515 results on '"Wolfsgruber, Steffen"'
Search Results
2. Different inflammatory signatures based on CSF biomarkers relate to preserved or diminished brain structure and cognition
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Hayek, Dayana, Ziegler, Gabriel, Kleineidam, Luca, Brosseron, Frederic, Nemali, Aditya, Vockert, Niklas, Ravichandran, Kishore A., Betts, Matthew J., Peters, Oliver, Schneider, Luisa-Sophie, Wang, Xiao, Priller, Josef, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Bartels, Claudia, Rostamzadeh, Ayda, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Laske, Christoph, Mengel, David, Synofzik, Matthis, Munk, Matthias H., Spottke, Annika, Roy, Nina, Roeske, Sandra, Kuhn, Elizabeth, Ramirez, Alfredo, Dobisch, Laura, Schmid, Matthias, Berger, Moritz, Wolfsgruber, Steffen, Yakupov, Renat, Hetzer, Stefan, Dechent, Peter, Ewers, Michael, Scheffler, Klaus, Schott, Björn H., Schreiber, Stefanie, Orellana, Adelina, de Rojas, Itziar, Marquié, Marta, Boada, Mercè, Sotolongo, Oscar, González, Pablo García, Puerta, Raquel, Düzel, Emrah, Jessen, Frank, Wagner, Michael, Ruiz, Augustín, Heneka, Michael T., and Maass, Anne
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- 2024
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3. Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study
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Brosseron, Frederic, Maass, Anne, Kleineidam, Luca, Ravichandran, Kishore Aravind, Kolbe, Carl-Christian, Wolfsgruber, Steffen, Santarelli, Francesco, Häsler, Lisa M., McManus, Róisín, Ising, Christina, Röske, Sandra, Peters, Oliver, Cosma, Nicoleta-Carmen, Schneider, Luisa-Sophie, Wang, Xiao, Priller, Josef, Spruth, Eike J., Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Schott, Björn H., Buerger, Katharina, Janowitz, Daniel, Dichgans, Martin, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Görß, Doreen, Laske, Christoph, Munk, Matthias H., Düzel, Emrah, Yakupow, Renat, Dobisch, Laura, Metzger, Coraline D., Glanz, Wenzel, Ewers, Michael, Dechent, Peter, Haynes, John Dylan, Scheffler, Klaus, Roy, Nina, Rostamzadeh, Ayda, Spottke, Annika, Ramirez, Alfredo, Mengel, David, Synofzik, Matthis, Jucker, Mathias, Latz, Eicke, Jessen, Frank, Wagner, Michael, and Heneka, Michael T.
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- 2023
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4. Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study
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Bernal, Jose, Schreiber, Stefanie, Menze, Inga, Ostendorf, Anna, Pfister, Malte, Geisendörfer, Jonas, Nemali, Aditya, Maass, Anne, Yakupov, Renat, Peters, Oliver, Preis, Lukas, Schneider, Luisa, Herrera, Ana Lucia, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Schott, Björn H., Rostamzadeh, Ayda, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Ewers, Michael, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Laske, Christoph, Munk, Matthias H., Spottke, Annika, Roy, Nina, Dobisch, Laura, Dechent, Peter, Scheffler, Klaus, Hetzer, Stefan, Wolfsgruber, Steffen, Kleineidam, Luca, Schmid, Matthias, Berger, Moritz, Jessen, Frank, Wirth, Miranka, Düzel, Emrah, and Ziegler, Gabriel
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- 2023
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5. Exploring the ATN classification system using brain morphology
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Heinzinger, Nils, Maass, Anne, Berron, David, Yakupov, Renat, Peters, Oliver, Fiebach, Jochen, Villringer, Kersten, Preis, Lukas, Priller, Josef, Spruth, Eike Jacob, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Bartels, Claudia, Jessen, Frank, Maier, Franziska, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Killimann, Ingo, Göerß, Doreen, Laske, Christoph, Munk, Matthias H., Spottke, Annika, Roy, Nina, Heneka, Michael T., Brosseron, Frederic, Dobisch, Laura, Ewers, Michael, Dechent, Peter, Haynes, John Dylan, Scheffler, Klaus, Wolfsgruber, Steffen, Kleineidam, Luca, Schmid, Matthias, Berger, Moritz, Düzel, Emrah, and Ziegler, Gabriel
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- 2023
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6. Brain reserve contributes to distinguishing preclinical Alzheimer’s stages 1 and 2
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Yildirim, Zerrin, Delen, Firuze, Berron, David, Baumeister, Hannah, Ziegler, Gabriel, Schütze, Hartmut, Glanz, Wenzel, Dobisch, Laura, Peters, Oliver, Freiesleben, Silka Dawn, Schneider, Luisa-Sophie, Priller, Josef, Spruth, Eike Jakob, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Schott, Björn-Hendrik, Meiberth, Dix, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Laske, Christoph, Munk, Matthias H., Spottke, Annika, Roy, Nina, Heneka, Michael, Brosseron, Frederic, Wagner, Michael, Roeske, Sandra, Ramirez, Alfredo, Ewers, Michael, Dechent, Peter, Hetzer, Stefan, Scheffler, Klaus, Kleineidam, Luca, Wolfsgruber, Steffen, Yakupov, Renat, Schmid, Matthias, Berger, Moritz, Gurvit, Hakan, Jessen, Frank, and Duzel, Emrah
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- 2023
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7. Linking early-life bilingualism and cognitive advantage in older adulthood
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Ballarini, Tommaso, Kuhn, Elizabeth, Röske, Sandra, Altenstein, Slawek, Bartels, Claudia, Buchholz, Friederike, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Gabelin, Tatjana, Glanz, Wenzel, Görß, Doreen, Haynes, John Dylan, Incesoy, Enise I., Janowitz, Daniel, Kilimann, Ingo, Kleineidam, Luca, Kobeleva, Xenia, Laske, Christoph, Lohse, Andrea, Maier, Franziska, Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Priller, Josef, Rauchmann, Boris-Stephan, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Düzel, Emrah, Jessen, Frank, and Wagner, Michael
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- 2023
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8. Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease
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Ersoezlue, Ersin, Rauchmann, Boris-Stephan, Schneider-Axmann, Thomas, Wagner, Michael, Ballarini, Tommaso, Tato, Maia, Utecht, Julia, Kurz, Carolin, Papazov, Boris, Guersel, Selim, Burow, Lena, Koller, Gabriele, Stöcklein, Sophia, Keeser, Daniel, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, and Perneczky, Robert
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- 2023
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9. Machine Learning–Based Perivascular Space Volumetry in Alzheimer Disease
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Deike, Katerina, primary, Decker, Andreas, additional, Scheyhing, Paul, additional, Harten, Julia, additional, Zimmermann, Nadine, additional, Paech, Daniel, additional, Peters, Oliver, additional, Freiesleben, Silka D., additional, Schneider, Luisa-Sophie, additional, Preis, Lukas, additional, Priller, Josef, additional, Spruth, Eike, additional, Altenstein, Slawek, additional, Lohse, Andrea, additional, Fliessbach, Klaus, additional, Kimmich, Okka, additional, Wiltfang, Jens, additional, Bartels, Claudia, additional, Hansen, Niels, additional, Jessen, Frank, additional, Rostamzadeh, Ayda, additional, Düzel, Emrah, additional, Glanz, Wenzel, additional, Incesoy, Enise I., additional, Butryn, Michaela, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Ewers, Michael, additional, Perneczky, Robert, additional, Rauchmann, Boris-Stephan, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Goerss, Doreen, additional, Laske, Christoph, additional, Munk, Matthias H., additional, Spottke, Annika, additional, Roy, Nina, additional, Wagner, Michael, additional, Roeske, Sandra, additional, Heneka, Michael T., additional, Brosseron, Frederic, additional, Ramirez, Alfredo, additional, Dobisch, Laura, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Yakupov, Renat, additional, Stark, Melina, additional, Schmid, Matthias C., additional, Berger, Moritz, additional, Hetzer, Stefan, additional, Dechent, Peter, additional, Scheffler, Klaus, additional, Petzold, Gabor C., additional, Schneider, Anja, additional, Effland, Alexander, additional, and Radbruch, Alexander, additional
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- 2024
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10. Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology
