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217 results on '"Wolf, Federica I."'

3. The relevance of magnesium homeostasis in COVID-19

Author

Trapani, Valentina, Rosanoff, Andrea, Baniasadi, Shadi, Barbagallo, Mario, Castiglioni, Sara, Guerrero-Romero, Fernando, Iotti, Stefano, Mazur, André, Micke, Oliver, Pourdowlat, Guitti, Scarpati, Giuliana, Wolf, Federica I., and Maier, Jeanette A.

Published
2022
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5. Mapping cellular magnesium using X-ray microfluorescence and atomic force microscopy

Author

Lagomarsino, Stefano, Iotti, Stefano, Farruggia, Giovanna, Cedola, Alessia, Trapani, Valentina, Fratini, Michela, Bukreeva, Inna, Notargiacomo, Andrea, Mastrototaro, Lucia, McNulty, Ian, Vogt, Stefan, Legnini, Daniel, Kim, Sangsoo, Maier, Jeanette A M, and Wolf, Federica I

Subjects
Quantitative Biology - Cell Behavior, Physics - Medical Physics
Abstract

Magnesium is the most abundant intracellular divalent cation. We present an innovative experimental approach to localizing intracellular magnesium that combines elemental and morphological information from individual cells with high-resolution spatial information. Integration of information from scanning fluorescence X-ray microscopy with information from atomic force microscopy was used to generate a magnesium concentration map and to determine the X-ray linear absorption coefficient map within a whole dehydrated mammary epithelial cell., Comment: 9 pages, 2 figures

Published
2010

7. Magnesium and vitamin D in long COVID syndrome; do they help?

Author

Wolf, Federica I and Trapani, Valentina

Subjects
POST-acute COVID-19 syndrome, VITAMIN D, MAGNESIUM, VITAMIN D deficiency, SYMPTOMS, DIETARY supplements, CALCIUM
Abstract

Since the start of the COVID-19 pandemic, it has become increasingly clear that the disease can have relevant multisystemic and long-term effects, and several studies have attempted to identify key determinants of the disease course. Here we discuss recent evidence suggesting that, in long COVID patients, combined magnesium and vitamin D deficiencies associate with a higher number of clinical manifestations, as compared to patients with normal levels of both nutrients. We highlight the potential synergistic effects of these deficiencies and propose that future studies should explore a causal link with the risk of developing long COVID. Most importantly, randomized clinical trials are needed to determine if magnesium and vitamin D supplementation can improve long COVID symptoms, providing a safe and affordable support therapy to the benefit of patients and society. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Intracellular concentration map of magnesium in whole cells by combined use of X-ray fluorescence microscopy and atomic force microscopy

Author

Lagomarsino, Stefano, Iotti, Stefano, Farruggia, Giovanna, Cedola, Alessia, Trapani, Valentina, Fratini, Michela, Bukreeva, Inna, Notargiacomo, Andrea, Mastrototaro, Lucia, Marraccini, Chiara, Sorrentino, Andrea, McNulty, Ian, Vogt, Stefan, Legnini, Daniel, Kim, Sangsoo, Gianoncelli, Alessandra, Maier, Jeanette A.M., and Wolf, Federica I.

Published
2011
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11. The relevance of magnesium homeostasis in COVID-19

Author

Trapani, Valentina, primary, Rosanoff, Andrea, additional, Baniasadi, Shadi, additional, Barbagallo, Mario, additional, Castiglioni, Sara, additional, Guerrero-Romero, Fernando, additional, Iotti, Stefano, additional, Mazur, André, additional, Micke, Oliver, additional, Pourdowlat, Guitti, additional, Scarpati, Giuliana, additional, Wolf, Federica I., additional, and Maier, Jeanette A., additional

Published
2021
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13. Variant ATRX Syndrome with Dysfunction of ATRX and MAGT1 Genes

Author

Qiao, Ying, Mondal, Kajari, Trapani, Valentina, Wen, Jiadi, Carpenter, Gillian, Wildin, Robert, Price, Magda E., Gibbons, Richard J., Eichmeyer, Jennifer, Jiang, Ruby, DuPont, Barbara, Martell, Sally, Lewis, Suzanne M. E., Robinson, Wendy P., OʼDriscoll, Mark, Wolf, Federica I., Zwick, Michael E., and Rajcan-Separovic, Evica

Published
2014
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15. Glasgow Magnesium Symposium 2022: Wrap up and depart.

Author

Wolf, Federica I., Trapani, Valentina, and Touyz, Rhian

Subjects
TRP channels, HOMEOSTASIS, MAGNESIUM, CETUXIMAB, STAT proteins
Abstract

The article presents the highlights of the hybrid XVI International Magnesium Symposium in Glasgow, Scotland in July 2022. Topics include updates on magnesium (Mg2+) research, the evaluation of pathologic hypo- or hyper-magnesemia conditions, and the role of Mg2+ in agriculture. Presenters include Roberta Cazzola of University of Milano, Stefano Iotti of University of Bologna, and Andrea Rosanoff of the Center for Magnesium Education & Research (CMER).

