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13 results on '"Wolpe, Abigail G."'

4. Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane

Author

DeLalio, Leon J., Billaud, Marie, Ruddiman, Claire A., Johnstone, Scott R., Butcher, Joshua T., Wolpe, Abigail G., Jin, Xueyao, Keller, T.C. Stevenson, IV, Keller, Alexander S., Rivière, Thibaud, Good, Miranda E., Best, Angela K., Lohman, Alexander W., Swayne, Leigh Anne, Penuela, Silvia, Thompson, Roger J., Lampe, Paul D., Yeager, Mark, and Isakson, Brant E.

Published
2019
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5. Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress

Author

Wolpe, Abigail G., primary, Luse, Melissa A., additional, Baryiames, Christopher, additional, Schug, Wyatt J., additional, Wolpe, Jacob B., additional, Johnstone, Scott R., additional, Dunaway, Luke S., additional, Juśkiewicz, Zuzanna J., additional, Loeb, Skylar A., additional, Askew Page, Henry R., additional, Chen, Yen-Lin, additional, Sabapathy, Vikram, additional, Pavelec, Caitlin M., additional, Wakefield, Brent, additional, Cifuentes-Pagano, Eugenia, additional, Artamonov, Mykhaylo V., additional, Somlyo, Avril V., additional, Straub, Adam C., additional, Sharma, Rahul, additional, Beier, Frank, additional, Barrett, Eugene J., additional, Leitinger, Norbert, additional, Pagano, Patrick J., additional, Sonkusare, Swapnil K., additional, Redemann, Stefanie, additional, Columbus, Linda, additional, Penuela, Silvia, additional, and Isakson, Brant E., additional

Published
2024
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7. Endothelial Pannexin 3 – B Cell Lymphoma‐6 Interactions Protect Against Oxidative Stress

Author

Wolpe, Abigail G., primary, Luse, Melissa A., additional, Johnstone, Scott R., additional, Xue, Jianxiang, additional, Sabapathy, Vikram, additional, Wakefield, Brent, additional, Sharma, Rahul, additional, Barr, Kevin, additional, Beier, Frank, additional, Laird, Dale, additional, Redemann, Stefanie, additional, Columbus, Linda, additional, Penuela, Silvia, additional, and Isakson, Brant E., additional

Published
2022
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8. Endothelial Pannexin 1 Regulates Cardiac Response to Myocardial Infarction

Author

Good, Miranda E., primary, Young, Alexander P., additional, Wolpe, Abigail G., additional, Ma, Manxiu, additional, Hall, Philip J., additional, Duffy, Colleen K., additional, Aronovitz, Mark J., additional, Martin, Gregory L., additional, Blanton, Robert M., additional, Leitinger, Norbert, additional, Johnstone, Scott R., additional, Wolf, Matthew J., additional, and Isakson, Brant E., additional

Published
2021
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10. Consideration of Pannexin 1 channels in COVID-19 pathology and treatment

Author

Swayne, Leigh Anne, primary, Johnstone, Scott R., additional, Ng, Chen Seng, additional, Sanchez-Arias, Juan C., additional, Good, Miranda E., additional, Penuela, Silvia, additional, Lohman, Alexander W., additional, Wolpe, Abigail G., additional, Laubach, Victor E., additional, Koval, Michael, additional, and Isakson, Brant E., additional

Published
2020
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12. Pannexin 1 Channels Control Cardiomyocyte Metabolism and Neutrophil Recruitment During Non-Ischemic Heart Failure.

Author

Pavelec CM, Young AP, Luviano HL, Orrell EE, Szagdaj A, Poudel N, Wolpe AG, Thomas SH, Yeudall S, Upchurch CM, Okusa MD, Isakson BE, Wolf MJ, and Leitinger N

Abstract

Pannexin 1 (PANX1), a ubiquitously expressed ATP release membrane channel, has been shown to play a role in inflammation, blood pressure regulation, and myocardial infarction. However, a possible role of PANX1 in cardiomyocytes in the progression of heart failure has not yet been investigated. We generated a novel mouse line with constitutive deletion of PANX1 in cardiomyocytes (Panx1 MyHC6 ). PANX1 deletion in cardiomyocytes had no effect on unstressed heart function but increased the glycolytic metabolism both in vivo and in vitro . In vitro , treatment of H9c2 cardiomyocytes with isoproterenol led to PANX1-dependent release of ATP and Yo-Pro-1 uptake, as assessed by pharmacological blockade with spironolactone and siRNA-mediated knock-down of PANX1. To investigate non-ischemic heart failure and the preceding cardiac hypertrophy we administered isoproterenol, and we demonstrate that Panx1 MyHC6 mice were protected from systolic and diastolic left ventricle volume increases and cardiomyocyte hypertrophy. Moreover, we found that Panx1 MyHC6 mice showed decreased isoproterenol-induced recruitment of immune cells (CD45 + ), particularly neutrophils (CD11b + , Ly6g + ), to the myocardium. Together these data demonstrate that PANX1 deficiency in cardiomyocytes impacts glycolytic metabolism and protects against cardiac hypertrophy in non-ischemic heart failure at least in part by reducing immune cell recruitment. Our study implies PANX1 channel inhibition as a therapeutic approach to ameliorate cardiac dysfunction in heart failure patients.

Published
2024
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13. Consideration of Pannexin 1 channels in COVID-19 pathology and treatment.

Author

Swayne LA, Johnstone SR, Ng CS, Sanchez-Arias JC, Good ME, Penuela S, Lohman AW, Wolpe AG, Laubach VE, Koval M, and Isakson BE

Subjects
Betacoronavirus drug effects, COVID-19, Coronavirus Infections drug therapy, Humans, Pandemics, Pneumonia, Viral diagnosis, Pneumonia, Viral drug therapy, SARS-CoV-2, Betacoronavirus pathogenicity, Connexins drug effects, Coronavirus Infections pathology, Coronavirus Infections virology, Nerve Tissue Proteins drug effects, Pneumonia, Viral pathology, Pneumonia, Viral virology
Published
2020
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