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2. Factors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial
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Pracoń, Radosław, Spertus, John A., Broderick, Samuel, Bangalore, Sripal, Rockhold, Frank W., Ruzyllo, Witold, Demchenko, Elena, Nageh, Thuraia, Grossman, Gabriel Blacher, Mavromatis, Kreton, Manjunath, Cholenahally N., Smanio, Paola E.P., Stone, Gregg W., Mancini, G.B. 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Arunima, Huda, Zohra, Wall, Matthew, Boan, Araceli, Lenges De Rosen, Veronica, Alam, Mahboob, Turner, Michael C., Hinton, Christine R, Mulhearn, Thomas J., Good, Arnold P., Archer, Beth A., Dionne, Julia S., Allardyce, Cheryl A., Sikora, Lindsey N., Czerniak, Jennifer H., Mull, Jennifer A., Ferguson, Elizabeth, Laube, Frances, Shammas, Nicolas W., Shammas, Gail A, Christensen, Lori, Park, Holly, Chilton, Robert, Hecht, Joan, Nguyen, Patricia K., Vo, Davis, Hirsch, James, Jezior, Matthew, Bindeman, Jody, Salkind, Sara, Espinosa, Dalisa, Desimone, Lori-Ann, Gordon, Paul C., Felix-Stern, Lina, Crain, Thomas, Gomes, Jassira, Gordon, Catherine, Stenberg, Robert, Mann, Aimee, McCreary, Theresa, Pedalino, Ronald P., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Wiesel, Joseph, Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Juang, George J., Gopaul, Candace, Hultberg, Karen, Huk, Tauqir, Hussain, Afshan, Al-Amoodi, Mohammed, Zambrano, 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Chakanalil Govindan, Sajeev, Raj, Janitha, Gopalan Nair, Rajesh, Ravindran, Reshma, Rajalekshmi, VS, Nataraj, Nandita, Moorthy, Nagaraja, Nayak, Soundarya, Mylarappa, Mahevamma, Narayanappa, Suryaprakash, Pandit, Neeraj, Bajaj, Sheromani, Kumar Nath, Ranjit, Yadav, Vandana, Mishra, Girish, Dwivedi, S.K., Tewari, Roma, Narain, V.S., Mishra, Meenakshi, Chandra, Sharad, Patel, Shivali, Singh, Suman, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Kaur, Baljeet, Aslam, Naved, Gupta, Sonika, Goyal, Abhishek, Bhargava, Balram, Suvarna, Chandini, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Kumar Verma, Sunil, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Kumar Choudhary, Shiv, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V K, Mathew, Anoop, Mannekkattukudy Kurian, Binoy, Punnoose, Eapen, Avdhoot Gadkari, Milind, Rupesh Karwa, Sheetal, Gadage, Siddharth, Kolhe, Suvarna, Umesh Pillay, Tapan, Satheesh, Santhosh, Vindhya, R. J., Jain, Peeyush, Seth, Ashok, Singh Meharwal, Zile, Mathur, Atul, Verma, Atul, Kaul, Upendra, Bhatia, Mona, Sachdeva, Ankush, Indira Devi, Thounaojam, Jungla, Nungshi, Christopher, Johann, Manjula Rani, K., Menon, Rajeev, Sowjanya Reddy, M., Kumar, Nirmal, Preethi, K., Oomman, Abraham, sidh, Rinu R, Mao, Robert, Ramakrishnan, T., Solomon, Hilda, Francis, Rajesh, Naik, Sudhir, Vamshi, Priya P., Parveen Khan, Sajeeda, Christopher, Johann, Preethi, Kotiboinna, Kumar, Nirmal, Grant, Purvez, Hande, Shweta, Sonawane, Poonam, Kachru, Ranjan, Dubey, Abhishek, Rawat, Kavita, Kumar, Ajit, Ganapathi, Sanjay, K, Jayakumar, CP, Vineeth, Sivadasanpillai, Harikrishnan, Chacko, Manas, Sasidharan, Bijulal, Babu, Suresh, TR, Kapilamoorthy, Christopher, Johann, Reddy, Sowjanya, Polamuri, Praneeth, Rani, Manjula, Kaul, Upendra, Arambam, Priyadarshani, Singh, Bebek, Senior, Roxy, Fox, Keith AA, Young, Grace M., Carruthers, Kathryn, Senior, Roxy, Elghamaz, Ahmed, Gurunathan, Sothinathan, Karogiannis, Nikolaos, Young, Grace M., Shah, Benoy N, Kinsey, Christopher, Trimlett, Richard HJ, Kavalakkat, Raisa, Rubens, Michael B, Evans, Jo, Nicol, Edward D, Hassan, Ikraam, Mittal, Tarun K, Hampson, Reinette, Andreas Gamma, Reto, Williams, Sarah, Holland, Kim, Swan, Karen, de Belder, Mark A, Atkinson, Bev, Thambyrajah, Jeet, Kunhunny, Swapna, Davies, John R, Lindsay, Steven J., Atkinson, Craig, Kurian, John, Krannila, Carita, Jamil, Haqeel, Vinod, Manitha, Raheem, Osama, Hoye, Angela, Chaytor, Lisa, Cox, Leanne, Morrow, Julie, Rowe, Kay, Donnelly, Patrick, Kelly, Stephanie, Valecka, Bernardas, Regan, Susan, Turnbull, Dawn, Chauhan, Anoop, Fleming, Catherine, Ghosh, Arijit, Gratrix, Karen, Preston, Stephen, Barr, Craig, Cartwright, Anne, Alfakih, Khaled, Knighton, Abigail, Byrne, Jonathan, Martin, Katherine, Webb, Ian, Henriksen, Peter, Flint, Laura, Harrison, James, OKane, Peter, Lakeman, Nicki, Ljubez, Anja, de Silva, Ramesh, Conway, Dwayne S. G., Wright, Judith, Exley, Donna, Sirker, Alexander A, Andiapen, Mervyn, Richards, Amy J., Hoole, Stephen P, Wong, Lisa, Witherow, Fraser N., Munro, Melanie J., Johnston, Nicola, Harbinson, Mark, McEvoy, Michelle, Walsh, Simon, Brown, Caroline, Douglas, Hanna, Luckie, Matthew, Charles, Thabitha, Kolakaluri, Laurel, Phillips, Hannah, Sobolewska, Jolanta, Morby, Louise, Hallett, Karen, Corbett, Carolyn, Winstanley, Lynne, Jeetley, Paramjit, Smit, Angelique, Patel, Niket, Kotecha, Tushar, Travill, Christopher, Gent, Susan, Karimullah, Iqbal, Hussain, Nafisa, Al-Bustami, Mahmud, Braganza, Denise, Haines, Fiona, Taaffe, Joanne, Henderson, Robert, Burton, Jane, Pointon, Kate, Colton, Maria, Naik, Surendra, King, Rachel, Mathew, Thomas, Brown, Ammani, Docherty, Andrew, Berry, Colin, McCloy, Lisa, Collison, Damien, Robb, Kate, Roditi, Giles, Paterson, Craig, Crawford, Wenda, Kelly, Joanne, McGregor, Lorraine, Moriarty, Andrew J, Mackin, Anne, Glover, Jason D., Knight, Janet P, Pradhan, Jiwan, Mikhail, Ghada, Bose, Tuhina, Francis, Darrel P., Dzavik, Vladimir, Goodman, Shaun, Gosselin, Gilbert, Gosselin, Gilbert, Proietti, Anna, Brousseau, Myriam, Corfias, Magalie, Blaise, Patricia, Harvey, Luc, Diaz, Ariel, Rheault, Philippe, Barrero, Miguel, Gagné, Carl-Éric, Alarie, Patricia, Pépin-Dubois, Yanek, Arcand, Linda, Costa, Ricardo, Roy, Isabelle, Tung Sia, Ying, Montpetit, Estelle, Lemay, Catherine, Gisbert, Alejandro, Gervais, Pierre, Rheault, Alain, Drouin, Katia, Carl Phaneuf, Denis, Bergeron, Christine, Gosselin, Gilbert, Shelley, Christine, Masson, Christine, Garg, Pallav, Carr, Sandy, Bone, Catherine, Chow, Benjamin J.W., Moga, Ermina, Hessian, Renee C., Kourzenkova, Janetta, Beanlands, Rob S., Walter, Olga, Davies, Richard F., Bainey, Kevin R., Hogg, Norma, Welsh, Suzanne, Cheema, Asim N., Bagai, Akshay, Wald, Ron, Goodman, Shaun, Kushniriuk, Khrystyna, Joseph Graham, John, Hussain, Mohammed, Peterson, Mark, Bello, Olugbenga, Chow, Chi-Ming, Abramson, Beth, Nazir Cheema, Asim, Syed, Ishba, Hussain, Mohammed, Kushniriuk, Khrystyna, Cha, James, Otis, Judy, Otis, Rebecca, Howarth, Andrew G, Seib, Michelle M, Rivest, Sandra M, Sandonato, Rosa, Wong, Graham, Chow, Jackie, Starovoytov, Andrew, Uchida, Naomi, Meadows, Ngaire, Uxa, Amar, Asif, Nadia, Tavares, Suzana, Galiwango, Paul, Bozek, Bev, Kassam, Saleem, Shier, Maria, Mukherjee, Ashok, Larmand, Lori-Ann, Ricci, A. Joseph, Janmohamed, Amir, Hart, Brenda, Lam, Andy, Marucci, Jane, Tai, Sharon, Mehta, Shamir, Brons, Sonya, Beck, Chris, Wong, Glenda, Etherington, Krystal, Arumairajah, Thippeekaa, Udell, Jacob, Aprile, Maria, Karlsson, Sara, Webber, Susan, Généreux, Philippe, Mercure, Chantale, Hameed, Adnan, Aedy, Nancy, Daba, Ledjalem, Farquharson, Fran, Siddiqui, Anam, Carlos Carvalho, Antonio, Lopes, Renato D., Hueb, Whady, Emy Takiuti, Myrthes, Cury Rezende, Paulo, Eustáquio Ribeiro Silva, Expedito, Ciappina Hueb, Alexandre, Pizzol Caetano, Leonardo, Schaan de Quadros, Alexandre, Abdala Karam Kalil, Renato, Peixoto Deiro, Aline, Luiz da Costa Vieira, José, Manica Muller, Alice, Antonieta Pereira de Moraes, Maria, Píccaro de Oliveira, Pedro, Maria Ascoli, Bruna, Bridi, Leonardo, Zottis Poletti, Sílvia, Savaris, Simone, Vitola, João V, Cerci, Rodrigo J, Zier, Sandra S., Farias, Fabio R, Veiga Jr, Vilmar, Fernandes, Miguel M, Antonio Marin-Neto, José, Schmidt, André, de Oliveira Lima Filho, Moysés, Franca da Cunha, Diego, Mendes Oliveira, Ricardo, Reynaldo