.” We illustrate how state-run social media employed fandom governance early in the COVID-19 pandemic when the country was convulsed with anxiety. As the state faced a crisis, state social media responded with a propagandistic display of state efficacy, broadcasting a round-the-clock livestream of a massive emergency hospital construction project. Chinese internet users playfully embellished imagery from the livestream. They unexpectedly transformed the construction vehicles into cute personified memes, with Baby Forklift and Baby Mud Barfer (a cement mixer) among the most popular. In turn, state social media strategically channeled this playful engagement in politically productive directions by resignifying the personified vehicles as celebrity idols. Combining social media studies with cultural and linguistic anthropology, we offer a processual account of the semiotic mediations involved in turning vehicles into memes, memes into idols, and citizens into fans. We show how, by embedding cute memes within modules of fandom management such as celebrity ranking lists, state social media rendered them artificially vulnerable to a fall in status. Fans, in turn, rallied around to “protect” these cute idols with small but significant acts of digital devotion and care, organizing themselves into fan circles and exhorting each other to vote. In elevating the memes to the status of celebrity idols, state social media thereby created a disposable pantheon of virtual avatars for the state, and consolidated state power around citizens’ voluntary response to vulnerability. We analyze fandom governance as a new development in the Chinese state’s long history of governing citizens through the management of emotion.

Published
2022

25. Therapeutic RNAi Targeting PCSK9 Acutely Lowers Plasma Cholesterol in Rodents and LDL Cholesterol in Nonhuman Primates

Author

Frank-Kamenetsky, Maria, Grefhorst, Aldo, Anderson, Norma N., Racie, Timothy S., Bramlage, Birgit, Akinc, Akin, Butler, David, Charisse, Klaus, Dorkin, Robert, Fan, Yupeng, Gamba-Vitalo, Christina, Hadwiger, Philipp, Jayaraman, Muthusamy, John, Matthias, Jayaprakash, K. Narayanannair, Maier, Martin, Nechev, Lubomir, Rajeev, Kallanthottathil G., Read, Timothy, Röhl, Ingo, Soutschek, Jürgen, Tan, Pamela, Wong, Jamie, Wang, Gang, Zimmermann, Tracy, de Fougerolles, Antonin, Vornlocher, Hans-Peter, Langer, Robert, Anderson, Daniel G., Manoharan, Muthiah, Koteliansky, Victor, Horton, Jay D., and Fitzgerald, Kevin

Published
2008
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30. Modeling relationship of pharmacokinetics, in vitro potency, and α4β7 receptor occupancy with intestinal cell trafficking in a gut-homing mouse model of IBD with MORF-057

Author

Redhu, Naresh S., primary, Hussain, Ali, additional, Srinivasan, Sathish, additional, Lee, Dooyoung, additional, Bannister, Brianna, additional, Blanco, Natalia, additional, Bonesteel, Raegan, additional, Camblin, Adam, additional, Cappellucci, Laura, additional, Cohen, Rhianna, additional, Harrison, Bryce, additional, Hahn, Kristopher N, additional, Kim, Kwangsoo, additional, Krumpoch, Megan, additional, Lin, Fu-Yang, additional, McManus, Kevin, additional, McShea, Molly, additional, Pondish, Jessica, additional, Linde, Peter, additional, Lugovskoy, Alex, additional, Mangada, Maloy, additional, Moy, Terence I., additional, Sang, Allison, additional, Gelais, Sarah St., additional, Sullivan, Andrew, additional, Troast, Dawn, additional, Zhong, Cheng, additional, Wang, Liangsu, additional, Cui, Dan, additional, Bursavich, Matthew G., additional, Lippa, Blaise, additional, Rogers, Bruce N., additional, Ray, Adrian S., additional, and Wong, Jamie, additional

Published
2021
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31. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

Author

Musunuru, Kiran, Strong, Alanna, Frank-Kamenetsky, Maria, Lee, Noemi E., Ahfeldt, Tim, Sachs, Katherine V., Li, Xiaoyu, Li, Hui, Kuperwasser, Nicolas, Ruda, Vera M., Pirruccello, James P., Muchmore, Brian, Prokunina- Olsson, Ludmila, Hall, Jennifer L., Schadt, Eric E., Morales, Carlos R., Lund-Katz, Sissel, Phillips, Michael C., Wong, Jamie, Cantley, William, Racie, Timothy, Ejebe, Kenechi G., Orho-Melander, Marju, Melander, Olle, Koteliansky, Victor, Fitzgerald, Kevin, Krauss, Ronald M., Cowan, Chad A., Kathiresan, Sekar, and Rader, Daniel J.

