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1. Online Demodulation and Trigger for Flux-ramp Modulated SQUID Signals

Author

Karcher, N., Muscheid, T., Wolber, T., Richter, D., Enss, C., Kempf, S., and Sander, O.

Subjects
Electrical Engineering and Systems Science - Signal Processing, Condensed Matter - Superconductivity, Physics - Instrumentation and Detectors
Abstract

Due to the periodic characteristics of SQUIDs, a suitable linearization technique is required for SQUID-based readout. Flux-ramp modulation is a common linearization technique and is typically applied for the readout of a microwave-SQUID-multiplexer as well as since recently also for dc-SQUIDs. Flux-ramp modulation requires another stage in the signal processing chain to demodulate the SQUID output signal before further processing. For cryogenic microcalorimenters, these events are given by fast exponentially rising and slowly exponentially decaying pulses which shall be detected by a trigger engine and recorded by a storage logic. Since the data rate can be decreased significantly by demodulation and event detection, it is desirable to do both steps on the deployed fast FPGA logic during measurement before passing the data to a general-purpose processor. In this contribution, we show the implementation of efficient multi-channel flux-ramp demodulation computed at run-time on a SoC-FPGA. Furthermore, a concept and implementation for an online trigger and buffer mechanism with its theoretical trigger loss rates depending on buffer size is presented. Both FPGA modules can be operated with up to 500 MHz clock frequency and can efficiently process 32 channels. Correct functionality and data reduction capability of the modules are demonstrated in measurements utilizing magnetic microcalorimeter irradiated with an Iron-55 source for event generation and read out by a microwave SQUID multiplexer., Comment: LTD19 - Proceeding

Published
2021
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5. Percutaneous left atrial appendage occlusion can impair pulmonary vein isolation with pulse field ablation

Author

Molitor, N, primary, Berger, F, additional, Breitenstein, A, additional, Chen, S, additional, Chun, J, additional, Galuszka, M, additional, Reichlin, T, additional, Roten, L, additional, Kueffer, T, additional, Lemoine, M, additional, Ouyang, F, additional, Wolber, T, additional, Brunckhorst, C, additional, Duru, F, additional, and Saguner, A, additional

Published
2024
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8. Simultaneous MMC Readout Using a Tailored <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>MUX Based Readout System

Author

Richter, D., Wegner, M., Ahrens, F., Enss, C., Karcher, N., Sander, O., Schuster, C., Weber, M., Wolber, T., and Kempf, S.

Abstract

Magnetic microcalorimeters (MMCs) are cryogenic, energy-dispersive single-particle detectors providing excellent energy resolution, intrinsically fast signal rise time, quantum efficiency close to 100%, large dynamic range as well as almost ideal linear response. One of the remaining challenges to be overcome to ultimately allow for the utilization of large-scale MMC based detector arrays with thousands to millions of individual pixels is the realization of a SQUID based multiplexing technique particularly tailored for MMC readout. Within this context, we report on the first demonstration of a frequency-division multiplexed readout of an MMC based detector array using both, a custom microwave SQUID multiplexer as well as a dedicated software-defined radio (SDR) readout electronics. We successfully performed a simultaneous readout up to eight multiplexer channels, each monitoring two detector pixels. We show that the signal shape is not changed as compared to a dc-SQUID readout and that similar values for the energy resolution can be obtained. Nevertheless, we observed an influence of the internal quality factor of the microwave resonators used for frequency encoding on the energy resolution that affects the resolution of the co-added sum spectrum.

Published
2023
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13. Comparison of benefit and mortality of implantable cardioverter-defibrillator therapy in patients Aged ≥75 years versus those <75 years

Author

Brüllmann, S, Dichtl, W, Paoli, U, Haegeli, L, Schmied, C, Steffel, J, Brunckhorst, C, Hintringer, F, Seifert, Burkhardt, Duru, F, Wolber, T, University of Zurich, and Wolber, T

Subjects
10209 Clinic for Cardiology, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2705 Cardiology and Cardiovascular Medicine
Published
2012

19. Interference of neodymium magnets with cardiac pacemakers and implantable cardioverter-defibrillators: an in vitro study

Author

Ryf S, Wolber T, Firat Duru, Luechinger R, University of Zurich, and Luechinger, R

Subjects
Neodymium, Pacemaker, Artificial, 1502 Bioengineering, 2502 Biomaterials, Biomedical Engineering, Biophysics, 2204 Biomedical Engineering, Health Informatics, Bioengineering, 610 Medicine & health, 1710 Information Systems, Defibrillators, Implantable, Biomaterials, 170 Ethics, Magnetics, Electromagnetic Fields, 10209 Clinic for Cardiology, 10237 Institute of Biomedical Engineering, Equipment Failure, Information Systems, 1304 Biophysics, 2718 Health Informatics
Abstract

Permanent magnets may interfere with the function of cardiac pacemakers and implantable cardioverter-defibrillators (ICDs). Neodymium-iron-boron (NdFeB) magnets have become widely available in recent years and are incorporated in various articles of daily life. We conducted an in-vitro study to evaluate the ability of NdFeB magnets for home and office use to cause interference with cardiac pacemakers and ICDs. The magnetic fields of ten NdFeB magnets of different size and shape were measured at increasing distances beginning from the surface until a field-strength (B-field) value of 0.5 mT was reached. Furthermore, for each magnet the distance was determined at which a sample pacemaker switched from magnet mode to normal mode. Depending on the size and remanence of individual magnets, a B-field value of 0.5 mT was found at distances ranging from 1.5 cm to 30 cm and a value of 1 mT at distances from 1 cm to 22 cm. The pacemaker behavior was influenced at distances from 1 cm to 24 cm. NdFeB magnets for home and office use may cause interference with cardiac pacemakers and ICDs at distances up to 24 centimeters. Patient education and product declarations should include information about the risk associated with these magnets.

Published
2008

20. Arrhythmic manifestations in patients with congenital left ventricular aneurysms and diverticula

Author

Haegeli, L M, Ercin, E, Wolber, T, Brunckhorst, C, Tanner, F C, Jenni, R, Lüscher, T F, Duru, F, Haegeli, L M, Ercin, E, Wolber, T, Brunckhorst, C, Tanner, F C, Jenni, R, Lüscher, T F, and Duru, F

Abstract

Congenital left ventricular aneurysms and diverticula (LVA/Ds) are rare cardiac malformations that can be detected using echocardiography or other imaging techniques. Some of these patients present with ventricular arrhythmias. This study investigated clinical characteristics of patients with congenital LVA/D presenting with arrhythmic manifestations. Over the previous 20 years 250 patients were diagnosed to have congenital LVA/D at our institution. Diagnosis was made using echocardiography after exclusion of coronary artery disease, local cardiac inflammatory processes, traumatic causes, or cardiomyopathies. At initial presentation 32 of the 250 patients (13%, average age 45 years, range 25 to 65, 21 men and 11 women) exhibited arrhythmias. At least 2 LVA/Ds were present in 6 of these patients. LVA/Ds were localized at the posterobasal, apical, anteroseptal, and anterolateral walls in 12, 11, 4, and 5 patients, respectively. The most common complaints at presentation were syncope or presyncope in 18 patients and palpitations in 11 patients. One patient had survived sudden cardiac death. Long-term electrocardiographic recordings showed ventricular tachycardia (VT) or ventricular fibrillation in 17 patients (53%). Twelve patients underwent electrophysiologic testing. Nine patients had inducible ventricular tachyarrhythmia, whereas induced tachycardia was similar to that during spontaneous arrhythmia in 7 patients. In conclusion, patients with congenital LVA/Ds who present with arrhythmic manifestations commonly have VT. Electrophysiologic testing can reproduce clinical VT in most of these patients.

