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1. The impact of the COVID-19 Pandemic on hypertension phenotypes (ESH ABPM COVID-19 study)

Author

Ostrowska, A, Wojciechowska, W, Rajzer, M, Weber, T, Bursztyn, M, Persu, A, Stergiou, G, Kiełbasa, G, Chrostowska, M, Doumas, M, Parati, G, Bilo, G, Grassi, G, Mancia, G, Januszewicz, A, Kreutz, R, Narkiewicz, K, Dubiela, A, Imprialos, K, Stavropoulos, K, de Freminville, J, Azizi, M, Cunha, P, Lewandowski, J, Strzelczyk, J, Wuerzner, G, Gosk-Przybyłek, M, Szwęch, E, Prejbisz, A, Van der Niepen, P, Kahan, T, Jekell, A, Spaak, J, Tsioufis, K, Ehret, G, Doroszko, A, Kubalski, P, Polonia, J, Styczkiewicz, K, Styczkiewicz, M, Mazur, S, Veglio, F, Rabbia, F, Eula, E, Águila, F, Sarzani, R, Spannella, F, Jarai, Z, Papadopoulos, D, Sublet, M, Grassos, C, Kahrimanidis, I, Gkaliagkousi, E, Triantafyllou, A, Grodzicki, T, Wizner, B, Seweryn, A, Moczulska, B, Ntineri, A, Robles, N, Widmiski, J, Zbroch, E, Ostrowska, Aleksandra, Wojciechowska, Wiktoria, Rajzer, Marek, Weber, Thomas, Bursztyn, Michael, Persu, Alexandre, Stergiou, George, Kiełbasa, Grzegorz, Chrostowska, Marzena, Doumas, Michaelis, Parati, Gianfranco, Bilo, Grzegorz, Grassi, Guido, Mancia, Giuseppe, Januszewicz, Andrzej, Kreutz, Reinhold, Narkiewicz, Krzysztof, Dubiela, Andżelina, Imprialos, Konstantinos, Stavropoulos, Konstantinos, de Freminville, Jean-Baptiste, Azizi, Michel, Cunha, Pedro Guimarães, Lewandowski, Jacek, Strzelczyk, Jakub, Wuerzner, Gregoire, Gosk-Przybyłek, Maria, Szwęch, Elżbieta, Prejbisz, Aleksander, Van der Niepen, Patricia, Kahan, Thomas, Jekell, Andreas, Spaak, Jonas, Tsioufis, Konstantinos, Ehret, Georg, Doroszko, Adrian, Kubalski, Piotr, Polonia, Jorge, Styczkiewicz, Katarzyna, Styczkiewicz, Marek, Mazur, Stanisław, Veglio, Franco, Rabbia, Franco, Eula, Elisabetta, Águila, Fernando Jaen, Sarzani, Riccardo, Spannella, Francesco, Jarai, Zoltan, Papadopoulos, Dimitrios, Sublet, Marilucy Lopez –, Grassos, Charalampos, Kahrimanidis, Ioannis, Gkaliagkousi, Eugenia, Triantafyllou, Areti, Grodzicki, Tomasz, Wizner, Barbara, Seweryn, Aleksandra, Moczulska, Beata, Ntineri, Angeliki, Robles, Nicolas Roberto, Widmiski, Jiri, Zbroch, Edyta, Ostrowska, A, Wojciechowska, W, Rajzer, M, Weber, T, Bursztyn, M, Persu, A, Stergiou, G, Kiełbasa, G, Chrostowska, M, Doumas, M, Parati, G, Bilo, G, Grassi, G, Mancia, G, Januszewicz, A, Kreutz, R, Narkiewicz, K, Dubiela, A, Imprialos, K, Stavropoulos, K, de Freminville, J, Azizi, M, Cunha, P, Lewandowski, J, Strzelczyk, J, Wuerzner, G, Gosk-Przybyłek, M, Szwęch, E, Prejbisz, A, Van der Niepen, P, Kahan, T, Jekell, A, Spaak, J, Tsioufis, K, Ehret, G, Doroszko, A, Kubalski, P, Polonia, J, Styczkiewicz, K, Styczkiewicz, M, Mazur, S, Veglio, F, Rabbia, F, Eula, E, Águila, F, Sarzani, R, Spannella, F, Jarai, Z, Papadopoulos, D, Sublet, M, Grassos, C, Kahrimanidis, I, Gkaliagkousi, E, Triantafyllou, A, Grodzicki, T, Wizner, B, Seweryn, A, Moczulska, B, Ntineri, A, Robles, N, Widmiski, J, Zbroch, E, Ostrowska, Aleksandra, Wojciechowska, Wiktoria, Rajzer, Marek, Weber, Thomas, Bursztyn, Michael, Persu, Alexandre, Stergiou, George, Kiełbasa, Grzegorz, Chrostowska, Marzena, Doumas, Michaelis, Parati, Gianfranco, Bilo, Grzegorz, Grassi, Guido, Mancia, Giuseppe, Januszewicz, Andrzej, Kreutz, Reinhold, Narkiewicz, Krzysztof, Dubiela, Andżelina, Imprialos, Konstantinos, Stavropoulos, Konstantinos, de Freminville, Jean-Baptiste, Azizi, Michel, Cunha, Pedro Guimarães, Lewandowski, Jacek, Strzelczyk, Jakub, Wuerzner, Gregoire, Gosk-Przybyłek, Maria, Szwęch, Elżbieta, Prejbisz, Aleksander, Van der Niepen, Patricia, Kahan, Thomas, Jekell, Andreas, Spaak, Jonas, Tsioufis, Konstantinos, Ehret, Georg, Doroszko, Adrian, Kubalski, Piotr, Polonia, Jorge, Styczkiewicz, Katarzyna, Styczkiewicz, Marek, Mazur, Stanisław, Veglio, Franco, Rabbia, Franco, Eula, Elisabetta, Águila, Fernando Jaen, Sarzani, Riccardo, Spannella, Francesco, Jarai, Zoltan, Papadopoulos, Dimitrios, Sublet, Marilucy Lopez –, Grassos, Charalampos, Kahrimanidis, Ioannis, Gkaliagkousi, Eugenia, Triantafyllou, Areti, Grodzicki, Tomasz, Wizner, Barbara, Seweryn, Aleksandra, Moczulska, Beata, Ntineri, Angeliki, Robles, Nicolas Roberto, Widmiski, Jiri, and Zbroch, Edyta