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Blömeke, Lara, primary, Rehn, Fabian, additional, Kraemer‐Schulien, Victoria, additional, Kutzsche, Janine, additional, Pils, Marlene, additional, Bujnicki, Tuyen, additional, Lewczuk, Piotr, additional, Kornhuber, Johannes, additional, Freiesleben, Silka D., additional, Schneider, Luisa‐Sophie, additional, Preis, Lukas, additional, Priller, Josef, additional, Spruth, Eike J., additional, Altenstein, Slawek, additional, Lohse, Andrea, additional, Schneider, Anja, additional, Fliessbach, Klaus, additional, Wiltfang, Jens, additional, Hansen, Niels, additional, Rostamzadeh, Ayda, additional, Düzel, Emrah, additional, Glanz, Wenzel, additional, Incesoy, Enise I., additional, Butryn, Michaela, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Ewers, Michael, additional, Perneczky, Robert, additional, Rauchmann, Boris‐Stephan, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Goerss, Doreen, additional, Laske, Christoph, additional, Munk, Matthias H., additional, Sanzenbacher, Carolin, additional, Spottke, Annika, additional, Roy‐Kluth, Nina, additional, Heneka, Michael T., additional, Brosseron, Frederic, additional, Wagner, Michael, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Stark, Melina, additional, Schmid, Matthias, additional, Jessen, Frank, additional, Bannach, Oliver, additional, Willbold, Dieter, additional, and Peters, Oliver, additional
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- 2024
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11. Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia
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Malo Gaubert, Andrea Dell’Orco, Catharina Lange, Antoine Garnier-Crussard, Isabella Zimmermann, Martin Dyrba, Marco Duering, Gabriel Ziegler, Oliver Peters, Lukas Preis, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Emrah Düzel, Frank Jessen, Miranka Wirth, for the DELCODE study group, Amthauer Holger, Cetindag Arda Can, Cosma Nicoleta Carmen, Diesing Dominik, Ehrlich Marie, Fenski Frederike, Freiesleben Silka Dawn, Fuentes Manuel, Hauser Dietmar, Hujer Nicole, Incesoy Enise Irem, Kainz Christian, Lange Catharina, Lindner Katja, Megges Herlind, Peters Oliver, Preis Lukas, Altenstein Slawek, Lohse Andrea, Franke Christiana, Priller Josef, Spruth Eike, Villar Munoz Irene, Barkhoff Miriam, Boecker Henning, Brosseron Frederic, Daamen Marcel, Engels Tanja, Faber Jennifer, Fließbach Klaus, Frommann Ingo, Grobe-Einsler Marcus, Hennes Guido, Herrmann Gabi, Jost Lorraine, Kalbhen Pascal, Kimmich Okka, Kobeleva Xenia, Kofler Barbara, McCormick Cornelia, Miebach Lisa, Miklitz Carolin, Müller Anna, Oender Demet, Polcher Alexandra, Purrer Veronika, Röske Sandra, Schneider Christine, Schneider Anja, Spottke Annika, Vogt Ina, Wagner Michael, wolfsgruber Steffen, Yilmaz Sagik, Bartels Claudia, Dechent Peter, Hansen Niels, Hassoun Lina, Hirschel Sina, Nuhn Sabine, Pfahlert Ilona, Rausch Lena, Schott Björn, Timäus Charles, Werner Christine, Wiltfang Jens, Zabel Lioba, Zech Heike, Bader Abdelmajid, Baldermann Juan Carlos, Dölle Britta, Drzezga Alexander, Escher Claus, Ghiasi Nasim Roshan, Hardenacke Katja, Jessen Frank, Lützerath Hannah, Maier Franziska, Marquardt Benjamin, Martikke Anja, Meiberth Dix, Petzler Snjezana, Rostamzadeh Ayda, Sannemann Lena, Schild Ann-Katrin, Sorgalla Susanne, Stockter Simone, Thelen Manuela, Tscheuschler Maike, Uhle Franziska, Zeyen Philip, Bittner Daniel, Cardenas-Blanco Arturo, Dobisch Laura, Düzel Emrah, Grieger-Klose Doreen, Hartmann Deike, Metzger Coraline, Nestor Peter, Ruß Christin, Schulze Franziska, Speck Oliver, Yakupov Renat, Ziegler Gabriel, Brauneis Christine, Bürger Katharina, Catak Cihan, Coloma Andrews Lisa, Dichgans Martin, Dörr Angelika, Ertl-Wagner Birgit, Frimmer Daniela, Huber Brigitte, Janowitz Daniel, Kreuzer Max, Markov Eva, Müller Claudia, Rominger Axel, Schmid (ehemals Spreider) Jennifer, Seegerer Anna, Stephan Julia, Zollver Adelgunde, Burow Lena, de Jonge Sylvia, Falkai Peter, Garcia Angarita Natalie, Görlitz Thomas, Gürsel Selim Üstün, Horvath Ildiko, Kurz Carolin, Meisenzahl-Lechner Eva, Perneczky Robert, Utecht Julia, Dyrba Martin, Janecek-Meyer Heike, Kilimann Ingo, Lappe Chris, Lau Esther, Pfaff Henrike, Raum Heike, Sabik Petr, Schmidt Monika, Schulz Heike, Schwarzenboeck Sarah, Teipel Stefan, Weber Marc-Andre, Buchmann Martina, Heger Tanja, Hinderer Petra, Kuder-Buletta Elke, Laske Christoph, Munk Matthias, Mychajliw Christian, Soekadar Surjo, sulzer Patricia, and Trunk Theresia
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white matter hyperintensities segmentation ,evaluation ,FLAIR ,deep learning ,aging ,Alzheimer’s disease ,Psychiatry ,RC435-571 - Abstract
BackgroundWhite matter hyperintensities (WMH), a biomarker of small vessel disease, are often found in Alzheimer’s disease (AD) and their advanced detection and quantification can be beneficial for research and clinical applications. To investigate WMH in large-scale multicenter studies on cognitive impairment and AD, appropriate automated WMH segmentation algorithms are required. This study aimed to compare the performance of segmentation tools and provide information on their application in multicenter research.MethodsWe used a pseudo-randomly selected dataset (n = 50) from the DZNE-multicenter observational Longitudinal Cognitive Impairment and Dementia Study (DELCODE) that included 3D fluid-attenuated inversion recovery (FLAIR) images from participants across the cognitive continuum. Performances of top-rated algorithms for automated WMH segmentation [Brain Intensity Abnormality Classification Algorithm (BIANCA), lesion segmentation toolbox (LST), lesion growth algorithm (LGA), LST lesion prediction algorithm (LPA), pgs, and sysu_media] were compared to manual reference segmentation (RS).ResultsAcross tools, segmentation performance was moderate for global WMH volume and number of detected lesions. After retraining on a DELCODE subset, the deep learning algorithm sysu_media showed the highest performances with an average Dice’s coefficient of 0.702 (±0.109 SD) for volume and a mean F1-score of 0.642 (±0.109 SD) for the number of lesions. The intra-class correlation was excellent for all algorithms (>0.9) but BIANCA (0.835). Performance improved with high WMH burden and varied across brain regions.ConclusionTo conclude, the deep learning algorithm, when retrained, performed well in the multicenter context. Nevertheless, the performance was close to traditional methods. We provide methodological recommendations for future studies using automated WMH segmentation to quantify and assess WMH along the continuum of cognitive impairment and AD dementia.
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- 2023
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12. Plasma amyloid beta X‐42/X‐40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease.
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Vogelgsang, Jonathan, Hansen, Niels, Stark, Melina, Wagner, Michael, Klafki, Hans, Morgado, Barbara Marcos, Jahn‐Brodmann, Anke, Schott, Björn, Esselmann, Hermann, Bauer, Chris, Schuchhardt, Johannes, Kleineidam, Luca, Wolfsgruber, Steffen, Peters, Oliver, Schneider, Luisa‐Sophie, Wang, Xiao, Menne, Felix, Priller, Josef, Spruth, Eike, and Altenstein, Slawek
- Abstract
INTRODUCTION: Blood‐based biomarkers are a cost‐effective and minimally invasive method for diagnosing the early and preclinical stages of amyloid positivity (AP). Our study aims to investigate our novel immunoprecipitation‐immunoassay (IP‐IA) as a test for predicting cognitive decline. METHODS: We measured levels of amyloid beta (Aβ)X‐40 and AβX‐42 in immunoprecipitated eluates from the DELCODE cohort. Receiver‐operating characteristic (ROC) curves, regression analyses, and Cox proportional hazard regression models were constructed to predict AP by Aβ42/40 classification in cerebrospinal fluid (CSF) and conversion to mild cognitive impairment (MCI) or dementia. RESULTS: We detected a significant correlation between AßX‐42/X‐40 in plasma and CSF (r = 0.473). Mixed‐modeling analysis revealed a substantial prediction of AßX‐42/X‐40 with an area under the curve (AUC) of 0.81 for AP (sensitivity: 0.79, specificity: 0.74, positive predictive value [PPV]: 0.71, negative predictive value [NPV]: 0.81). In addition, lower AβX‐42/X‐40 ratios were associated with negative PACC5 slopes, suggesting cognitive decline. DISCUSSION: Our results suggest that assessing the plasma AβX‐42/X‐40 ratio via our semiautomated IP‐IA is a promising biomarker when examining patients with early or preclinical AD. Highlights: New plasma Aβ42/Aβ40 measurement using immunoprecipitation–immunoassayPlasma Aβ42/Aβ40 associated with longitudinal cognitive declinePromising biomarker to detect subjective cognitive decline at‐risk for brain amyloid positivity [ABSTRACT FROM AUTHOR]
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- 2024
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13. A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings.