Published
2011

21. Patient satisfaction and clinical outcome following outpatient radiofrequency catheter ablation of supraventricular tachycardia

Author

Wolber, T, On, C J, Brunckhorst, C, Schmied, C, Steffel, J, Lüscher, T F, Duru, F, Wolber, T, On, C J, Brunckhorst, C, Schmied, C, Steffel, J, Lüscher, T F, and Duru, F

Abstract

Background: Catheter ablation is an effective and safe treatment for various arrhythmic disorders. Patients are frequently admitted for an overnight stay after the ablation procedure to monitor for possible postprocedural complications or recurrence of the arrhythmia. The aim of this study was to assess patient satisfaction in patients with supraventricular tachycardia following catheter ablation on an outpatient basis.Methods: 243 consecutive patients (129 male, 53%; mean age 49 ± 17 years) underwent electrophysiological study and radiofrequency catheter ablation either on an outpatient basis or a hospitalization that included at least an overnight hospital stay (inpatient) at a university hospital. All patients were asked to complete a specially designed questionnaire that addressed patient satisfaction as well as the clinical outcome after ablation at six months. Results: The ablation procedure was performed on an outpatient basis in 119 patients (49%). The long-term procedural success rate was 99%. The overall patient satisfaction with the ablation procedure and with the clinical outcome at six months was 90%. There were no significant differences between outpatient and inpatient groups with respect to ablation results and patient satisfaction. Patients in the outpatient group returned to work after 2.8 ± 1.9 days as compared to 3.9 ± 2.2 days in the inhospital group (p = 0.001). Conclusion: Overall patient satisfaction and self-reported clinical outcome are comparable for outpatient and inpatient catheter ablations. Patients undergoing outpatient procedures may return to work earlier. Therefore, outpatient ablation procedures may be considered for selected patients without significant comorbidities.

Published
2010

22. Predictors of appropriate implantable cardioverter-defibrillator therapy during long-term follow-up of patients with coronary artery disease

Author

Blumer, J, Wolber, T, Hellermann, J, Holzmeister, J, Binggeli, C, Duru, F, Brunckhorst, C, Blumer, J, Wolber, T, Hellermann, J, Holzmeister, J, Binggeli, C, Duru, F, and Brunckhorst, C

Abstract

Indications for implantable cardioverter defibrillators (ICDs) are expanding. Defining long-term predictors of ICD therapies might help to identify those patients who will benefit most from implantation of an ICD. The objective of this study was to examine long-term predictors of appropriate ICD therapy among patients with coronary disease at high risk of sudden cardiac death. An analysis of 245 patients with coronary disease, who had been implanted with an ICD for primary or secondary prevention of sudden cardiac death, was performed. Time to appropriate ICD therapy, defined as antitachycardia pacing or shock, was evaluated by the Kaplan-Meier method. Cox regression analysis was performed to determine hazard ratios for factors predicting appropriate ICD therapies. During a mean (SD) follow-up of 41 (33) months, 115 patients (53%) experienced appropriate ICD therapy. Independent predictors of appropriate ICD therapy included advanced age, left ventricular ejection fraction (LVEF) < 35%, and impaired renal function, with covariate-adjusted hazard ratios of 1.36 per 10 years (95% CI, 1.11 - 1.66; P = 0.003), 1.78 (95% CI, 1.21 - 2.63; P = 0.004), and 1.59 (95% CI, 1.00 - 2.54; P = 0.050), respectively. Remote myocardial infarction (> 6 months prior to ICD implantation) was associated with higher probability of appropriate ICD therapy among patients with LVEF > 35% (adjusted HR 2.68 [95% CI, 1.05 - 6.86; P = 0.04]), but not among patients with LVEF < 35% (adjusted HR 1.09 [95% CI, 0.58 - 2.04; P = 0.79]). Left ventricular ejection fraction, advanced age, and renal impairment are long-term predictors of appropriate ICD therapy in patients with coronary disease at high risk of sudden cardiac death. Patients with an ejection fraction above 35% have few arrhythmic events early after the myocardial infarction but appropriate therapies become more frequent late after the myocardial infarction, possibly due to progression of the disease.

Published
2009

23. Electrophysiological findings in patients with isolated left ventricular non-compaction

Author

Steffel, J, Kobza, R, Namdar, M, Wolber, T, Brunckhorst, C, Lüscher, T F, Jenni, R, Duru, F, Steffel, J, Kobza, R, Namdar, M, Wolber, T, Brunckhorst, C, Lüscher, T F, Jenni, R, and Duru, F

Abstract

AIMS: Patients with isolated left ventricular non-compaction (IVNC) are at high risk for developing ventricular tachyarrhythmias. However, no analysis of invasive electrophysiological (EP) findings in these patients has yet been performed. METHODS AND RESULTS: We performed a retrospective analysis of EP findings in 24 patients with IVNC. Ventricular tachyarrhythmias were inducible in nine patients; of these, two patients had sustained monomorphic ventricular tachycardia (VT) and two patients had ventricular fibrillation. No specific electrocardiographic or echocardiographic finding was predictive of VT inducibility. Three of the 9 patients with inducible VT experienced ventricular tachyarrhythmias during the follow-up of 61.4+/-50 months, whereas no tachyarrhythmias or sudden deaths were noted in 12 patients without inducible VT during the follow-up of 30+/-19 months (3 patients in the latter group were lost to follow-up). Supraventricular tachyarrhythmias were inducible in seven patients. CONCLUSION: Our present study provides the first comprehensive analysis of EP findings in patients with IVNC. Ventricular and supraventricular arrhythmias can readily be induced in these patients, whereas the inducibility of a sustained monomorphic VT is relatively low. Further studies including long-term follow-up are required to investigate the role of EP testing for arrhythmic risk stratification in these patients.

Published
2009

24. Cardiopulmonary exercise testing in mild heart failure: impact of the mode of exercise on established prognostic predictors

Author

Maeder, M T, Wolber, T, Ammann, P, Myers, J, Brunner-La Rocca, H P, Hack, D, Riesen, W, Rickli, H, Maeder, M T, Wolber, T, Ammann, P, Myers, J, Brunner-La Rocca, H P, Hack, D, Riesen, W, and Rickli, H

Abstract

OBJECTIVES: In patients with heart failure (HF), peak oxygen consumption (peak VO(2)), the relationship between minute ventilation and carbon dioxide production (VE/VCO(2) slope) and heart rate recovery (HRR) are established prognostic predictors. However, treadmill exercise has been shown to elicit higher peak VO(2) values than bicycle exercise. We sought to assess whether the VE/VCO(2) slope and HRR in HF also depend on the exercise mode. METHODS: Twenty-one patients with mild HF on chronic beta-blocker therapy underwent treadmill and bicycle cardiopulmonary exercise testing for measurement of peak VO(2) and the VE/VCO(2) slope. In patients with sinus rhythm (n = 16), HRR at 1 (HRR-1) and 2 min (HRR-2) after exercise termination was assessed. RESULTS: Peak VO(2) was higher during treadmill as compared with bicycle testing (21.7 +/- 4.6 vs. 19.6 +/- 3.4 ml/kg/min; p = 0.006). HRR-1 tended to be slower (15 bpm, interquartile range 8-19, vs. 18 bpm, interquartile range 11-22; p = 0.16), and HRR-2 was significantly slower after treadmill exercise (26 bpm, interquartile range 20-39, vs. 31 bpm, interquartile range 22-41; p = 0.04). In contrast, VE/VCO(2) slope values did not differ between the test modes (32.9 +/- 5.5 vs. 32.3 +/- 5.0; p = 0.56). CONCLUSIONS: In contrast to peak VO(2) and HRR, the VE/VCO(2) slope is not affected by the exercise mode in patients with mild HF.