Published
2022
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20. [beta]-carotene regulates NF-[kappa]B DNA-binding activity by a redox mechanism in human leukemia and colon adenocarcinoma cells

Author

Palozza, Paola, Serini, Simona, Torsello, Angela, Di Nicuolo, Fiorella, Piccioni, Elisabetta, Ubaldi, Vanessa, Pioli, Claudio, Wolf, Federica I., and Calviello, Gabriella

Subjects
Beta carotene, Cancer cells -- Physiological aspects, Food/cooking/nutrition
Abstract

We demonstrated previously that [beta]-carotene may affect cell growth by a redox mechanism. The purpose of this study was to determine whether the redox-sensitive transcription factor nuclear factor (NF)-[kappa]B may be involved in the growth-inhibitory and proapoptotic effects of the carotenoid. To test this hypothesis, human leukemic cells (HL-60) and colon adenocarcinoma cells (LS-174 and WiDr) were treated with [beta]-carotene, alone or in combination with [alpha]-tocopherol or N-acetylcysteine, and changes in 1) cell oxidative status, 2) cell growth and apoptosis, 3) DNA-binding activity of NF-[kappa]B and 4) expression of c-myc, a NF-[kappa]B target gene involved in apoptosis, were evaluated. In HL-60 cells, [beta]-carotene induced a significant increase in reactive oxygen species (ROS) production (P < 0.001) and in oxidized glutathione (GSSG) content (P < 0.005) at concentrations [greater than or equal to] 10 [micro]mol/L. These effects were always accompanied by a sustained elevation of NF-[kappa]B and by a significant inhibition (P < 0.002) of cell growth. NF-[kappa]B DNA-binding activity increased at 3 h and persisted for at least 48 h. Colon adenocarcinoma cells displayed substantial differences in their sensitivity to [beta]-carotene, exhibiting increased ROS levels and activation of NF-[kappa]B at concentrations much lower in LS-174 cells (2.5-5.0 [micro]mol/L) than in WiDr cells (50-100/ [micro]mol/L). In all cell lines studied, [alpha]-tocopherol and N-acetylcysteine inhibited the effects of [beta]-carotene on NF-[kappa]B, cell growth and apoptosis, and normalized the increased expression of c-myc induced by the carotenoid. These data suggest that the redox regulation of NF-[kappa]B induced by [beta]-carotene is involved in the growth-inhibitory and proapoptotic effects of the carotenoid in tumor cells. KEY WORDS: * [beta]-carotene * NF-[kappa]B * redox status * cell growth * apoptosis

Published
2003

30. A pilot experience of common European infectious diseases curriculum for medical students: the IDEAL summer school

Author

Charlier, Caroline, primary, Wolf, Federica I, additional, Vlieghe, Erika, additional, Planquette, Benjamin, additional, Damme, Pierre Van, additional, Gaetano , Katleen de, additional, Buffet, Pierre, additional, Henry, Benoît, additional, Cevik, Muge, additional, Leen, Clifford, additional, Laurenson, Ian, additional, Cameron, Helen, additional, Ogavu, Joseph, additional, Nabankema, Evelyn, additional, Omona, Venice, additional, Valnaud, Pauline, additional, Mackintosh, Claire, additional, Johannessen, Ingólfur, additional, geertruyden, Jean-Pierre Van, additional, Jeunne, Claire Le, additional, and Cauda, Roberto, additional

Published
2019
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33. International infectious diseases teaching to undergraduate medical students: A successful European collaborative experience*

Author

Charlier, Caroline, Johannessen, Ingólfur, Mackintosh, Claire L., Wilks, David, Cauda, Roberto, Wolf, Federica I., and Jeunne, Claire Le

Subjects
medicine, Settore MED/04 - PATOLOGIA GENERALE, undergraduate pahse of education, core curriculum, outcome-based curriculum, teaching&learning, core curriculum, outcome-based curriculum, undergraduate pahse of education, medicine, teaching&learning
Abstract

Context: The emerging global-health paradigm requires medical teaching to be continuously redefined and updated; to this end, transnational approaches should be encouraged and medical training harmonized. Infectious diseases (ID) teaching in the current context of emerging infections, fast-increasing bacterial resistance and large-scale human migration, was chosen to develop a common international course. Objective: We report the successful implementation of a joint European undergraduate course aiming to (i) develop a common ID core curriculum among European medical schools; (ii) promote mobility among teachers and students (iii) promote international cooperation among European teachers. Methods: The course was built around teachers’ mobility. It was delivered in English by a team of European medical educators from Paris Descartes University, Università Cattolica del Sacro Cuore in Rome and the University of Edinburgh to groups of 25–30 undergraduate medical students at each university. Partner Institutions officially recognized the course as substitutive of or additive to the regular curriculum. Results: The course has been running for 3 years and received excellent satisfaction scores by students and staff as regards to scientific content, pedagogy and international exchanges. Conclusion: This cooperative approach demonstrates the feasibility of a harmonized European undergraduate medical education, having ID as a test experiment for future developments.