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Baumeister, Hannah, Vogel, Jacob W, Insel, Philip S, Kleineidam, Luca, Wolfsgruber, Steffen, Stark, Melina, Gellersen, Helena M, Yakupov, Renat, Schmid, Matthias C, Lüsebrink, Falk, Brosseron, Frederic, Ziegler, Gabriel, Freiesleben, Silka D, Preis, Lukas, Schneider, Luisa-Sophie, Spruth, Eike J, Altenstein, Slawek, Lohse, Andrea, Fliessbach, Klaus, and Vogt, Ina R
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MILD cognitive impairment ,ATROPHY ,EXECUTIVE function ,CEREBRAL atrophy ,ALZHEIMER'S disease ,ALZHEIMER'S patients - Abstract
Memory clinic patients are a heterogeneous population representing various aetiologies of pathological ageing. It is not known whether divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer's disease patients, are prevalent and clinically meaningful in this group of older adults. To uncover distinct atrophy subtypes, we applied the Subtype and Stage Inference (SuStaIn) algorithm to baseline structural MRI data from 813 participants enrolled in the DELCODE cohort (mean ± standard deviation, age = 70.67 ± 6.07 years, 52% females). Participants were cognitively unimpaired (n = 285) or fulfilled diagnostic criteria for subjective cognitive decline (n = 342), mild cognitive impairment (n = 118) or dementia of the Alzheimer's type (n = 68). Atrophy subtypes were compared in baseline demographics, fluid Alzheimer's disease biomarker levels, the Preclinical Alzheimer Cognitive Composite (PACC-5) as well as episodic memory and executive functioning. PACC-5 trajectories over up to 240 weeks were examined. To test whether baseline atrophy subtype and stage predicted clinical trajectories before manifest cognitive impairment, we analysed PACC-5 trajectories and mild cognitive impairment conversion rates of cognitively unimpaired participants and those with subjective cognitive decline. Limbic-predominant and hippocampal-sparing atrophy subtypes were identified. Limbic-predominant atrophy initially affected the medial temporal lobes, followed by further temporal regions and, finally, the remaining cortical regions. At baseline, this subtype was related to older age, more pathological Alzheimer's disease biomarker levels, APOE ε4 carriership and an amnestic cognitive impairment. Hippocampal-sparing atrophy initially occurred outside the temporal lobe, with the medial temporal lobe spared up to advanced atrophy stages. This atrophy pattern also affected individuals with positive Alzheimer's disease biomarkers and was associated with more generalized cognitive impairment. Limbic-predominant atrophy, in all participants and in only unimpaired participants, was linked to more negative longitudinal PACC-5 slopes than observed in participants without or with hippocampal-sparing atrophy and increased the risk of mild cognitive impairment conversion. SuStaIn modelling was repeated in a sample from the Swedish BioFINDER-2 cohort. Highly similar atrophy progression patterns and associated cognitive profiles were identified. Cross-cohort model generalizability, at both the subject and the group level, was excellent, indicating reliable performance in previously unseen data. The proposed model is a promising tool for capturing heterogeneity among older adults at early at-risk states for Alzheimer's disease in applied settings. The implementation of atrophy subtype- and stage-specific end points might increase the statistical power of pharmacological trials targeting early Alzheimer's disease. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease
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Franzmeier, Nicolai, Düzel, Emrah, Jessen, Frank, Buerger, Katharina, Levin, Johannes, Duering, Marco, Dichgans, Martin, Haass, Christian, Suárez-Calvet, Marc, Fagan, Anne M, Paumier, Katrina, Benzinger, Tammie, Masters, Colin L, Morris, John C, Perneczky, Robert, Janowitz, Daniel, Catak, Cihan, Wolfsgruber, Steffen, Wagner, Michael, Teipel, Stefan, Kilimann, Ingo, Ramirez, Alfredo, Rossor, Martin, Jucker, Mathias, Chhatwal, Jasmeer, Spottke, Annika, Boecker, Henning, Brosseron, Frederic, Falkai, Peter, Fliessbach, Klaus, Heneka, Michael T, Laske, Christoph, Nestor, Peter, Peters, Oliver, Fuentes, Manuel, Menne, Felix, Priller, Josef, Spruth, Eike J, Franke, Christiana, Schneider, Anja, Kofler, Barbara, Westerteicher, Christine, Speck, Oliver, Wiltfang, Jens, Bartels, Claudia, Caballero, Miguel Ángel Araque, Metzger, Coraline, Bittner, Daniel, Weiner, Michael, Lee, Jae-Hong, Salloway, Stephen, Danek, Adrian, Goate, Alison, Schofield, Peter R, Bateman, Randall J, and Ewers, Michael
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Clinical Trials and Supportive Activities ,Brain Disorders ,Aging ,Basic Behavioral and Social Science ,Dementia ,Neurosciences ,Behavioral and Social Science ,Acquired Cognitive Impairment ,Clinical Research ,Alzheimer's Disease ,Neurodegenerative ,Biomedical Imaging ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Adult ,Alzheimer Disease ,Amyloid beta-Protein Precursor ,Brain Mapping ,Cognitive Dysfunction ,Female ,Frontal Lobe ,Functional Laterality ,Humans ,Imaging ,Three-Dimensional ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Mutation ,Nerve Net ,Presenilin-1 ,Presenilin-2 ,Alzheimer's disease ,cognitive reserve ,resting state connectivity ,memory ,dementia biomarkers ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities in the presence of brain pathology. A major open question is which brain mechanisms may support higher reserve capacity, i.e. relatively high cognitive performance at a given level of Alzheimer's pathology. Higher functional MRI-assessed functional connectivity of a hub in the left frontal cortex is a core candidate brain mechanism underlying reserve as it is associated with education (i.e. a protective factor often associated with higher reserve) and attenuated cognitive impairment in prodromal Alzheimer's disease. However, no study has yet assessed whether such hub connectivity of the left frontal cortex supports reserve throughout the evolution of pathological brain changes in Alzheimer's disease, including the presymptomatic stage when cognitive decline is subtle. To address this research gap, we obtained cross-sectional resting state functional MRI in 74 participants with autosomal dominant Alzheimer's disease, 55 controls from the Dominantly Inherited Alzheimer's Network and 75 amyloid-positive elderly participants, as well as 41 amyloid-negative cognitively normal elderly subjects from the German Center of Neurodegenerative Diseases multicentre study on biomarkers in sporadic Alzheimer's disease. For each participant, global left frontal cortex connectivity was computed as the average resting state functional connectivity between the left frontal cortex (seed) and each voxel in the grey matter. As a marker of disease stage, we applied estimated years from symptom onset in autosomal dominantly inherited Alzheimer's disease and cerebrospinal fluid tau levels in sporadic Alzheimer's disease cases. In both autosomal dominant and sporadic Alzheimer's disease patients, higher levels of left frontal cortex connectivity were correlated with greater education. For autosomal dominant Alzheimer's disease, a significant left frontal cortex connectivity × estimated years of onset interaction was found, indicating slower decline of memory and global cognition at higher levels of connectivity. Similarly, in sporadic amyloid-positive elderly subjects, the effect of tau on cognition was attenuated at higher levels of left frontal cortex connectivity. Polynomial regression analysis showed that the trajectory of cognitive decline was shifted towards a later stage of Alzheimer's disease in patients with higher levels of left frontal cortex connectivity. Together, our findings suggest that higher resilience against the development of cognitive impairment throughout the early stages of Alzheimer's disease is at least partially attributable to higher left frontal cortex-hub connectivity.