Published
2008

25. Long-term predictors of mortality in ICD patients with non-ischaemic cardiac disease: impact of renal function

Author

Schefer, T, Wolber, T, Binggeli, C, Holzmeister, J, Brunckhorst, C, Duru, F, Schefer, T, Wolber, T, Binggeli, C, Holzmeister, J, Brunckhorst, C, and Duru, F

Abstract

BACKGROUND: Randomized trials have demonstrated that implantable cardioverter defibrillator (ICD) therapy may reduce the risk of death in patients with non-ischaemic cardiomyopathy (CMP). In this study, we aimed at determining the long-term benefit of ICD therapy among patients with dilated CMP (DCM) and among those with other non-ischaemic cardiac diseases (NICDs). METHODS AND RESULTS: We performed a single-centre longitudinal study to assess the outcomes of 176 patients with NICDs who were implanted with an ICD for primary or secondary prevention of cardiac death. The cumulative survival rate after 1, 2, 5, and 10 years was 91, 87, 78, and 65%, respectively. Mortality risk did not differ significantly between patients with DCM and those with other NICDs. Atrial fibrillation, recurrent ventricular arrhythmias requiring ICD therapy, and right ventricular pacing, but not delayed intrinsic ventricular conduction, were associated with higher risk. New York Heart Association (NYHA) functional class > or =III was an independent predictor of adverse outcome among patients with DCM [hazard ratio (HR) 5.27, P = 0.01], whereas reduced left ventricular function with ejection fraction <35% (HR 12.1, P < 0.001) and anti-arrhythmic drug use (HR 4.82, P = 0.03) were independent predictors among those with other NICDs. Renal insufficiency with estimated glomerular filtration rate <60 mL/min/1.73 m(2) (HR 5.9, P < 0.001) was a strong independent predictor of mortality among all patients with NICD, irrespective of underlying cardiac condition. CONCLUSION: In ICD patients with DCM, higher NYHA functional class is associated with adverse outcomes. Impaired left ventricular function and anti-arrhythmic drug use predict higher mortality among patients with non-dilated, NICDs. Impaired renal function is a strong predictor of mortality in all patients with NICD.

