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2. Late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature

Author

Wolf, Lindsey L, Nijagal, Amar, Flores, Alejandro, and Buchmiller, Terry L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Emerging Infectious Diseases, Digestive Diseases, Abdominal Pain, Adolescent, Female, Follow-Up Studies, Gastric Outlet Obstruction, Humans, Laparoscopy, Male, Pyloric Stenosis, Hypertrophic, Pylorus, Treatment Outcome, Gastric outlet obstruction, Pyloric stenosis, Delayed presentation, Paediatrics and Reproductive Medicine, Pediatrics, Clinical sciences, Paediatrics
Abstract

We report late-onset hypertrophic pyloric stenosis in a 17-year-old female. She presented with abdominal pain and an episode of upper gastrointestinal hemorrhage and subsequently developed gastric outlet obstruction. Work-up revealed circumferential pyloric thickening, delayed gastric emptying, and a stenotic, elongated pyloric channel. Biopsies showed benign gastropathy, negative for Helicobacter pylori, without eosinophilic infiltrates. Botulinum toxin injection provided limited relief. Diagnostic laparoscopy confirmed the hypertrophic pylorus and we performed laparoscopic pyloromyotomy. The patient tolerated the procedure well and had complete symptom resolution at 1-year follow-up. Hypertrophic pyloric stenosis is a rare cause of gastric outlet obstruction in adolescents and may be managed successfully with laparoscopic pyloromyotomy.

Published
2016

16. Cost-effectiveness of an intervention to improve adherence to antiretroviral therapy in HIV-infected patients

Author

Freedberg, Kenneth A., Hirschhorn, Lisa R., Schackman, Bruce R., Wolf, Lindsey L., Weinstein, Milton C., Goldin, Susan, Paltiel, A.. David, Katz, Carol, Goldie, Sue J., and Losina, Elena

Subjects
Highly active antiretroviral therapy -- Economic aspects, Patient compliance -- Analysis, AIDS (Disease) -- Care and treatment, Health
Abstract

An analysis was carried out to assess the cost-effectiveness of a nursing intervention on antiretroviral adherence using data from a randomized controlled clinical trial as input to a computer-based simulation model of HIV disease. The findings reveal that adherence interventions with modest effectiveness are likely to provide long-term survival benefit to patients and to be cost-effective compared with other uses of HIV care funds.

Published
2006

20. Incidence and risk factors for sepsis after childhood splenectomy

Author

Madenci, Arin L., primary, Armstrong, Lindsey B., additional, Kwon, Nicollette K., additional, Jiang, Wei, additional, Wolf, Lindsey L., additional, Koehlmoos, Tracey P., additional, Ricca, Robert L., additional, Weldon, Christopher B., additional, Haider, Adil H., additional, and Weil, Brent R., additional

Published
2019
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21. Opioid Prescription Patterns for Children Following Laparoscopic Appendectomy

Author

Sonderman, Kristin A., primary, Wolf, Lindsey L., additional, Madenci, Arin L., additional, Kwon, Nicollette K., additional, Armstrong, Lindsey B., additional, Wanis, Kerollos Nashat, additional, Taylor, Kathryn, additional, Uribe-Leitz, Tarsicio, additional, Koehlmoos, Tracey P., additional, Ricca, Robert L., additional, Weil, Brent R., additional, Weldon, Christopher B., additional, Haider, Adil H., additional, and Rice-Townsend, Samuel E., additional

Published
2018
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22. Hernia recurrence following inguinal hernia repair in children

Author

Taylor, Kathryn, primary, Sonderman, Kristin A., additional, Wolf, Lindsey L., additional, Jiang, Wei, additional, Armstrong, Lindsey B., additional, Koehlmoos, Tracey P., additional, Weil, Brent R., additional, Ricca, Robert L., additional, Weldon, Christopher B., additional, Haider, Adil H., additional, and Rice-Townsend, Samuel E., additional

Published
2018
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26. Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis

Author

Liu, Wenjin, primary, Snell, Jeff M., additional, Jeck, William R., additional, Hoadley, Katherine A., additional, Wilkerson, Matthew D., additional, Parker, Joel S., additional, Patel, Nirali, additional, Mlombe, Yohannie B., additional, Mulima, Gift, additional, Liomba, N. George, additional, Wolf, Lindsey L., additional, Shores, Carol G., additional, Gopal, Satish, additional, and Sharpless, Norman E., additional

Published
2017
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29. Implications of the Patient Protection and Affordable Care Act on Insurance Coverage and Rehabilitation Use Among Young Adult Trauma Patients

Author

Zogg, Cheryl K., primary, Payró Chew, Fernando, additional, Scott, John W., additional, Wolf, Lindsey L., additional, Tsai, Thomas C., additional, Najjar, Peter, additional, Olufajo, Olubode A., additional, Schneider, Eric B., additional, Haut, Elliott R., additional, Haider, Adil H., additional, and Canner, Joseph K., additional

Published
2016
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30. Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis

Author

Liu, Wenjin, primary, Snell, Jeff M., additional, Jeck, William R., additional, Hoadley, Katherine A., additional, Wilkerson, Matthew D., additional, Parker, Joel S., additional, Patel, Nirali, additional, Mlombe, Yohannie B., additional, Mulima, Gift, additional, Liomba, N. George, additional, Wolf, Lindsey L., additional, Shores, Carol G., additional, Gopal, Satish, additional, and Sharpless, Norman E., additional