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- 2018
15. Prominent Non-Memory Deficits in Alzheimer’s Disease Are Associated with Faster Disease Progression
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Scheltens, Nienke ME, Tijms, Betty M, Heymans, Martijn W, Rabinovici, Gil D, Cohn-Sheehy, Brendan I, Miller, Bruce L, Kramer, Joel H, Wolfsgruber, Steffen, Wagner, Michael, Kornhuber, Johannes, Peters, Oliver, Scheltens, Philip, van der Flier, Wiesje M, and Alzheimer’s Disease Neuroimaging Initiative, German Dementia Competence Network
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Biological Psychology ,Psychology ,Neurodegenerative ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Clinical Research ,Neurosciences ,Acquired Cognitive Impairment ,Brain Disorders ,Aging ,Alzheimer's Disease ,Dementia ,2.1 Biological and endogenous factors ,Aetiology ,Mental health ,Neurological ,Good Health and Well Being ,Aged ,Alzheimer Disease ,Cross-Sectional Studies ,Disease Progression ,Female ,Follow-Up Studies ,Humans ,Kaplan-Meier Estimate ,Male ,Memory Disorders ,Neuropsychological Tests ,Phenotype ,Superior Sagittal Sinus ,Time Factors ,Alzheimer's disease ,clustering ,cognition ,dementia ,disease progression ,mortality ,phenotypes ,subtypes ,Amsterdam Dementia Cohort ,Alzheimer’s Disease Neuroimaging Initiative ,German Dementia Competence Network ,University of San Francisco Memory and Aging Center ,Alzheimer’s disease ,Clinical Sciences ,Cognitive Sciences ,Neurology & Neurosurgery ,Clinical sciences ,Biological psychology - Abstract
BackgroundAlzheimer's disease (AD) is a heterogeneous disorder.ObjectiveTo investigate whether cognitive AD subtypes are associated with different rates of disease progression.MethodsWe included 1,066 probable AD patients from the Amsterdam Dementia Cohort (n = 290), Alzheimer's Disease Neuroimaging Initiative (n = 268), Dementia Competence Network (n = 226), and University of California, San Francisco (n = 282) with available follow-up data. Patients were previously clustered into two subtypes based on their neuropsychological test results: one with most prominent memory impairment (n = 663) and one with most prominent non-memory impairment (n = 403). We examined associations between cognitive subtype and disease progression, as measured with repeated Mini-Mental State Examination (MMSE) and Clinical Dementia Rating scale sum of boxes (CDR sob), using linear mixed models. Furthermore, we investigated mortality risk associated with subtypes using Cox proportional hazard analyses.ResultsPatients were 71±9 years old; 541 (51%) were female. At baseline, pooled non-memory patients had worse MMSE scores (23.1±0.1) and slightly worse CDR sob (4.4±0.1) than memory patients (MMSE 24.0±0.1; p
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- 2018
16. Cognitive subtypes of probable Alzheimer's disease robustly identified in four cohorts
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Scheltens, Nienke ME, Tijms, Betty M, Koene, Teddy, Barkhof, Frederik, Teunissen, Charlotte E, Wolfsgruber, Steffen, Wagner, Michael, Kornhuber, Johannes, Peters, Oliver, Cohn‐Sheehy, Brendan I, Rabinovici, Gil D, Miller, Bruce L, Kramer, Joel H, Scheltens, Philip, van der Flier, Wiesje M, Network, German Dementia Competence, San Francisco Memory and Aging Center, University of California, and Cohort, Amsterdam Dementia
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Biological Psychology ,Psychology ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Dementia ,Neurodegenerative ,Alzheimer's Disease ,Aging ,Brain Disorders ,Clinical Research ,Acquired Cognitive Impairment ,Neurosciences ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Aged ,Aged ,80 and over ,Alzheimer Disease ,Amyloid beta-Peptides ,Apolipoprotein E4 ,Cluster Analysis ,Cognition Disorders ,Cohort Studies ,Denmark ,Disease Progression ,Female ,Germany ,Humans ,Magnetic Resonance Imaging ,Male ,Mental Status Schedule ,Middle Aged ,Neuropsychological Tests ,Peptide Fragments ,United States ,Alzheimer's disease ,Cognition ,Heterogeneity ,Subtypes ,Atypical ,Neuropsychology ,German Dementia Competence Network ,University of California San Francisco Memory and Aging Center ,Amsterdam Dementia Cohort ,Clinical Sciences ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionPatients with Alzheimer's disease (AD) show heterogeneity in profile of cognitive impairment. We aimed to identify cognitive subtypes in four large AD cohorts using a data-driven clustering approach.MethodsWe included probable AD dementia patients from the Amsterdam Dementia Cohort (n = 496), Alzheimer's Disease Neuroimaging Initiative (n = 376), German Dementia Competence Network (n = 521), and University of California, San Francisco (n = 589). Neuropsychological data were clustered using nonnegative matrix factorization. We explored clinical and neurobiological characteristics of identified clusters.ResultsIn each cohort, a two-clusters solution best fitted the data (cophenetic correlation >0.9): one cluster was memory-impaired and the other relatively memory spared. Pooled analyses showed that the memory-spared clusters (29%-52% of patients) were younger, more often apolipoprotein E (APOE) ɛ4 negative, and had more severe posterior atrophy compared with the memory-impaired clusters (all P
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- 2017
17. The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease
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Franzmeier, Nicolai, Ren, Jinyi, Damm, Alexander, Monté-Rubio, Gemma, Boada, Mercè, Ruiz, Agustín, Ramirez, Alfredo, Jessen, Frank, Düzel, Emrah, Rodríguez Gómez, Octavio, Benzinger, Tammie, Goate, Alison, Karch, Celeste M., Fagan, Anne M., McDade, Eric, Buerger, Katharina, Levin, Johannes, Duering, Marco, Dichgans, Martin, Suárez-Calvet, Marc, Haass, Christian, Gordon, Brian A., Lim, Yen Ying, Masters, Colin L., Janowitz, Daniel, Catak, Cihan, Wolfsgruber, Steffen, Wagner, Michael, Milz, Esther, Moreno-Grau, Sonia, Teipel, Stefan, Grothe, Michel J, Kilimann, Ingo, Rossor, Martin, Fox, Nick, Laske, Christoph, Chhatwal, Jasmeer, Falkai, Peter, Perneczky, Robert, Lee, Jae-Hong, Spottke, Annika, Boecker, Henning, Brosseron, Frederic, Fliessbach, Klaus, Heneka, Michael T., Nestor, Peter, Peters, Oliver, Fuentes, Manuel, Menne, Felix, Priller, Josef, Spruth, Eike J., Franke, Christiana, Schneider, Anja, Westerteicher, Christine, Speck, Oliver, Wiltfang, Jens, Bartels, Claudia, Araque Caballero, Miguel Ángel, Metzger, Coraline, Bittner, Daniel, Salloway, Stephen, Danek, Adrian, Hassenstab, Jason, Yakushev, Igor, Schofield, Peter R., Morris, John C., Bateman, Randall J., and Ewers, Michael
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- 2021
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18. The characterisation of subjective cognitive decline
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Jessen, Frank, Amariglio, Rebecca E, Buckley, Rachel F, van der Flier, Wiesje M, Han, Ying, Molinuevo, José Luis, Rabin, Laura, Rentz, Dorene M, Rodriguez-Gomez, Octavio, Saykin, Andrew J, Sikkes, Sietske A M, Smart, Colette M, Wolfsgruber, Steffen, and Wagner, Michael
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- 2020
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19. Perivascular spaces in the brain enlarge over time; A three‐year longitudinal study
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Bernal, Jose, primary, Menze, Inga, additional, Yakupov, Renat, additional, Kaya, Pinar, additional, Aki, Cagla, additional, Pfister, Malte, additional, Geisendörfer, Jonas, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Fließbach, Klaus, additional, Wiltfang, Jens, additional, Buerger, Katharina, additional, Perneczky, Robert, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Spottke, Annika, additional, Heneka, Michael T., additional, Wagner, Michael, additional, Ramirez, Alfredo, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Jessen, Frank, additional, Schreiber, Stefanie, additional, Düzel, Emrah, additional, and Ziegler, Gabriel, additional
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- 2023
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20. Altered Resting‐state fMRI BOLD Signal Fluctuations in the Spectrum of Alzheimer’s Dementia and in Patients with White Matter Hyperintensities
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Behrenbruch, Niklas, primary, Incesoy, Enise I, additional, Bernal, Jose, additional, Menze, Inga, additional, Vockert, Niklas, additional, Kleineidam, Luca, additional, Buerger, Katharina, additional, Wolfsgruber, Steffen, additional, Spottke, Annika, additional, Fließbach, Klaus, additional, Laske, Christoph, additional, Perneczky, Robert, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Heneka, Michael T., additional, Wagner, Michael, additional, Tipel, Stefan, additional, Wiltfang, Jens, additional, Speck, Oliver, additional, Perosa, Valentina, additional, Yakupov, Renat, additional, Jessen, Frank, additional, Düzel, Emrah, additional, Mattern, Hendrik, additional, Schreiber, Stefanie, additional, Ziegler, Gabriel, additional, and Maass, Anne, additional
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- 2023
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21. Longitudinal changes of self‐ and informant‐reported cognitive decline in elderly with regard to clinical progression and amyloid‐status
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Kuhn, Elizabeth, primary, Stark, Melina, additional, Kleineidam, Luca, additional, Wolfsgruber, Steffen, additional, Boecker, Henning, additional, Bürger, Katharina, additional, Düzel, Emrah, additional, Fliessbach, Klaus, additional, Gaertner, Florian, additional, Heneka, Michael T., additional, Laske, Christoph, additional, Perneczky, Robert, additional, Peters, Oliver, additional, Priller, Josef, additional, Schmid, Matthias, additional, Schneider, Anja, additional, Spottke, Annika, additional, Teipel, Stefan, additional, Wiltfang, Jens, additional, Jessen, Frank, additional, and Wagner, Michael, additional