Published
2008

27. Poster Session 1

Author

Deshmukh, A., primary, Sharma, S. S., additional, Gobal, F. G., additional, Singla, S. S., additional, Hebbar, P. H., additional, Paydak, H. P., additional, Igarashi, M., additional, Tada, H., additional, Sekiguchi, Y., additional, Yamasaki, H., additional, Kuroki, K., additional, Machino, T., additional, Yoshida, K., additional, Aonuma, K., additional, Shavadia, J., additional, Otieno, H., additional, Yonga, G., additional, Jinah, A., additional, Qvist, J. F., additional, Soerensen, P. H., additional, Dixen, U., additional, Ramirez-Marrero, M. A., additional, Perez-Villardon, B., additional, Gaitan-Roman, D., additional, Jimenez-Navarro, M., additional, Delgado-Prieto, J. L., additional, De Teresa-Galvan, E., additional, De Mora-Martin, M., additional, Deshmukh, A., additional, Hebbar, P. B., additional, Wei, W. X., additional, Bardari, S., additional, Zecchin, M., additional, Salame', R., additional, Vitali Serdoz, L., additional, Di Lenarda, A., additional, Guerrini, N., additional, Barbati, G., additional, Sinagra, G., additional, Hanazawa, K., additional, Kaitani, K., additional, Nakagawa, Y., additional, Lenaerts, I., additional, Driesen, R., additional, Hermida, N., additional, Heidbuchel, H., additional, Janssens, S., additional, Balligand, J. L., additional, Sipido, K. R., additional, Willems, R., additional, Sehra, R., additional, Krummen, D., additional, Briggs, C., additional, Narayan, S., additional, Tanaka, Y., additional, Hirao, K., additional, Nakamura, T., additional, Inaba, O., additional, Yagishita, A., additional, Higuchi, K., additional, Hachiya, H., additional, Isobe, M., additional, Kallergis, E., additional, Kanoupakis, E. M., additional, Mavrakis, H. E., additional, Goudis, C. A., additional, Maliaraki, N. E., additional, Vardas, P. E., additional, Kiuchi, K., additional, Piorkowski, C., additional, Kircher, S., additional, Gaspar, T., additional, Watanabe, N., additional, Bollmann, A., additional, Hindricks, G., additional, Wauters, K., additional, Grosse, A., additional, Raffa, S., additional, Brunelli, M., additional, Geller, J. C., additional, Maggioni, A. P., additional, Gonzini, L., additional, Gussoni, G., additional, Vescovo, G., additional, Gulizia, M., additional, Pirelli, S., additional, Mathieu, G., additional, Di Pasquale, G., additional, Salame, R., additional, Magnani, S., additional, Sakamoto, T., additional, Kumagai, K., additional, Fuke, E., additional, Nishiuchi, S., additional, Hayashi, T., additional, Miki, Y., additional, Naito, S., additional, Oshima, S., additional, Hof, I. E., additional, Vonken, E., additional, Velthuis, B. K., additional, Meine, M., additional, Hauer, R. N. W., additional, Loh, K. P., additional, Na, J. O., additional, Choi, C. U., additional, Kim, E. J., additional, Rha, S. W., additional, Park, C. G., additional, Seo, H. S., additional, Oh, D. J., additional, Lim, H. E., additional, Wichterle, D., additional, Bulkova, V., additional, Fiala, M., additional, Chovancik, J., additional, Simek, J., additional, Peichl, P., additional, Cihak, R., additional, Kautzner, J., additional, Glick, A., additional, Viskin, S., additional, Belhassen, B., additional, Navarrete, A., additional, Conte, F., additional, Ishti, A., additional, Sai, D., additional, Moran, M., additional, Chitovova, Z., additional, Ahmed, H., additional, Mares, K., additional, Skoda, J., additional, Sediva, L., additional, Petru, J., additional, Reddy, V. Y., additional, Neuzil, P., additional, Schmidt, M., additional, Dorwarth, U., additional, Leber, A., additional, Wankerl, M., additional, Krieg, J., additional, Straube, F., additional, Reif, S., additional, Hoffmann, E., additional, Mikhaylov, E., additional, Tikhonenko, V., additional, Lebedev, D., additional, Shin, S. Y., additional, Yong, H. S., additional, Choi, J. I., additional, Kim, S. H., additional, Matsuo, S., additional, Yamane, T., additional, Hioki, M., additional, Ito, K., additional, Narui, R., additional, Date, T., additional, Sugimoto, K., additional, Yoshimura, M., additional, Rolf, S., additional, Sommer, P., additional, Batalov, R., additional, Popov, S., additional, Antonchenko, I., additional, Suslova, T., additional, Fichtner, S., additional, Czudnochowsky, U., additional, Estner, H. L., additional, Ammar, S., additional, Reents, T., additional, Jilek, C., additional, Hessling, G., additional, Deisenhofer, I., additional, Pokushalov, E., additional, Romanov, A., additional, Corbucci, G., additional, Artemenko, S., additional, Losik, D., additional, Shabanov, V., additional, Turov, A., additional, Elesin, D., additional, Abramov, M., additional, Sanders, P., additional, Jais, P., additional, Roberts-Thomson, K., additional, Fukumoto, K., additional, Takatsuki, S., additional, Kimura, T., additional, Nishiyama, N., additional, Aizawa, Y., additional, Sato, T., additional, Miyoshi, S., additional, Fukuda, K., additional, Roux, Y., additional, Tenkorang, J., additional, Carroz, P., additional, Schlaepfer, J., additional, Pascale, P., additional, Forclaz, A., additional, Fromer, M., additional, Pruvot, E., additional, Sknouril, L., additional, Nevralova, R., additional, Dorda, M., additional, Januska, J., additional, Santi, R., additional, Geller, C., additional, Nakamura, K., additional, Kasseno, K., additional, Taniguchi, K., additional, Wutzler, A., additional, Huemer, M., additional, Parwani, A., additional, Boldt, L. H., additional, Blaschke, D., additional, Dietz, R., additional, Haverkamp, W., additional, Coutu, B., additional, Malanuk, R., additional, Ait Said, M., additional, Vicentini, A., additional, Schade, S., additional, Ando, K., additional, Rousseauplasse, A., additional, Deering, T., additional, Picarra, B. C., additional, Santos, A. R., additional, Dionisio, P., additional, Semedo, P., additional, Matos, R., additional, Leitao, M., additional, Jacinto, A., additional, Trinca, M., additional, Wan, C., additional, Glad, J., additional, Szymkiewicz, S., additional, Habibovic, M., additional, Versteeg, H., additional, Pelle, A. J. M., additional, Theuns, D. A. M. J., additional, Jordaens, L., additional, Pedersen, S. S., additional, Pakarinen, S., additional, Toivonen, L., additional, Taggeselle, J., additional, Frey, A., additional, Birkenhagen, A., additional, Kohler, S., additional, Maier, S. K. G., additional, Lobitz, N., additional, Paule, S., additional, Becher, J., additional, Mustafa, G., additional, Ibrahim, A., additional, King, G., additional, Foley, B., additional, Wilkoff, B., additional, Freedman, R., additional, Hayes, D., additional, Kalbfleisch, S., additional, Kutalek, S., additional, Schaerf, R., additional, Fazal, I. A., additional, Tynan, M., additional, Plummer, C. J., additional, Mccomb, J. M., additional, Oto, A., additional, Aytemir, K., additional, Yorgun, H., additional, Canpolat, U., additional, Kaya, E. B., additional, Tokgozoglu, L., additional, Kabakci, G., additional, Ozkutlu, H., additional, Greenberg, S., additional, Hamati, F., additional, Styperek, R., additional, Alonso, J., additional, Peress, D., additional, Bolanos, O., additional, Augostini, R., additional, Pelini, M., additional, Zhang, S., additional, Stoycos, S., additional, Witsaman, S., additional, Mowrey, K., additional, Bremer, J., additional, Oza, A., additional, Ciconte, G., additional, Mazzone, P., additional, Paglino, G., additional, Marzi, A., additional, Vergara, P., additional, Sora, N., additional, Gulletta, S., additional, Della Bella, P., additional, Nagashima, M., additional, Goya, M., additional, Soga, Y., additional, Hiroshima, K., additional, Andou, K., additional, Hayashi, K., additional, An, Y., additional, Nobuyoshi, M., additional, Kutarski, A., additional, Malecka, B., additional, Pietura, R., additional, Osmancik, P., additional, Herman, D., additional, Stros, P., additional, Kocka, V., additional, Tousek, P., additional, Linkova, H., additional, Bortnik, M., additional, Occhetta, E., additional, Dell'era, G., additional, Degiovanni, A., additional, Plebani, L., additional, Marino, P. N., additional, Gorev, M. V., additional, Alimov, D. G., additional, Raju, P., additional, Kully, S., additional, Ugni, S., additional, Furniss, S., additional, Lloyd, G., additional, Patel, N. R., additional, Richards, M. W., additional, Warren, C. E., additional, Anderson, M. H., additional, Hero, M., additional, Rey, J. L., additional, Ouali, S., additional, Azzez, S., additional, Kacem, S., additional, Hammas, S., additional, Ben Salem, H., additional, Neffeti, E., additional, Remedi, F., additional, Boughzela, E., additional, Kronborg, M. B., additional, Mortensen, P. T., additional, Poulsen, S. H., additional, Nielsen, J. C., additional, Simantirakis, E. N., additional, Kontaraki, J. E., additional, Arkolaki, E. G., additional, Chrysostomakis, S. I., additional, Nyktari, E. G., additional, Patrianakos, A. P., additional, Funck, R. C., additional, Harink, C., additional, Mueller, H. H., additional, Koelsch, S., additional, Maisch, B., additional, Bolzani, V., additional, Costandi, P., additional, Shehada, R. E., additional, Butala, N., additional, Coppola, B., additional, Taborsky, M., additional, Heinc, P., additional, Fedorco, M., additional, Doupal, V., additional, Di Cori, A., additional, Zucchelli, G., additional, Soldati, E., additional, Segreti, L., additional, De Lucia, R., additional, Viani, S., additional, Paperini, L., additional, Bongiorni, M. G., additional, Gutleben, K. J., additional, Kranig, W., additional, Barr, C., additional, Morgenstern, M. M., additional, Simon, M., additional, Dalal, Y. H., additional, Landolina, M., additional, Pierantozzi, A., additional, Agricola, T., additional, Lunati, M., additional, Pisano', E., additional, Lonardi, G., additional, Bardelli, G., additional, Zucchi, G., additional, Thibault, B., additional, Dubuc, M., additional, Karst, E., additional, Ryu, K., additional, Paiement, P., additional, Carlson, M. D., additional, Farazi, T., additional, Alhous, H., additional, Mont, L., additional, Porres, J. M., additional, Alzueta, J., additional, Beiras, X., additional, Fernandez-Lozano, I., additional, Macias, A., additional, Ruiz, R., additional, Brugada, J., additional, Viani, S. M., additional, Seifert, M., additional, Schau, T., additional, Moeller, V., additional, Meyhoefer, J., additional, Butter, C., additional, Ganiere, V., additional, Niculescu, V., additional, Domenichini, G., additional, Stettler, C., additional, Defaye, P., additional, Burri, H., additional, Stockburger, M., additional, De Teresa, E., additional, Lamas, G., additional, Desaga, M., additional, Koenig, C., additional, Cobo, E., additional, Navarro, X., additional, Wiegand, U., additional, Blich, M., additional, Carasso, S., additional, Suleiman, M., additional, Marai, I., additional, Gepstein, L., additional, Boulos, M., additional, Sasov, M., additional, Liska, B., additional, Margitfalvi, P., additional, Malacky, T., additional, Svetlosak, M., additional, Goncalvesova, E., additional, Hatala, R., additional, Takaya, Y., additional, Noda, T., additional, Yamada, Y., additional, Okamura, H., additional, Satomi, K., additional, Shimizu, W., additional, Aihara, N., additional, Kamakura, S., additional, Proclemer, A., additional, Boveda, S., additional, Oswald, H., additional, Scipione, P., additional, Da Costa, A., additional, Brzozowski, W., additional, Tomaszewski, A., additional, Wysokinski, A., additional, Arbelo, E., additional, Tamborero, D., additional, Vidal, B., additional, Tolosana, J. 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E., additional, Iacoviello, M., additional, Nacci, F., additional, Luzzi, G., additional, Puzzovivo, A., additional, Memeo, M., additional, Quadrini, F., additional, Favale, S., additional, Trucco, M. E., additional, Arce, M., additional, Palazzolo, J., additional, Uribe, W., additional, Maggi, R., additional, Furukawa, T., additional, Croci, F., additional, Solano, A., additional, Brignole, M., additional, Lebreiro, A., additional, Sousa, A., additional, Correia, A. S., additional, Lourenco, P., additional, Oliveira, S., additional, Paiva, M., additional, Freitas, J., additional, Maciel, M. J., additional, Linker, N., additional, Rieger, G., additional, Garutti, C., additional, Edvardsson, N., additional, Salguero Bodes, R., additional, De Riva Silva, M., additional, Fontenla Cerezuela, A., additional, Lopez Gil, M., additional, Mejia Martinez, E., additional, Jurado Roman, A., additional, Garcia Alvarez, S., additional, Arribas Ynsaurriaga, F., additional, Petix, N. R., additional, Del Rosso, A., additional, Guarnaccia, V., additional, Zipoli, A., additional, Rabajoli, F., additional, Foglia Manzillo, G., additional, Tolardo, C., additional, Checchinato, C., additional, Chiaravallotti, S., additional, Santarone, M., additional, Spinnler, M. T., additional, Podoleanu, C., additional, Frigy, A., additional, Dobreanu, D., additional, Ginghina, C., additional, and Carasca, E., additional