Abbud Chierice, João, Polanczyk, Carísi A., Rucatti, Guilherme G, Furtado, Mariana V., Igansi, Fernanda, Smidt, Luis F., Haeffner, Mauren P, Carlos Carvalho, Antonio, Almeida, Viviane, Pucci, Gustavo, Sanchez de Souza, Gabriela, Lyra, Flavio, Rabelo Alves Junior, Alvaro, Almeida, Mayana, dos Santos, Viviane, Dracoulakis, Marianna D. A., Oliveira, Natalia S, Lima, Rodolfo G. S. D, Figueiredo, Estevao, Edilena Paulino Azevedo, Bruna, Ricardo Caramori, Paulo, Bizzaro Santos, Marco, Germann, Amanda, Gomes, Vitor, Homem, Rosa, Magedanz, Ellen, Tumelero, Rogerio, Laimer, Rosane, Tognon, Alexandre, Dall’Orto, Frederico, Mesquita, Claudio T., Santos, Roberta P, Colafranseschi, Alexandre S., Oliveira, Amarino C., Carvalho, Luiz A., Palazzo, Isabella C., Sousa, Andre S., Eustáquio Ribeiro da Silva, Expedito, Gabriel Melo de Barros e Silva, Pedro, Yumi Okada, Mariana, de Pádua Silva Baptista, Luciana, Paula Batista, Ana, Jamus Rodrigues, Marcelo, Nogueira Rabaça, Aline, Valério Coimbra de Resende, Marcos, Francisco Saraiva, Jose, Miranda Trama, Larissa, Silva, Talita, Thais de Souza Ormundo, Camila, Vicente, Carla, Costantini, Costantino, Pinheiro, Caroline, Komar, Daniele, Szwed, Hanna, Demkow, Marcin, Kepka, Cezary, Teresinska, Anna, Walesiak, Olga, Kryczka, Karolina, Malinowska, Katarzyna, Henzel, Jan, Solecki, Mateusz, Kaczmarska, Edyta, Mazurek, Tomasz, Maksym, Jakub, Wojtera, Karolina, Fojt, Anna, Szczerba, Ewa, Drozdz, Jaroslaw, Czarniak, Bartosz, Frach, Malgorzata, Szymczyk, Konrad, Niedzwiecka, Iwona, Sobczak, Sebastian, Ciurus, Tomasz, Jakubowski, Piotr, Misztal-Teodorczyk, Magdalena, Teodorczyk, Dawid, Swiderek, Marta, Fratczak, Aleksandra, Wojtala, Ewelina, Szkopiak, Marcin, Lebioda, Patrycja, Wlodarczyk, Michal, Plachcinska, Anna, Kusmierek, Jacek, Miller, Magdalena, Marciniak, Halina, Wojtczak-Soska, Karolina, Łuczak, Katarzyna, Tarchalski, Tomasz, Cichocka-Radwan, Anna, Szwed, Hanna, Karwowski, Jaroslaw, Anna Szulczyk, Grazyna, Witkowski, Adam, Kukuła, Krzysztof, Celińska-Spodar, Małgorzta, Zalewska, Joanna, Gajos, Grzegorz, Bury, Krzysztof, Pruszczyk, Piotr, Łabyk, Andrzej, Roik, Marek, Szramowska, Agnieszka, Zdończyk, Olga, Łoboz-Grudzień, Krystyna, Jaroch, Joanna, Sokalski, Leszek, Brzezińska, Barbara, Lesiak, Maciej, Łanocha, Magdalena, Reczuch, Krzysztof W., Kolodziej, Adam, Kalarus, Zbigniew, Swiatkowski, Andrzej, Szulik, Mariola, Musial, Wlodzimierz J., Marcinkiewicz-Siemion, Marta, Bockeria, Olga, Bockeria, Leo, Bockeria, Olga, Petrosyan, Karen, Kudzoeva, Zalina, Trifonova, Tatiana, Aripova, Nodira, Chernyavskiy, Alexander M., Naryshkin, Ivan A., Kretov, Evgeniy I., Kuleshova, Alena, Grazhdankin, Igor O., Malaev, Dastan, Bershtein, Leonid L., Sayganov, Sergey A., Subbotina, Irina, Kuzmina-Krutetskaya, Anastasia M., Gumerova, Victoria, Zbyshevskaya, Elizaveta V., Katamadze, Nana O., Nikolaeva, Olga B., Kozlov, Pavel S., Kozulin, Vikentiy Y., Lubinskaya, Ekaterina I., Luis Lopez-Sendon, Jose, Castro, Almudena, Lopez-Sendon, Jose, Fernández-Figares, Virginia, Castro, Almudena, Refoyo Salicio, Elena, Guzman, Gabriela, Galeote, Gabriel, Valbuena, Silvia, Peteiro, Jesús, Dolores Martínez-Ruíz, María, Pérez-Fernández, Ruth, Blanco-Calvo, Moisés, Cuenca-Castillo, José J, Alonso-Álvarez, Encarnación, Flores-Ríos, Xacobe, García-González, Paula, Prada-Delgado, Óscar, Barge-Caballero, Gonzalo, Ramon Gonzalez Juanatey, Jose, Seijas Amigo, Jose, Souto Bayarri, Miguel, Pubull Nuñez, Virginia, Ocaranza Sanchez, Raymundo, Cid Alvarez, Belen, Peña Gil, Carlos, Martinez Monzonis, Amparo, Sionis, Alessandro, Fernández Martínez, Ana, Vila Perales, Montserrat, Maria Padró, Josep, Serra Peñaranda, Antonio, García Picart, Joan, Ginel Iglesias, Antonino, Garcia-Moll Marimon, Xavier, Pons Lladó, Guillem, Carreras Costa, Francesc, Miro, Vicente, Igual, Begoña, Diez, Jose L, Calvillo, Pilar, Ortuño, F. Marin, Valdés Chávarri, M., Quintana Giner, M., Tello Montolliu, A., Romero Aniorte, A.I., Pinar Bermudez, E., Rivera Caravaca, JM., De La Morena, G., Gracida Blancas, Montserrat, Cañavate, Olga, Guerrero, Sonia, Riera, Silvia, Enrique Castillo Luena, Jose, Enrique Castillo Luena, Jose, Lasala, Maria, Fernandez-Aviles, Francisco, Lorenzo, Maria, Sobrino, Olga, Vazquez, Alexandra, Jiang, Lixin, Chen, Jiyan, Dong, Haojian, He, Peiyu, Xia, Chunli, Yang, Junqing, Zhong, Qi, Wu, Yongjian, Tian, Yanmeng, Li, Dongze, Ma, Yitong, Li, Xiaomei, Yang, Yining, Ma, Xiang, Yu, Zixiang, Zhao, Qian, Ji, Zheng, Li, Chunguang, Zhang, Lei, Zhao, Yu, Zhu, Bolin, Yang, Xinchun, Chen, Mulei, Chi, Hongjie, Wang, Yang, Zhang, Jing, Lin, Wenhua, Jing, Rui, Liu, Jingjing, Zeng, Hesong, Zhou, Qiang, Xu, Chang, Li, Zhuxi, Li, Junhua, Xiong, Luyang, Fu, Xin, Gao, Dan, Jiang, Dengke, Leng, Ran, Wang, Xutong, Yuan, Qianqian, Zhang, Lili, Yang, Bin, Bai, Ziliang, Li, Jianhua, Qi, Jie, Wang, Fei, Wang, Haitao, Yang, 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- Published
- 2024
- Full Text
- View/download PDF
3. Irreversibility of Structure Tensors of Modules
- Author
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Wojtala, Maciej
- Subjects
Computer Science - Computational Complexity ,Mathematics - Algebraic Geometry - Abstract
Determining the matrix multiplication exponent $\omega$ is one of the greatest open problems in theoretical computer science. We show that it is impossible to prove $\omega = 2$ by starting with structure tensors of modules of fixed degree and using arbitrary restrictions. It implies that the same is impossible by starting with $1_A$-generic non-diagonal tensors of fixed size with minimal border rank. This generalizes the work of Bl\"aser and Lysikov [3]. Our methods come from both commutative algebra and complexity theory., Comment: Suggestions applied
- Published
- 2021
4. Irreversibility of structure tensors of modules
- Author
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Wojtala, Maciej
- Published
- 2023
- Full Text
- View/download PDF
5. Insights into the binding of half-sandwich phosphino Ir(III) and Ru(II) complexes to deoxyribonucleic acid, albumin and apo-transferrin: Experimental and theoretical investigation
- Author
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Kozieł, Sandra, Wojtala, Daria, Szmitka, Magdalena, Kędzierski, Paweł, Bieńko, Dariusz, and Komarnicka, Urszula K.
- Published
- 2024
- Full Text
- View/download PDF
6. Lower back pain caused by radiculopathy induced by lumbar stenosis - literature review
- Author
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Michał Turek, Aleksandra Winiarz, Paula Szlendak, Katarzyna Toś, Kacper Wojtala, Sylwia Grosman, Agata Węgrzyniak, Dominik Drobek, Katarzyna Wąsala, and Wojciech Wokurka
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back pain ,radiculopathy ,lumbar stenosis ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction: Lumbar spine pain is a common clinical problem. Due to the multitude of causes of pain, it is important to know the most common ones in order to choose an effective method of treatment. The aim of this study: Summary of current knowledge regarding back pain caused by radiculopathy associated with lumbar stenosis. Material and method: The review includes publications published in 1995-2020. The search of the publications in the Pubmed database was carried out using the following keywords: back pain, radiculopathy, lumbar stenosis. Description of the stage of the knowledge: Lumbar radiculopathy caused by lumbar stenosis is a common clinical problem, especially in older age groups. In diagnostics, an interview with the patient, physical examination and imaging tests - especially CT and MRI - are important. In most patients, conservative treatment is sufficient - the use of analgesics and anti-inflammatory drugs and physiotherapy. In justified cases, surgical treatment should be considered as the most effective causative treatment of the disease. In the last 20 years, the availability of both diagnostic methods has increased and new surgical techniques have appeared, aiming at minimally invasive treatment. Summary: Radiculopathy caused by lumbar stenosis is a contributing factor to the occurrence of pain, which can hinder the normal functioning of the patient.Proper diagnosis, identification of the impact and methods of treatment, both conservative and surgical, can help the patient and affect his quality of life. Early diagnosis and treatment are crucial for the effective treatment of pain associated with radiculopathy caused by lumbar stenosis.
