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4. Less restrictions in daily life: a clinical practice guideline for children with cancer.

Author

Stavleu, Debbie C., Mulder, Renée L., Kruimer, Demi M., Kremer, Leontien C. M., Tissing, Wim J. E., Loeffen, Erik A. H., Beek, Laura R., Evers, Janneke H. P., Hagleitner, Melanie M., Martens, Daniëlle H. J., Noordzij, Jeroen G., Ophorst, Ida, Ottens, Janneke R., Plieger, Willemijn, Quaak, Marjolijn S. W., Schuerhoff, Tirza, Spijkerman, Judith, van der Steeg, Alida F. W., van de Wetering, Marianne D., and Wolfs, Tom F. W.

Abstract

Purpose: In current clinical practice, recommendations regarding restrictions in daily life for children with cancer are often lacking or not evidence-based. Critically reviewing the evidence and formulating recommendations are therefore of great importance as social restrictions (e.g., swimming, school attendance, sports) can impair the quality of life of these children severely. Therefore, our aim was to develop a clinical practice guideline for clinicians, children, and their parents regarding social restrictions in children with cancer. Methods: A comprehensive multidisciplinary panel was assembled, comprising 21 professionals and patient representatives. A systematic literature review was performed, including dual appraisal of all citations. The GRADE methodology was used to extract, summarize, and assess the evidence. Multiple in-person meetings were held to rank outcomes, discuss evidence, complete evidence-to-decision frameworks, and formulate recommendations. Final recommendations were unanimously supported by all panel members. Results: Six studies, including 758 children, formed the evidence base for the recommendations. Given the scarcity of the available evidence and various designs of studies in children with cancer, additional evidence was extracted from adult oncology guidelines, and shared expert opinions were utilized. In total, 14 recommendations were formulated of which multiple result in changes in current policy and standard of practice in the Netherlands. Topics covered in this guideline are swimming, having pets, visiting the zoo or farm, performing sports or high-velocity events, attending school or kindergarten, and use of public transport. This guideline is not intended to provide recommendations for patients after end of treatment, for palliative care settings, or for children undergoing a stem cell transplantation. Conclusions: In this clinical practice guideline, we provide recommendations regarding restrictions in daily life in children with cancer. These include evidence-based recommendations and, in the absence of sufficient evidence, recommendations based on expert evidence. With these recommendations, we provide guidance for clinicians, children, and parents and contribute to improving quality of life for children with cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment)

Author

van Houten, Chantal B., Cohen, Asi, Engelhard, Dan, Hays, John P., Karlsson, Roger, Moore, Edward, Fernández, David, Kreisberg, Racheli, Collins, Laurence V., de Waal, Wouter, de Winter-de Groot, Karin M., Wolfs, Tom F. W., Meijers, Pieter, Luijk, Bart, Oosterheert, Jan Jelrik, Heijligenberg, Rik, Sankatsing, Sanjay U. C., Bossink, Aik W. J., Stubbs, Andrew, Stein, Michal, Reisfeld, Sharon, Klein, Adi, Rachmilevitch, Ronit, Ashkar, Jalal, Braverman, Itzhak, Kartun, Valery, Chistyakov, Irena, Bamberger, Ellen, Srugo, Isaac, Odeh, Majed, Schiff, Elad, Dotan, Yaniv, Boico, Olga, Navon, Roy, Friedman, Tom, Etshtein, Liat, Paz, Meital, Gottlieb, Tanya M., Pri-Or, Ester, Kronenfeld, Gali, Simon, Einav, Oved, Kfir, Eden, Eran, and Bont, Louis J.

Published
2019
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8. Pharmacokinetic investigations of isavuconazole in paediatric cancer patients show reduced exposure of isavuconazole after opening capsules for administration via a nasogastric tube.

Author

Bury, Didi, Wolfs, Tom F W, Heine, Rob ter, Muilwijk, Eline W, Elst, Kim C M van der, Tissing, Wim J E, and Brüggemann, Roger J M

Subjects
*NASOENTERAL tubes, *CHILD patients, *CHILDHOOD cancer, *DRUG dosage, *CANCER patients, *MONTE Carlo method
Abstract