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2011
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29. Poster session IV * Friday 10 December 2010, 14:00-18:00

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Mora, B., primary, Base, E., additional, Schmid, W., additional, Andreas, M., additional, Weber, U., additional, Junreitmaier, M., additional, Foerster, F., additional, Hiesmayr, M., additional, Tschernich, H. D., additional, Guldbrand, D., additional, Goetzsche, O., additional, Eika, B., additional, Fumagalli, S., additional, Francini, S., additional, Gabbai, D., additional, Pedri, S., additional, Casalone Rinaldi, M., additional, Makhanian, Y., additional, Sollami, R., additional, Tarantini, F., additional, Marchionni, N., additional, Azcarate, P. M., additional, Castano, S., additional, Rodriguez-Manero, M., additional, Arraiza, M., additional, Levy, B., additional, Barba, J., additional, Rabago, G., additional, Bastarrika, G., additional, Rus, H., additional, Radoi, M., additional, Ciurea, C., additional, Boda, D., additional, Erdei, T., additional, Denes, M., additional, Mihalcz, A., additional, Kardos, A., additional, Foldesi, C. S., additional, Temesvari, A., additional, Lengyel, M., additional, Cameli, M., additional, Lisi, M., additional, Righini, F., additional, Ballo, P., additional, Henein, M., additional, Mondillo, S., additional, Nistri, S., additional, Galderisi, M., additional, Ballo, P. C., additional, Pagliani, L., additional, Olivotto, I., additional, Santoro, A., additional, Papesso, B., additional, Innelli, P., additional, Cecchi, F., additional, Hristova, K., additional, Katova, T. Z., additional, Kostova, V., additional, Simova, Y., additional, Nesheva, N., additional, Ivanovic, B., additional, Tadic, M. T., additional, Simic, D. S., additional, Rao, C. M., additional, Aguglia, D., additional, Casciola, G., additional, Imbesi, C., additional, Marvelli, A., additional, Sgro, M., additional, Benedetto, D., additional, Tripepi, G., additional, Zoccali, C., additional, Benedetto, F. A., additional, Mantziari, L., additional, Kamperidis, V., additional, Damvopoulou, E., additional, Ventoulis, I., additional, Giannakoulas, G., additional, Paraskevaidis, S., additional, Vassilikos, V., additional, Karvounis, H., additional, Styliadis, I. H., additional, Sonder, T. K., additional, Loegstrup, B. B., additional, Lambrechtsen, J., additional, Van Bortel, L. M., additional, Segers, P., additional, Egstrup, K., additional, Tho, A., additional, Moceri, P., additional, Bertora, D., additional, Gibelin, P., additional, Cho, E. J., additional, Choi, K. Y., additional, Kim, B. J., additional, Kim, D. B., additional, Jang, S. W., additional, Park, C. S., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, J. H., additional, Donal, E., additional, Coquerel, N., additional, Bodi, S., additional, Thebault, C., additional, Kervio, G., additional, Carre, F., additional, Daly, M. J., additional, Fairley, S. L., additional, Doherty, R., additional, Ashfield, K., additional, Kirkpatrick, R., additional, Smith, B., additional, Buchanan, J., additional, Hill, L., additional, Dixon, L. J., additional, Rosca, M., additional, O' Connor, K., additional, Magne, J., additional, Romano, G., additional, Calin, A., additional, Popescu, B. A., additional, Beladan, C. 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Y., additional, Cakmak, N., additional, Altay, S., additional, Terzi, S., additional, Yesilcimen, K., additional, Garcia Orta, R., additional, Moreno, E., additional, Lopez, M., additional, Uribe, I., additional, Vidal, M., additional, Ruiz-Lopez, M. F., additional, Gonzalez-Molina, M., additional, Oyonarte, J. M., additional, Lopez, S., additional, Azpitarte, J., additional, Szymanski, C., additional, Levine, R. A., additional, Zheng, H., additional, Handschumacher, M. D., additional, Tawakol, A., additional, Hung, J., additional, Le Ven, F., additional, Etienne, Y., additional, Jobic, Y., additional, Frachon, I., additional, Castellant, P., additional, Fatemi, M., additional, Blanc, J. J., additional, Tribouilloy, C., additional, Grigioni, F., additional, Avierinos, J.-F., additional, Barbieri, A., additional, Buiciuc, O., additional, Enriquez-Sarano, M., additional, Said, K., additional, Farag, A. K., additional, El-Ramly, M., additional, Rizk, H., additional, Iorio, A., additional, Pinamonti, B., additional, Bobbo, M., additional, Merlo, M., additional, Massa, L., additional, Faganello, G., additional, Di Lenarda, A., additional, Sinagra, G., additional, Margato, R., additional, Ribeiro, H., additional, Ferreira, C., additional, Matias, A., additional, Fontes, P., additional, Moreira, J. I., additional, Milan, A., additional, Puglisi, E., additional, Magnino, C., additional, Fabbri, A., additional, Leone, D., additional, Vairo, A., additional, Crudo, V., additional, Iannaccone, A., additional, Milazzo, V., additional, Veglio, F., additional, Maroz-Vadalazhskaya, N., additional, Ostrovskiy, I., additional, Imbalzano, E., additional, Saitta, A., additional, Cusma-Piccione, M., additional, Di Bella, G., additional, Nava, R., additional, Ferro, M., additional, Falanga, G., additional, Frigy, A., additional, Buzogany, J., additional, Szabados, C. S., additional, Dan, L., additional, Carasca, E., additional, Ikonomidis, I., additional, Lekakis, J., additional, Tzortzis, S., additional, Kremastinos, D. T., additional, Papadopoulos, C., additional, Paraskevaidis, I., additional, Triantafyllidi, H., additional, Trivilou, P., additional, Venetsanou, K., additional, Anastasiou-Nana, M., additional, Wierzbowska-Drabik, K., additional, Kurpesa, M., additional, Trzos, E., additional, Rechcinski, T., additional, Mozdzan, M., additional, Kasprzak, J. D., additional, Kosmala, W., additional, Kotwica, T., additional, Przewlocka-Kosmala, M., additional, Mysiak, A., additional, Skultetyova, D., additional, Filipova, S., additional, Chnupa, P., additional, Pechlivanidis, G., additional, Dimitroula, H., additional, Tsai, W.-C., additional, Liu, Y.-W., additional, Lin, C.-C., additional, Huang, Y.-Y., additional, Tsai, L.