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- 2023
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22. Contributions of enlarged perivascular spaces and white matter hyperintensities to cognitive performance in the Alzheimer’s disease continuum – shared and unique effects
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Menze, Inga, primary, Bernal, Jose, additional, Yakupov, Renat, additional, Kaya, Pinar, additional, Aki, Cagla, additional, Pfister, Malte, additional, Geisendörfer, Jonas, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Fliessbach, Klaus, additional, Wiltfang, Jens, additional, Bürger, Katharina, additional, Perneczky, Robert, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Spottke, Annika, additional, Heneka, Michael T., additional, Wagner, Michael, additional, Ramirez, Alfredo, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Jessen, Frank, additional, Schreiber, Stefanie, additional, Düzel, Emrah, additional, and Ziegler, Gabriel, additional
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- 2023
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23. Associations Between Lifetime Musical Activity and Resting‐State Functional Connectivity in Higher‐Order Brain Networks
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Liebscher, Maxie, primary, Dell'Orco, Andrea, additional, Böttcher, Adriana, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Fließbach, Klaus, additional, Wiltfang, Jens, additional, Jessen, Frank, additional, Duzel, Emrah, additional, Buerger, Katharina, additional, Perneczky, Robert, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Spottke, Annika, additional, Wagner, Michael, additional, Heneka, Michael T., additional, Wolfsgruber, Steffen, additional, Roeske, Sandra, additional, and Wirth, Miranka, additional
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- 2023
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24. Longitudinal morphometry of medial temporal lobe subregions in earlyAlzheimer’s disease
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Baumeister, Hannah, primary, Gellersen, Helena M, additional, Kleineidam, Luca, additional, Wolfsgruber, Steffen, additional, Bürger, Katharina, additional, Laske, Christoph, additional, Perneczky, Robert, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Spottke, Annika, additional, Teipel, Stefan, additional, Wiltfang, Jens, additional, Heneka, Michael T., additional, Düzel, Emrah, additional, Jessen, Frank, additional, and Berron, David, additional
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- 2023
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25. Minor neuropsychological deficits in SCD: Association with AD biomarkers and cognitive decline
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Stark, Melina, primary, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Fliessbach, Klaus, additional, Wiltfang, Jens, additional, Jessen, Frank, additional, Düzel, Emrah, additional, Bürger, Katharina, additional, Perneczky, Robert, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Spottke, Annika, additional, Heneka, Michael T., additional, and Wagner, Michael, additional
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- 2023
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26. Altered BOLD Signal Fluctuations in precuneus relate to inflammatory markers and vascular risk in the AD spectrum
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Maass, Anne, primary, Behrenbruch, Niklas, additional, Incesoy, Enise I, additional, Brosseron, Frederic, additional, Menze, Inga, additional, Bernal, Jose, additional, Hayek, Dayana, additional, Kleineidam, Luca, additional, Bürger, Katharina, additional, Fliessbach, Klaus, additional, Laske, Christoph, additional, Perneczky, Robert, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Spottke, Annika, additional, Teipel, Stefan, additional, Wiltfang, Jens, additional, Wolfsgruber, Steffen, additional, Yakupov, Renat, additional, Wagner, Michael, additional, Jessen, Frank, additional, Duzel, Emrah, additional, Schreiber, Stefanie, additional, Heneka, Michael T., additional, and Ziegler, Gabriel, additional
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- 2023
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27. Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline
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Stark, Melina, primary, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Frommann, Ingo, additional, Altenstein, Slawek, additional, Bartels, Claudia, additional, Brosseron, Frederic, additional, Buerger, Katharina, additional, Burow, Lena, additional, Butryn, Michaela, additional, Ewers, Michael, additional, Fliessbach, Klaus, additional, Gabelin, Tatjana, additional, Glanz, Wenzel, additional, Goerss, Doreen, additional, Gref, Daria, additional, Hansen, Niels, additional, Heneka, Michael T., additional, Hinderer, Petra, additional, Incesoy, Enise I, additional, Janowitz, Daniel, additional, Kilimann, Ingo, additional, Kimmich, Okka, additional, Laske, Christoph, additional, Munk, Matthias H., additional, Perneczky, Robert, additional, Peters, Oliver, additional, Preis, Lukas, additional, Priller, Josef, additional, Rauchmann, Boris-Stephan, additional, Rostamzadeh, Ayda, additional, Roy-Kluth, Nina, additional, Sanzenbacher, Carolin, additional, Schneider, Anja, additional, Schott, Björn H., additional, Spottke, Annika, additional, Spruth, Eike Jakob, additional, Teipel, Stefan, additional, Vogt, Ina R, additional, Wiltfang, Jens, additional, Duzel, Emrah, additional, Jessen, Frank, additional, and Wagner, Michael, additional
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- 2023
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28. Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment
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Bainbridge, Wilma A., Berron, David, Schütze, Hartmut, Cardenas-Blanco, Arturo, Metzger, Coraline, Dobisch, Laura, Bittner, Daniel, Glanz, Wenzel, Spottke, Annika, Rudolph, Janna, Brosseron, Frederic, Buerger, Katharina, Janowitz, Daniel, Fliessbach, Klaus, Heneka, Michael, Laske, Christoph, Buchmann, Martina, Peters, Oliver, Diesing, Dominik, Li, Siyao, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Schneider, Anja, Kofler, Barbara, Teipel, Stefan, Kilimann, Ingo, Wiltfang, Jens, Bartels, Claudia, Wolfsgruber, Steffen, Wagner, Michael, Jessen, Frank, Baker, Chris I., and Düzel, Emrah
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- 2019
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29. Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia
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Boada, Mercè, de Deyn, Peter Paul, Jones, Roy, Frisoni, Giovanni, Spiru, Luiza, Nobili, Flavio, Freund-Levi, Yvonne, Soininen, Hilkka, Verhey, Frans, Wallin, Åsa K., Touchon, Jacques, Rikkert, Marcel Olde, Rigaud, Anne-Sophie, Bullock, Roger, Tsolaki, Magda, Vellas, Bruno, Wilcock, Gordon, Hampel, Harald, Froelich, Lutz, Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Cavedo, Enrica, Chiesa, Patrizia, Colliot, Olivier, Dubois, Bruno, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Houot, Marion, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Lista, Simone, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, Thiebaud de Schotten, Michel, Vergallo, Andrea, Younsi, Nadjia, Slot, Rosalinde E.R., Sikkes, Sietske A.M., Berkhof, Johannes, Brodaty, Henry, Buckley, Rachel, Dardiotis, Efthimios, Guillo-Benarous, Francoise, Kochan, Nicole A., Luck, Tobias, Maruff, Paul, Molinuevo, José Luis, Kornhuber, Johannes, Reisberg, Barry, Riedel-Heller, Steffi G., Risacher, Shannon L., Roehr, Susanne, Sachdev, Perminder S., Scarmeas, Nikolaos, Scheltens, Philip, Shulman, Melanie B., Saykin, Andrew J., Verfaillie, Sander C.J., Visser, Pieter Jelle, Vos, Stephanie J.B., Wagner, Michael, Wolfsgruber, Steffen, Jessen, Frank, and van der Flier, Wiesje M.
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- 2019
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30. Symptomatic clusters related to amyloid positivity in cognitively unimpaired individuals
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Sannemann, Lena, primary, Bartels, Claudia, additional, Brosseron, Frederic, additional, Buerger, Katharina, additional, Fliessbach, Klaus, additional, Freiesleben, Silka Dawn, additional, Frommann, Ingo, additional, Glanz, Wenzel, additional, Heneka, Michael T., additional, Janowitz, Daniel, additional, Kilimann, Ingo, additional, Kleineidam, Luca, additional, Lammerding, Dominik, additional, Laske, Christoph, additional, Munk, Matthias H. J., additional, Perneczky, Robert, additional, Peters, Oliver, additional, Priller, Josef, additional, Rauchmann, Boris-Stephan, additional, Rostamzadeh, Ayda, additional, Roy-Kluth, Nina, additional, Schild, Ann-Katrin, additional, Schneider, Anja, additional, Schneider, Luisa-Sophie, additional, Spottke, Annika, additional, Spruth, Eike Jakob, additional, Teipel, Stefan, additional, Wagner, Michael, additional, Wiltfang, Jens, additional, Wolfsgruber, Steffen, additional, Duezel, Emrah, additional, and Jessen, Frank, additional
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- 2023
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31. Physical exercise and cognitive function across the life span: Results of a nationwide population-based study
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Gaertner, Beate, Buttery, Amanda K., Finger, Jonas D., Wolfsgruber, Steffen, Wagner, Michael, and Busch, Markus A.