Published
2024

2. The impact of the COVID-19 pandemic on blood pressure control in patients with treated hypertension-results of the European Society of Hypertension Study (ESH ABPM COVID-19 Study)

Author

Wojciechowska, W, Rajzer, M, Kreutz, R, Weber, T, Bursztyn, M, Persu, A, Stergiou, G, Parati, G, Bilo, G, Pac, A, Grassi, G, Mancia, G, Januszewicz, A, Wojciechowska, Wiktoria, Rajzer, Marek, Kreutz, Reinhold, Weber, Thomas, Bursztyn, Michael, Persu, Alexandre, Stergiou, George, Parati, Gianfranco, Bilo, Grzegorz, Pac, Agnieszka, Grassi, Guido, Mancia, Giuseppe, Januszewicz, Andrzej, Wojciechowska, W, Rajzer, M, Kreutz, R, Weber, T, Bursztyn, M, Persu, A, Stergiou, G, Parati, G, Bilo, G, Pac, A, Grassi, G, Mancia, G, Januszewicz, A, Wojciechowska, Wiktoria, Rajzer, Marek, Kreutz, Reinhold, Weber, Thomas, Bursztyn, Michael, Persu, Alexandre, Stergiou, George, Parati, Gianfranco, Bilo, Grzegorz, Pac, Agnieszka, Grassi, Guido, Mancia, Giuseppe, and Januszewicz, Andrzej