-M., additional, Park, S. M., additional, Kim, Y. H., additional, Shin, S. M., additional, Shim, W. J., additional, Gonzalez Mansilla, A., additional, Torres Macho, J., additional, Sanchez Sanchez, V., additional, Diez, P., additional, Delgado, J., additional, Borruel, S., additional, Saenz De La Calzada, C., additional, Pyxaras, S., additional, Valentincic, M., additional, Barbati, G., additional, Lo Giudice, F., additional, Perkan, A., additional, Magnani, S., additional, Palecek, T., additional, Ambroz, D., additional, Jansa, P., additional, Lindner, J., additional, Vitovec, M., additional, Polacek, P., additional, Jiratova, K., additional, Linhart, A., additional, Baskurt, M., additional, Dogan, G. M., additional, Abaci, O., additional, Kaya, A., additional, Kucukoglu, S., additional, Duszanska, A., additional, Kukulski, T., additional, Skoczylas, I., additional, Majsnerowska, A., additional, Nowowiejska-Wiewiora, A., additional, Streb, W., additional, Szulik, M., additional, Polonski, L., additional, Kalarus, Z., additional, Yerly, P. O., additional, Prella, M., additional, Joly, A., additional, Nicod, L., additional, Aubert, J. D., additional, Aebischer, N., additional, Dores, H., additional, Leal, S., additional, Rosario, I., additional, Correia, M. J., additional, Monge, J., additional, Grilo, A. M., additional, Arroja, I., additional, Fonseca, C., additional, Aleixo, A., additional, Silva, A., additional, Perez-David, E., additional, Sanchez-Alegre, M., additional, Gomez Anta, I., additional, De La Torre, J., additional, Alarcon, J., additional, Garcia Robles, J. A., additional, Lafuente, J., additional, Garcia Alonso, C. J., additional, Vallejo Camazon, N., additional, Gonzalez Guardia, A., additional, Nunez, R., additional, Bosch Carabante, C., additional, Mateu, L., additional, Gual Capllonch, F., additional, Ferrer Sistach, E., additional, Lopez Ayerbe, J., additional, Bayes Genis, A., additional, Tomaszewski, A., additional, Kutarski, A., additional, Tomaszewski, M., additional, Bramos, D., additional, Kalantaridou, A., additional, Takos, D., additional, Skaltsiotis, E., additional, Trika, C., additional, Tsirikos, N., additional, Pamboukas, C., additional, Kottis, G., additional, Toumanidis, S., additional, Aggeli, C., additional, Felekos, I., additional, Roussakis, G., additional, Kazazaki, C., additional, Lampropoulos, K., additional, Lagoudakou, S., additional, Stergiou, C., additional, Pitsavos, C., additional, Stefanadis, C., additional, Kihara, C., additional, Murata, K., additional, Wada, Y., additional, Tanaka, T., additional, Uchida, K., additional, Okuda, S., additional, Susa, T., additional, Matsuzaki, M., additional, Abrahamsson, A., additional, Gudmundsson, P., additional, Brodin, L., additional, Knebel, F., additional, Schattke, S., additional, Sanad, W., additional, Schimke, I., additional, Schroeckh, S., additional, Brechtel, L., additional, Lock, J., additional, Makauskiene, R., additional, Baumann, G., additional, Borges, A. C., additional, Moelmen-Hansen, H. E., additional, Wisloff, U., additional, Aamot, I. L., additional, Stoylen, A., additional, Ingul, C. B., additional, Estensen, M.-E., additional, Beitnes, J. O., additional, Grindheim, G., additional, Henriksen, T., additional, Aaberge, L., additional, Smiseth, O. A., additional, Gullestad, L., additional, Aakhus, S., additional, Agoston, G., additional, Moggi Pignone, A., additional, Capati, E., additional, Badano, L., additional, Moreo, A., additional, Bombardieri, S., additional, Varga, A., additional, Carrideo, M., additional, Faricelli, S., additional, Corazzini, A., additional, Ippedico, R., additional, Ruggieri, B., additional, Di Blasio, A., additional, D'angelo, E., additional, Di Baldassarre, A., additional, Ripari, P., additional, Gallina, S., additional, Kentrschynskyj, A., additional, Hylander, B., additional, Jacobson, S., additional, Pagels, A., additional, Dumitrescu, S. I., additional, Tintoiu, I., additional, Greere, V., additional, Cristian, G., additional, Chiriac, L., additional, Pinte, F., additional, Droc, I., additional, Neagoe, G., additional, Stanciu, S., additional, Voicu, V. A., additional, Kuch-Wocial, A., additional, Pruszczyk, P., additional, Szmigielski, C. A., additional, Szulc, M., additional, Styczynski, G., additional, Sinski, M., additional, Kaczynska, A., additional, Ryabikov, A., additional, Malyutina, S., additional, Halcox, J., additional, Bobak, M., additional, Nikitin, Y. U., additional, Marmot, M., additional, Barbosa, D., additional, Kiss, G., additional, Orderud, F., additional, Amundsen, B., additional, Jasaityte, R., additional, Loeckx, D., additional, Claus, P., additional, Torp, H., additional, D'hooge, J., additional, Kuhl, J. T., additional, Lonborg, J., additional, Fuchs, A., additional, Andersen, M., additional, Vejlstrup, N., additional, Engstrom, T., additional, Moller, J. E., additional, Kofoed, K. F., additional, Smith, L. A., additional, Bhan, A., additional, Paul, M., additional, Monaghan, M. J., additional, Zaborska, B., additional, Stec, S., additional, Sikora-Frac, M., additional, Krynski, T., additional, Kulakowski, P., additional, Pushparajah, K., additional, Dashwood, D., additional, Barlow, A., additional, Nugent, K., additional, Miller, O., additional, Simpson, J., additional, Valeur, N., additional, Ersboll, M. K., additional, Kjaergaard, J., additional, Greibe, R., additional, Risum, N., additional, Hassager, C., additional, Kober, L., additional, Popovic, D., additional, Nedeljkovic, I., additional, Petrovic, M., additional, Vujisic-Tesic, B., additional, Arandjelovic, A., additional, Stojiljkovic, S., additional, Jakovljevic, B., additional, Damjanovic, S., additional, Ostojic, M., additional, Agrios, I. A., additional, Bramos, D. B., additional, Skaltsiotis, H. S., additional, Takos, D. T., additional, Kaladaridis, A., additional, Vasiladiotis, N. V., additional, Kottis, G. K., additional, Antoniou, A. A., additional, Pamboucas, C. P., additional, Toumanidis, S. T. T., additional, Locorotondo, G., additional, Porto, I., additional, Paraggio, L., additional, Fedele, E., additional, Barchetta, S., additional, De Caterina, A. R., additional, Rebuzzi, A. G., additional, Crea, F., additional, Galiuto, L., additional, Lipiec, P., additional, Szymczyk, E., additional, Michalski, B., additional, Wozniakowski, B., additional, Stefanczyk, L., additional, Rotkiewicz, A., additional, Shim, A., additional, Vainer, J., additional, Habets, J., additional, Lousberg, A., additional, Pont De, C., additional, Waltenberger, J., additional, Farouk, H., additional, Heshmat, H., additional, Adel, A., additional, El Chilali, K., additional, Baghdady, Y., additional, Sorour, K., additional, Gustafsson, U., additional, Larsson, M., additional, Bjallmark, A., additional, Lindqvist, P., additional, A'roch, R., additional, Haney, M., additional, Waldenstrom, A., additional, Mladenovic, Z., additional, Tavciovski, D., additional, Mijailovic, Z., additional, Djordjevic - Dikic, A., additional, Obradovic, S., additional, Matunovic, R., additional, Jovic, Z., additional, Djuric, P., additional, Aase, S., additional, Dalen, H., additional, Sarkola, T., additional, Redington, A. N., additional, Keeley, F., additional, Bradley, T., additional, Jaeggi, E., additional, and Sahlen, H., additional

Published
2010
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31. Poster Session 2: Results (pacing), indications (pacing)

Author

Sankaranarayanan, R., primary, James, M. A., additional, Burtchaell, S., additional, Holloway, R., additional, Hoyt, R. H., additional, Mchenry, B., additional, Fedewa, M. M., additional, Penot, J. P., additional, Jacquot, C., additional, Bonet, J. F., additional, Pochet, H., additional, Jean, S., additional, Fressonnet, R., additional, Penot, M. P., additional, Weiss, A., additional, Abecasis, J. A., additional, Leal, S., additional, Monge, J., additional, Fartouce, S., additional, Santos, J. M., additional, Silva, A., additional, Costa, R., additional, Leao, M. I. P., additional, Mori, R. F., additional, Giannini, G., additional, Costa, S. P. L., additional, Silva, K. R., additional, Penteado, I. M., additional, Palka, P., additional, Lange, A., additional, Donnelly, J. E., additional, Adsett, M., additional, Hayes, J. R., additional, Stafford, W. J., additional, Hirayama, Y., additional, Kawamura, Y., additional, Sato, N., additional, Saito, T., additional, Hotta, D., additional, Kikuchi, K., additional, Ohori, K., additional, Hasebe, N., additional, Cabrera Bueno, F., additional, Alzueta, J., additional, Fernandez-Pastor, J., additional, Pena-Hernandez, J. L., additional, Molina-Mora, M. J., additional, Barrera, A., additional, De Teresa, E., additional, Ayala Paredes, F., additional, Roux, J. F., additional, Scazzuso, F., additional, Lavallee, L., additional, Poirier, M., additional, Chaumont, J., additional, Iorgulescu, C., additional, Vasile, A., additional, Dorobantu, M., additional, Vatasescu, R.- G., additional, Lefflerova, K., additional, Lupinek, P., additional, Bytesnik, J., additional, Cihak, R., additional, Krausova, R., additional, Vancura, V., additional, Kautzner, J., additional, Blich, M., additional, Suleiman, M., additional, Zeidan Shwiri, T., additional, Marai, I., additional, Boulos, M., additional, Amikam, S., additional, Lilli, A., additional, Magnacca, M., additional, Svetlich, C., additional, D'addario, S., additional, Baratto, M. T., additional, Ghidini Ottonelli, A., additional, Savino, K., additional, Casolo, G., additional, Wolber, T., additional, On, C., additional, Binggeli, C., additional, Holzmeister, J., additional, Brunckhorst, C., additional, and Duru, F., additional

Published
2009
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42. Reply to the letter of Yildiz et al.

Author

Wolber, T.

Subjects
*LETTERS to the editor, *CORONARY artery stenosis
Abstract

A response by T. Wolber to a letter to the editor about his article on coronary stenosis with elevated levels of N-terminal pro-brain natriuretic peptide in the previous issue is presented.

Published
2007
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46. Long-term predictors of mortality in ICD patients with non-ischaemic cardiac disease: impact of renal function

Author

Firat Duru, Christian Binggeli, Thomas Wolber, Johannes Holzmeister, Corinna Brunckhorst, Thomy Schefer, University of Zurich, and Wolber, T

Subjects
Adult, Male, Longitudinal study, medicine.medical_specialty, medicine.medical_treatment, Cardiomyopathy, Myocardial Ischemia, Renal function, 610 Medicine & health, Disease, Comorbidity, Risk Assessment, 2705 Cardiology and Cardiovascular Medicine, law.invention, Sudden cardiac death, 2737 Physiology (medical), Randomized controlled trial, law, Risk Factors, Physiology (medical), Internal medicine, medicine, Humans, cardiovascular diseases, Longitudinal Studies, Aged, Aged, 80 and over, business.industry, Incidence, Atrial fibrillation, Middle Aged, Implantable cardioverter-defibrillator, medicine.disease, Prognosis, Survival Analysis, Defibrillators, Implantable, Survival Rate, 10076 Center for Integrative Human Physiology, 10209 Clinic for Cardiology, cardiovascular system, Cardiology, 570 Life sciences, biology, Female, Kidney Diseases, Cardiology and Cardiovascular Medicine, business, Cardiomyopathies
Abstract

Randomized trials have demonstrated that implantable cardioverter defibrillator (ICD) therapy may reduce the risk of death in patients with non-ischaemic cardiomyopathy (CMP). In this study, we aimed at determining the long-term benefit of ICD therapy among patients with dilated CMP (DCM) and among those with other non-ischaemic cardiac diseases (NICDs).We performed a single-centre longitudinal study to assess the outcomes of 176 patients with NICDs who were implanted with an ICD for primary or secondary prevention of cardiac death. The cumulative survival rate after 1, 2, 5, and 10 years was 91, 87, 78, and 65%, respectively. Mortality risk did not differ significantly between patients with DCM and those with other NICDs. Atrial fibrillation, recurrent ventricular arrhythmias requiring ICD therapy, and right ventricular pacing, but not delayed intrinsic ventricular conduction, were associated with higher risk. New York Heart Association (NYHA) functional classor =III was an independent predictor of adverse outcome among patients with DCM [hazard ratio (HR) 5.27, P = 0.01], whereas reduced left ventricular function with ejection fraction35% (HR 12.1, P0.001) and anti-arrhythmic drug use (HR 4.82, P = 0.03) were independent predictors among those with other NICDs. Renal insufficiency with estimated glomerular filtration rate60 mL/min/1.73 m(2) (HR 5.9, P0.001) was a strong independent predictor of mortality among all patients with NICD, irrespective of underlying cardiac condition.In ICD patients with DCM, higher NYHA functional class is associated with adverse outcomes. Impaired left ventricular function and anti-arrhythmic drug use predict higher mortality among patients with non-dilated, NICDs. Impaired renal function is a strong predictor of mortality in all patients with NICD.

Published
2008

47. Impact of clinical radiation audits on patient radiation exposure in cardiac implantable electronic device procedures.