Published
2016
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33. The Independent Effect of Highly Active Antiretroviral Therapy on Severe Opportunistic Disease Incidence and Mortality in HIV-Infected Adults in Côte D'Ivoire

Author

Losina, Elena, primary, Yazdanpanah, Yazdan, additional, Deuffic-Burban, Sylvie, additional, Wang, Bingxia, additional, Wolf, Lindsey L, additional, Messou, Eugène, additional, Gabillard, Delphine, additional, Seyler, Catherine, additional, Freedberg, Kenneth A, additional, and Anglaret, Xavier, additional

Published
2007
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34. CD4+T-cell-guided structured treatment interruptions of antiretroviral therapy in HIV disease: Projecting beyond clinical trials

Author

Yazdanpanah, Yazdan, Wolf, Lindsey L, Anglaret, Xavier, Gabillard, Delphine, Walensky, Rochelle P, Moh, Raoul, Danel, Christine, Sloan, Caroline E, Losina, Elena, and Freedberg, Kenneth A

Abstract

Background International trials have shown that CD4+T-cell-guided structured treatment interruptions (STI) of antiretroviral therapy (ART) lead to worse outcomes than continuous treatment. We simulated continuous ART and STI strategies with higher CD4+T-cell interruption/reintroduction thresholds than those assessed in actual trials.Methods Using a model of HIV, we simulated cohorts of African adults with different baseline CD4+T-cell counts (=200; 201-350; and 351-500 cells/µl). We varied ART initiation criteria (immediate; CD4+T-cell count <350 cells/µl or =350 cells/µl with severe HIV-related disease; and CD4+T-cell count <200 cells/µl or =200 cells/µl with severe HIV- related disease), and ART interruption/reintroduction thresholds (350/250; 500/350; and 700/500 cells/µl). First-line therapy was non- nucleoside reverse transcriptase inhibitor (NNRTI)-based and second-line therapy was protease inhibitor (PI)-based.Results STI generally reduced life expectancy compared with continuous ART. Life expectancy increased with earlier ART initiation and higher interruption/reintroduction thresholds. STI reduced life expectancy by 48–69 and 11–30 months compared with continuous ART when interruption/reintroduction thresholds were 350/250 and 500/350 cells/µl, depending on ART initiation criteria. When patients interrupted/reintroduced ART at 700/500 cells/µl, life expectancies ranged from 2 months lower to 1 month higher than continuous ART. STI-related life expectancy increased with decreased risk of virological resistance after ART interruptions.Conclusions STI with NNRTI-based regimens was almost always less effective than continuous treatment, regardless of interruption/reintroduction thresholds. The risks associated with STI decrease only if patients start ART earlier, interrupt/reintroduce treatment at very high CD4+T-cell thresholds (700/500 cells/µl) and use first-line medications with higher resistance barriers, such as PIs.

Published
2010
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35. CD4+ T-cell-guided structured treatment interruptions of antiretroviral therapy in HIV disease: projecting beyond clinical trials.

Author

Yazdanpanah Y, Wolf LL, Anglaret X, Gabillard D, Walensky RP, Moh R, Danel C, Sloan CE, Losina E, and Freedberg KA

Subjects
Anti-HIV Agents therapeutic use, CD4 Lymphocyte Count, Computer Simulation, Cote d'Ivoire, Drug Administration Schedule, HIV Infections virology, HIV-1 drug effects, Humans, Life Expectancy, Treatment Outcome, Anti-HIV Agents administration & dosage, CD4-Positive T-Lymphocytes drug effects, HIV Infections drug therapy
Abstract

Background: International trials have shown that CD4+ T-cell-guided structured treatment interruptions (STI) of antiretroviral therapy (ART) lead to worse outcomes than continuous treatment. We simulated continuous ART and STI strategies with higher CD4+ T-cell interruption/reintroduction thresholds than those assessed in actual trials., Methods: Using a model of HIV, we simulated cohorts of African adults with different baseline CD4+ T-cell counts (< or = 200; 201-350; and 351-500 cells/microl). We varied ART initiation criteria (immediate; CD4+ T-cell count < 350 cells/microl or > or = 350 cells/microl with severe HIV-related disease; and CD4+ T-cell count <200 cells/microl or > or = 200 cells/microl with severe HIV-related disease), and ART interruption/reintroduction thresholds (350/250; 500/350; and 700/500 cells/microl). First-line therapy was non-nucleoside reverse transcriptase inhibitor (NNRTI)-based and second-line therapy was protease inhibitor (PI)-based., Results: STI generally reduced life expectancy compared with continuous ART. Life expectancy increased with earlier ART initiation and higher interruption/reintroduction thresholds. STI reduced life expectancy by 48-69 and 11-30 months compared with continuous ART when interruption/reintroduction thresholds were 350/250 and 500/350 cells/microl, depending on ART initiation criteria. When patients interrupted/reintroduced ART at 700/500 cells/microl, life expectancies ranged from 2 months lower to 1 month higher than continuous ART. STI-related life expectancy increased with decreased risk of virological resistance after ART interruptions., Conclusions: STI with NNRTI-based regimens was almost always less effective than continuous treatment, regardless of interruption/reintroduction thresholds. The risks associated with STI decrease only if patients start ART earlier, interrupt/reintroduce treatment at very high CD4+ T-cell thresholds (700/500 cells/microl) and use first-line medications with higher resistance barriers, such as PIs.

Published
2010
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