Objectives To study the isavuconazole pharmacokinetics in a real-life paediatric cohort and confirm whether the isavuconazole exposures are within the adult exposure range. Furthermore, we are the first to describe unbound isavuconazole pharmacokinetics. Methods In this prospective, observational study, the isavuconazole dosing regimen was as follows (IV/oral/nasogastric tube): 5.4 mg/kg isavuconazole (maximum 200 mg/dose) three times daily on Days 1 and 2, followed by 5.4 mg/kg isavuconazole (maximum 200 mg/dose) once daily. At least one pharmacokinetic curve was assessed. Non-linear mixed effects modelling was used for analysis. Monte Carlo simulations were performed with the above mentioned maintenance dose for IV administrations and a weight band dosing regimen for oral/nasogastric tube administrations: I) <18 kg (100 mg daily); II) 18–37 kg (150 mg daily); III)>37 kg (200 mg daily). Results Seventeen paediatric patients with a median age of 9 years (range 1–17) and median weight of 26.0 kg (range 8.4–78.5) were evaluated. A two-compartment model describing linear pharmacokinetics of the unbound concentrations and saturable protein binding fitted the isavuconazole concentrations best. The absolute bioavailability of isavuconazole was 41.0% (95% CI: 32.4%–50.8%). The median (IQR) simulated exposures (AUC0–24h, SS) of the total isavuconazole concentrations after IV and oral/nasogastric tube administration were 87.7 mg·h/L (70.5–105.1) and 50.3 mg·h/L (39.0–62.4), respectively. The unbound isavuconazole fraction (unbound/total) ranged from 0.5% to 2.3%. Conclusions This study revealed low bioavailability after nasogastric tube administration with opened capsules. Isavuconazole exposures were in the expected range following IV administration. Total and unbound isavuconazole pharmacokinetics were reported with a 5-fold range in the unbound fraction. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Pharmacokinetic investigations of isavuconazole in paediatric cancer patients show reduced exposure of isavuconazole after opening capsules for administration via a nasogastric tube

Author

Infectiezieken, Infectieziekten patientenzorg, Child Health, Infection & Immunity, Apotheek Klinische Farmacie, PMC Medisch specialisten, Bury, Didi, Wolfs, Tom F W, Ter Heine, Rob, Muilwijk, Eline W, van der Elst, Kim C M, Tissing, Wim J E, Brüggemann, Roger J M, Infectiezieken, Infectieziekten patientenzorg, Child Health, Infection & Immunity, Apotheek Klinische Farmacie, PMC Medisch specialisten, Bury, Didi, Wolfs, Tom F W, Ter Heine, Rob, Muilwijk, Eline W, van der Elst, Kim C M, Tissing, Wim J E, and Brüggemann, Roger J M

Published
2023

11. Adoption is not associated with immunological and virological outcomes in children with perinatally acquired HIV infection in the Netherlands

Author

van den Hof, Malon, Smit, Colette, van Rossum, Annemarie M. C., Fraaij, Pieter L. A., Wolfs, Tom F. W., Geelen, Sibyl P. M., Scherpbier, Henriette J., Schölvinck, Elisabeth H., van Aerde, Koen, Reiss, Peter, Wit, Ferdinand W. N. M., Pajkrt, Dasja, Pediatrics, Epidemiology and Data Science, APH - Methodology, APH - Societal Participation & Health, ARD - Amsterdam Reproduction and Development, Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology, AII - Amsterdam institute for Infection and Immunity, Global Health, AII - Infectious diseases, and APH - Aging & Later Life

Subjects
SDG 3 - Good Health and Well-being
Abstract

Objectives To provide an overview of the demographics, treatment characteristics and long-term outcomes of children with perinatal HIV-1 infection (PHIV) living in the Netherlands (NL) and to specifically investigate whether outcomes differ by children's adoption status. Design A prospective population-based open cohort including children with PHIV in NL. Methods We included children with PHIV who had entered HIV care in NL since 2007, in view of a sharp increase in the number of adopted children with PHIV since that year. We compared the proportion with virologic suppression and CD4+T-cell count over time between the following groups of children with PHIV: adopted and born outside NL, non-adopted born in NL, and non-adopted born outside NL, using generalized estimating equations and linear mixed effects models, respectively. To account for the variation in cohort inclusion, we analyzed data of children exposed to at least one year of antiretroviral therapy (ART). Results We included 148 children (827.5 person-years of follow-up, 72% adopted, age at start care in NL 2.4 (0.5-5.3)). Under-18 mortality was zero. Over the years, a boosted PI-based regimen was most often prescribed. The use of integrase inhibitors increased since 2015. Nonadopted children born in NL were less likely to achieve virological suppression compared to adopted children (OR 0.66, 95%CI 0.51-0.86, p = 0.001), which disappeared after excluding one child with suspected treatment nonadherence (OR 0.85, 95%CI 0.57-1.25, p = 0.400). CD4+T-cell Z-score trajectories were not significantly different between groups. Conclusions Despite considerable and increasing diversity of the population of children with PHIV in NL, geographical origin and adoption status do not seem to pose important challenges in achieving good immunological and virological outcomes.

Published
2023

13. Carbapenems: inzetten als het moet, vermijden als het kan

Author

de Stoppelaar, Sacha F., ten Oever, Jaap, Wertheim, Heiman F. L., van Hest, Reinier M., van Mens, Suzan, van Dijk, Karin, van Agtmael, Michiel A., Wolfs, Tom F. W., MUMC+: DA MMI Staf (9), Medische Microbiologie, RS: FHML non-thematic output, Pharmacy, AII - Infectious diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Medical Microbiology and Infection Prevention, and Internal medicine

Subjects
Anti-Bacterial Agents/therapeutic use, Carbapenems/therapeutic use, Humans, Netherlands
Abstract

Surveillance data and literature have shown a worldwide increase in infections with resistant bacteria, which has led to increased prescriptions of carbapenems, which in turn has led to increased carbapenem resistance. There is also an increasing use of carbapenems in the Netherlands, a county usually very conservative in antibiotic use. Carbapenem sparing strategies are essential in an attempt to prevent further rise of infections caused by carbapenem resistant bacteria. This article discusses carbapenem sparing strategies with old forgotten antibiotics and novel antibiotics from a Dutch perspective.