Abstract

Background: We aimed to determine the influence of coronavirus disease 2019 (COVID-19) pandemic on blood pressure (BP) control assessed by ambulatory blood pressure monitoring (ABPM). Methods: Office BP and ABPM data from two visits conducted within a 9-15 months interval were collected from patients treated for hypertension. In the prepandemic group, both visits took place before, while in the pandemic group, Visit-1 was done before and Visit-2 during the pandemic period. Results: Of 1811 collected patients 191 were excluded because they did not meet the required ABPM time frames. Thus, the study comprised 704 patients from the pandemic and 916 from the prepandemic group. Groups did not differ in sex, age, duration of hypertension, frequency of first line antihypertensive drug use and mean 24 h BP on Visit-1. The prevalence of sustained uncontrolled hypertension was similar in both groups. On Visit-2 mean 24 h BP, daytime and nighttime systolic BP and diastolic BP were higher in the pandemic compared to the prepandemic group (P < 0.034). The prevalence of sustained uncontrolled hypertension on Visit-2 was higher in the pandemic than in the prepandemic group [0.29 (95% confidence interval (95% CI): 0.26-0.33) vs. 0.25 (95% CI: 0.22-0.28), P < 0.037]. In multivariable adjusted analyses a significant difference in BP visit-to-visit change was observed, with a more profound decline in BP between visits in the prepandemic group. Conclusions: This study using ABPM indicates a negative impact of the COVID-19 pandemic on BP control. It emphasizes the need of developing strategies to maintain BP control during a pandemic such as the one induced by COVID-19.

Published
2024

3. Ambulatory blood pressure monitoring in treated patients with hypertension in the COVID-19 pandemic - The study of European society of hypertension (ESH ABPM COVID-19 study)

Author

Wojciechowska, W, Rajzer, M, Weber, T, Prejbisz, A, Dobrowolski, P, Ostrowska, A, Bilo, G, Mancia, G, Kreutz, R, Januszewicz, A, Wojciechowska W., Rajzer M., Weber T., Prejbisz A., Dobrowolski P., Ostrowska A., Bilo G., Mancia G., Kreutz R., Januszewicz A., Wojciechowska, W, Rajzer, M, Weber, T, Prejbisz, A, Dobrowolski, P, Ostrowska, A, Bilo, G, Mancia, G, Kreutz, R, Januszewicz, A, Wojciechowska W., Rajzer M., Weber T., Prejbisz A., Dobrowolski P., Ostrowska A., Bilo G., Mancia G., Kreutz R., and Januszewicz A.

Abstract

Purpose: The coronavirus disease 2019 (COVID-19) pandemic and the subsequent lockdown profoundly affected almost all aspects of daily life including health services worldwide. The established risk factors for increased blood pressure (BP) and hypertension may also demonstrate significant changes during the pandemic. This study aims to determine the impact of the COVID-19 pandemic on BP control and BP phenotypes as assessed with 24-hour ambulatory BP monitoring (ABPM). Materials and Methods: This is a multi-centre, observational, retrospective and comparative study involving Excellence Centres of the European Society of Hypertension across Europe. Along with clinical data and office BP, ABPM recordings will be collected in adult patients with treated arterial hypertension. There will be two groups in the study: Group 1 will consist of participants who have undergone two ABPM recordings - the second one occurring during the COVID-19 pandemic, i.e. after March 2020, and the first one 9–15 months prior to the second. Participants in Group 2 will have two repeated ABPM recordings - both performed before the pandemic within a similar 9–15 month interval between the recordings. Within each group, we will analyse and compare BP variables and phenotypes (including averaged daytime and night-time BP, BP variability, dipper and non-dipper status, white-coat and masked hypertension) between the two respective ABPM recordings and compare these changes between the two groups. The target sample size will amount to least 590 participants in each of the study groups, which means a total of at least 2360 ABPM recordings overall. Expected outcomes: As a result, we expect to identify the impact of a COVID-19 pandemic on blood pressure control and the quality of medical care in order to develop the strategy to control cardiovascular risk factors during unpredictable global events.

Published
2023

5. The rationale, protocol and preliminary results of the ESH ABPM COVID-19 study

Author

Wojciechowska, W, Rajzer, M, Weber, T, Prejbis, A, Dobrowolski, P, Ostrowska, A, Bilo, G, Mancia, G, Kreutz, R, Januszewicz, A, Wojciechowska W., Rajzer M., Weber T., Prejbis A., Dobrowolski P., Ostrowska A., Bilo G., Mancia G., Kreutz R., Januszewicz A., Wojciechowska, W, Rajzer, M, Weber, T, Prejbis, A, Dobrowolski, P, Ostrowska, A, Bilo, G, Mancia, G, Kreutz, R, Januszewicz, A, Wojciechowska W., Rajzer M., Weber T., Prejbis A., Dobrowolski P., Ostrowska A., Bilo G., Mancia G., Kreutz R., and Januszewicz A.