Subjects
Cholesterol -- Genetic aspects -- Health aspects, Heart attack -- Genetic aspects, Genetic variation -- Health aspects -- Genetic aspects, Phenotype -- Health aspects -- Genetic aspects
Abstract

Recent genome-wide association studies (GWASs) have identified a locus on chromosome 1p13 strongly associated with both plasma low-density lipoprotein cholesterol (LDL-C) and myocardial infarction (MI) in humans. Here we show through a series of studies in human cohorts and human-derived hepatocytes that a common noncoding polymorphism at the 1p13 locus, rs12740374, creates a C/EBP (CCAAT/enhancer binding protein) transcription factor binding site and alters the hepatic expression of the SORT1 gene. With small interfering RNA (siRNA) knockdown and viral overexpression in mouse liver, we demonstrate that Sorf7 alters plasma LDL-C and very low-density lipoprotein (VLDL) particle levels by modulating hepatic VLDL secretion. Thus, we provide functional evidence for a novel regulatory pathway for lipoprotein metabolism and suggest that modulation of this pathway may alter risk for MI in humans. We also demonstrate that common noncoding DNA variants identified by GWASs can directly contribute to clinical phenotypes., MI is the leading cause of death in the developed world. LDL-C is a causal risk factor for the disease, as demonstrated by the increased and early burden of MI [...]

Published
2010
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32. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Author

Feuerer, Markus, Herrero, Laura, Cipolletta, Daniela, Naaz, Afia, Wong, Jamie, Nayer, Ali, Lee, Jongsoon, Goldfine, Allison B., Benoist, Christophe, Shoelson, Steven, and Mathis, Diane

Subjects
T cells -- Health aspects -- Research -- Genetic aspects -- Physiological aspects, Obesity -- Complications and side effects -- Research -- Risk factors -- Care and treatment -- Genetic aspects, Type 2 diabetes -- Risk factors -- Care and treatment -- Research -- Complications and side effects -- Genetic aspects, Fat cells -- Physiological aspects -- Genetic aspects -- Research -- Health aspects, Biological sciences, Health
Abstract

Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which promotes insulin resistance and type-2 diabetes. These findings raise the question of how fat inflammation can escape the powerful armamentarium of cells and molecules normally responsible for guarding against a runaway immune response. [CD4.sup.+] [Foxp3.sup.+] T regulatory ([T.sub.reg]) cells with a unique phenotype were highly enriched in the abdominal fat of normal mice, but their numbers were strikingly and specifically reduced at this site in insulin-resistant models of obesity. Loss-of-function and gain-of-function experiments revealed that these [T.sub.reg] cells influenced the inflammatory state of adipose tissue and, thus, insulin resistance. Cytokines differentially synthesized by fat-resident regulatory and conventional T cells directly affected the synthesis of inflammatory mediators and glucose uptake by cultured adipocytes. These observations suggest that harnessing the anti-inflammatory properties of [T.sub.reg] cells to inhibit elements of the metabolic syndrome may have therapeutic potential., Type 2 diabetes and other elements of the metabolic syndrome have increased at an alarming rate over the past several decades. There has been a parallel rise in the incidence [...]