Published
2022

14. Carbapenems:take it when needed but leave it if you can

Author

de Stoppelaar, Sacha F., ten Oever, Jaap, Wertheim, Heiman F. L., van Hest, Reinier M., van Mens, Suzan, van Dijk, Karin, van Agtmael, Michiel A., and Wolfs, Tom F. W.

Abstract

Surveillance data and literature have shown a worldwide increase in infections with resistant bacteria, which has led to increased prescriptions of carbapenems, which in turn has led to increased carbapenem resistance. There is also an increasing use of carbapenems in the Netherlands, a county usually very conservative in antibiotic use. Carbapenem sparing strategies are essential in an attempt to prevent further rise of infections caused by carbapenem resistant bacteria. This article discusses carbapenem sparing strategies with old forgotten antibiotics and novel antibiotics from a Dutch perspective.

Published
2022

16. Mucormycosis in Children With Hematologic Malignancies: A Case Series and Review of the Literature

Author

Loeffen, Yvette G T, Scharloo, Fenna, Goemans, Bianca F, Heitink-Polle, Katja M J, Lindemans, Caroline A, van der Bruggen, Tjomme, Hagen, Ferry, Wolfs, Tom F W, Loeffen, Yvette G T, Scharloo, Fenna, Goemans, Bianca F, Heitink-Polle, Katja M J, Lindemans, Caroline A, van der Bruggen, Tjomme, Hagen, Ferry, and Wolfs, Tom F W

Abstract

BACKGROUND: Mucormycosis is classified as the third leading cause of invasive fungal disease in immunocompromised patients and is characterized by high morbidity and mortality (33%-56%). The aim of this study is to describe presentation, treatment and outcome of Dutch pediatric hemato-oncology patients recently diagnosed with mucormycosis and to review the literature to gain more insight specifically into contemporary outcome data.METHODS: Ten cases were diagnosed in the Princess Máxima Center for Pediatric Oncology from 2018 to 2021 and were retrospectively reviewed. In addition, 9 case series (n = 148) were included from literature.RESULTS: In our case series, 5 patients of 10 children (age 2-17 years) had disseminated invasive fungal disease. Four patients had localized pulmonary disease and 1 had a localized renal infection. One diagnosis was made postmortem. The underlying diseases were acute lymphoblastic leukemia (n = 6), acute myeloid leukemia (n = 2) and lymphoma (n=2). Seven patients received combination therapy comprising of a lipid amphotericin B formulation and a triazole, surgery was performed in 67%. All neutropenic patients received granulocyte transfusions and/or granulocyte colony-stimulating factor. Mucormycosis-related mortality was 20%. In the literature review, mucormycosis-related mortality was 36% for all patients and 66% for patients with disseminated disease. Survival rates were similar over the past 2 decades. The most common underlying disorder was acute lymphoblastic leukemia. Liposomal amphotericin B was the mainstay of treatment. Seventy percent of patients underwent surgery.CONCLUSIONS: Although survival of mucormycosis improved significantly overtime, it plateaued in the past decades. This series shows that with screening, early diagnostics and early antifungal and if possible surgical treatment, mortality is low and even disseminated disease is salvageable if approached aggressively with a combination of surg

Published
2022

17. The diagnostic value of nasal microbiota and clinical parameters in a multi-parametric prediction model to differentiate bacterial versus viral infections in lower respiratory tract infections

Author

Li, Yunlei, primary, van Houten, Chantal B., additional, Boers, Stefan A., additional, Jansen, Ruud, additional, Cohen, Asi, additional, Engelhard, Dan, additional, Kraaij, Robert, additional, Hiltemann, Saskia D., additional, Ju, Jie, additional, Fernández, David, additional, Mankoc, Cristian, additional, González, Eva, additional, de Waal, Wouter J., additional, de Winter-de Groot, Karin M., additional, Wolfs, Tom F. W., additional, Meijers, Pieter, additional, Luijk, Bart, additional, Oosterheert, Jan Jelrik, additional, Sankatsing, Sanjay U. C., additional, Bossink, Aik W. J., additional, Stein, Michal, additional, Klein, Adi, additional, Ashkar, Jalal, additional, Bamberger, Ellen, additional, Srugo, Isaac, additional, Odeh, Majed, additional, Dotan, Yaniv, additional, Boico, Olga, additional, Etshtein, Liat, additional, Paz, Meital, additional, Navon, Roy, additional, Friedman, Tom, additional, Simon, Einav, additional, Gottlieb, Tanya M., additional, Pri-Or, Ester, additional, Kronenfeld, Gali, additional, Oved, Kfir, additional, Eden, Eran, additional, Stubbs, Andrew P., additional, Bont, Louis J., additional, and Hays, John P., additional