Published
2022

6. Effects of uric acid-lowering therapy in patients with essential arterial hypertension

Author

Gruszka, K, Drozdz, T, Wojciechowska, W, Jankowski, P, Terlecki, M, Bijak, M, Hering, D, Bilo, G, Drozdz, D, Rajzer, M, Gruszka K., Drozdz T., Wojciechowska W., Jankowski P., Terlecki M., Bijak M., Hering D., Bilo G., Drozdz D., Rajzer M., Gruszka, K, Drozdz, T, Wojciechowska, W, Jankowski, P, Terlecki, M, Bijak, M, Hering, D, Bilo, G, Drozdz, D, Rajzer, M, Gruszka K., Drozdz T., Wojciechowska W., Jankowski P., Terlecki M., Bijak M., Hering D., Bilo G., Drozdz D., and Rajzer M.

Abstract

Objectives Asymptomatic hyperuricemia (AHU) is elevated serum uric acid (UA) without symptoms. This study aimed to determine the effects of AHU treatment with allopurinol on selected hypertension-mediated organ damage (HMOD) indices in patients with uncomplicated essential arterial hypertension (AH). Methods Patients aged 30-70 years with AHU and AH grade 1-2 with adequate blood pressure (BP) control, without previous urate-lowering therapy (ULT), were divided into two groups: (a) ULT (receiving allopurinol) and (b) control (age- and sex-matched patients without ULT). Both received a UA-lowering diet. BP (office, 24 h and central), echocardiographic parameters, carotid intima-media thickness (IMT) and lab tests [high-sensitivity C-reactive protein (hs-CRP)] were measured at baseline and at 6 months follow-up. Results Of 100 participants, 87 (44 ULT, 43 controls) completed the study. At 6 months follow-up, there was a greater reduction in serum UA concentration in the ULT group than in the control group. Patients receiving allopurinol had significant reductions in office systolic and diastolic BP, central systolic BP, pulse pressure, IMT (0.773 ± 0.121 vs. 0.752 ± 0.13 mm, P = 0.044) and hs-CRP (3.36 ± 2.73 vs. 2.74 ± 1.91 mg/L, P = 0.028) compared to controls. Multivariate regression analysis revealed the independent relationship between reduction in IMT and UA lowering (P < 0.026). Conclusion In patients with AH and AHU, treatment with allopurinol leads to improvement in BP control and reduction in HMOD intensity, in particular IMT. The decrease in hs-CRP concentration associated with ULT may have a beneficial effect on a patient's long-term prognosis.

Published
2022

7. THE IMPACT OF COVID-19 PANDEMIC ON BLOOD PRESSURE CONTROL IN PATIENTS WITH TREATED HYPERTENSION. RESULTS OF EUROPEAN SOCIETY OF HYPERTENSION STUDY (ESH ABPM COVID-19 STUDY)

Author

Wojciechowska, W, Rajzer, M, Weber, T, Chrostowska, M, Doumas, M, De Fréminville, J, Lewandowski, J, Wuerzner, G, Gosk-Przybylek, M, Parati, G, Van Der Niepen, P, Kahan, T, Bursztyn, M, Persu, A, Stergiou, G, Bilo, G, Grassi, G, Mancia, G, Kreutz, R, Januszewicz, A, De Fréminville, JB, Stergiou, GS, Wojciechowska, W, Rajzer, M, Weber, T, Chrostowska, M, Doumas, M, De Fréminville, J, Lewandowski, J, Wuerzner, G, Gosk-Przybylek, M, Parati, G, Van Der Niepen, P, Kahan, T, Bursztyn, M, Persu, A, Stergiou, G, Bilo, G, Grassi, G, Mancia, G, Kreutz, R, Januszewicz, A, De Fréminville, JB, and Stergiou, GS

Published
2023

9. Experience with BFM 1990 Protocol Treatment of Recurrent Childhood Lymphoblastic Leukemia. Report of the Polish Children’s Leukemia/Lymphoma Study Group

Author

Bogusławska-Jaworska, J., Chybicka, A., Wojciechowska, W., Gorczyńska, E., Armata, J., Balwierz, W., Bubała, H., Filiks-Litwin, B., Kołecki, P., Kowalczyk, J., Łukowska, K., Matysiak, M., Rokicka-Milewska, R., Sońta-Jakimczyk, D., Strojny, W., Wieczorek, M., Zelenay, E., Hiddemann, W., editor, Büchner, T., editor, Wörmann, B., editor, Ritter, J., editor, Creutzig, U., editor, Keating, M., editor, and Plunkett, W., editor