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- 2023
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7. Armored heart as an image of constrictive pericarditis - a review of the literature
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Wojciech Wokurka, Agata Węgrzyniak, Dominik Drobek, Aleksandra Winiarz, Paula Szlendak, Katarzyna Toś, Kacper Wojtala, Michał Turek, Katarzyna Wąsala, and Sylwia Grosman
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armored heart ,constrictive pericarditis ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction: Pericarditis is diagnosed among 5% patients hospitalized due to chest pain. It is included in pericardial syndromes together with constrictive pericarditis, pericardial effusion and cardiac tamponade. There are many documented etiological factors leading to pericarditis, most commonly divided into infectious and non-infectious ones. The disease typically presents with chest pain, ECG changes, pericardial rub and pericardial effusion. The diagnosis is made with the results of parameters found in patients’ blood and imaging tests. Treatment is usually based on pharmacological therapy, although in some cases the pericardial surgery is necessary. One of the characteristic changes in imaging diagnostics in patients with pericarditis is thickening of pericardial layers, the so-called armored heart. Aim of the study: The aim of the study was to find clear diagnostic criteria for armored heart as a unique type of constrictive pericarditis. Materials and methods: Articles available in the databases of medical publications: PubMed, Google Scholar, SCOPUS were analysed using the search phrase: armored heart* AND (pericarditis OR acute pericarditis). Results: The search phrase was included in 18 records. After the initial verification, repetitive, unavailable and foreign papers were rejected. Finally, 3 manuscripts were included in further analyses. No clear criteria were found to classify constrictive pericarditis as an armored heart. Conclusions: Armored heart is a 'subtype' of constrictive pericarditis. It seems that this term is used subjectively, based on imaging studies.
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- 2023
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8. Current clinicopathological characterisation of adamantinoma - a review of the literature
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Agata Węgrzyniak, Wojciech Wokurka, Dominik Drobek, Aleksandra Winiarz, Paula Szlendak, Katarzyna Toś, Kacper Wojtala, Michał Turek, Katarzyna Wąsala, and Sylwia Grosman
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adamantinoma ,other mesenchymal tumours of bone ,differentiated adamantinoma ,osteofibrous dysplasia-like adamantinoma ,rare bone tumour ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction and purpose Adamantinoma is an exceedingly rare, primary bone tumour, that in most cases affects the diaphysis of the long bones, especially the tibia. Histologically it is epithelial cells clusters surrounded by spindle-cell osteofibrous components. Adamantinoma has metastatic potential to the lungs and local lymph nodes. Both the rarity of the disease and its nonspecific symptoms complicate diagnosis and treatment. Reviewing the up-to-date data regarding adamantinoma was the purpose of the work. State of knowledge During the 5th edition of the World Health Organization (WHO) classification of bone tumours in 2020 adamantionoma was classified in the newly established bone tumour class of the other mesenchymal tumours of bone. What is more its name was specified to adamantionoma of the long bone. According to literature and newest classification adamantinoma is divided into 3 types; the most common classic adamantinoma as well as less frequent OFD-like adamantinoma (osteofibrous like adamantinoma) and dedifferentiated adamantinoma. Diagnosis is challenging due to the rarity of occurrence, insufficient knowledge and misinterpretation of imaging studies resulting in the diagnosis of adamantinoma as other bone and soft tissue tumours. Conclusions Confirmation of the immunohistochemical profile, as well as the genetic profile of adamantionoma, which are increasingly well-defined, is essential for diagnosis. Imaging studies still remain the first method used in the diagnostic process. MRI appears to be the most suitable method for the imaging diagnosis of adamantinoma, due to excellent imaging of the tumour extent, including its surrounding soft tissue involvement and possible metastases. As far as treatment is concerned, there are still no precise guidelines and the best option remains tumour resection with large margins
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- 2023
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9. Future of cardiovascular diagnosis with the support of artificial intelligence
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Ania Rymarz, Ewa Grabowska, Laura Wojtala, Lena Musiał, Agnieszka Możdżyńska, Kamil Kapłon, Izabela Kamińska, Dominika Kojder, and Małgorzata Sierpień
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artificial intelligence ,deep learning ,cardiology ,machine learning ,echocardiography ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction: Term Artificial inteligence was used for the first time by John McCarthy in 1956, from that time we can observe its great development, espiecially in the past decade. Nowadays, Artificial inteligence present a great influence in every aspect of human life, also health care. In times of digitalizaton, great data bases it can enable an improvment in all aspects of healthcare system such as prevention, screening and treatment of diseases. Purpose:The main purpose of the work was to present the basic aspects related to artificial intelligence. Another important aspect of the article was to indicate the possibilities related to their use in cardiology to improve the effectiveness of doctors and make medical treatment more detailed and personalized, but also to clarify terms related do AI, such as machine learning or deep learning. Materials and methods: For the purpose of writing this article, the available literature was reviewed. Using keywords such as artificial inteligence, cardiology, machine learning, echocardiography, deep learning, data bases PubMed we ware searching for various clinical trials, meta analysis and randomized controlled trials from past 5 years. Results: According to the data published on the website of the World Health Organization (WHO), cardiovascular diseases remain the main cause of mortality worldwide. It is the reason of the great interest in its use in cardiology. Algorithms based on artificial intelligence are also used in electrocardiography. The use of artificial intelligence can improve the estimation of cardiovascular risk. Its use in the healing process is also being investigated. Conclusion: Artificial intelligence is used in many fields, including medicine. Its use may have a positive impact on the quality of medical care. Artificial intelligence also has numerous limitations. Due to this, it is necessary to develop and improve artificial intelligence.