Published
2022
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21. COVID-19 - Impact on Childhood Haematology Patients

Author

Wolfs, T, Attarbaschi, A, Balduzzi, A, Bernardo, M, Bomken, S, Borkhardt, A, Bourquin, J, Dufour, C, Gennery, A, Grainger, J, Hasle, H, Hrusak, O, Izraeli, S, Mechinaud, F, Trka, J, Vormoor, J, Wolfs, Tom F W, Attarbaschi, Andishe, Balduzzi, Adriana, Bernardo, Maria Ester, Bomken, Simon, Borkhardt, Arndt, Bourquin, Jean-Pierre, Dufour, Carlo, Gennery, Andrew, Grainger, John, Hasle, Henrik, Hrusak, Ondrej, Izraeli, Shai, Mechinaud, Francoise, Trka, Jan, Vormoor, Josef, Wolfs, T, Attarbaschi, A, Balduzzi, A, Bernardo, M, Bomken, S, Borkhardt, A, Bourquin, J, Dufour, C, Gennery, A, Grainger, J, Hasle, H, Hrusak, O, Izraeli, S, Mechinaud, F, Trka, J, Vormoor, J, Wolfs, Tom F W, Attarbaschi, Andishe, Balduzzi, Adriana, Bernardo, Maria Ester, Bomken, Simon, Borkhardt, Arndt, Bourquin, Jean-Pierre, Dufour, Carlo, Gennery, Andrew, Grainger, John, Hasle, Henrik, Hrusak, Ondrej, Izraeli, Shai, Mechinaud, Francoise, Trka, Jan, and Vormoor, Josef

Published
2020

22. COVID-19 - Impact on Childhood Haematology Patients

Author

Wolfs, Tom F W, Attarbaschi, Andishe, Balduzzi, Adriana, Bernardo, Maria Ester, Bomken, Simon, Borkhardt, Arndt, Bourquin, Jean-Pierre, Dufour, Carlo, Gennery, Andrew, Grainger, John, Hasle, Henrik, Hrusak, Ondrej, Izraeli, Shai, Mechinaud, Francoise, Trka, Jan, Vormoor, Josef, Wolfs, Tom F W, Attarbaschi, Andishe, Balduzzi, Adriana, Bernardo, Maria Ester, Bomken, Simon, Borkhardt, Arndt, Bourquin, Jean-Pierre, Dufour, Carlo, Gennery, Andrew, Grainger, John, Hasle, Henrik, Hrusak, Ondrej, Izraeli, Shai, Mechinaud, Francoise, Trka, Jan, and Vormoor, Josef

Published
2020

23. Pharmacokinetic evaluation of twice-a-week micafungin for prophylaxis of invasive fungal disease in children with acute lymphoblastic leukaemia: a prospective observational cohort study.

Author

Bury, Didi, Wolfs, Tom F W, Heine, Rob ter, Muilwijk, Eline W, Tissing, Wim J E, Brüggemann, Roger J, and Ter Heine, Rob

Subjects
*LYMPHOBLASTIC leukemia, *ACUTE leukemia, *COHORT analysis, *MYCOSES, *MONTE Carlo method, *ACUTE diseases, *CHILD patients
Abstract

Objectives: To determine the pharmacokinetics of twice-a-week micafungin prophylaxis in paediatric leukaemic patients to provide the rationale for this approach.Methods: Twice-a-week micafungin at a dose of 9 mg/kg (maximum 300 mg) was given during the leukaemic induction treatment with at least one pharmacokinetic assessment. Non-linear mixed-effects modelling was used for analysis. For model building, our paediatric data were strengthened with existing adult data. Monte Carlo simulations were performed with twice-a-week dosing regimens of 5, 7 and 9 mg/kg and flat dosing per weight band. Simulated paediatric exposures were compared with the exposure in adults after a once-daily 100 mg regimen.Results: Sixty-one paediatric patients were included with a median age and weight of 4.0 years (range 1.0-17) and 19.5 kg (range 8.60-182), respectively. A two-compartment model best fitted the data. CL and central Vd were lower (P < 0.01) in paediatric patients compared with adults. Predicted exposures (AUC0-168 h) for the 5, 7 and 9 mg/kg and flat dosing per weight band regimens exceeded the adult reference exposure.Conclusions: All twice-a-week regimens appeared to result in adequate exposure for Candida therapy, with simulated exposures well above the adult reference exposure. These findings provide the rationale for the pharmacokinetic equivalence of twice-a-week and once-daily micafungin regimens. The greater micafungin exposures seem to be caused by a slower-than-anticipated CL in our paediatric leukaemic patients. The generalizability of our results for Aspergillus prophylaxis cannot be provided without assumptions on target concentrations and within-class identical efficacy. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Results of 2 years of treatment with protease-inhibitor-containing antiretroviral therapy in Dutch children infected with human immunodeficiency virus type 1. (HIV/AIDS: Major Article)