Published
1998
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11. Association of Fatal and Nonfatal Cardiovascular Outcomes With 24-Hour Mean Arterial Pressure

Author

Melgarejo, Jesus D., primary, Yang, Wen-Yi, additional, Thijs, Lutgarde, additional, Li, Yan, additional, Asayama, Kei, additional, Hansen, Tine W., additional, Wei, Fang-Fei, additional, Kikuya, Masahiro, additional, Ohkubo, Takayoshi, additional, Dolan, Eamon, additional, Stolarz-Skrzypek, Katarzyna, additional, Huang, Qi-Fang, additional, Tikhonoff, Valérie, additional, Malyutina, Sofia, additional, Casiglia, Edoardo, additional, Lind, Lars, additional, Sandoya, Edgardo, additional, Filipovský, Jan, additional, Gilis-Malinowska, Natasza, additional, Narkiewicz, Krzysztof, additional, Kawecka-Jaszcz, Kalina, additional, Boggia, José, additional, Wang, Ji-Guang, additional, Imai, Yutaka, additional, Vanassche, Thomas, additional, Verhamme, Peter, additional, Janssens, Stefan, additional, O’Brien, Eoin, additional, Maestre, Gladys E., additional, Staessen, Jan A., additional, Zhang, Zhen-Yu, additional, Seidlerová, J., additional, Tichá, M., additional, Ibsen, H., additional, Jeppesen, J., additional, Rasmussen, S., additional, Torp-Pedersen, C., additional, Pizzioli, A., additional, Hashimoto, J., additional, Hoshi, H., additional, Inoue, R., additional, Metoki, H., additional, Obara, T., additional, Satoh, H., additional, Totsune, K., additional, Adamkiewicz-Piejko, A., additional, Cwynar, M., additional, Gąsowski, J., additional, Grodzicki, T., additional, Lubaszewski, W., additional, Olszanecka, A., additional, Wizner, B., additional, Wojciechowska, W., additional, Zyczkowska, J., additional, Nikitin, Y., additional, Pello, E., additional, Simonova, G., additional, Voevoda, M., additional, Andrén, B., additional, Berglund, L., additional, Björklund-Bodegård, K., additional, Zethelius, B., additional, Bianchi, M., additional, Moreira, V., additional, Schettini, C., additional, Schwedt, E., additional, and Senra, H., additional

Published
2021
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12. Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes

Author

Yang, Wen-Yi, Melgarejo, Jesus D, Thijs, Lutgarde, Zhang, Zhen-Yu, Boggia, Jose, Wei, Fang-Fei, Hansen, Tine W, Asayama, Kei, Ohkubo, Takayoshi, Jeppesen, Jorgen, Dolan, Eamon, Stolarz-Skrzypek, Katarzyna, Malyutina, Sofia, Casiglia, Edoardo, Lind, Lars, Filipovsky, Jan, Maestre, Gladys E, Li, Yan, Wang, Ji-Guang, Imai, Yutaka, Kawecka-Jaszcz, Kalina, Sandoya, Edgardo, Narkiewicz, Krzysztof, O'Brien, Eoin, Verhamme, Peter, Staessen, Jan A, Mujaj, B, Cauwenberghs, N, Kuznetsova, T, Yang, W-Y, Yu, C-G, Sheng, C-S, Huang, Q-F, Seidlerova, J, Ticha, M, Ibsen, H, Rasmussen, S, Torp-Pedersen, C, Pizzioli, A, Tikhonoff, V, Hashimoto, J, Hoshi, H, Inoue, R, Kikuya, M, Metoki, H, Obara, T, Satoh, H, Totsune, K, Gilis-Malinowska, N, Adamkiewicz-Piejko, A, Cwynar, M, Gasowski, J, Grodzicki, T, Lubaszewski, W, Olszanecka, A, Wizner, B, Wojciechowska, W, Zyczkowska, J, Nikitin, Y, Pello, E, Simonova, G, Voevoda, M, Andren, B, Berglund, L, Bjorklund-Bodegard, K, Zethelius, B, Bianchi, M, Moreira, V, Schettini, C, Schwedt, E, Senra, H, RS: CARIM - R3.02 - Hypertension and target organ damage, and RS: Carim - V02 Hypertension and target organ damage

