Search

Your search keyword '"Wohlgemuth, Walter A"' showing total 423 results
Start Over Author "Wohlgemuth, Walter A"
423 results on '"Wohlgemuth, Walter A"'

1. Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition

Author

Kapp, Friedrich G., Bazgir, Farhad, Mahammadzade, Nagi, Mehrabipour, Mehrnaz, Vassella, Erik, Bernhard, Sarah M., Döring, Yvonne, Holm, Annegret, Karow, Axel, Seebauer, Caroline, Platz Batista da Silva, Natascha, Wohlgemuth, Walter A., Oppenheimer, Aviv, Kröning, Pia, Niemeyer, Charlotte M., Schanze, Denny, Zenker, Martin, Eng, Whitney, Ahmadian, Mohammad R., Baumgartner, Iris, and Rössler, Jochen

Published
2024
Full Text
View/download PDF

2. Outcome of bleomycin electrosclerotherapy of slow-flow malformations in adults and children

Author

Schmidt, Vanessa F., Cangir, Özlem, Meyer, Lutz, Goldann, Constantin, Hengst, Susanne, Brill, Richard, von der Heydt, Susanne, Waner, Milton, Puhr-Westerheide, Daniel, Öcal, Osman, Ümütlü, Muzaffer Reha, Mansour, Nabeel, Rudolph, Jan, Sint, Alena, Obereisenbuchner, Florian, Häberle, Beate, Ricke, Jens, Seidensticker, Max, Wohlgemuth, Walter A., and Wildgruber, Moritz

Published
2024
Full Text
View/download PDF

3. Hodgkin lymphoma: hypodense lesions in mediastinal masses

Author

Damek, Adrian, Kurch, Lars, Franke, Friedrich Christian, Attarbaschi, Andishe, Beishuizen, Auke, Cepelova, Michaela, Ceppi, Francesco, Daw, Stephen, Dieckmann, Karin, Fernández-Teijeiro, Ana, Feuchtinger, Tobias, Flerlage, Jamie E., Fosså, Alexander, Georgi, Thomas W., Hasenclever, Dirk, Hraskova, Andrea, Karlen, Jonas, Klekawka, Tomasz, Kluge, Regine, Körholz, Dieter, Landman-Parker, Judith, Leblanc, Thierry, Mauz-Körholz, Christine, Metzler, Markus, Pears, Jane, Steglich, Jonas, Uyttebroeck, Anne, Vordermark, Dirk, Wallace, William Hamish, Wohlgemuth, Walter Alexander, and Stoevesandt, Dietrich

Published
2024
Full Text
View/download PDF

4. Pulmonary lesions in early response assessment in pediatric Hodgkin lymphoma: prevalence and possible implications for initial staging

Author

Stoevesandt, Dietrich, Ludwig, Christiane, Mauz-Körholz, Christine, Körholz, Dieter, Hasenclever, Dirk, McCarten, Kathleen, Flerlage, Jamie E., Kurch, Lars, Wohlgemuth, Walter A., Landman-Parker, Judith, Wallace, William H., Fosså, Alexander, Vordermark, Dirk, Karlén, Jonas, Cepelová, Michaela, Klekawka, Tomasz, Attarbaschi, Andishe, Hraskova, Andrea, Uyttebroeck, Anne, Beishuizen, Auke, Dieckmann, Karin, Leblanc, Thierry, Daw, Stephen, and Steglich, Jonas

Published
2024
Full Text
View/download PDF

6. Prevalence of infectious diseases, immunity to vaccine-preventable diseases and chronic medical conditions among Ukrainian refugees in Germany – A cross sectional study from the German Network University Medicine (NUM)

Author

Brinkmann, Folke, Friedrichs, Anette, Behrens, Georg MN, Behrens, Pia, Berner, Reinhard, Caliebe, Amke, Denkinger, Claudia M., Giesbrecht, Katharina, Gussew, Alexander, Hoffmann, Anna Theresa, Hojenski, Leonhard, Hovardovska, Olga, Dopfer-Jablonka, Alexandra, Kaasch, Achim J., Kobbe, Robin, Kraus, Monika, Lindner, Andreas, Maier, Christoph, Mitrov, Lazar, Nauck, Matthias, de Miranda, Susana Nunes, Scherer, Margarete, Schmiedel, Yvonne, Stahl, Dana, Timmesfeld, Nina, Toepfner, Nicole, Vehreschild, Janne, Wohlgemuth, Walter A., Petersmann, Astrid, and Vehreschild, Maria J.G.T.