Author

van Rossum, Annemarie M.C., Geelen, Sibyl P.M., Hartwig, Nico G., Wolfs, Tom F. W., Weemaes, Corry M. R., Scherpbier, Henriette J., van Lochem, Ellen G., Hop, Wim C. J., Schutten, Martin, Osterhaus, Albert D. M. E., Burger, David M., and Groat, Ronald de

Subjects
Protease inhibitors -- Usage, Antiviral agents -- Usage, Drug therapy -- Usage, HIV (Viruses) -- Drug therapy, Children -- Diseases, Health, Health care industry
Published
2002

28. Expert panel diagnosis demonstrated high reproducibility as reference standard in infectious diseases

Author

van Houten, Chantal B, Naaktgeboren, Christiana A, Ashkenazi-Hoffnung, Liat, Ashkenazi, Shai, Avis, Wim, Chistyakov, Irena, Corigliano, Teresa, Galetto-Lacour, Annik, Gangoiti, Iker, Gervaix, Alain, Glikman, Daniel, Ivaskeviciene, Inga, Kuperman, Amir A, Lacroix, Laurence Elisabeth, Loeffen, Yvette, Luterbacher, Fanny, Meijssen, Clemens B, Mintegi, Santiago, Nasrallah, Basheer, Papan, Cihan, van Rossum, Annemarie M C, Rudolph, Henriette, Stein, Michal, Tal, Roie, Tenenbaum, Tobias, Usonis, Vytautas, de Waal, Wouter, Weichert, Stefan, Wildenbeest, Joanne G, de Winter-de Groot, Karin M, Wolfs, Tom F W, Mastboim, Niv, Gottlieb, Tanya M, Cohen, Asi, Oved, Kfir, Eden, Eran, Feigin, Paul D, Shani, Liran, Bont, Louis J, IMPRIND consortium, Pediatrics, Erasmus MC other, and Orthopedics and Sports Medicine

Subjects
Male, Pediatrics, medicine.medical_specialty, Epidemiology, Clinical Decision-Making, Fever of Unknown Origin, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Lower respiratory tract infection, Diagnosis, Medicine, Humans, 030212 general & internal medicine, Medical diagnosis, book, Reference standards, Expert Testimony, Respiratory Tract Infections, Reproducibility, ddc:618, Expert panel, business.industry, Diagnostic Tests, Routine, Gold standard, Infant, Reproducibility of Results, Standard of Care, Gold standard (test), Reference Standards, medicine.disease, 3. Good health, Reference standard, Child, Preschool, Pediatric Infectious Disease, book.journal, Infectious diseases, Female, business, 030217 neurology & neurosurgery, Kappa
Abstract

Objective If a gold standard is lacking in a diagnostic test accuracy study, expert diagnosis is frequently used as reference standard. However, interobserver and intraobserver agreements are imperfect. The aim of this study was to quantify the reproducibility of a panel diagnosis for pediatric infectious diseases. Study Design and Setting Pediatricians from six countries adjudicated a diagnosis (i.e., bacterial infection, viral infection, or indeterminate) for febrile children. Diagnosis was reached when the majority of panel members came to the same diagnosis, leaving others inconclusive. We evaluated intraobserver and intrapanel agreement with 6 weeks and 3 years’ time intervals. We calculated the proportion of inconclusive diagnosis for a three-, five-, and seven-expert panel. Results For both time intervals (i.e., 6 weeks and 3 years), intrapanel agreement was higher (kappa 0.88, 95%CI: 0.81-0.94 and 0.80, 95%CI: NA) compared to intraobserver agreement (kappa 0.77, 95%CI: 0.71-0.83 and 0.65, 95%CI: 0.52-0.78). After expanding the three-expert panel to five or seven experts, the proportion of inconclusive diagnoses (11%) remained the same. Conclusion A panel consisting of three experts provides more reproducible diagnoses than an individual expert in children with lower respiratory tract infection or fever without source. Increasing the size of a panel beyond three experts has no major advantage for diagnosis reproducibility.

Published
2019

31. Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin

Author

MMB Kweek en Resistentie A, Infection & Immunity, SCT patientenzorg, Infectieziekten patientenzorg, Child Health, Fluit, Ad C, Rentenaar, Rob J, Ekkelenkamp, Miquel B, Severs, Tim T, Mavinkurve-Groothuis, Annelies M C, Rogers, Malbert R C, Bruin, Marrie C A, Wolfs, Tom F W, MMB Kweek en Resistentie A, Infection & Immunity, SCT patientenzorg, Infectieziekten patientenzorg, Child Health, Fluit, Ad C, Rentenaar, Rob J, Ekkelenkamp, Miquel B, Severs, Tim T, Mavinkurve-Groothuis, Annelies M C, Rogers, Malbert R C, Bruin, Marrie C A, and Wolfs, Tom F W

Published
2019

33. Correction : Long-Term Changes of Subcutaneous Fat Mass in HIV-Infected Children on Antiretroviral Therapy: A Retrospective Analysis of Longitudinal Data from Two Pediatric HIV-Cohorts

Author

Cohen, Sophie, Innes, Steve, Geelen, SPM, Wells, Jonathan C. K., Smit, Colette, Wolfs, Tom F W, van Eck-Smit, Berthe L. F., Kuijpers, Taco W., Reiss, Peter, Scherpbier, Henriette J., Pajkrt, Dasja, and Bunders, Madeleine J.

