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21 results on '"Wodzak, Michelle"'

4. Is Initiating NOACs for Atrial Arrhythmias Safe in Adults with Congenital Heart Disease?

Author

Yang, Hayang, Bouma, Berto J., Mulder, Barbara J M, Heidendael, J. F., Veen, G., Konings, Thelma C, Sieswerda, G. T.J., Meijboom, F. J., Post, M. C., van Dijk, A., Budts, W., Morissens, M., Ladouceur-Wodzak, Michelle, Tobler, D., Schwerzmann, M., Rutz, T., Bouchardy, J., Greutmann, M., Scognamiglio, G., Skoglund, K., Christersson, C., Gumbiene, L., Laukyte, M., Khairy, P., Aboulhosn, J., Veldtman, G., Webb, G., Broberg, C. S., Opotowsky, A. R., Shafer, K., Tsai, S. F., Moe, T., Niwa, K., Mizuno, A., Cardiology, ACS - Heart failure & arrhythmias, ACS - Atherosclerosis & ischemic syndromes, University of Zurich, Mulder, Barbara J M, Gumbienė, Lina, Laukytė, M., ACS - Amsterdam Cardiovascular Sciences, APH - Personalized Medicine, APH - Aging & Later Life, Other departments, and ACS - Pulmonary hypertension & thrombosis

Subjects
Male, Congenital heart disease, Atrial arrhythmia, Anticoagulation, Non vitamin K antagonist oral anticoagulant, Heart disease, Administration, Oral, 030204 cardiovascular system & hematology, 0302 clinical medicine, 2736 Pharmacology (medical), Medicine, Pharmacology (medical), 030212 general & internal medicine, Prospective Studies, Registries, Prospective cohort study, Thromboembolic event, General Medicine, Middle Aged, 3004 Pharmacology, 10209 Clinic for Cardiology, Cardiology, Registry data, Female, Cardiology and Cardiovascular Medicine, Major bleeding, Adult, Heart Defects, Congenital, medicine.medical_specialty, Short Communication, 610 Medicine & health, Hemorrhage, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, Internal medicine, Thromboembolism, Humans, In patient, cardiovascular diseases, Adverse effect, Pharmacology, business.industry, Bleeding, Anticoagulants, Arrhythmias, Cardiac, Atrial arrhythmias, medicine.disease, Observational study, business
Abstract

Background In recent years, non-vitamin K antagonist (VKA) oral anticoagulants (NOACs) have been increasingly prescribed to adults with congenital heart disease (CHD) and atrial arrhythmias without good evidence for either safety or efficacy. To address this gap, we initiated an ongoing prospective global registry (NOTE: non-vitamin K antagonist oral anticoagulants for thromboembolic prevention in patients with congenital heart disease). Using the NOTE registry data, the present study aimed to evaluate the occurrence of any adverse events during the initiation phase (first 30 days) of NOACs in adults with CHD and atrial arrhythmias. Methods and Results For this prospective observational study, 99 adults with CHD and atrial arrhythmias (median age 49 years [IQR 38-61], 53% male) who initiated NOACs at or after the inclusion point were analysed. Thromboembolic events, major bleeding and other minor adverse events were assessed after the first 30 days since the initiation of NOACs. In 54 patients transitioning from VKA to NOACs, 8 minor adverse events (5 minor bleeding; 3 side-effects; 1 drop-out due to minor bleeding) occurred within 30 days after the transition. No adverse events were reported in 46 VKA-naive patients within 30 days after the initiation of NOACs. Conclusions Initiation of NOACs and transition from VKA to NOACs seem to be safe during the first month, without major adverse events and with only limited minor side effects in adults with CHD and atrial arrhythmias. This global ongoing prospective registry enables precise collection of important clinical information in real-world adults with CHD, managed with NOACs. Electronic supplementary material The online version of this article (doi:10.1007/s10557-017-6745-y) contains supplementary material, which is available to authorized users.