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- 2023
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10. Influence of lifestyle on the course of endometriosis
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Paula Szlendak, Aleksandra Winiarz, Michał Turek, Katarzyna Toś, Dominik Drobek, Kacper Wojtala, Sylwia Grosman, Wojciech Wokurka, Agata Węgrzyniak, and Katarzyna Wąsala
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endometriosis ,diet ,anti-inflammatory diet ,lifestyle ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction: Endometriosis is considered a chronic disease, which significantly worsens the quality of life of women suffering from it. So far, the pathogenesis has not been clarified, and therefore no causal treatment has been invented. A number of pharmacological substances are available, however, they are mainly classified as symptomatic treatment. Patients are looking for all kinds of therapies, including alternative ones, e.g. modification of diet and physical activity. Aim of the study: A review of current research on the pathogenesis of endometriosis, recommended forms of treatment, as well as the impact of individual nutrients and physical activity on the development and course of endometriosis. Material and method: The review covers publications published in 2018-2023. The search for publications in the Pubmed electronic database was carried out using the following keywords: endometriosis, treatment, diet, anti-inflammatory diet. Description of the state of knowledge: Most of the analyzed studies indicate the complexity of the pathogenesis of endometriosis, and therefore also the treatment. In addition, the literature has shown that substances such as vitamin D, curcumin, quercetin, resveratrol, polyunsaturated fatty acids and vitamins C and E, as well as physical activity, can have a positive impact on the development, severity of symptoms, and the quality of life of patients with endometriosis. Summary: The best forms of diagnosis and pharmacological and non-pharmacological treatment of endometriosis are sought. A number of medicinal substances are available, but they still do not allow patients to be cured. Studies show that modifying the diet and introducing individual nutrients can also have a positive effect on the course and treatment of endometriosis. It is necessary to conduct further studies evaluating the pathogenesis, methods of treatment of endometriosis, as well as the impact of lifestyle modifications on it.
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- 2023
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11. Novel battery thermal management via scalable dew-point evaporative cooling
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Lin, Jie, Chu, Howie N., Thu, Kyaw, Wojtala, Malgorzata, Gao, Fei, and Chua, Kian Jon
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- 2023
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12. Analysis of gender differences of the sternum in population of 240 adult patients – original article
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Wojciech Wokurka, Agata Węgrzyniak, Dominik Drobek, Aleksandra Winiarz, Paula Szlendak, Katarzyna Toś, Kacper Wojtala, Michał Turek, Katarzyna Wąsala, and Sylwia Grosman
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sternum ,sexual dimorphism ,vitropsy ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction and purpose: The sternum is one of the bones that build up the anterior chest wall. It consists of three parts: manubrium, body and xiphoid process. It has been observed that this bone exhibits sexual dimorphism, which can be used in many fields of science. The aim of the study was to find morphological parameters showing sexual dimorphism that allow unambiguous sex identification. Material and method: 240 patients (140 women and 100 men) underwent chest CT and the following measurements were taken: angle of the sternum, length of the manubrium, body and xiphoid process, sum of the length of the manubrium and body, total length of the sternum. The thickness of all three parts of it and the width of the manubrium and body were also measured. Statistical analyses were performed using the Mann-Whitney "U" test. Values of p < 0. 05 were considered statistically significant. Results: The results of all statistical analyses did not show statistical significance as a basis for the definitive determination of gender. However, some trends between the sexes have been observed, but these cannot be regarded as universal principles of gender identification. Conclusions: There is a need for further researches on finding metric parameters of the sternum allowing gender identification, carried out on large population groups. To achieve this goal, the results of imaging tests, which are often used in diagnostics, including post-mortem examinations - Vitropsy, may be useful.
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- 2023
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13. Blood sample as a promising diagnostic tool in oncology - literature review
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Dominik Drobek, Kacper Wojtala, Michał Turek, Aleksandra Winiarz, Paula Szlendak, Katarzyna Toś, Katarzyna Wąsala, Sylwia Grosman, Agata Węgrzyniak, and Wojciech Wokurka
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ctDNA ,circulating tumor DNA ,CTC ,liquid biopsy ,tumor ,cancer ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction Cancer is one of the leading causes of death worldwide. The molecular characterization of solid tumors has provided significant advances in oncology, and genome profiling using circulating tumor DNA (ctDNA) has helped improve the quality of medical care for patients with cancer. Liquid biopsy is a diagnostic molecular test to demonstrate the presence of circulating tumor DNA or circulating tumor cells released from primary or metastatic solid tumors. In addition, the minimally invasive nature of the liquid biopsy enables quick verification of the grade of malignancy. Observation of ctDNA in blood tests is of great importance at the treatment stage, it allows to determine resistance to the applied treatment, response to therapy and to predict relapse before it occurs. Aim of the study The aim of this review is to present information on the use of circulating tumor DNA together with circulating tumor cells in oncological diagnostics. Materials and methods The work was created based on the PubMed database. Articles were searched in English using the following keywords: ctDNA, CTC, cfDNA. Results Currently, ctDNA analysis is an alternative to traditional molecular diagnostics of cancer tissue, assessment of the effectiveness of therapy, monitoring of tumor dynamics, monitoring of progression and predicting recurrence. Summary There are not many diagnostic methods for detecting ctDNA. Due to the short length of the fragments and the low content in the samples, ctDNA analysis requires more sensitive techniques to ensure its reliability compared to methods used in solid tissue biopsies. Existing techniques of ctDNA analysis focus mainly on the identification of mutations in advanced stages of cancer, less often on early diagnosis.
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- 2023
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14. Supplementation of evening primrose oil (EPO) - benefits and limitations. Results of the latest studies
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Sylwia Grosman, Aleksandra Winiarz, Katarzyna Wąsala, Wojciech Wokurka, Michał Turek, Paula Szlendak, Katarzyna Toś, Kacper Wojtala, Agata Węgrzyniak, and Dominik Drobek
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supplements ,herbal medicine ,evening primrose oil (EPO) ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction One of the most frequently used herbal drugs in the pharmaceutical industry is Oenothera biennis, traditionally called evening primrose. Oil extracted from seeds of a plant is a rich source of unsaturated fatty acids- omega 6 essential fatty acids (EFAs). Healing properties of evening primrose oil (EPO) have been used for ages in order to alleviate symptoms of various medical conditions. Nowadays, studies and clinical trials are conducted with the aim of verifying its effectiveness. The aim of the study Summarize current knowledge on the effectiveness of evening primrose oil in treatments of various diseases. Material and methods The search of the Pubmed database was carried out using keywords, in order to find the latest publications. Summary Despite limitations, research shows that supplements containing evening primrose oil (EPO) demonstrate promising results in treatments of various medical conditions, including menopause, premenstrual syndrome, skin problems or multiple sclerosis. However, more well-designed clinical trials are needed to evaluate long-term effectiveness.