Published
2024
Full Text
View/download PDF

8. Bleomycin electrosclerotherapy (BEST) for the treatment of vascular malformations. An International Network for Sharing Practices on Electrochemotherapy (InspECT) study group report

Author

Muir Tobian, Bertino Giulia, Groselj Ales, Ratnam Lakshmi, Kis Erika, Odili Joy, McCafferty Ian, Wohlgemuth Walter A, Cemazar Maja, Krt Aljosa, Bosnjak Masa, Zanasi Alessandro, Battista Michela, de Terlizzi Francesca, Campana Luca G, and Sersa Gregor

Subjects
vascular malformations, bleomycin electrosclerotherapy, bleomycin, electrochemotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Biomedical applications of electroporation are expanding out of the field of oncology into vaccination, treatment of arrhythmias and now in the treatment of vascular malformations. Bleomycin is a widely used sclerosing agent in the treatment of various vascular malformations. The application of electric pulses in addition to bleomycin enhances the effectiveness of the drug, as demonstrated by electrochemotherapy, which utilizes bleomycin in the treatment of tumors. The same principle is used in bleomycin electrosclerotherapy (BEST). The approach seems to be effective in the treatment of low-flow (venous and lymphatic) and, potentially, even high-flow (arteriovenous) malformations. Although there are only a few published reports to date, the surgical community is interested, and an increasing number of centers are applying BEST in the treatment of vascular malformations. Within the International Network for Sharing Practices on Electrochemotherapy (InspECT) consortium, a dedicated working group has been constituted to develop standard operating procedures for BEST and foster clinical trials.

Published
2023
Full Text
View/download PDF

9. Clinical Outcome and Quality of Life of Multimodal Treatment of Extracranial Arteriovenous Malformations: The APOLLON Study Protocol

Author

Schmidt, Vanessa F., Masthoff, Max, Vielsmeier, Veronika, Seebauer, Caroline T., Cangir, Özlem, Meyer, Lutz, Mükke, Antje, Lang, Werner, Schmid, Axel, Sporns, Peter B., Brill, Richard, Wohlgemuth, Walter A., da Silva, Natascha Platz Batista, Seidensticker, Max, Schinner, Regina, Küppers, Julia, Häberle, Beate, Haubner, Frank, Ricke, Jens, Zenker, Martin, Kimm, Melanie A., and Wildgruber, Moritz

Published
2023
Full Text
View/download PDF

10. Image-Guided Embolotherapy of Arteriovenous Malformations of the Face

Author

Schmidt, Vanessa F., Masthoff, Max, Brill, Richard, Sporns, Peter B., Köhler, Michael, Schulze-Zachau, Victor, Takes, Martin, Ehrl, Denis, Puhr-Westerheide, Daniel, Kunz, Wolfgang G., Shemwetta, Mwivano Dunstan, Mbuguje, Eric M., Naif, Azza A., Sarkar, Abizer, Ricke, Jens, Seidensticker, Max, Wohlgemuth, Walter A., and Wildgruber, Moritz

Published
2022
Full Text
View/download PDF

23. Hodgkin lymphoma:hypodense lesions in mediastinal masses

Author

Damek, Adrian, Kurch, Lars, Franke, Friedrich Christian, Attarbaschi, Andishe, Beishuizen, Auke, Cepelova, Michaela, Ceppi, Francesco, Daw, Stephen, Dieckmann, Karin, Fernández-Teijeiro, Ana, Feuchtinger, Tobias, Flerlage, Jamie E., Fosså, Alexander, Georgi, Thomas W., Hasenclever, Dirk, Hraskova, Andrea, Karlen, Jonas, Klekawka, Tomasz, Kluge, Regine, Körholz, Dieter, Landman-Parker, Judith, Leblanc, Thierry, Mauz-Körholz, Christine, Metzler, Markus, Pears, Jane, Steglich, Jonas, Uyttebroeck, Anne, Vordermark, Dirk, Wallace, William Hamish, Wohlgemuth, Walter Alexander, Stoevesandt, Dietrich, Damek, Adrian, Kurch, Lars, Franke, Friedrich Christian, Attarbaschi, Andishe, Beishuizen, Auke, Cepelova, Michaela, Ceppi, Francesco, Daw, Stephen, Dieckmann, Karin, Fernández-Teijeiro, Ana, Feuchtinger, Tobias, Flerlage, Jamie E., Fosså, Alexander, Georgi, Thomas W., Hasenclever, Dirk, Hraskova, Andrea, Karlen, Jonas, Klekawka, Tomasz, Kluge, Regine, Körholz, Dieter, Landman-Parker, Judith, Leblanc, Thierry, Mauz-Körholz, Christine, Metzler, Markus, Pears, Jane, Steglich, Jonas, Uyttebroeck, Anne, Vordermark, Dirk, Wallace, William Hamish, Wohlgemuth, Walter Alexander, and Stoevesandt, Dietrich

Abstract

Hypodense volumes (HDV) in mediastinal masses can be visualized in a computed tomography scan in Hodgkin lymphoma. We analyzed staging CT scans of 1178 patients with mediastinal involvement from the EuroNet-PHL-C1 trial and explored correlations of HDV with patient characteristics, mediastinal tumor volume and progression-free survival. HDV occurred in 350 of 1178 patients (29.7%), typically in larger mediastinal volumes. There were different patterns in appearance with single lesions found in 243 patients (69.4%), multiple lesions in 107 patients (30.6%). Well delineated lesions were found in 248 cases (70.1%), diffuse lesions were seen in 102 cases (29.1%). Clinically, B symptoms occurred more often in patients with HDV (47.7% compared to 35.0% without HDV (p = 0.039)) and patients with HDV tended to be in higher risk groups. Inadequate overall early-18F-FDG-PET-response was strongly correlated with the occurrence of hypodense lesions (p < 0.001). Patients with total HDV > 40 ml (n = 80) had a 5 year PFS of 79.6% compared to 89.7% (p = 0.01) in patients with HDV < 40 ml or no HDV. This difference in PFS is not caused by treatment group alone. HDV is a common phenomenon in HL with mediastinal involvement.