Published
2017

5. Is Initiating NOACs for Atrial Arrhythmias Safe in Adults with Congenital Heart Disease?

Author

Team Medisch, Circulatory Health, Cardiologie, Cardiologie patientenzorg, Yang, Hayang, Bouma, Berto J., Mulder, Barbara J M, Heidendael, J. F., Veen, G., Konings, Thelma C, Sieswerda, G. T.J., Meijboom, F. J., Post, M. C., van Dijk, A., Budts, W., Morissens, M., Ladouceur-Wodzak, Michelle, Tobler, D., Schwerzmann, M., Rutz, T., Bouchardy, J., Greutmann, M., Scognamiglio, G., Skoglund, K., Christersson, C., Gumbiene, L., Laukyte, M., Khairy, P., Aboulhosn, J., Veldtman, G., Webb, G., Broberg, C. S., Opotowsky, A. R., Shafer, K., Tsai, S. F., Moe, T., Niwa, K., Mizuno, A., On behalf of The Non vitamin K antagonist Oral anticoagulants for ThromboEmbolic prevention in adult congenital heart disease (NOTE) investigators, Team Medisch, Circulatory Health, Cardiologie, Cardiologie patientenzorg, Yang, Hayang, Bouma, Berto J., Mulder, Barbara J M, Heidendael, J. F., Veen, G., Konings, Thelma C, Sieswerda, G. T.J., Meijboom, F. J., Post, M. C., van Dijk, A., Budts, W., Morissens, M., Ladouceur-Wodzak, Michelle, Tobler, D., Schwerzmann, M., Rutz, T., Bouchardy, J., Greutmann, M., Scognamiglio, G., Skoglund, K., Christersson, C., Gumbiene, L., Laukyte, M., Khairy, P., Aboulhosn, J., Veldtman, G., Webb, G., Broberg, C. S., Opotowsky, A. R., Shafer, K., Tsai, S. F., Moe, T., Niwa, K., Mizuno, A., and On behalf of The Non vitamin K antagonist Oral anticoagulants for ThromboEmbolic prevention in adult congenital heart disease (NOTE) investigators

Published
2017

7. Targeted antibiotic delivery using low temperature-sensitive liposomes and magnetic resonance-guided high-intensity focused ultrasound hyperthermia

Author

Wardlow, Rachel, primary, Bing, Chenchen, additional, VanOsdol, Joshua, additional, Maples, Danny, additional, Ladouceur-Wodzak, Michelle, additional, Harbeson, Michele, additional, Nofiele, Joris, additional, Staruch, Robert, additional, Ramachandran, Akhilesh, additional, Malayer, Jerry, additional, Chopra, Rajiv, additional, and Ranjan, Ashish, additional

Published
2016
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8. Metabolic Heterogeneity in Human Lung Tumors

Author

Hensley, Christopher T., primary, Faubert, Brandon, additional, Yuan, Qing, additional, Lev-Cohain, Naama, additional, Jin, Eunsook, additional, Kim, Jiyeon, additional, Jiang, Lei, additional, Ko, Bookyung, additional, Skelton, Rachael, additional, Loudat, Laurin, additional, Wodzak, Michelle, additional, Klimko, Claire, additional, McMillan, Elizabeth, additional, Butt, Yasmeen, additional, Ni, Min, additional, Oliver, Dwight, additional, Torrealba, Jose, additional, Malloy, Craig R., additional, Kernstine, Kemp, additional, Lenkinski, Robert E., additional, and DeBerardinis, Ralph J., additional

Published
2016
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10. Non-Invasive Targeted Peripheral Nerve Ablation Using 3D MR Neurography and MRI-Guided High-Intensity Focused Ultrasound (MR-HIFU): Pilot Study in a Swine Model

Author

Arts-assistenten Radiologie, Cancer, MS Radiologie, Huisman, Merel, Staruch, Robert M, Ladouceur-Wodzak, Michelle, van den Bosch, Maurice A, Burns, Dennis K, Chhabra, Avneesh, Chopra, Rajiv, Arts-assistenten Radiologie, Cancer, MS Radiologie, Huisman, Merel, Staruch, Robert M, Ladouceur-Wodzak, Michelle, van den Bosch, Maurice A, Burns, Dennis K, Chhabra, Avneesh, and Chopra, Rajiv

Published
2015

12. Distal coronary embolization following acute myocardial infarction increases early infarct size and late left ventricular wall thinning in a porcine model

Author

Thomas, Reuben M., primary, Lim, Sang Yup, additional, Qiang, Beiping, additional, Osherov, Azriel B., additional, Ghugre, Nilesh R., additional, Noyan, Hossein, additional, Qi, Xiuling, additional, Wolff, Rafael, additional, Ladouceur-Wodzak, Michelle, additional, Berk, Thomas A., additional, Butany, Jagdish, additional, Husain, Mansoor, additional, Wright, Graham A., additional, and Strauss, Bradley H., additional