Abstract

[This corrects the article DOI: 10.1371/journal.pone.0120927.].

Published
2018

37. Outcome of Preterm Infants With Postnatal Cytomegalovirus Infection

Author

Gunkel, Julia, De Vries, Linda S., Jongmans, Marian, Koopman-Esseboom, Corine, van Haastert, Ingrid C, Eijsermans, Maria C J, van Stam, Carolien, van Zanten, Bert G A, Wolfs, Tom F W, Nijman, Joppe, Gunkel, Julia, De Vries, Linda S., Jongmans, Marian, Koopman-Esseboom, Corine, van Haastert, Ingrid C, Eijsermans, Maria C J, van Stam, Carolien, van Zanten, Bert G A, Wolfs, Tom F W, and Nijman, Joppe

Abstract

OBJECTIVES: To assess whether preterm infants with postnatal cytomegalovirus infection develop neurologic sequelae in early childhood.METHODS: Infants <32 weeks' gestation were prospectively screened for cytomegalovirus (CMV) at term-equivalent age. Neurodevelopment was compared between CMV-positive and CMV-negative infants by using the Griffiths Mental Development Scales (GMDS) at 16 months' corrected age (CA); the Bayley Scales of Infant and Toddler Development, Third Edition or the GMDS at 24 to 30 months' CA; and the Wechsler Preschool and Primary Scale of Intelligence, Third Edition and Movement Assessment Battery for Children, Second Edition at 6 years of age. At 6 years old, hearing was assessed in CMV-positive children.RESULTS: Neurodevelopment was assessed in 356 infants at 16 months' CA, of whom 49 (14%) were infected and 307 (86%) were noninfected. Infected infants performed significantly better on the GMDS locomotor scale. There were no differences at 24 to 30 months' CA on the Bayley Scales of Infant and Toddler Development, Third Edition or GMDS. At 6 years of age, infected children scored lower on the Wechsler Preschool and Primary Scale of Intelligence, Third Edition, but mean scores were within normal range, reaching significance only in verbal IQ (96 [SD 17] vs 103 [SD 15] points; P = .046). Multiple regression indicated no impact of CMV status but significant influence of maternal education and ethnicity on verbal IQ. No significant differences in motor development were found and none of the infected children developed sensorineural hearing loss.CONCLUSIONS: In this cohort study, postnatal cytomegalovirus infection in preterm children did not have an adverse effect on neurodevelopment within the first 6 years of life.

Published
2018

38. Outcome of Preterm Infants With Postnatal Cytomegalovirus Infection

Author

Faculteit Sociale Wetenschappen, Leerstoel Jongmans, Education and Learning: Cognitive and Motor Disabilities, Gunkel, Julia, De Vries, Linda S., Jongmans, Marian, Koopman-Esseboom, Corine, van Haastert, Ingrid C, Eijsermans, Maria C J, van Stam, Carolien, van Zanten, Bert G A, Wolfs, Tom F W, Nijman, Joppe, Faculteit Sociale Wetenschappen, Leerstoel Jongmans, Education and Learning: Cognitive and Motor Disabilities, Gunkel, Julia, De Vries, Linda S., Jongmans, Marian, Koopman-Esseboom, Corine, van Haastert, Ingrid C, Eijsermans, Maria C J, van Stam, Carolien, van Zanten, Bert G A, Wolfs, Tom F W, and Nijman, Joppe

Published
2018

39. Correction: Long-Term Changes of Subcutaneous Fat Mass in HIV-Infected Children on Antiretroviral Therapy: A Retrospective Analysis of Longitudinal Data from Two Pediatric HIV-Cohorts

Author

Divisieleiding O&O, Other research (not in main researchprogram), Infectieziekten patientenzorg, Child Health, Infection & Immunity, Cohen, Sophie, Innes, Steve, Geelen, SPM, Wells, Jonathan C. K., Smit, Colette, Wolfs, Tom F W, van Eck-Smit, Berthe L. F., Kuijpers, Taco W., Reiss, Peter, Scherpbier, Henriette J., Pajkrt, Dasja, Bunders, Madeleine J., Divisieleiding O&O, Other research (not in main researchprogram), Infectieziekten patientenzorg, Child Health, Infection & Immunity, Cohen, Sophie, Innes, Steve, Geelen, SPM, Wells, Jonathan C. K., Smit, Colette, Wolfs, Tom F W, van Eck-Smit, Berthe L. F., Kuijpers, Taco W., Reiss, Peter, Scherpbier, Henriette J., Pajkrt, Dasja, and Bunders, Madeleine J.