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- 2018
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32. Different Cognitive Complaint Profiles in Memory Clinic and Depressive Patients
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Miebach, Lisa, Wolfsgruber, Steffen, Frommann, Ingo, Buckley, Rachel, and Wagner, Michael
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- 2018
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33. CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume
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Düzel, Emrah, Berron, David, Schütze, Hartmut, Cardenas-Blanco, Arturo, Metzger, Coraline, Betts, Matthew, Ziegler, Gabriel, Chen, Yi, Dobisch, Laura, Bittner, Daniel, Glanz, Wenzel, Reuter, Martin, Spottke, Annika, Rudolph, Janna, Brosseron, Frederic, Buerger, Katharina, Janowitz, Daniel, Fliessbach, Klaus, Heneka, Michael, Laske, Christoph, Buchmann, Martina, Nestor, Peter, Peters, Oliver, Diesing, Dominik, Li, Siyao, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Ramirez, Alfredo, Schneider, Anja, Kofler, Barbara, Speck, Oliver, Teipel, Stefan, Kilimann, Ingo, Dyrba, Martin, Wiltfang, Jens, Bartels, Claudia, Wolfsgruber, Steffen, Wagner, Michael, and Jessen, Frank
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- 2018
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34. Computer-assisted prediction of clinical progression in the earliest stages of AD
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Rhodius-Meester, Hanneke F.M., Liedes, Hilkka, Koikkalainen, Juha, Wolfsgruber, Steffen, Coll-Padros, Nina, Kornhuber, Johannes, Peters, Oliver, Jessen, Frank, Kleineidam, Luca, Molinuevo, José Luis, Rami, Lorena, Teunissen, Charlotte E., Barkhof, Frederik, Sikkes, Sietske A.M., Wesselman, Linda M.P., Slot, Rosalinde E.R., Verfaillie, Sander C.J., Scheltens, Philip, Tijms, Betty M., Lötjönen, Jyrki, and van der Flier, Wiesje M.
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- 2018
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35. A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease
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Rauchmann, Boris-Stephan, primary, Gross, Patrizia, additional, Ersoezlue, Ersin, additional, Wagner, Michael, additional, Tommaso, Ballarini, additional, Kurz, Carolin, additional, Tatò, Maia, additional, Utecht, Julia, additional, Papazov, Boris, additional, Guersel, Selim, additional, Totzke, Marie, additional, Trappmann, Lena, additional, Burow, Lena, additional, Koller, Gabriele, additional, Stöcklein, Sophia, additional, Keeser, Daniel, additional, Altenstein, Slawek, additional, Bartels, Claudia, additional, Buerger, Katharina, additional, Dechent, Peter, additional, Dobisch, Laura, additional, Ewers, Michael, additional, Fliessbach, Klaus, additional, Freiesleben, Silka Dawn, additional, Glanz, Wenzel, additional, Goeerss, Doreen, additional, Gref, Daria, additional, Haynes, John Dylan, additional, Janowitz, Daniel, additional, Kilimann, Ingo, additional, Kimmich, Okka, additional, Kleineidam, Luca, additional, Laske, Christoph, additional, Lohse, Andrea, additional, Maier, Franziska, additional, Metzger, Coraline D., additional, Munk, Matthias H., additional, Peters, Oliver, additional, Preis, Lukas, additional, Priller, Josef, additional, Roeske, Sandra, additional, Roy, Nina, additional, Sanzenbacher, Carolin, additional, Scheffler, Klaus, additional, Schneider, Anja, additional, Schott, Björn Hendrik, additional, Spottke, Annika, additional, Spruth, Eike Jakob, additional, Teipel, Stefan, additional, van Lent, Debora Melo, additional, Wiltfang, Jens, additional, Wolfsgruber, Steffen, additional, Yakupov, Renat, additional, Düzel, Emrah, additional, Jessen, Frank, additional, and Perneczky, Robert, additional
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- 2023
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36. Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts
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Jiang, Xueyan, primary, Hu, Xiaochen, additional, Daamen, Marcel, additional, Wang, Xiaoqi, additional, Fan, Chunqiu, additional, Meiberth, Dix, additional, Spottke, Annika, additional, Roeske, Sandra, additional, Fliessbach, Klaus, additional, Spruth, Eike Jakob, additional, Altenstein, Slawek, additional, Lohse, Andrea, additional, Hansen, Niels, additional, Glanz, Wenzel, additional, Incesoy, Enise I., additional, Dobisch, Laura, additional, Janowitz, Daniel, additional, Rauchmann, Boris‐Stephan, additional, Ramirez, Alfredo, additional, Kilimann, Ingo, additional, Munk, Matthias H., additional, Wang, Xiao, additional, Schneider, Luisa‐Sophie, additional, Gabelin, Tatjana, additional, Roy, Nina, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Hetzer, Stefan, additional, Dechent, Peter, additional, Ewers, Michael, additional, Scheffler, Klaus, additional, Amthauer, Holger, additional, Buchert, Ralph, additional, Essler, Markus, additional, Drzezga, Alexander, additional, Rominger, Axel, additional, Krause, Bernd J., additional, Reimold, Matthias, additional, Priller, Josef, additional, Schneider, Anja, additional, Wiltfang, Jens, additional, Buerger, Katharina, additional, Perneczky, Robert, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Peters, Oliver, additional, Düzel, Emrah, additional, Wagner, Michael, additional, Jiang, Jiehui, additional, Jessen, Frank, additional, Boecker, Henning, additional, and Han, Ying, additional
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- 2023
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37. Which types of mental work demands may be associated with reduced risk of dementia?
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Abholz, Heinz-Harald, Brettschneider, Christian, Bachmann, Cadja, Bickel, Horst, Blank, Wolfgang, van den Bussche, Hendrik, Eifflaender-Gorfer, Sandra, Eisele, Marion, Ernst, Annette, Fuchs, Angela, Heser, Kathrin, Jessen, Frank, Kaduszkiewicz, Hanna, Kaufeler, Teresa, Köhler, Mirjam, König, Hans-Helmut, Koppara, Alexander, Lange, Carolin, Lubisch, Diana, Luck, Tobias, Luppa, Melanie, Maier, Wolfgang, Mayer, Manfred, Mösch, Edelgard, Pentzek, Michael, Posselt, Tina, Prokein, Jana, Riedel-Heller, Steffi, Röhr, Susanne, Scherer, Martin, Schumacher, Anna, Stein, Janine, Steinmann, Susanne, Tebarth, Franziska, Wagner, Michael, Weckbecker, Klaus, Weeg, Dagmar, Werle, Jochen, Weyerer, Siegfried, Wiese, Birgitt, Wolfsgruber, Steffen, Zimmermann, Thomas, Then, Francisca S., Mamone, Silke, and Riedel-Heller, Steffi G.
