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Objective: Peri-infarct Depolarizations (PIDs) are a type of spreading Depolarization (SD) that has been linked to infarct volume expansion following an ischemic stroke. Therapeutic hypothermia has been found to provide a neuroprotective effect after an ischemic stroke and may improve outcomes. Therefore, [for full text, please go to the a.m. URL]

Objective: In the central nervous system, autoregulation is an adaptive mechanism to maintain a constant perfusion despite changes in blood pressure. In the recent years, studies have shown, that several pathologies like traumatic brain injury, ischemic stroke, or cerebral tumors result in an impaired [for full text, please go to the a.m. URL]

Objective: Since the first description by Nevin and Kiloh the compression syndrome of anterior interosseous nerve has been the subject of controversial discussion. Recently, the use of MR-neurography (MRN) and high-resolution neurosonography (HRNS) spawned the idea of neuritis as only agent causing [for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Navigated pedicle screw placement can be performed using intraoperative computerized tomography (CT) or digital volume tomography (DVT). An additional benefit of using high-resolution intraoperative imaging, such as DVT, is the possibility to immediately assess screw placement with the chance[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Spreading Depolarization (SD) occurs frequently after malignant hemispheric stroke (MHS) and may promote lesion growth. In the experimental setting, several physiologic parameters were shown to influence SD and its features. In this study we analyzed the impact of temperature (T°), intracranial[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Over the last years, endothelial cells (ECs) have come into scientific focus in peripheral nerve research, as they were shown to be a major constituent of the blood-nerve-barrier (BNB) and provide axonal guidance in peripheral nerve regeneration. However, mainly animal models and commercially[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Spreading depolarization (SD) occurs in high frequency in patients with malignant hemispheric stroke (MHS) and is coupled to different hyperaemic or hypoaemic blood flow responses. Body temperature is a major trigger for SDs and influences the accompanied flow coupling. Here, we investigated[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Formerly we characterized the process of spontaneous collateral remodeling (arteriogenesis) in a model of chronic cerebral hypoperfusion. Recent evidence in the field of peripheral artery and coronary heart disease research suggests that this process is accompanied by upregulation of the [for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Recently, we characterized cerebral arteriogenesis in a mouse model of chronic cerebral ischemia. However, proximal vessel occlusion in cerebral hemodynamic compromise is usually caused by atherosclerotic cerebrovascular disease. Here, Apolipoprotein E (ApoE) serves as a main cholesterol [for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Spreading depolarization (SD) occurs in high frequency in patients with malignant hemispheric stroke (MHS) and is coupled either to hyperaemic or hypoaemic blood flow responses. After experimental focal ischaemia SD is a significant cause for secondary stroke progression during the initial[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Developmental venous anomalies (DVAs) are considered to be congenital anatomical variants of venous drainage. In most cases unspecific symptoms lead to their diagnosis. We describe a 35-year-old patient presenting with headache and dizziness. MRI was suspicious for arteriovenous malformation and the dorsal horn of the right lateral ventricle was enlarged. Digital subtraction angiography showed complex venous malformations with abnormal supratentorial venous drainage and bilateral cerebellar DVAs with associated varix nodes. This is a unique case of complex supra- and infratentorial abnormal venous drainage. After considering the complexity of these venous anomalies and the fact that the patient was asymptomatic there was no reasonable indication for treatment.

Objective: The primary objective of this study was to compare the results of two different sacropelvic fixation techniques to conventional stabilization to the sacrum. Our focus were patients with multilevel degenerative spine disease and the need for a multilevel correction and stabilization with a[for full text, please go to the a.m. URL], 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Bone marrow derived endothelial progenitor cells (EPC) contribute to adult blood vessel formation and may play a role in the increased collateral vessel growth seen in patients with coronary artery disease and chronic cerebral hypoperfusion. This might open the venue for future cellular therapies[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Current intraoperative monitoring techniques lack adequate surveillance of cerebral blood flow (CBF). Laser Speckle Imaging (LSI) can be used for non-invasive and direct assessment of cortical perfusion. The purpose of this study was to establish precision rates (positive and negative predictive[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: Laser Speckle Contrast Analysis (LASCA) is the gold standard for intraoperative assessment of relative cortical perfusion. The aim of the present study was to validate LASCA as a tool for real-time assessment of relative cortical perfusion in patients undergoing direct cerebral revascularization.[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: In-hospital lesion progression is a major complication in patients with ischemic stroke. Experimental and clinical research has resulted in potential relief strategies during the early period by clot lysis. However, at later points in time, there is still no treatment option to protect the[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: Cortical Spreading Depolarization (CSD) was measured in close association with delayed ischemic neuronal deficit (DIND) in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, the assumed prime mechanism of DIND is the induction of proximal vasospasm triggered by breakdown products[for full text, please go to the a.m. URL], 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010

Objective: In ordr to investigate alternative strategies of artificial vessel growth, there has been an increased interest in experimental models of chronic cerebral ischemia in transgenic mice. Therefore, we evaluated a reproducible model of chronic cerebral ischemia in C57/BL6 mice. Methods:[for full text, please go to the a.m. URL], 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien

Objective: The linear correlation coefficient of PtiO2 / CPP or ICP / CPP serves as a quantitative index for the status of cerebral autoregulation, yet it is merely a surrogate marker for the true hemodynamic situation best characterized by invasive CBF measurement. Furthermore, the delay [for full text, please go to the a.m. URL], 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien