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Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. The study assessed epidemiology, clinical characteristics, risk factors, and outcomes. The study examined 1312 patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. Of these, 59.5% required hospitalization, with 13.5% needing ICU admission. The overall mortality rate was 10.6%, varying by virus: parainfluenza (21.3%), influenza (8.8%), metapneumovirus (7.1%), RSV (5.9%), or SARS-CoV-2 (5.0%). Poor outcomes were significantly associated with smoking history, severe lymphopenia, secondary bacterial infections, and ICU admission. This study highlights the severe risk CARV poses to patients with HM, especially those undergoing active treatment. The high rates of hospitalization and mortality stress the need for better prevention, early diagnosis, and targeted therapies. Given the severe outcomes with certain viruses like parainfluenza, tailored strategies are crucial to improving patient outcomes in future CARV seasons., (© 2024 The Author(s). American Journal of Hematology published by Wiley Periodicals LLC.)

The kinetics of hydrolysis of 4-ethoxy-2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (III) in aqueous solutions at 333, 343, 353 and 363 K over the pH range 0.4-5.0 was investigated. The decomposition was observed by means of the HPLC method. A sample solution was chromatographed on octadecyl-packed column (LiChrosorb 100 RP-18 column 250 x 4.0 mm I.D., dp 5 microm) using a mixture of acetonitrile and phosphate buffer (pH 2, 0.01 mol/L) as an eluent (45:55, v/v--phase A or 30:70, v/v--phase B). The UV detection was performed at a wavelength of 239 nm. The stability of compound III was found to be dependent on pH. The pH-rate profile indicated specific acid- and base-catalyzed reactions as well as spontaneous water-catalyzed degradation. The ionic strength effect, the pKa value (2.9; 6.0), the pHmin value (2.1) and thermodynamic parameters of the reaction (energy of activation (Ea), enthalpy (DeltaH(not equal to)) and entropy (DeltaS(not equal to were determined.