Subjects
Adult, Male, medicine.medical_specialty, Ambulatory blood pressure, PREDICTION, Cost-Benefit Analysis, Population, Blood Pressure, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Medicine, Humans, CORONARY-HEART-DISEASE, 030212 general & internal medicine, Longitudinal Studies, 0101 mathematics, Risk factor, education, International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (IDACO) Investigators, Stroke, Original Investigation, Proportional Hazards Models, RISK, education.field_of_study, HYPERTENSION, business.industry, Proportional hazards model, 010102 general mathematics, Hazard ratio, Blood Pressure Determination, General Medicine, Blood Pressure Monitoring, Ambulatory, Middle Aged, medicine.disease, PREVENTION, Circadian Rhythm, PATTERN, Blood pressure, Cardiovascular Diseases, Cardiology, Female, business, Cohort study
Abstract

IMPORTANCE: Blood pressure (BP) is a known risk factor for overall mortality and cardiovascular (CV)-specific fatal and nonfatal outcomes. It is uncertain which BP index is most strongly associated with these outcomes. OBJECTIVE: To evaluate the association of BP indexes with death and a composite CV event. DESIGN, SETTING, AND PARTICIPANTS: Longitudinal population-based cohort study of 11 135 adults from Europe, Asia, and South America with baseline observations collected from May 1988 to May 2010 (last follow-ups, August 2006-October 2016). EXPOSURES: Blood pressure measured by an observer or an automated office machine; measured for 24 hours, during the day or the night; and the dipping ratio (nighttime divided by daytime readings). MAIN OUTCOMES AND MEASURES: Multivariable-adjusted hazard ratios (HRs) expressed the risk of death or a CV event associated with BP increments of 20/10 mm Hg. Cardiovascular events included CV mortality combined with nonfatal coronary events, heart failure, and stroke. Improvement in model performance was assessed by the change in the area under the curve (AUC). RESULTS: Among 11 135 participants (median age, 54.7 years, 49.3% women), 2836 participants died (18.5 per 1000 person-years) and 2049 (13.4 per 1000 person-years) experienced a CV event over a median of 13.8 years of follow-up. Both end points were significantly associated with all single systolic BP indexes (P

Published
2019

31. Structure and function of large arteries in hypertension in relation to oxidative stress markers.

Author

Klima, L, Kawecka Jaszcz, K, Stolarz Skrzypek, K, Menne, J, Fijorek, K, Olszanecka, A, Wojciechowska, W, Bilo, G, Czarnecka, D, Klima L, Kawecka Jaszcz K, Stolarz Skrzypek K, Menne J, Fijorek K, Olszanecka A, Wojciechowska W, Czarnecka D., BILO, GRZEGORZ, Klima, L, Kawecka Jaszcz, K, Stolarz Skrzypek, K, Menne, J, Fijorek, K, Olszanecka, A, Wojciechowska, W, Bilo, G, Czarnecka, D, Klima L, Kawecka Jaszcz K, Stolarz Skrzypek K, Menne J, Fijorek K, Olszanecka A, Wojciechowska W, Czarnecka D., and BILO, GRZEGORZ

Abstract

Background: The relationship between hypertension and oxidative stress remains unexplained. Nevertheless, it is well established that reactive oxygen species have an influence on the arterial wall, endothelial function and therefore determine blood pressure. Aim: The evaluation of selected oxidative stress markers in hypertensive patients and an assessment of the relationship between oxidative stress markers and the arterial structure and function. We also aimed to investigate whether the influence of oxidative stress on remodelling of arteries, their structural and functional changes is independent of hypertension or is related to hypertension. Methods: Altogether 217 subjects (114 female, 103 male) were enrolled from hypertensive families. The mean age was 45.5 ± 16 years, and the group included 155 hypertensives. In every subject, the pulse wave velocity and intima-media thickness (IMT) in carotid arteries were measured as well as selected oxidative stress markers such as asymmetric dimethylarginin (ADMA), symmetric dimethylarginin (SDMA), advanced oxidation protein products (AOPP) and oxidised low density lipoproteins (ox-LDL). Results: The results of multivariate analysis show that in hypertensive patients: the ADMA level increased with increasing peripheral pulse pressure (b = 0.003; p < 0.001), and AOPP was related to higher carotid IMT (b = 0.91; p = 0.036). In normotensive subjects, the following associations were found: between ADMA and central pulse pressure (b = 0.006; p = 0.008), between SDMA and the peripheral augmentation index (b = -0.03; p = 0.014), between AOPP and the peripheral augmentation index (b = 0.011; p = 0.04), and between ox-LDL/LDL ratio and the peripheral augmentation index (b = -0.025; p = 0.004). The SDMA/ADMA ratio was associated with estimated glomerular filtration rate in both groups (b = -0.0061; p < 0.0001 and b = -0.005; p < 0.017, respectively). In hypertensives, we observed a relation with peripheral pulse pressure (b = -0.00