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- 2017
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38. Prevalence of abnormal Alzheimer’s disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples
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Wolfsgruber, Steffen, Molinuevo, José Luis, Wagner, Michael, Teunissen, Charlotte E., Rami, Lorena, Coll-Padrós, Nina, Bouwman, Femke H., Slot, Rosalinde E. R., Wesselman, Linda M. P., Peters, Oliver, Luther, Katja, Buerger, Katharina, Priller, Josef, Laske, Christoph, Teipel, Stefan, Spottke, Annika, Heneka, Michael T., Düzel, Emrah, Drzezga, Alexander, Wiltfang, Jens, Sikkes, Sietske A. M., van der Flier, Wiesje M., Jessen, Frank, and on behalf of the Euro-SCD working group
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- 2019
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39. Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts
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Jiang, Xueyan, Hu, Xiaochen, Daamen, Marcel, Wang, Xiaoqi, Fan, Chunqiu, Meiberth, Dix, Spottke, Annika, Roeske, Sandra, Fliessbach, Klaus, Spruth, Eike Jakob, Altenstein, Slawek, Lohse, Andrea, Hansen, Niels, Glanz, Wenzel, Incesoy, Enise I, Dobisch, Laura, Janowitz, Daniel, Rauchmann, Boris-Stephan, Ramirez, Alfredo, Kilimann, Ingo, Munk, Matthias H, Wang, Xiao, Schneider, Luisa-Sophie, Gabelin, Tatjana, Roy, Nina, Wolfsgruber, Steffen, Kleineidam, Luca, Hetzer, Stefan, Dechent, Peter, Ewers, Michael, Scheffler, Klaus, Amthauer, Holger, Buchert, Ralph, Essler, Markus, Drzezga, Alexander, Rominger, Axel, Krause, Bernd J, Reimold, Matthias, Priller, Josef, Schneider, Anja, Wiltfang, Jens, Buerger, Katharina, Perneczky, Robert, Teipel, Stefan, Laske, Christoph, Peters, Oliver, Düzel, Emrah, Wagner, Michael, Jiang, Jiehui, Jessen, Frank, Boecker, Henning, and Han, Ying
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hippocampus ,Epidemiology ,Health Policy ,functional connectivity ,610 Medicine & health ,insula ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,amyloid deposition ,cross-cultural harmonization ,ddc:610 ,Neurology (clinical) ,Centiloid ,subjective cognitive decline ,Geriatrics and Gerontology - Abstract
INTRODUCTION: It remains unclear whether functional brain networks are consistently altered in individuals with subjective cognitive decline (SCD) of diverse ethnic and cultural backgrounds and whether the network alterations are associated with an amyloid burden.METHODS: Cross-sectional resting-state functional magnetic resonance imaging connectivity (FC) and amyloid-positron emission tomography (PET) data from the Chinese Sino Longitudinal Study on Cognitive Decline and German DZNE Longitudinal Cognitive Impairment and Dementia cohorts were analyzed.RESULTS: Limbic FC, particularly hippocampal connectivity with right insula, was consistently higher in SCD than in controls, and correlated with SCD-plus features. Smaller SCD subcohorts with PET showed inconsistent amyloid positivity rates and FC-amyloid associations across cohorts.DISCUSSION: Our results suggest an early adaptation of the limbic network in SCD, which may reflect increased awareness of cognitive decline, irrespective of amyloid pathology. Different amyloid positivity rates may indicate a heterogeneous underlying etiology in Eastern and Western SCD cohorts when applying current research criteria. Future studies should identify culture-specific features to enrich preclinical Alzheimer's disease in non-Western populations.HIGHLIGHTS: Common limbic hyperconnectivity across Chinese and German subjective cognitive decline (SCD) cohorts was observed. Limbic hyperconnectivity may reflect awareness of cognition, irrespective of amyloid load. Further cross-cultural harmonization of SCD regarding Alzheimer's disease pathology is required.
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- 2023
40. Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease
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Billette, Ornella V, Ziegler, Gabriel, Dahmen, Philip, Dechent, Peter, Dobisch, Laura, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Göerß, Doreen, Haynes, John Dylan, Heneka, Michael T, Kilimann, Ingo, Aruci, Merita, Kimmich, Okka, Kleineidam, Luca, Laske, Christoph, Lohse, Andrea, Rostamzadeh, Ayda, Metzger, Coraline, Munk, Matthias H, Peters, Oliver, Preis, Lukas, Priller, Josef, Schütze, Hartmut, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Ramirez, Alfredo, Röske, Sandra, Roy, Nina, Teipel, Stefan, Wagner, Michael, Wiltfang, Jens, Kizilirmak, Jasmin M, Wolfsgruber, Steffen, Yakupov, Renat, Zeidman, Peter, Jessen, Frank, Schott, Björn, Düzel, Emrah, Maass, Anne, Group, DELCODE Study, Richter, Anni, Altenstein, Slawek, Bartels, Claudia, Brosseron, Frederic, and Cardenas-Blanco, Arturo
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Alzheimer Disease/diagnosis ,Amyloid beta-Peptides ,Cognitive Dysfunction/diagnostic imaging ,diagnosis [Alzheimer Disease] ,diagnostic imaging [Cognitive Dysfunction] ,Magnetic Resonance Imaging ,Temporal Lobe/diagnostic imaging ,Temporal Lobe ,Magnetic Resonance Imaging/methods ,diagnostic imaging [Parietal Lobe] ,Parietal Lobe/diagnostic imaging ,methods [Magnetic Resonance Imaging] ,diagnostic imaging [Temporal Lobe] ,Alzheimer Disease ,Parietal Lobe ,Humans ,Cognitive Dysfunction ,ddc:610 ,Neurology (clinical) ,Biomarkers - Abstract
Background and ObjectivesWe assessed whether novelty-related fMRI activity in medial temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the clinical spectrum of increased Alzheimer disease (AD) risk as previously suggested. Specifically, we tested for potentially increased activity in individuals with a higher AD risk due to subjective cognitive decline (SCD) or mild cognitive impairment (MCI). We further tested whether activity differences related to diagnostic groups were accounted for by CSF markers of AD or brain atrophy.MethodsWe studied 499 participants aged 60–88 years from the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE) who underwent task-fMRI. Participants included 163 cognitively normal (healthy control, HC) individuals, 222 SCD, 82 MCI, and 32 patients with clinical diagnosis of mild AD. CSF levels of β-amyloid 42/40 ratio and phosphorylated-tau181 were available from 232 participants. We used region-based analyses to assess novelty-related activity (novel > highly familiar scenes) in entorhinal cortex, hippocampus, and precuneus as well as whole-brain voxel-wise analyses. First, general linear models tested differences in fMRI activity between participant groups. Complementary regression models tested quadratic relationships between memory impairment and activity. Second, relationships of activity with AD CSF biomarkers and brain volume were analyzed. Analyses were controlled for age, sex, study site, and education.ResultsIn the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. This nonlinear pattern was confirmed by a quadratic relationship between memory impairment and precuneus activity. Precuneus activity was not related to AD biomarkers or brain volume. In contrast to the precuneus, hippocampal activity was reduced in AD dementia compared with all other groups and related to AD biomarkers.DiscussionNovelty-related activity in the precuneus follows a nonlinear pattern across the clinical spectrum of increased AD risk. Although the underlying mechanism remains unclear, increased precuneus activity might represent an early signature of memory impairment. Our results highlight the nonlinearity of activity alterations that should be considered in clinical trials using functional outcome measures or targeting hyperactivity.
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- 2022
41. Gender differences in the effect of social support on health-related quality of life: results of a population-based prospective cohort study in old age in Germany
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Hajek, André, Brettschneider, Christian, Lange, Carolin, Posselt, Tina, Wiese, Birgitt, Steinmann, Susanne, Weyerer, Siegfried, Werle, Jochen, Pentzek, Michael, Fuchs, Angela, Stein, Janine, Luck, Tobias, Bickel, Horst, Mösch, Edelgard, Wolfsgruber, Steffen, Heser, Kathrin, Maier, Wolfgang, Scherer, Martin, Riedel-Heller, Steffi G., and König, Hans-Helmut
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- 2016
42. Linking self-perceived cognitive functioning questionnaires using item response theory: The subjective cognitive decline initiative
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Rabin, Laura A, Sikkes, Sietske A M, Boada, Mercè, Chételat, Gaël, Dubois, Bruno, Ellis, Kathryn A, Gifford, Katherine A, Jefferson, Angela L, Jessen, Frank, Johnson, Sterling, Katz, Mindy J, Lipton, Richard B, Tommet, Douglas, Luck, Tobias, Margioti, Eleni, Maruff, Paul, Molinuevo, Jose Luis, Perrotin, Audrey, Petersen, Ronald C, Rami, Lorena, Reisberg, Barry, Rentz, Dorene M, Riedel-Heller, Steffi G, Jones, Richard N, Risacher, Shannon L, Rodriguez-Gomez, Octavio, Sachdev, Perminder S, Saykin, Andrew J, Scarmeas, Nikolaos, Smart, Colette, Snitz, Beth E, Sperling, Reisa A, Taler, Vanessa, van der Flier, Wiesje M, Crane, Paul K, van Harten, Argonde C, Wagner, Michael, Wolfsgruber, Steffen, Initiative, Alzheimer’s Disease Neuroimaging, Aging, Canadian Longitudinal Study on, Health, Disparities, Aging Brain Study: Health, Elbulok-Charcape, Milushka M, Dubbelman, Mark A, Koscik, Rebecca, Amariglio, Rebecca E, and Buckley, Rachel F
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Cognition ,diagnosis [Cognitive Dysfunction] ,Psychometrics ,Surveys and Questionnaires ,Humans ,Bayes Theorem ,ddc:610 ,Self Report ,Aged - Abstract