Published
2017
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34. Dietary Magnesium Alleviates Experimental Murine Colitis Through Upregulation of the Transient Receptor Potential Melastatin 6 Channel

Author

Trapani, Valentina, primary, Petito, Valentina, additional, Di Agostini, Angelica, additional, Arduini, Daniela, additional, Hamersma, Willem, additional, Pietropaolo, Giuseppe, additional, Luongo, Francesca, additional, Arena, Vincenzo, additional, Stigliano, Egidio, additional, Lopetuso, Loris R, additional, Gasbarrini, Antonio, additional, Wolf, Federica I, additional, and Scaldaferri, Franco, additional

Published
2018
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35. The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on covid-19.

Author

Wolf, Federica I., Maier, Jeanette A., Rosanoff, Andrea, Barbagallo, Mario, Baniasadi, Shadi, Castiglioni, Sara, Fu-Chou Cheng, Day, Sherrie Colaneri, Costello, Rebecca B., Dominguez, Ligia J., Elin, Ronald J., Gamboa-Gomez, Claudia, Guerrero-Romero, Fernando, Ka Kahe, Kisters, Klaus, Kolisek, Martin, Kraus, Anton, Iotti, Stefano, Mazur, Andre, and Mercado-Atri, Moises

Subjects
MAGNESIUM, CORONARY artery disease, COVID-19 pandemic, COVID-19, MAGNETS
Abstract

The article presents the magnesium global network to promote research on magnesium in diseases focusing on covid-19. Topics discussed include this prompted establishment of a worldwide collaborative network with regular virtual meetings to brainstorm the associations between magnesium and COVID-19; and hypothesize that magnesium deficiency, a common but mostly unrecognized state in modern global societies, could be an important component of the susceptibility to SARS-CoV-2 infection.

Published
2021
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36. 8-Hydroxyquinoline derivatives as fluorescent sensors for magnesium in living cells

Author

Farruggia, Giovanna, Iotti, Stefano, Prodi, Luca, Montalti, Marco, Zaccheroni, Nelsi, Savage, Paul B., Trapani, Valentina, Sale, Patrizio, and Wolf, Federica I.

Subjects
Magnesium oxide -- Structure, Magnesium oxide -- Optical properties, Magnesium oxide -- Chemical properties, Fluorescence spectroscopy -- Analysis, Volumetric analysis, Chemistry
Abstract

The spectroscopic and photochemical characterization of two diaza-18-crown-6-hydroxyquinoline derivatives (DCHQ) and their application in total Mg(super 2+) assessment and in confocal imaging as effective Mg(super 2+) indicators are described. The results show that DCHQ derivatives serve as new tools for the study of Mg(super 2+) regulation, allowing sensitive and straightforward detection of both static and dynamic signals.

Published
2006

41. Magnesium in the Central Nervous System

Author

Trapani, Valentina, Mastrototaro, Lucia, and Wolf, Federica I.

Subjects
Settore MED/04 - PATOLOGIA GENERALE, apoptosis, magnesium, apoptosis, magnesium
Published
2011

45. Variant ATRX Syndrome with Dysfunction ofATRXandMAGT1Genes

Author

Qiao, Ying, primary, Mondal, Kajari, additional, Trapani, Valentina, additional, Wen, Jiadi, additional, Carpenter, Gillian, additional, Wildin, Robert, additional, Price, E. Magda, additional, Gibbons, Richard J., additional, Eichmeyer, Jennifer, additional, Jiang, Ruby, additional, DuPont, Barbara, additional, Martell, Sally, additional, Lewis, Suzanne M. E., additional, Robinson, Wendy P., additional, O'Driscoll, Mark, additional, Wolf, Federica I., additional, Zwick, Michael E., additional, and Rajcan-Separovic, Evica, additional

Published
2013
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47. A guided tour of presentations at the XIV International Magnesium Symposium "Magnesium in Health & Disease" Roma, Villa Malta, June 23-24, 2016.

Author

Rosanoff, Andrea and Wolf, Federica I.

Subjects
PHYSIOLOGICAL effects of magnesium, HUMAN body, INTRACELLULAR pathogens, PATHOGENIC microorganisms, MAGNESIUM group, ALKALINE earth metals, PHYSIOLOGY
Abstract

The authors reflect on the papers presented at the XIV International Magnesium Symposium entitled "Magnesium in Health & Disease" held in Roma, Villa Malta from June 23-24, 2016. Topics discussed include the fluctuating concentration of intracellular magnesium, the magnesium transport proteins, and the impact of magnesium intake on human health.

Published
2016
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