Published
2013

35. Age dependency of central and peripheral systolic blood pressures: Cross-sectional and longitudinal observations in European populations

Author

Wojciechowska, W, Stolarz Skrzypek, K, Tikhonoff, Valerie, Richart, T, Seidlerová, J, Cwynar, M, Thijs, L, Li, Y, Kuznetsova, T, Filipovský, J, Casiglia, Edoardo, Grodzicki, T, Kawecka Jaszcz, K, O'Rourke, M, Staessen, Ja, On Behalf Of The European Project On Genes In Hypertension Investigators, Epidemiologie, and RS: CARIM School for Cardiovascular Diseases

Subjects
Male, Aging, central blood pressure, Pulsatile flow, Blood Pressure, 030204 cardiovascular system & hematology, 0302 clinical medicine, cardiovascular disease, risk factors, Longitudinal Studies, 030212 general & internal medicine, Age Factors, General Medicine, Middle Aged, Sphygmomanometers, Peripheral, Pulse pressure, Europe, Carotid Arteries, medicine.anatomical_structure, Cardiovascular Diseases, Pulsatile Flow, Cardiology, Female, epidemiology, Cardiology and Cardiovascular Medicine, Adult, medicine.medical_specialty, Systole, Sphygmomanometer, White People, Prehypertension, peripheral blood pressure, 03 medical and health sciences, Sex Factors, Internal medicine, Internal Medicine, medicine, Humans, business.industry, Blood Pressure Determination, Surgery, Cross-Sectional Studies, Blood pressure, ageing, Multivariate Analysis, Vascular resistance, Vascular Resistance, business
Abstract

Background. As arteries become stiffer with ageing, reflected waves move faster and augment late systolic pressure. We investigated the age dependency of peripheral and central systolic pressure, pressure amplification (peripheral systolic blood pressure - central systolic blood pressure), and peripheral and central systolic augmentation (maximal systolic pressure minus the first peak of the pressure wave). Methods. We randomly recruited 1420 White Europeans (mean age, 41.7 years). peripheral systolic blood pressure and central systolic blood pressure were measured by means of an oscillometric sphygmomanometer and pulse wave analysis, respectively. Results. In cross-sectional analyses (731 women, 689 men), central systolic blood pressure and central systolic augmentation increased more with age than peripheral systolic blood pressure and peripheral systolic augmentation. These age-related increases were greater in women than men. The age-related decrease in pressure amplification was similar in both sexes. In longitudinal analyses (208 women, 190 men), the annual increases in central systolic blood pressure and central systolic augmentation were steeper (p < 0.001) than those in peripheral systolic blood pressure and peripheral systolic augmentation with no sex differences (p ≥ 0.068), except for peripheral systolic augmentation, which was larger in women (p = 0.002). Longitudinally, pressure amplification decreased more with age in women than men (p = 0.012). In multivariable-adjusted analyses, age was the overriding determinant of peripheral systolic blood pressure and central systolic blood pressure. Conclusion. With ageing, peripheral systolic blood pressure approximates to central systolic blood pressure. This might explain why in older subjects peripheral systolic blood pressure becomes the main predictor of cardiovascular complications. ispartof: Blood Pressure vol:21 issue:1 pages:58-68 ispartof: location:England status: published

Published
2012

38. PP.19.17

Author

Franczyk, A., primary, Stolarz-Skrzypek, K., additional, Olszanecka, A., additional, Wojciechowska, W., additional, Wesolowska, A., additional, Kawecka-Jaszcz, K., additional, and Czarnecka, D., additional

Published
2015
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39. PP.18.01

Author

Wojciechowska, W., primary, Stolarz-Skrzypek, K., additional, Olszanecka, A., additional, Klima, L., additional, Gasowski, J., additional, Grodzicki, T., additional, and Czarnecka, D., additional

Published
2015
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41. Effects of cardiac resynchronization therapy on sleep apnea, quality of sleep and daytime sleepiness in patients with chronic heart failure

Author

Czarnecka, D., Kusiak, A., Wiliński, J., Styczkiewicz, K., Wojciechowska, W., Bacior, B., Jastrzebski, M., Sondej, T., Malgorzata Kloch, Loster, M., and Kawecka-Jaszcz, K.