Published
2015
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17. Unexpected calcification after direct intravascular injection of autologous bone marrow-derived cells in a chronic total occlusion model

Author

Nili, Nafiseh, primary, Lim, Sang Yup, additional, Qiang, Beiping, additional, Qi, Xiuling, additional, Weisbrod, Max J., additional, Ladouceur-Wodzak, Michelle, additional, Gofine, Naomi, additional, Berk, Thomas A., additional, Saperia, Jamie, additional, Wright, Graham A., additional, and Strauss, Bradley H., additional

Published
2014
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18. Therapeutic angiogenesis with VEGF164 for facilitation of guidewire crossing in experimental arterial chronic total occlusions

Author

Teitelbaum, Aaron A., primary, Qi, Xiuling, additional, Osherov, Azriel B., additional, Fraser, Ashley R., additional, Ladouceur-Wodzak, Michelle, additional, Munce, Nigel, additional, Qiang, Beiping, additional, Weisbrod, Max, additional, Bierstone, Daniel, additional, Erlich, Ilana, additional, Sparkes, John D., additional, Wright, Graham A., additional, and Strauss, Bradley H., additional

Published
2013
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19. Characterisation of a novel porcine coronary artery CTO model

Author

Fefer, Paul, primary, Robert, Normand, additional, Qiang, Beiping, additional, Liu, Garry, additional, Munce, Nigel, additional, Anderson, Kevan, additional, Osherov, Azriel, additional, Ladouceur-Wodzak, Michelle, additional, Qi, Xiuling, additional, Dick, Alexander, additional, Weisbrod, Max, additional, Samuel, Michelle, additional, Butany, Jagdish, additional, Wright, Graham, additional, and Strauss, Bradley, additional

Published
2012
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20. Inhibition of intimal hyperplasia after stenting by over-expression of p15: A member of the INK4 family of cyclin-dependent kinase inhibitors

Author

Segev, Amit, primary, Nili, Nafiseh, additional, Qiang, Beiping, additional, Osherov, Azriel B., additional, Giordano, Frank J., additional, Jaffe, Ronen, additional, Gauldie, Jack, additional, Sparkes, John D., additional, Fraser, Ashley R., additional, Ladouceur-Wodzak, Michelle, additional, Butany, Jagdish, additional, and Strauss, Bradley H., additional

Published
2011
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21. Trans-cranial opening of the blood-brain barrier in targeted regions using a stereotaxic brain atlas and focused ultrasound energy.

Author

Bing C, Ladouceur-Wodzak M, Wanner CR, Shelton JM, Richardson JA, and Chopra R

Abstract

Objective: The blood-brain barrier (BBB) protects the brain by preventing the entry of large molecules; this poses a major obstacle for the delivery of drugs to the brain. A novel technique using focused ultrasound (FUS) energy combined with microbubble contrast agents has been widely used for non-invasive trans-cranial BBB opening. Traditionally, FUS research is conducted with magnetic resonance imaging (MRI) guidance, which is expensive and poses physical limitations due to the magnetic field. A system that could allow researchers to test brain therapies without MR intervention could facilitate and accelerate translational research., Methods: In this study, we present a novel FUS system that uses a custom-built FUS generator mounted on a motorized stereotaxic apparatus with embedded brain atlas to locally open the BBB in rodents. The system was initially characterized using a tissue-mimicking phantom. Rodent studies were also performed to evaluate whether non-invasive, localized BBB opening could be achieved using brain atlas-based targeting. Brains were exposed to pulsed focused ultrasound energy at 1.06 MHz in rats and 3.23 MHz in mice, with the focal pressure estimated to be 0.5-0.6 MPa through the skull. BBB opening was confirmed in gross tissue sections by the presence of Evans blue leakage in the exposed region of the brain and by histological assessment., Results: The targeting accuracy of the stereotaxic system was better than 0.5 mm in the tissue-mimicking phantom. Reproducible localized BBB opening was verified with Evans blue dye leakage in 32/33 rats and had a targeting accuracy of ±0.3 mm. The use of higher frequency exposures in mice enabled a similar precision of localized BBB opening as was observed with the low frequency in the rat model., Conclusions: With this dedicated small-animal motorized stereotaxic-FUS system, we achieved accurate targeting of focused ultrasound exposures in the brain for non-invasive opening of the BBB. This system can be used as an alternative to MR-guided FUS and offers researchers the ability to perform efficient studies (30 min per experiment including preparation) at a reduced cost in a conventional laboratory environment.

Published
2014
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