Published
2009

37. Cycling to UBC Vancouver : Barriers for Individuals that live within 10km

Author

Hu, Christina, Sidhu, Harry, Wong, Jamie, Woodward, Courtney, and Wright, Amanda

Subjects
education
Abstract

The purpose of this project is to identify cycling barriers to individuals who live less than ten kilometers away from the University of British Columbia (UBC) Point Grey campus and gather suggestions for improvements that can be implemented in the future. Despite the increase of numbers in cycling within Vancouver, British Columbia (Centre for Active Transportation, 2019), UBC cycling rates for students continue to decline (UBC Transportation Status Report, 2019). Data was collected using quantitative and qualitative methods with a structured survey and open-ended questions. Participants were recruited to take part in the study through the promotion of social media posts as well as being directly contacted by members of the study. The study was completed by participants through the online program Qualtrics. Based on our findings, we have highlighted four main themes of barriers to cycling: Safety, weather, cycling infrastructure, and other (consisting of costs, timing and scheduling). Although almost all participants are comfortable riding a bike, few actually feel safe while cycling to UBC. Poor road conditions, due to aspects like weather, and the lack of safe bike paths around UBC prevent participants from cycling to campus. Many mentioned a key factor that may encourage more people to cycle involves education and awareness surrounding cycling etiquettes and safety. The primary barrier to cycling for this population was weather. The majority of participants agreed that weather impacts their choice to cycle and harsh weather prevents them from cycling. Due to Vancouver’s unpredictable weather, it seems to have a domino effect on other barriers such as safety and infrastructure. While we are unable to control the weather, there are other measures that can be taken into action to reduce weather being a major barrier to cycling. In terms of infrastructure, increased bicycle security and the need of safer bike lanes on and around campus was a recurrent necessity for cycling. The majority of participants agreed that they would feel nervous locking their bike up on campus. In addition, the lack of bike paths to and around campus make it difficult for cyclers to be safe while staying alert for pedestrians. Additional barriers to cycling based on participants’ responses was due to class scheduling making it difficult to manage a bike in-between class. The lack of ease and lengthy duration of cycling to and around campus was also seen as a common barrier. A limited number of participants thought cycling was the more cost-effective choice of transportation thereby many participants were concerned with the maintenance and costs of a bike. One of the main limitations to this study was the lack of sample diversity due to the recruitment process. The majority of participants were students due to promotion being limited to other members of the community. Further research should be done in order to get a greater perspective of participants who live less than 10km away, including more faculty and community residents. Disclaimer: “UBC SEEDS provides students with the opportunity to share the findings of their studies, as well as their opinions, conclusions and recommendations with the UBC community. The reader should bear in mind that this is a student project/report and is not an official document of UBC. Furthermore readers should bear in mind that these reports may not reflect the current status of activities at UBC. We urge you to contact the research persons mentioned in a report or the SEEDS Coordinator about the current status of the subject matter of a project/report.”

Published
2020
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39. Tu1283 PRECLINICAL CHARACTERIZATION OF AN ORAL SMALL MOLECULE INHIBITOR TARGETING THE INTEGRIN α4β7 FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES (IBD)

Author

Wong, Jamie, primary, Bursavich, Matthew, additional, Blanco, Natalia, additional, Camblin, Adam, additional, Cappellucci, Laura, additional, Cohen, Rhianna, additional, Cui, Dan, additional, Hahn, Kris, additional, Krumpoch, Megan, additional, Lee, Dooyoung, additional, Lin, Fu-Yang, additional, Lippa, Blaise, additional, Lugovskoy, Alex, additional, McShea, Molly, additional, Mangada, Maloy, additional, Mostafavi, Siavash, additional, Moy, Terence, additional, Ray, Adrian S., additional, Redhu, Naresh Singh, additional, Sang, Allison, additional, Sullivan, Andrew, additional, Traber, Peter G., additional, Troast, Dawn, additional, Zhong, Cheng, additional, Wang, Liangsu, additional, and Rogers, Bruce N., additional

Published
2020
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42. Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease

Author

Ferreira, Nicola, primary, Andoniou, Christopher E., additional, Perks, Kara L., additional, Ermer, Judith A., additional, Rudler, Danielle L., additional, Rossetti, Giulia, additional, Periyakaruppiah, Ambika, additional, Wong, Jamie K. Y., additional, Rackham, Oliver, additional, Noakes, Peter G., additional, Degli-Esposti, Mariapia A., additional, and Filipovska, Aleksandra, additional

Published
2020
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48. Centromere-linkage analysis and consolidation of the zebrafish genetic map

Author

Johnson, Stephen L., Gates, Michael A., Johnson, Michele, Talbot, William S., Horne, Sally, Baik, Kris, Rude, Sunny, Wong, Jamie R., and Postlethwait, John H.

Subjects
Vertebrates -- Genetic aspects, Mutation (Biology) -- Research, Danio -- Genetic aspects, Biological sciences
Abstract

The ease of isolating mutations in zebrafish will contribute to an understanding of a variety of processes common to all vertebrates. To facilitate genetic analysis of such mutations, we have identified DNA polymorphisms closely linked to each of the 25 centromeres of zebrafish, placed centromeres on the linkage map, increased the number of mapped PCR-based markers to 652, and consolidated the number of linkage groups to the number of chromosomes. This work makes possible centromere-linkage analysis, a novel, rapid method to assign mutations to a specific linkage group using half-tetrads.

Published
1996

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