Subjects
polysomnography, polisomnografia, niewydolność serca, heart failure, sleep apnea syndromes, zespół bezdechu śródsennego, terapia resynchronizująca, cardiac resynchronization
Published
2010

44. Identification of the hemodynamic modulators and hemodynamic status in uncontrolled hypertensive patients

Author

Viigimaa, M., primary, Talvik, A., additional, Wojciechowska, W., additional, Kawecka-Jaszcz, K., additional, Toft, I., additional, Stergiou, G. S., additional, Nasothimiou, E. G., additional, Kotsis, V., additional, Agabiti Rosei, E., additional, Salvetti, M., additional, Dorobantu, M., additional, Martell-Claros, N., additional, Abad-Cardiel, M., additional, Hernández-Hernández, R., additional, Doménech, M., additional, and Coca, A., additional

Published
2013
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45. Carotid Plaques Correlates in Patients With Familial Hypercholesterolemia.

Author

Waluś-Miarka, Małgorzata, Czarnecka, D., Wojciechowska, W., Kloch-Badełek, M., Kapusta, M., Sanak, M., Wójcik, M., Małecki, M. T., Starzyk, J., and Idzior-Waluś, B.

Subjects
ATHEROSCLEROSIS, CAROTID artery, CONFIDENCE intervals, ENZYME-linked immunosorbent assay, RESEARCH funding, STATISTICS, T-test (Statistics), DATA analysis, DATA analysis software, DESCRIPTIVE statistics, FAMILIAL hypercholesterolemia, ODDS ratio, MANN Whitney U Test
Abstract

Patients with familial hypercholesterolemia (FH) are at increased risk of premature cardiovascular disease. We compared factors associated with the presence of carotid plaques and carotid intima–media thickness (cIMT), markers of subclinical atherosclerosis, in 241 patients with FH (98, 40.7% men; mean age 41 ± 18.4 years). Patients with FH having carotid plaques (36.5%) had mean age, apolipoprotein (apo) B, glucose, apoA1, systolic blood pressure (SBP) and diastolic BP, waist/hip ratio (WHR), and body mass index higher than patients without plaques. Logistic regression revealed that apoB (odds ratio [OR] per 1 unit change 1.03, P = .005), high-density lipoprotein cholesterol (HDL-C; OR per 1 standard deviation [SD] change 0.59, P = .015), and non-HDL-C (OR per 1SD change 1.53, P = .04) were significantly associated with the presence of plaques. The cIMT correlated with obesity parameters, BP, apoB, glucose, high-sensitivity C-reactive protein, creatinine, γ-glutamyl transpeptidase, and alanine transaminase (P < .001). Regression analysis revealed that cIMT was significantly associated with apoB, SBP, and WHR. These results confirm the role of apoB-containing lipoproteins and low HDL-C with the presence of carotid plaques and apoB, BP, and WHR with cIMT. [ABSTRACT FROM AUTHOR]

Published
2016
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47. AGE DEPENDENCY OF CENTRAL AND PERIPHERAL SYSTOLIC BLOOD PRESSURES: CROSS-SECTIONAL AND LONGITUDINAL OBSERVATIONS IN EUROPEAN POPULATIONS

Author

Wojciechowska, W., primary, Stolarz-Skrzypek, K., additional, Tikhonoff, V., additional, Richart, T., additional, Seidlerová, J., additional, Cwynar, M., additional, Thijs, L., additional, Li, Y., additional, Kuznetsova, T., additional, Filipovskú, J., additional, Casiglia, E., additional, Grodzicki, T., additional, Kawecka-Jaszcz, K., additional, OʼRourke, M., additional, and Staessen, J., additional

Published
2011
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