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- 2023
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15. Premenstrual Syndrome and Premenstrual Dysphoric Disorder From the theory to the clinical approach
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Danuta Maciejewska, Kamil Kapłon, Laura Wojtala, Weronika Pawlak, Weronika Pawłocik, and Michalina Dudkiewicz
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premenstrual dysphoric disorder (PMDD) ,Premenstrual syndrome (PMS) ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Mental state of women during their reproductive age fluctuates with the changes in menstrual cycle phases. However, only some of them develop psychiatric disorders. The aim of the study is to present the importance of Premenstrual Syndrome and Premenstrual Dysphoric Disorder as important diseases at the edge of gynecology and psychiatry. Many symptoms classified as premenstrual have been described in the literature. Mood swings turn out to be the most important psychological symptom of the disorders whereas bloating is a common somatic manifestation. Despite some difficulties in the establishment of the exact cause, diagnostic criteria for both have been developed and are the basis on which the clinician makes a final diagnosis. The paper also describes the current state of knowledge about the treatment of Premenstrual Syndrome and Premenstrual Dysphoric Disorder. The continuous increase in the importance of non-pharmacological methods such as lifestyle changes and cognitive-behavioral therapy was emphasized. Manners of pharmacological treatment were also described, including SSRIs and hormonal drugs, which should be selected individually, depending on the characteristics of the clinical picture.
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- 2023
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16. Knee pain in children as a symptom of hip disease: a case study
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Katarzyna Toś, Aleksandra Winiarz, Paula Szlendak, Wojciech Wokurka, Michał Turek, Kacper Wojtala, Sylwia Grosman, Agata Węgrzyniak, Dominik Drobek, and Katarzyna Wąsala
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knee pain in children ,transient synovitis ,septic arthritis ,Legg-Calve-Perthes Disease ,Slipped Capital Femoral Epiphysis ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction Knee pain in the pediatric population is a very common health issue in family doctor practice and its cause is not always obvious and easy to determine. It is important to remember that knee pain can also occur as a projection of the obturator nerve conducting signals from the hip joint. During physical examination the hip joint should be also carefully examined. Diagnostic imaging such as radiographs are helpful in evaluating bone parts, whereas ultrasonography and MRI can reveal pathology in periarticular soft tissue. Laboratory tests can help to rule out a septic process and reveal other associated conditions. The aim The aim of this work was to analyze the patient’s case of transient synovitis of the hip manifested by knee pain and discuss other hip joint causes of knee pain in the pediatric population. Case report An individual case report of the five-year-old male patient suffered from non-traumatic knee pain and inability to walk with analysis of undertaken diagnostic and treatment management. Results The patient was correctly diagnosed with transient synovitis of the hip joint and successfully treated due to a thorough physical examination and right diagnostic tests carried out by the emergency physician. Conclusions In every case of non-traumatic knee pain, hip pathology should be always ruled out. Carefully performed physical examination, basic laboratory tests and imagining allow practitioners to make the right diagnosis.
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- 2023
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17. The impact of shift work and sleep deficiency on health
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Agnieszka Możdżyńska, Laura Wojtala, Weronika Pawlak, Weronika Pawłocik, Lena Musiał, Julia Szymańska, Ewa Grabowska, Kamil Kapłon, Anna Rymarz, and Dominika Kojder
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shift work ,sleep deprivation ,sleep disorders ,sleep-wake cycle ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Shift work refers to work that takes place at different hours, including at night. It is estimated that 15% to 20% of the working population works in shift work, particularly in the healthcare, energy, communication systems, public safety, and hospitality industries. Research indicates that shift work, particularly night work, can lead to health problems such as fatigue, exposure to harmful work environments, increased risk of workplace accidents, and sleep disorders. Night work is also associated with increased risk of hypertension, nervous system dysfunction, cardiovascular dysfunction. Those working at night are also more prone to hormonal disorders, digestive disorders, lowered immunity, and cancer. Sleep-wake cycle disorders, such as excessive sleepiness during waking hours and insomnia at night, are symptoms of shift work intolerance syndrome, which can occur after several months or years of shift work. It is estimated that over 20% of shift workers suffer from sleep-wake cycle disorders, and various factors such as chronotype, age, gender, family and social obligations, medications, medical and psychiatric conditions, and shift work experience can impact tolerance of shift work. The treatment of sleep and wake disorders related to shift work includes planning for main sleep and supplementary naps, appropriate exposure to light, treatment with melatonin, taking sleeping and psychostimulant medications.
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- 2023
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18. Design, synthesis and magneto-structural analysis of Cu(II)-coordination networks sustained by N[sbnd]H⋯O and O[sbnd]H⋯O hydrogen bond
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Yadav, Archana, Bieńko, A., Bieńko, D.C., Wojtala, D., and Siddiqui, Kafeel Ahmad
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- 2022
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19. Governmental Food Safety Professional Workforce Estimation Model
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Fogarty, Kieran, Harmer, Bryan, Kami, Craig, Weiss, Chris, Dezendorf, Paul K., and Wojtala, Gerald
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Food -- Safety and security measures ,Public health personnel -- Supply and demand -- Training ,Labor supply -- Models ,Company business management ,Environmental issues ,Health - Abstract
Governmental food safety professionals (FSPs) play a critical role in verifying that the food industry is fulfilling its responsibilities. Without the ability to accurately estimate the workforce population of FSPs, there is a high likelihood of misalignment of governmental spending and other allocated resources that raises potential concerns regarding the effectiveness of the U.S. food safety system. The development of our Governmental Food Safety Professional Workforce Estimation Model was based on a rigorous process to gain a better understanding of the estimated number of FSPs within various nonfederal governmental agencies. The modeling process indicated the population of the nonfederal governmental FSP workforce in the U.S. to be an estimated 43,289. This estimate does not include the federal FSP workforce population, which would significantly increase the projected overall FSP governmental workforce population. This study provides a workforce estimation model that can a) aid in the allocation of crucial federal resources to fill gaps in staffing and competency-based training and b) increase awareness of the need for and access to a standardized training curriculum for this country's FSPs., Introduction Modern food safety systems recognize that those who produce, manufacture, or offer food for sale have the ultimate responsibility to ensure the safety of the food they handle. In [...]
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- 2022
20. Dietary Therapies in Pediatric Crohn’s Disease
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Izabela Kamińska, Weronika Pawłocik, Weronika Pawlak, Ewa Grabowska, Julia Szymańska, Laura Wojtala, Anna Rymarz, Dominika Kojder, Małgorzata Piekarska, and Klaudia Jedlina
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crohn’s disease ,dietary therapy ,pediatrics ,exclusion diets ,nutritional treatment ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction and Purpose: Crons’ disease is a chronic illness of the digestive system. Its etiology is multifactorial and one of the factors is nutrition. That is why the researchers are trying to labour the valuable types of dietary therapy, which could be used in treatment of pediatric CD. The purpose of our review is to point out the impact of dietary therapy on achieving remission in pediatric Crohn’s disease. Materials and methods: We have reviewed the literature from the PubMed database searching for clinical trials, meta analysis and randomized controlled trials from the past years. The keywords we agreed on offered us the most informative articles and made us hope for the further development of our article. Brief Description Of The State Of Knowledge: Steroid therapy is the principle of CD treatment, but it has a number of side effects that influence the quality of pediatric patients’ life. It has been shown that the use of dietary therapies (EEN, CDED+PEN, SCD) enables the achievement of clinical and biochemical remission, mucosal healing and regulation of dysbiosis. There are many hypotheses explaining this effect, probably the reason of this is the exclusion from the diet of food products that provoke inflammatory processes. Summary: Despite its effectiveness, dietary therapies require motivation and full commitment from patients in order to achieve results. That is why it is so important to conduct further research in this area so that the selected therapy is as acceptable and tolerated by the patient as possible. In addition, education of children and parents, psychological and dietary support are also crucial in the treatment process.