Published
2018

40. A host-protein based assay to differentiate between bacterial and viral infections in preschool children (OPPORTUNITY) : A double-blind, multicentre, validation study

Author

van Houten, Chantal B., de Groot, Joris A H, Klein, Adi, Srugo, Isaac, Chistyakov, Irena, de Waal, Wouter, Meijssen, Clemens B., Avis, Wim, Wolfs, Tom F W, Shachor-Meyouhas, Yael, Stein, Michal, Sanders, Elisabeth A M, Bont, Louis J., van Houten, Chantal B., de Groot, Joris A H, Klein, Adi, Srugo, Isaac, Chistyakov, Irena, de Waal, Wouter, Meijssen, Clemens B., Avis, Wim, Wolfs, Tom F W, Shachor-Meyouhas, Yael, Stein, Michal, Sanders, Elisabeth A M, and Bont, Louis J.

Published
2017

41. A host-protein based assay to differentiate between bacterial and viral infections in preschool children (OPPORTUNITY): A double-blind, multicentre, validation study

Author

Infectieziekten onderzoek1 (Bont), Child Health, Epi Methoden Team 1, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Methodologie, MS Neonatologie, Infectieziekten patientenzorg, Immuno/reuma onderzoek 7 (Montfrans), Immuno/reuma patientenzorg, CTI Bont, van Houten, Chantal B., de Groot, Joris A H, Klein, Adi, Srugo, Isaac, Chistyakov, Irena, de Waal, Wouter, Meijssen, Clemens B., Avis, Wim, Wolfs, Tom F W, Shachor-Meyouhas, Yael, Stein, Michal, Sanders, Elisabeth A M, Bont, Louis J., Infectieziekten onderzoek1 (Bont), Child Health, Epi Methoden Team 1, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Methodologie, MS Neonatologie, Infectieziekten patientenzorg, Immuno/reuma onderzoek 7 (Montfrans), Immuno/reuma patientenzorg, CTI Bont, van Houten, Chantal B., de Groot, Joris A H, Klein, Adi, Srugo, Isaac, Chistyakov, Irena, de Waal, Wouter, Meijssen, Clemens B., Avis, Wim, Wolfs, Tom F W, Shachor-Meyouhas, Yael, Stein, Michal, Sanders, Elisabeth A M, and Bont, Louis J.

Published
2017

42. Country of Birth Does Not Influence Long-term Clinical, Virologic, and Immunological Outcome of HIV-Infected Children Living in the Netherlands : A Cohort Study Comparing Children Born in the Netherlands With Children Born in Sub-Saharan Africa

Author

Cohen, Sophie, van Bilsen, Ward P. H., Smit, Colette, Fraaij, Pieter L. A., Warris, Adilia, Kuijpers, Taco W., Geelen, SPM, Wolfs, Tom F. W., Scherpbier, Henriette J., van Rossum, Annemarie M. C., Pajkrt, Dasja, and Dutch Pediat HIV Study Grp

Subjects
RISK, ACTIVE ANTIRETROVIRAL THERAPY, antiretroviral therapy, DISEASE PROGRESSION, HIV, IMMUNODEFICIENCY-VIRUS TYPE-1, IMMUNE RECONSTITUTION, ETHNICITY, VIRAL LOAD, children, SURVIVAL, Journal Article, Comparative Study, NEW-YORK-CITY, HIV-1-INFECTED CHILDREN, country of birth, Netherlands
Abstract

Background:Immigrant HIV-infected adults in industrialized countries show a poorer clinical and virologic outcome compared with native patients. We aimed to investigate potential differences in clinical, immunological, and virologic outcome in Dutch HIV-infected children born in the Netherlands (NL) versus born in Sub-Saharan Africa (SSA) in a national cohort analysis.Methods:We included all HIV-infected children registered between 1996 and 2013. Descriptive statistics, mixed-effects models, and Cox proportional hazard models were used to investigate differences between groups.Results:In total, 319 HIV-infected children were registered. The majority of these children were born in SSA (n = 148, 47%) or NL (n = 113, 36%) and most were black (n = 158, 61%). Children born in NL were diagnosed at a median age of 1.2 years and initiated combination antiretroviral therapy (cART) at a median age of 2.6 years, compared with 3.7 and 5.3 years, respectively, for children born in SSA (HIV diagnosis: P

Published
2015

43. Current evidence on hospital antimicrobial stewardship objectives : A systematic review and meta-analysis

Author

Schuts, Emelie C., Hulscher, Marlies E J L, Mouton, Johan W., Verduin, Cees M., Stuart, James W T Cohen, Overdiek, Hans W P M, van der Linden, Paul D., Natsch, Stephanie, Hertogh, Cees M P M, Wolfs, Tom F W, Schouten, Jeroen A., Kullberg, Bart Jan, Prins, Jan M., Schuts, Emelie C., Hulscher, Marlies E J L, Mouton, Johan W., Verduin, Cees M., Stuart, James W T Cohen, Overdiek, Hans W P M, van der Linden, Paul D., Natsch, Stephanie, Hertogh, Cees M P M, Wolfs, Tom F W, Schouten, Jeroen A., Kullberg, Bart Jan, and Prins, Jan M.