Author

Sazgary L, Samara ET, Stüssi A, Saltybaeva N, Guckenberger M, Ruschitzka F, Wolber T, Molitor N, Hofer D, Guan F, Suna G, Hermes-Laufer J, Breitenstein A, Brunckhorst CB, Duru F, and Saguner AM

Subjects
Humans, Clinical Audit, Fluoroscopy, Male, Female, Defibrillators, Implantable, Radiation Exposure prevention & control, Radiation Exposure adverse effects, Pacemaker, Artificial
Abstract

Competing Interests: Disclosures Dr Saguner received educational grants through his institution from Abbott, Bayer Healthcare, Biosense Webster, Biotronik, Boston Scientific, Bristol-Myers Squibb/Pfizer, and Medtronic and speaker/advisory board/consulting fees from Bayer Healthcare, Biotronik, Medtronic, Novartis, Pfizer, StrideBio, and Zoll. The rest of the authors report no conflicts of interest.

Published
2024
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49. Evolution and triggers of defibrillator shocks in patients with arrhythmogenic right ventricular cardiomyopathy.

Author

Molitor N, Hofer D, Çimen T, Gasperetti A, Akdis D, Costa S, Jenni R, Breitenstein A, Wolber T, Winnik S, Fokstuen S, Fu G, Medeiros-Domingo A, Ruschitzka F, Brunckhorst C, Duru F, and Saguner AM

Subjects
Humans, Male, Adult, Middle Aged, Retrospective Studies, Follow-Up Studies, Arrhythmias, Cardiac therapy, Arrhythmias, Cardiac complications, Death, Sudden, Cardiac etiology, Death, Sudden, Cardiac prevention & control, Death, Sudden, Cardiac epidemiology, Inflammation, Arrhythmogenic Right Ventricular Dysplasia complications, Arrhythmogenic Right Ventricular Dysplasia diagnosis, Arrhythmogenic Right Ventricular Dysplasia therapy, Hypokalemia complications, Defibrillators, Implantable adverse effects, Tachycardia, Ventricular therapy, Tachycardia, Ventricular complications
Abstract

Introduction: Implantable cardioverter-defibrillators (ICDs) can prevent sudden cardiac death due to ventricular arrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). The aim of our study was to assess the cumulative burden, evolution and potential triggers of appropriate ICD shocks during long-term follow-up, which may help to reduce and further refine individual arrhythmic risk in this challenging disease., Methods: This retrospective cohort study included 53 patients with definite ARVC according to the 2010 Task Force Criteria from the multicentre Swiss ARVC Registry with an implanted ICD for primary or secondary prevention. Follow-up was conducted by assessing all available patient records from patient visits, hospitalisations, blood samples, genetic analysis, as well as device interrogation and tracings., Results: Fifty-three patients (male 71.7%, mean age 43±2.2 years, genotype positive 58.5%) were analysed during a median follow-up of 7.9 (IQR 10) years. In 29 (54.7%) patients, 177 appropriate ICD shocks associated with 71 shock episodes occurred. Median time to first appropriate ICD shock was 2.8 (IQR 3.6) years. Long-term risk of shocks remained high throughout long-term follow-up. Shock episodes occurred mainly during daytime (91.5%, n=65) and without seasonal preference. We identified potentially reversible triggers in 56 of 71 (78.9%) appropriate shock episodes, the main triggers representing physical activity, inflammation and hypokalaemia., Conclusion: The long-term risk of appropriate ICD shocks in patients with ARVC remains high during long-term follow-up. Ventricular arrhythmias occur more often during daytime, without seasonal preference. Reversible triggers are frequent with the most common triggers for appropriate ICD shocks being physical activity, inflammation and hypokalaemia in this patient population., Competing Interests: Competing interests: AMS received educational grants through his institution from Abbott, Bayer Healthcare, Biosense Webster, Biotronik, Boston Scientific, BMS/Pfizer, Medtronic and Novartis, and speaker/consultant fees from Bayer Healthcare, Biotronik, BMS/Pfizer, Daiichi-Sankyo, Medtronic, Novartis and Stride Bio. DH reports educational grants, consultant or speaker fees and fellowship support from Abbott, Bayer, Biotronik, Biosense Webster, Boston Scientific, Medtronic, Novartis, Pfizer and Spectranetics/Philips. AB has received consultant and/or speaker fees from Abbott, Bayer Healthcare, Biosense Webster, Biotronik, Boston Scientific, Bristol-Myers Squibb, Cook Medical, Daiichi Sankyo, Medtronic, Pfizer, Spectranetics/Philipps and ZOLL. AM-D is the founder of SwissDNAlysis. FR has not received personal payments by pharmaceutical companies or device manufacturers in the last 3 years (remuneration for the time spent in activities, such as participation as steering committee member of clinical trials and member of the Pfizer Research Award selection committee in Switzerland were made directly to the University of Zurich). The Department of Cardiology (University Hospital of Zurich/University of Zurich) reports research, educational and/or travel grants from Abbott, Amgen, Astra Zeneca, Berlin Heart, B. Braun, Biosense Webster, Biosensors Europe AG, Biotronik, BMS, Boehringer Ingelheim, Boston Scientific, Bracco, Cardinal Health Switzerland, Corteria, Daiichi, Diatools AG, Edwards Lifesciences, Guidant Europe NV (BS), Hamilton Health Sciences, Kaneka Corporation, Kantar, Labormedizinisches Zentrum, Medtronic, MSD, Mundipharma Medical Company, Novartis, Novo Nordisk, Orion, Pfizer, Quintiles Switzerland Sarl, Roche Diagnostics, Sahajanand IN, Sanofi, Sarstedt AG, Servier, SIS Medical, SSS International Clinical Research, Terumo Deutschland, Trama Solutions, V-Wave, Vascular Medical, Vifor, Wissens Plus and ZOLL. The research and educational grants do not impact on FR's personal remuneration. The other authors have nothing to disclose related to the content of this article., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2023
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50. Transseptal Puncture Guided by Three-Dimensional Electroanatomical Mapping: Early Experience Using a Simplified Approach in Adults with Congenital Heart Disease.

Author

Guan F, Gass M, Berger F, Akdis D, Duru F, and Wolber T

Abstract

Aims: The widespread use of three-dimensional (3D) mapping systems and echocardiography in the field of cardiac electrophysiology has made it possible to perform transseptal punctures (TSP) with low or no fluoroscopy. However, such attempts in adults with congenital heart disease (ACHD) who have previously undergone surgical or interventional treatment are limited. Therefore, we sought to explore the feasibility and safety of an approach to perform zero- or low-fluoroscopy TSP in ACHD patients undergoing left atrial cardiac ablation procedures., Methods and Results: This study included 45 ACHD patients who underwent TSP for ablation of left-sided tachycardias (left atrium or pulmonary venous atrium). Computed tomography (CT) of the heart was performed in all patients prior to ablation. 3D mapping of the right-sided heart chambers before TSP was used to superimpose the registered anatomy, which was subsequently used for the mapping-guided TSP technique. TSP was performed with zero-fluoroscopy in 27 patients, and the remaining 18 patients had a mean fluoroscopy exposure of 315.88 ± 598.43 μGy.m 2 and a mean fluoroscopy duration of 1.9 ± 5.4 min. No patient in this cohort experienced TSP-related complications., Conclusion: Our study describes a fluoroscopy-free or low-dose fluoroscopy approach for TSP in ACHD patients undergoing catheter ablation of left-sided tachyarrhythmias who had been previously treated surgically or interventionally due to congenital heart defects. By superimposing 3D electroanatomic mapping with cardiac CT anatomy, this protocol proved to be highly effective, feasible and safe.

Published
2023
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