Published
2024

32. Deep learning-based differentiation of peripheral high-flow and low-flow vascular malformations in T2-weighted short tau inversion recovery MRI.

Author

Hammer, Simone, Nunes, Danilo Weber, Hammer, Michael, Zeman, Florian, Akers, Michael, Götz, Andrea, Balla, Annika, Doppler, Michael Christian, Fellner, Claudia, Platz Batista da Silva, Natascha, Thurn, Sylvia, Verloh, Niklas, Stroszczynski, Christian, Wohlgemuth, Walter Alexander, Palm, Christoph, and Uller, Wibke

Subjects
CONVOLUTIONAL neural networks, HUMAN abnormalities, MAGNETIC resonance imaging, RARE diseases
Abstract

BACKGROUND: Differentiation of high-flow from low-flow vascular malformations (VMs) is crucial for therapeutic management of this orphan disease. OBJECTIVE: A convolutional neural network (CNN) was evaluated for differentiation of peripheral vascular malformations (VMs) on T2-weighted short tau inversion recovery (STIR) MRI. METHODS: 527 MRIs (386 low-flow and 141 high-flow VMs) were randomly divided into training, validation and test set for this single-center study. 1) Results of the CNN's diagnostic performance were compared with that of two expert and four junior radiologists. 2) The influence of CNN's prediction on the radiologists' performance and diagnostic certainty was evaluated. 3) Junior radiologists' performance after self-training was compared with that of the CNN. RESULTS: Compared with the expert radiologists the CNN achieved similar accuracy (92% vs. 97%, p = 0.11), sensitivity (80% vs. 93%, p = 0.16) and specificity (97% vs. 100%, p = 0.50). In comparison to the junior radiologists, the CNN had a higher specificity and accuracy (97% vs. 80%, p < 0.001; 92% vs. 77%, p < 0.001). CNN assistance had no significant influence on their diagnostic performance and certainty. After self-training, the junior radiologists' specificity and accuracy improved and were comparable to that of the CNN. CONCLUSIONS: Diagnostic performance of the CNN for differentiating high-flow from low-flow VM was comparable to that of expert radiologists. CNN did not significantly improve the simulated daily practice of junior radiologists, self-training was more effective. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

33. Incorporating a-priori information in deep learning models for quantitative susceptibility mapping via adaptive convolution.

Author

Graf, Simon, Wohlgemuth, Walter A., and Deistung, Andreas

Abstract

Quantitative susceptibility mapping (QSM) has attracted considerable interest for tissue characterization (e.g., iron and calcium accumulation, myelination, venous vasculature) in the human brain and relies on extensive data processing of gradient-echo MRI phase images. While deep learning-based field-tosusceptibility inversion has shown great potential, the acquisition parameters applied in clinical settings such as image resolution or image orientation with respect to the magnetic field have not been fully accounted for. Furthermore, the lack of comprehensive training data covering a wide range of acquisition parameters further limits the current QSM deep learning approaches. Here, we propose the integration of a priori information of imaging parameters into convolutional neural networks with our approach, adaptive convolution, that learns the mapping between the additional presented information (acquisition parameters) and the changes in the phase images associated with these varying acquisition parameters. By associating a-priori information with the network parameters itself, the optimal set of convolution weights is selected based on data-specific attributes, leading to generalizability towards changes in acquisition parameters. Moreover, we demonstrate the feasibility of pretraining on synthetic data and transfer learning to clinical brain data to achieve substantial improvements in the computation of susceptibility maps. The adaptive convolution 3D U-Net demonstrated generalizability in acquisition parameters on synthetic and in-vivo data and outperformed models lacking adaptive convolution or transfer learning. Further experiments demonstrate the impact of the side information on the adaptive model and assessed susceptibility map computation on simulated pathologic data sets and measured phase data. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

36. Somatic RIT1 indels identified in arteriovenous malformations hyperactivate RAS-MAPK signaling and are amenable to MEK inhibition

Author

Kapp, Friedrich G, primary, Bazgir, Farhad, additional, Mahammadzade, Nagi, additional, Vassella, Erik, additional, Doring, Yvonne, additional, Holm, Annegret, additional, Karow, Axel, additional, Seebauer, Caroline, additional, Platz Batista da Silva, Natascha, additional, Wohlgemuth, Walter A, additional, Kroning, Pia, additional, Niemeyer, Charlotte M, additional, Schanze, Denny, additional, Zenker, Martin, additional, Eng, Whitney, additional, Ahmadian, Mohammad Reza, additional, Baumgartner, Iris, additional, and Roessler, Jochen, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results