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- 2023
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21. Juvenile idiopathic arthritis – classification and methods of treatment
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Weronika Pawłocik, Laura Wojtala, Weronika Pawlak, Julia Szymańska, Agnieszka Możdżyńska, Lena Musiał, Ewa Grabowska, Kamil Kapłon, Katarzyna Pacek, and Izabela Kamińska
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Juvenile idiopathic arthritis ,arthritis ,pediatric ,biological treatment ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of unknown etiology that affect children. According to the definition of JIA, the disease begins before the age of 16 and lasts more than 6 weeks. The International League of Associations for Rheumatology (ILAR) has divided juvenile idiopathic arthritis into seven categories: systemic, oligoarticular, polyarticular RF (-), polyarticular RF (+), psoriatic, enthesitis-related and undifferentiated arthritis. Purpose The aim of this review is to present the classification, etiopathogenesis, diagnosis, treatment and complications of juvenile idiopathic arthritis. Methods Literature searches in PubMed, Google Scholarship, and open source books were used to gather information. Results Complex interactions between cells of the immune system are responsible for the pathophysiology of JIA and indicate the need to divide the disease into clinical subtypes, the heterogeneity of which requires different therapeutic actions. There are many groups of drugs with different mechanisms of action used in the treatment of JIA, including: T lymphocyte inhibitors, anti-TNFα, JAK inhibitors, IL-1 and IL-6 blockers. Despite the great progress and the commitment of scientists, there is still no treatment strategy to completely stop the development of the disease. Conclusions Scientific research conducted around the world has led to the recognition of numerous pathways leading to the formation of the inflammatory process and the symptoms of JIA. Knowledge of these mechanisms allows scientists to conduct research on further drugs, the aim of which is to find a treatment strategy that prevents permanent joint damage, improves treatment results, and enables sustainable remission. It is necessary to expand knowledge about the pathways responsible for the formation of the inflammatory process, the interruption of which would allow complete inhibition of the development of the disease.
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- 2023
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22. Mindfulness based interventions in the treatment of obesity
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Aleksandra Winiarz, Wojciech Wokurka, Michał Turek, Paula Szlendak, Katarzyna Toś, Kacper Wojtala, Sylwia Grosman, Agata Węgrzyniak, Dominik Drobek, and Katarzyna Wąsala
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mindful eating ,mindfulness ,weight loss ,obesity ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction: Obesity is a chronic, multifactorial disease that leads to many complications. Many methods of treating obesity are available, but they are often not effective enough. Due to the strong connection between psychological factors and the development of obesity, it can be useful to include mindfulness training in treatment. The aim of this study: Summarize current knowledge on the effectiveness of mindfulness training in the treatment of obesity and evaluate the effect of mindfulness on weight loss. Material and method: The review includes publications published in 2012-2022. The search of publications in the Pubmed database was carried out using the following keywords: mindful eating, mindfulness, weight loss, obesity. Description of the stage of the knowledge: The use of mindfulness techniques in the treatment of eating disorders is becoming more popular. A growing number of studies evaluating the effects of mindfulness on weight loss are emerging, but the results are inconclusive. Mindfulness training is effective in improving eating habits and promoting lifestyle changes. Mindfulness training combined with behavioral treatments for obesity has positive effects on weight loss. Summary: Research shows that mindfulness training may be a promising intervention in obesity treatment because it increases self-awareness and promotes lifestyle changes. However, more research is needed to assess the long-term effectiveness of mindfulness for weight control.
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- 2023
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23. Association between caesarean section and childhood asthma development
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Lena Musiał, Agnieszka Możdżyńska, Weronika Pawłocik, Laura Wojtala, Julia Szymańska, Weronika Pawlak, Ewa Grabowska, Kamil Kapłon, Anna Rymarz, and Dominika Kojder
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caesarean section ,asthma ,vaginal delivery ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
According to the World Health Organization (WHO), the rates of caesarean section delivery, which is the most common surgical procedure in gynecology and obstetrics, are increasing globally and amount to 21%. In Poland percentage of caesarean sections (CS) is one of the highest in Europe and amount to 42.2%. The reason for this is the extension of medical indications, but also an increase in the number of CS at the request of pregnant women. Although CS can be a lifesaving procedure, it can also cause many health complications for both - the woman and the child. Numerous studies indicate that caesarean delivery is associated with childhood asthma. Several hypotheses of the pathogenesis of this relationship have been presented. One of them, which is based on the hygiene hypothesis indicates that mode of delivery can cause different bacteria colonization in infants. Lack of contact of fetus with the mother’s vaginal flora during CS labor may cause improper immune system maturation. Another hypothesis is that reduced exposure to stress hormones and mechanical forces during CS labor can indicate infant respiratory complications such as respiratory distress syndrome (RDS) or transient tachypnea of the newborn (TTN). It is suggested that these abnormalities have an impact on asthma development in later life. On the other hand, there are studies which do not confirm that mode of delivery has an influence on the induction of asthma. Due to the significant heterogeneity of studies and unclear risk factors and pathomechanism of the childhood asthma it is impossible to strong confirm the association between caesarean section and asthma developing.
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- 2023
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24. Polycystic Ovary Syndrome - increased risk of depression development. Links and risk factors
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Julia Szymańska, Kamil Kapłon, Weronika Pawłocik, Laura Wojtala, Weronika Pawlak, Dominika Kojder, Izabela Kamińska, Ewa Grabowska, Lena Musiał, and Agnieszka Możdżyńska
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PCOS ,Depression ,Obesity ,female infertility ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
PCOS is a common endocrine disorder affecting up to 6-10% of women in reproductive age. Patients suffer from many manifestations of this disease including symptoms of hyperandrogenism (hirsutism, acne, androgenetic alopecia), ovulation disorders, infertility, overweight and obesity, glucose-insulin homeostasis disorders (insulin resistance, type 2 diabetes). Many studies emphasize the relationship between the presence of PCOS in patients and the appearance of depression. The median incidence of depression in women with this syndrome was 36.6%, while in the group of women without PCOS it was 14.2%. The exact mechanism of this relationship is still unknown, but many factors may play an important role in it, e.g. increased BMI, infertility, high cortisol levels, body image, vitamin D deficiency or elevated inflammation markers.
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- 2023
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25. Antiphospholipid Syndrome and Pregnancy
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Ewa Grabowska, Weronika Pawłocik, Weronika Pawlak, Laura Wojtala, Julia Szymańska, Kamil Kapłon, Agnieszka Możdżyńska, Lena Musiał, Anna Rymarz, and Izabela Kamińska
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antiphospholipid syndrome ,obstretical complications ,antiphospholipid antibodies ,thrombosis ,pregnancy ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Antiphospholipid syndrome is an autoimmune disease with a wide spectrum of manifestations from different organs, therefore it is challenging to diagnose. The disease presents antiphospholipid antibodies such as anticardiolipin antibodies (aCL), lupus anticoagulant (LA) and antiβ2-glycoprotein 1 antibodies (β2GPI). The most common symptoms include thrombosis in veins and arteries and obstretical complications such as early miscarriage, intrauterine fetal death, intrauterine growth restriction (IUGR), placental insufficiency, premature labor and eclampsia. To diagnose a patient with APS certain criteria have been chosen, where at least one clinical and one laboratory criterion must be present. In many cases it takes a lot of time before a proper diagnosis has been made, when a female patient presents obstretical complications. Adequate pharmacological treatment increases the odds of live birth rate from 20-30% to 70-80%. Scientific research shows correlation between antiphospholipid syndrome, infertility and premature ovarian insufficiency. Treatment mostly consists of heparin and low-dose aspirin, in certain cases hydrochloroquine is prescribed. Aside from pharamcological therapy, it is very important to minimize the effects of modifiable risk factors. The following article focuses on complications, diagnosing and therapy in pregnant women suffering from Antiphospholipid syndrome. All sources can be found in Pubmed’s website database.
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- 2023
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26. Basal cell carcinoma in the elderly Cryosurgery or surgery – a case study with reference to the literature
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Kamil Kapłon, Laura Wojtala, Weronika Pawlak, Weronika Pawłocik, Lena Musiał, Agnieszka Możdżyńska, Julia Szymańska, Ewa Grabowska, Anna Rymarz, and Dominika Kojder
- Subjects
Carcinoma ,Basal Cell ,Cryosurgery ,General Surgery ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction The aging of society leads to an increase in the occurrence of basal cell carcinoma (BCC). BCC includes both superficial and nodular lesions with a good prognosis as well as foci that are difficult to treat and require a multidisciplinary approach. There are two basic methods of treating BCC, surgery to remove the tumor and cryosurgery. The paper presents a case of an 82-year-old female patient suffering from BCC in a non-advanced stage of the disease with the presentation of subsequent stages of treatment. Aim of the study An attempt was made to confront an alternative method of BCC treatment by cryosurgery with the first-choice procedure - surgical excision of the tumor with a margin of healthy tissues. Description of the case An individual clinical case study including the patient's medical records. Conclusions The work emphasizes the importance of comprehensive care for a patient diagnosed with BCC. Individualization of the diagnostic and therapeutic process is the basis for dealing with the elderly patient.