Published
2016

44. Current evidence on hospital antimicrobial stewardship objectives: A systematic review and meta-analysis

Author

Infectieziekten patientenzorg, Child Health, Infection & Immunity, Schuts, Emelie C., Hulscher, Marlies E J L, Mouton, Johan W., Verduin, Cees M., Stuart, James W T Cohen, Overdiek, Hans W P M, van der Linden, Paul D., Natsch, Stephanie, Hertogh, Cees M P M, Wolfs, Tom F W, Schouten, Jeroen A., Kullberg, Bart Jan, Prins, Jan M., Infectieziekten patientenzorg, Child Health, Infection & Immunity, Schuts, Emelie C., Hulscher, Marlies E J L, Mouton, Johan W., Verduin, Cees M., Stuart, James W T Cohen, Overdiek, Hans W P M, van der Linden, Paul D., Natsch, Stephanie, Hertogh, Cees M P M, Wolfs, Tom F W, Schouten, Jeroen A., Kullberg, Bart Jan, and Prins, Jan M.

Published
2016

46. Long-Term Changes of Subcutaneous Fat Mass in HIV-Infected Children on Antiretroviral Therapy : A Retrospective Analysis of Longitudinal Data from Two Pediatric HIV-Cohorts

Author

Cohen, Sophie, Innes, Steve, Geelen, SPM, Wells, Jonathan C. K., Smit, Colette, Wolfs, Tom F. W., van Eck-Smit, Berthe L. F., Kuijpers, Taco W., Reiss, Peter, Scherpbier, Henriette J., Pajkrt, Dasja, Bunders, Madeleine J., Cohen, Sophie, Innes, Steve, Geelen, SPM, Wells, Jonathan C. K., Smit, Colette, Wolfs, Tom F. W., van Eck-Smit, Berthe L. F., Kuijpers, Taco W., Reiss, Peter, Scherpbier, Henriette J., Pajkrt, Dasja, and Bunders, Madeleine J.

Published
2015

48. Long-Term Changes of Subcutaneous Fat Mass in HIV-Infected Children on Antiretroviral Therapy: A Retrospective Analysis of Longitudinal Data from Two Pediatric HIV-Cohorts

Author

Infectieziekten patientenzorg, Other research (not in main researchprogram), Child Health, Infection & Immunity, Cohen, Sophie, Innes, Steve, Geelen, SPM, Wells, Jonathan C. K., Smit, Colette, Wolfs, Tom F. W., van Eck-Smit, Berthe L. F., Kuijpers, Taco W., Reiss, Peter, Scherpbier, Henriette J., Pajkrt, Dasja, Bunders, Madeleine J., Infectieziekten patientenzorg, Other research (not in main researchprogram), Child Health, Infection & Immunity, Cohen, Sophie, Innes, Steve, Geelen, SPM, Wells, Jonathan C. K., Smit, Colette, Wolfs, Tom F. W., van Eck-Smit, Berthe L. F., Kuijpers, Taco W., Reiss, Peter, Scherpbier, Henriette J., Pajkrt, Dasja, and Bunders, Madeleine J.

Published
2015

49. Country of Birth Does Not Influence Long-term Clinical, Virologic, and Immunological Outcome of HIV-Infected Children Living in the Netherlands: A Cohort Study Comparing Children Born in the Netherlands With Children Born in Sub-Saharan Africa

Author

Infectieziekten patientenzorg, Other research (not in main researchprogram), Child Health, Infection & Immunity, Cohen, Sophie, van Bilsen, Ward P. H., Smit, Colette, Fraaij, Pieter L. A., Warris, Adilia, Kuijpers, Taco W., Geelen, SPM, Wolfs, Tom F. W., Scherpbier, Henriette J., van Rossum, Annemarie M. C., Pajkrt, Dasja, Dutch Pediat HIV Study Grp, Infectieziekten patientenzorg, Other research (not in main researchprogram), Child Health, Infection & Immunity, Cohen, Sophie, van Bilsen, Ward P. H., Smit, Colette, Fraaij, Pieter L. A., Warris, Adilia, Kuijpers, Taco W., Geelen, SPM, Wolfs, Tom F. W., Scherpbier, Henriette J., van Rossum, Annemarie M. C., Pajkrt, Dasja, and Dutch Pediat HIV Study Grp

Published
2015

50. Neuro-imaging findings in infants with congenital cytomegalovirus infection: Relation to trimester of infection

Author

PMC Research, Arts-assistenten Kinderen, MS Neonatologie, Infectieziekten patientenzorg, Child Health, Infection & Immunity, Brain, Oosterom, Natanja, Nijman, Joppe, Gunkel, Julia, Wolfs, Tom F W, Groenendaal, Floris, Verboon-Maciolek, Malgosia A., De Vries, Linda S., PMC Research, Arts-assistenten Kinderen, MS Neonatologie, Infectieziekten patientenzorg, Child Health, Infection & Immunity, Brain, Oosterom, Natanja, Nijman, Joppe, Gunkel, Julia, Wolfs, Tom F W, Groenendaal, Floris, Verboon-Maciolek, Malgosia A., and De Vries, Linda S.

Published
2015

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