Self-perceived cognitive functioning, considered highly relevant in the context of aging and dementia, is assessed in numerous ways-hindering the comparison of findings across studies and settings. Therefore, the present study aimed to link item-level self-report questionnaire data from international aging studies.We harmonized secondary data from 24 studies and 40 different questionnaires with item response theory (IRT) techniques using a graded response model with a Bayesian estimator. We compared item information curves to identify items with high measurement precision at different levels of the self-perceived cognitive functioning latent trait. Data from 53,030 neuropsychologically intact older adults were included, from 13 English language and 11 non-English (or mixed) language studies.We successfully linked all questionnaires and demonstrated that a single-factor structure was reasonable for the latent trait. Items that made the greatest contribution to measurement precision (i.e., 'top items') assessed general and specific memory problems and aspects of executive functioning, attention, language, calculation, and visuospatial skills. These top items originated from distinct questionnaires and varied in format, range, time frames, response options, and whether they captured ability and/or change.This was the first study to calibrate self-perceived cognitive functioning data of geographically diverse older adults. The resulting item scores are on the same metric, facilitating joint or pooled analyses across international studies. Results may lead to the development of new self-perceived cognitive functioning questionnaires guided by psychometric properties, content, and other important features of items in our item bank. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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- 2023
43. A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum
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Ersoezlue, Ersin, Perneczky, Robert, Keeser, Daniel, Papazov, Boris, Totzke, Marie, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Tato, Maia, Glanz, Wenzel, Haynes, John Dylan, Heneka, Michael T, Janowitz, Daniel, Kilimann, Ingo, Kleineidam, Luca, Laske, Christoph, Maier, Franziska, Munk, Matthias H, Peters, Oliver, Utecht, Julia, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H, Spottke, Annika, Spruth, Eike J, Teipel, Stefan, Kurz, Carolin, Unterfeld, Chantal, Wagner, Michael, Wang, Xiao, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, Rauchmann, Boris-Stephan, group, DELCODE study, Häckert, Jan, Guersel, Selim, Burow, Lena, Koller, Gabriele, and Stoecklein, Sophia
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cognition ,General Neuroscience ,resting-state functional connectivity ,General Medicine ,cognitive reserve ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Clinical Psychology ,pathology [Alzheimer Disease] ,intrinsic network connectivity ,Neural Pathways ,Humans ,functional MRI ,ddc:610 ,Geriatrics and Gerontology ,Nerve Net ,diagnostic imaging [Brain] ,Alzheimer’s disease - Abstract
Background: Cognitive reserve (CR) explains inter-individual differences in the impact of the neurodegenerative burden on cognitive functioning. A residual model was proposed to estimate CR more accurately than previous measures. However, associations between residual CR markers (CRM) and functional connectivity (FC) remain unexplored. Objective: To explore the associations between the CRM and intrinsic network connectivity (INC) in resting-state networks along the neuropathological-continuum of Alzheimer’s disease (ADN). Methods: Three hundred eighteen participants from the DELCODE cohort were stratified using cerebrospinal fluid biomarkers according to the A(myloid-β)/T(au)/N(eurodegeneration) classification. CRM was calculated utilizing residuals obtained from a multilinear regression model predicting cognition from markers of disease burden. Using an independent component analysis in resting-state fMRI data, we measured INC of resting-state networks, i.e., default mode network (DMN), frontoparietal network (FPN), salience network (SAL), and dorsal attention network. The associations of INC with a composite memory score and CRM and the associations of CRM with the seed-to-voxel functional connectivity of memory-related were tested in general linear models. Results: CRM was positively associated with INC in the DMN in the entire cohort. The A+T+N+ group revealed an anti-correlation between the SAL and the DMN. Furthermore, CRM was positively associated with anti-correlation between memory-related regions in FPN and DMN in ADN and A+T/N+. Conclusion: Our results provide evidence that INC is associated with CRM in ADN defined as participants with amyloid pathology with or without cognitive symptoms, suggesting that the neural correlates of CR are mirrored in network FC in resting-state.
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- 2023
44. Cognitive functioning in the general population: Factor structure and association with mental disorders—The neuropsychological test battery of the mental health module of the German Health Interview and Examination Survey for Adults (DEGS1‐MH)
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Wagner, Michael, Wolfsgruber, Steffen, Gaertner, Beate, Kleineidam, Luca, Buttery, Amanda K., Jacobi, Frank, Van der Elst, Wim, Jolles, Jelle, Hapke, Ulfert, Wittchen, Hans‐Ulrich, Maier, Wolfgang, and Busch, Markus A.
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- 2018
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45. Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study
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Miebach, Lisa, Wolfsgruber, Steffen, Polcher, Alexandra, Peters, Oliver, Menne, Felix, Luther, Katja, Incesoy, Enise, Priller, Josef, Spruth, Eike, Altenstein, Slawek, Buerger, Katharina, Catak, Cihan, Janowitz, Daniel, Perneczky, Robert, Utecht, Julia, Laske, Christoph, Buchmann, Martina, Schneider, Anja, Fliessbach, Klaus, Kalbhen, Pascal, Heneka, Michael T., Brosseron, Frederic, Spottke, Annika, Roy, Nina, Teipel, Stefan J., Kilimann, Ingo, Wiltfang, Jens, Bartels, Claudia, Düzel, Emrah, Dobisch, Laura, Metzger, Coraline, Meiberth, Dix, Ramirez, Alfredo, Jessen, Frank, and Wagner, Michael
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- 2019
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46. Personalized risk for clinical progression in cognitively normal subjects—the ABIDE project
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van Maurik, Ingrid S., Slot, Rosalinde E. R., Verfaillie, Sander C. J., Zwan, Marissa D., Bouwman, Femke H., Prins, Niels D., Teunissen, Charlotte E., Scheltens, Philip, Barkhof, Frederik, Wattjes, Mike P., Molinuevo, Jose Luis, Rami, Lorena, Wolfsgruber, Steffen, Peters, Oliver, Jessen, Frank, Berkhof, Johannes, van der Flier, Wiesje M., and for the Alzheimer’s Disease Neuroimaging Initiative
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- 2019
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47. Cognitive performance before and after the onset of subjective cognitive decline in old age
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Koppara, Alexander, Wagner, Michael, Lange, Carolin, Ernst, Annette, Wiese, Birgitt, König, Hans-Helmut, Brettschneider, Christian, Riedel-Heller, Steffi, Luppa, Melanie, Weyerer, Siegfried, Werle, Jochen, Bickel, Horst, Mösch, Edelgard, Pentzek, Michael, Fuchs, Angela, Wolfsgruber, Steffen, Beauducel, André, Scherer, Martin, Maier, Wolfgang, and Jessen, Frank
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- 2015
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48. Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type
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Popp, Julius, Wolfsgruber, Steffen, Heuser, Isabella, Peters, Oliver, Hüll, Michael, Schröder, Johannes, Möller, Hans-Jürgen, Lewczuk, Piotr, Schneider, Anja, Jahn, Holger, Luckhaus, Christian, Perneczky, Robert, Frölich, Lutz, Wagner, Michael, Maier, Wolfgang, Wiltfang, Jens, Kornhuber, Johannes, and Jessen, Frank
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- 2015
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49. Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old
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Melo van Lent, Debora, primary, Egert, Sarah, additional, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Weinhold, Leonie, additional, Wagner-Thelen, Holger, additional, Stoffel-Wagner, Birgit, additional, Bickel, Horst, additional, Wiese, Birgitt, additional, Weyerer, Siegfried, additional, Pentzek, Michael, additional, Jessen, Frank, additional, Schmid, Matthias, additional, Maier, Wolfgang, additional, Scherer, Martin, additional, Riedel-Heller, Steffi G., additional, Ramirez, Alfredo, additional, and Wagner, Michael, additional
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- 2022
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50. Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve
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Kleineidam, Luca, primary, Wolfsgruber, Steffen, additional, Weyrauch, Anne-Sophie, additional, Zulka, Linn E., additional, Forstmeier, Simon, additional, Roeske, Sandra, additional, van den Bussche, Hendrik, additional, Kaduszkiewicz, Hanna, additional, Wiese, Birgitt, additional, Weyerer, Siegfried, additional, Werle, Jochen, additional, Fuchs, Angela, additional, Pentzek, Michael, additional, Brettschneider, Christian, additional, König, Hans-Helmut, additional, Weeg, Dagmar, additional, Bickel, Horst, additional, Luppa, Melanie, additional, Rodriguez, Francisca S., additional, Freiesleben, Silka Dawn, additional, Erdogan, Selin, additional, Unterfeld, Chantal, additional, Peters, Oliver, additional, Spruth, Eike J., additional, Altenstein, Slawek, additional, Lohse, Andrea, additional, Priller, Josef, additional, Fliessbach, Klaus, additional, Kobeleva, Xenia, additional, Schneider, Anja, additional, Bartels, Claudia, additional, Schott, Björn H., additional, Wiltfang, Jens, additional, Maier, Franziska, additional, Glanz, Wenzel, additional, Incesoy, Enise I., additional, Butryn, Michaela, additional, Düzel, Emrah, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Ewers, Michael, additional, Rauchmann, Boris-Stephan, additional, Perneczky, Robert, additional, Kilimann, Ingo, additional, Görß, Doreen, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Munk, Matthias H. J., additional, Spottke, Annika, additional, Roy, Nina, additional, Brosseron, Frederic, additional, Heneka, Michael T., additional, Ramirez, Alfredo, additional, Yakupov, Renat, additional, Scherer, Martin, additional, Maier, Wolfgang, additional, Jessen, Frank, additional, Riedel-Heller, Steffi G., additional, and Wagner, Michael, additional
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- 2022
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