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- 2023
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27. Diagnosis and management of lip filler complications – a case study with literature review
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Laura Wojtala, Kamil Kapłon, Weronika Pawłocik, Julia Szymańska, Weronika Pawlak, Agnieszka Możdżyńska, Lena Musiał, Anna Rymarz, Izabela Kamińska, and Ewa Grabowska
- Subjects
aesthetic medicine ,hyaluronic acid ,lip filler treatment ,allergic reaction ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction Aesthetic medicine treatments are becoming more popular in the 21st century due to the changing beauty standards and the treatments’ ability to help slow down the aging process. One of the most asked for treatments is a lip filler using hyaluronic acid. The popularity and frequency of the said treatment are directly connected to the rising number of complications in this area. The right diagnosis of lip filler complications allows to implement correct management and therefore therapeutic success for the patient. The aim The aim of the work was to analyze and discuss patient’s complications and implemented medical management after lip filler treatment using hyaluronic acid. Case report An individual case study that included clinical examination, medical and photographic documentation analysis. Results The patient was diagnosed with one of the most common complications after lip filler which is swelling. The swelling was a result of an allergic reaction and was classified as severe. Medical management using corticosteroid and antihistamines was implemented with a good therapeutic outcome. Conclusions Implemented management using corticosteroids and antihistamines for severe swelling after lip filler is effective. Due to the rising number of treatments using soft tissue fillers, it is expected that more patients will present with complications after aesthetic medicine procedures.
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- 2023
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- View/download PDF
28. Strategie narracyjne w komunikatach prasowych polskich aktorów politycznych a sekurytyzacja wojny na Ukrainie
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Jakub Wojtala and Bartłomiej Różycki
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wojna na ukrainie ,strategie narracyjne ,bezpieczeństwo ,sekurytyzacja ,postawy społeczne ,Social Sciences ,Political science - Abstract
Wybuch wojny na Ukrainie ukierunkował uwagę głównych polskich aktorów politycznych na kwestie związane z bezpieczeństwem. W niniejszym artykule przeanalizowane zostaną ich strategie narracyjne dotyczące tego tematu. Celem będzie odpowiedź na pytanie o intencje, jakie towarzyszą poruszaniu zagadnienia trwającego konfliktu przez pryzmat teorii sekurytyzacji, która może być stosowana do kształtowania określonego przekazu politycznego. Przekaz taki służyć może wpływaniu na postawy społeczne bądź też realizowaniu szerszej strategii politycznej danego aktora.
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- 2022
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29. Evaluation of anticancer activity in vitro of a stable copper(I) complex with phosphine-peptide conjugate
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Urszula K. Komarnicka, Barbara Pucelik, Daria Wojtala, Monika K. Lesiów, Grażyna Stochel, and Agnieszka Kyzioł
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Medicine ,Science - Abstract
Abstract [CuI(2,9-dimethyl-1,10-phenanthroline)P(p-OCH3-Ph)2CH2SarcosineGlycine] (1-MPSG), highly stable in physiological media phosphino copper(I) complex—is proposed herein as a viable alternative to anticancer platinum-based drugs. It is noteworthy that, 1-MPSG significantly and selectively reduced cell viability in a 3D spheroidal model of human lung adenocarcinoma (A549), in comparison with non-cancerous HaCaT cells. Confocal microscopy and an ICP-MS analysis showed that 1-MPSG effectively accumulates inside A549 cells with colocalization in mitochondria and nuclei. A precise cytometric analysis revealed a predominance of apoptosis over the other types of cell death. In the case of HaCaT cells, the overall cytotoxicity was significantly lower, indicating the selective activity of 1-MPSG towards cancer cells. Apoptosis also manifested itself in a decrease in mitochondrial membrane potential along with the activation of caspases-3/9. Moreover, the caspase inhibitor (Z-VAD-FMK) pretreatment led to decreased level of apoptosis (more pronouncedly in A549 cells than in non-cancerous HaCaT cells) and further validated the caspases dependence in 1-MPSG-induced apoptosis. Furthermore, the 1-MPSG complex presumably induces the changes in the cell cycle leading to G2/M phase arrest in a dose-dependent manner. It was also observed that the 1-MPSG mediated intracellular ROS alterations in A549 and HaCaT cells. These results, proved by fluorescence spectroscopy, and flow cytometry, suggest that investigated Cu(I) compound may trigger apoptosis also through ROS generation.
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- 2021
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30. Increased neural motor activation and functional reorganization in patients with idiopathic rapid eye movement sleep behavior disorder
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Brcina, Nikolina, Hohenfeld, Christian, Heidbreder, Anna, Mirzazade, Shahram, Krahe, Janna, Wojtala, Jennifer, Binkofski, Ferdinand, Schulz, Jörg B., Schiefer, Johannes, Reetz, Kathrin, and Dogan, Imis
- Published
- 2021
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31. The Role of Lysine-Specific Demethylase 1 (LSD1) in Shaping the Endothelial Inflammatory Response
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Martyna Wojtala, Dorota Rybaczek, Ewelina Wielgus, Marta Sobalska-Kwapis, Dominik Strapagiel, and Aneta Balcerczyk
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Physiology ,QP1-981 ,Biochemistry ,QD415-436 - Published
- 2021
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32. A new CERAD total score with equally weighted z-scores and additional executive and non-amnestic „CERAD-Plus“ tests enhances cognitive diagnosis in patients with Parkinson's disease: Evidence from the LANDSCAPE study
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Lillig, Robert, Ophey, Anja, Schulz, Jörg B., Reetz, Kathrin, Wojtala, Jennifer, Storch, Alexander, Liepelt-Scarfone, Inga, Becker, Sara, Berg, Daniela, Balzer-Geldsetzer, Monika, Kassubek, Jan, Hilker-Roggendorf, Rüdiger, Witt, Karsten, Mollenhauer, Brit, Trenkwalder, Claudia, Roeske, Sandra, Wittchen, Hans-Ullrich, Riedel, Oliver, Dodel, Richard, and Kalbe, Elke
- Published
- 2021
- Full Text
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33. Ionic Liquids as Environmental Pollutants—Analysis of the Effect of Tetrabutylammonium Chloride on the Growth and Development of Wheat and Cucumber
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Barbara Pawłowska, Dagmara Wojtala, and Robert Biczak
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phytotoxicity ,chlorophyll fluorescence ,photosynthetic pigments content ,ionic liquids ,Chemical technology ,TP1-1185 - Abstract
Ionic liquids are a huge group of chemical compounds that have found, or may, in the future, find, applications in various industries. These compounds are characterized by excellent physical, chemical, and biological properties, but a big problem is their environmental impact. One of the representatives of this group of compounds is tetrabutylammonium chloride ([TBA][Cl]). In this present study, the effects of [TBA][Cl] were evaluated on two popular plant species—a monocotyledonous plant—wheat (Triticum aestivum L.) and a dicotyledonous plant—cucumber (Cucumis sativus L.). The results showed that the compound caused a pronounced inhibition of plant growth and roots, as well as plant fresh weight yield. An increase in plant dry weight was observed at the same time. Despite the decrease in the content of photosynthetic pigments, no major changes were observed in chlorophyll fluorescence. All observed changes were strongly related to the applied concentration of the compound.
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- 2023
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- View/download PDF
34. A Sensor-Aided System for Physical Perfect Control Applications in the Continuous-Time Domain
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Paweł Majewski, Wojciech P. Hunek, Dawid Pawuś, Krzysztof Szurpicki, and Tomasz Wojtala
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continuous-time systems ,perfect control ,practical implementation ,real-life plant ,state-space description ,Chemical technology ,TP1-1185 - Abstract
The recently introduced continuous-time perfect control algorithm has revealed a great potential in terms of the maximum-speed and maximum-accuracy behaviors. However, the discussed inverse model-originated control strategy is associated with considerable energy consumption, which has exceeded a technological limitation in a number of industrial cases. In order to prevent such an important drawback, several solutions could be considered. Therefore, an innovative perfect control scheme devoted to the multivariable real-life objects is investigated in this paper. Henceforth, the new IMC-related approach, strongly supported by the vital sensor-aided system, can successfully be employed in every real-time engineering task, where the precision of conducted processes plays an important role. Theoretical and practical examples strictly confirm the big implementation potential of the new established method over existing ones. It has been seen that the new perfect control algorithm outperforms the classical control law in the form of LQR (considered in two separate ways), which is clearly manifested by almost all simulation examples. For instance, in the case of the multi-tank system, the performance indices ISE, RT, and MOE for LQR without an integration action have been equal to 2.431, 2.4×102, and 3.655×10−6, respectively, whilst the respective values 1.638, 1.58×102, and 1.514×10−7 have been received for the proposed approach.
- Published
- 2023
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35. Can Mn coordination compounds be good candidates for medical applications?
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Kozieł, Sandra, primary, Wojtala, Daria, additional, Szmitka, Magdalena, additional, Sawka, Jacek, additional, and Komarnicka, Urszula K., additional
- Published
- 2024
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36. Large Magnetic Anisotropy in Mono- and Binuclear cobalt(II) Complexes: The Role of the Distortion of the Coordination Sphere in Validity of the Spin-Hamiltonian Formalism
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Choroba, Katarzyna, primary, Palion-Gazda, Joanna, additional, Machura, Barbara, additional, Bieńko, Alina, additional, Wojtala, Daria, additional, Bieńko, Dariusz, additional, Rajnák, Cyril, additional, Boča, Roman, additional, Ozarowski, Andrew, additional, and Ozerov, Mykhaylo, additional
- Published
- 2024
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37. Cover Feature: Cellular Mechanistic Considerations on Cytotoxic Mode of Action of Phosphino Ru(II) and Ir(III) Complexes (Eur. J. Inorg. Chem. 33/2023)
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Wojtala, Daria B., primary, Komarnicka, Urszula K., additional, Kyzioł, Agnieszka, additional, Kozieł, Sandra, additional, Szmitka, Magdalena, additional, Słowikowski, Mateusz, additional, Kulczyńska, Julia, additional, and Stochel, Grażyna, additional
- Published
- 2023
- Full Text
- View/download PDF
38. Evaluation of anticancer activity in vitro of a stable copper(I) complex with phosphine-peptide conjugate
- Author
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Komarnicka, Urszula K., Pucelik, Barbara, Wojtala, Daria, Lesiów, Monika K., Stochel, Grażyna, and Kyzioł, Agnieszka
- Published
- 2021
- Full Text
- View/download PDF
39. Piceatannol effectively counteracts glyceraldehyde-3-phosphate dehydrogenase aggregation and nuclear translocation in hippocampal cells
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Gerszon, Joanna, Wojtala, Martyna, Michlewska, Sylwia, and Rodacka, Aleksandra
- Published
- 2019
- Full Text
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40. Antibactericidal Ir(III) and Ru(II) Complexes with Phosphine‐Alkaloid Conjugate and Their Interactions with Biomolecules: A Case of N‐Methylphenethylamine
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Wojtala, Daria, primary, Kozieł, Sandra, additional, Witwicki, Maciej, additional, Niorettini, Alessandro, additional, Guz‐Regner, Katarzyna, additional, Bugla‐Płoskońska, Gabriela, additional, Caramori, Stefano, additional, and Komarnicka, Urszula K., additional
- Published
- 2023
- Full Text
- View/download PDF
41. Cellular mechanistic considerations on cytotoxic mode of action of phosphino Ru(II) and Ir(III) complexes
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Wojtala, Daria B., primary, Komarnicka, Urszula K., additional, Kyziol, Agnieszka, additional, Kozieł, Sandra, additional, Szmitka, Magdalena, additional, Słowikowski, Mateusz, additional, Kulczyńska, Julia, additional, and Stochel, Grażyna, additional
- Published
- 2023
- Full Text
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42. Current clinicopathological characterisation of adamantinoma - a review of the literature
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Węgrzyniak, Agata, primary, Wokurka, Wojciech, additional, Drobek, Dominik, additional, Winiarz, Aleksandra, additional, Szlendak, Paula, additional, Toś, Katarzyna, additional, Wojtala, Kacper, additional, Turek, Michał, additional, Wąsala, Katarzyna, additional, and Grosman, Sylwia, additional
- Published
- 2023
- Full Text
- View/download PDF
43. Future of cardiovascular diagnosis with the support of artificial intelligence
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Rymarz, Anna, primary, Grabowska, Ewa, additional, Wojtala, Laura, additional, Musiał, Lena, additional, Możdżyńska, Agnieszka, additional, Kapłon, Kamil, additional, Kamińska, Izabela, additional, Kojder, Dominika, additional, and Sierpień, Małgorzata, additional
- Published
- 2023
- Full Text
- View/download PDF
44. Lower back pain caused by radiculopathy induced by lumbar stenosis - literature review
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Turek, Michał, primary, Winiarz, Aleksandra, additional, Szlendak, Paula, additional, Toś, Katarzyna, additional, Wojtala, Kacper, additional, Grosman, Sylwia, additional, Węgrzyniak, Agata, additional, Drobek, Dominik, additional, Wąsala, Katarzyna, additional, and Wokurka, Wojciech, additional
- Published
- 2023
- Full Text
- View/download PDF
45. Armored heart as an image of constrictive pericarditis - a review of the literature
- Author
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Wokurka, Wojciech, primary, Węgrzyniak, Agata, additional, Drobek, Dominik, additional, Winiarz, Aleksandra, additional, Szlendak, Paula, additional, Toś, Katarzyna, additional, Wojtala, Kacper, additional, Turek, Michał, additional, Wąsala, Katarzyna, additional, and Grosman, Sylwia, additional
- Published
- 2023
- Full Text
- View/download PDF
46. Influence of lifestyle on the course of endometriosis
- Author
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Szlendak, Paula, primary, Winiarz, Aleksandra, additional, Turek, Michał, additional, Toś, Katarzyna, additional, Drobek, Dominik, additional, Wojtala, Kacper, additional, Grosman, Sylwia, additional, Wokurka, Wojciech, additional, Węgrzyniak, Agata, additional, and Wąsala, Katarzyna, additional
- Published
- 2023
- Full Text
- View/download PDF
47. Insights into the binding of half-sandwich phosphino Ir(III) and Ru(II) complexes to deoxyribonucleic acid, albumin and apo-transferrin: experimental and theoretical investigation
- Author
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Kozieł, Sandra, primary, Wojtala, Daria, additional, Szmitka, Magdalena, additional, Kędzierski, Paweł, additional, Bieńko, Dariusz, additional, and Komarnicka, Urszula K., additional
- Published
- 2023
- Full Text
- View/download PDF
48. Piceatannol effectively counteracts glyceraldehyde-3-phosphate dehydrogenase aggregation and nuclear translocation in hippocampal cells
- Author
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Joanna Gerszon, Martyna Wojtala, Sylwia Michlewska, and Aleksandra Rodacka
- Subjects
Glyceraldehyde-3-phosphate dehydrogenase ,Piceatannol ,Polyphenol ,Neuroprotection ,Nutrition. Foods and food supply ,TX341-641 - Abstract
There is increasing evidence that supplementation with superfoods is one of the available solution to prevent or slow down the progression of neurodegenerative diseases. Especially polyphenols have been reported to exert strong neuroprotective properties. Taking into consideration our latest discovery, where we demonstrated that piceatannol inhibits glyceraldehyde-3-phosphate dehydrogenase (GAPDH) aggregation (in tube) we decided to explore its effect on hippocampal cells.We investigated how piceatannol influence on oxidatively modified GAPDH in hippocampal cells by using confocal microscopy, flow cytometry, western blot analysis, spectrophotometric assays. Additional we assessed effect of piceatannol on level of Bdnf and Sirt1 mRNA (RT-PCR) and the activity of GPx, GR, GST, Cat.We found that piceatannol significantly suppresses GAPDH nuclear translocation as well as protein aggregation induced by excessive stress.The piceatannol anti-aggregation activity and ability to counteract GAPDH nuclear translocation place this compound as a new drug candidate for in vivo tests.
- Published
- 2019
- Full Text
- View/download PDF
49. Irreversibility of Structure Tensors of Modules.
- Author
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Maciej Wojtala
- Published
- 2021
50. Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes
- Author
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Malinska, Dominika, Szymański, Jędrzej, Patalas-Krawczyk, Paulina, Michalska, Bernadeta, Wojtala, Aleksandra, Prill, Monika, Partyka, Małgorzata, Drabik, Karolina, Walczak, Jarosław, Sewer, Alain, Johne, Stephanie, Luettich, Karsta, Peitsch, Manuel C., Hoeng, Julia, Duszyński, Jerzy, Szczepanowska, Joanna, van der Toorn, Marco, and Wieckowski, Mariusz R.
- Published
- 2018
- Full Text
- View/download PDF
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