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400 results on '"Woźniak, Agnieszka"'

5. Machine learning for rhabdomyosarcoma histopathology

Author

Frankel, Arthur O., Lathara, Melvin, Shaw, Celine Y., Wogmon, Owen, Jackson, Jacob M., Clark, Mattie M., Eshraghi, Navah, Keenen, Stephanie E., Woods, Andrew D., Purohit, Reshma, Ishi, Yukitomo, Moran, Nirupama, Eguchi, Mariko, Ahmed, Farhat Ul Ain, Khan, Sara, Ioannou, Maria, Perivoliotis, Konstantinos, Li, Pin, Zhou, Huixia, Alkhaledi, Ahmad, Davis, Elizabeth J., Galipeau, Danielle, Randall, R.L., Wozniak, Agnieszka, Schoffski, Patrick, Lee, Che-Jui, Huang, Paul H., Jones, Robin L., Rubin, Brian P., Darrow, Morgan, Srinivasa, Ganapati, Rudzinski, Erin R., Chen, Sonja, Berlow, Noah E., and Keller, Charles

Published
2022
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6. The Effects of Lead and Cross-Talk Between Lead and Pea Aphids on Defence Responses of Pea Seedlings.

Author

Morkunas, Iwona, Woźniak, Agnieszka, Bednarski, Waldemar, Ostrowski, Adam, Kęsy, Jacek, Glazińska, Paulina, Wojciechowska, Julia, Bocianowski, Jan, Rucińska-Sobkowiak, Renata, Mai, Van Chung, Karolewski, Zbigniew, Labudda, Mateusz, Batista, Anielkis, and Jeandet, Philippe

Subjects
*PEA aphid, *ABSCISIC acid, *LEAD, *SALICYLIC acid, *JASMONIC acid, *PEAS
Abstract

The main goal of this study was to investigate the effect of lead (Pb) at various concentrations, as an abiotic factor, and the cross-talk between Pb and pea aphid (Acyrthosiphon pisum (Harris)) (Hemiptera: Aphididae), as a biotic factor, on the defence responses of pea seedlings (Pisum sativum L. cv. Cysterski). The analysis of growth parameters for pea seedlings demonstrated that Pb at a low concentration, i.e., 0.025–0.0625 mM Pb(NO3)2, caused a hormesis effect, i.e., stimulation of seedling growth, whereas Pb at higher concentrations, i.e., 0.01–0.325 mM Pb(NO3)2, inhibited growth, which manifested as the inhibition of length and fresh biomass. The differences in the level of the main defence-related phytohormones, such as abscisic acid (ABA), jasmonic acid (JA) and salicylic acid (SA), and indole-3-acetic acid (IAA)—an auxin stimulating plant cell growth—depended on the dose of Pb, aphid infestation and direct contact of the stress factor with the organ. A high accumulation of soluble sugars in the organs of pea seedlings both at sublethal doses and hormetic doses at early experimental time points was observed. At 0 h and 24 h of the experiment, the hormetic doses of Pb significantly stimulated invertase activities, especially in the roots. Moreover, an increase was observed in the pisatin concentration in pea seedlings growing in the presence of different concentrations of Pb and in the case of cross-talk between Pb and A. pisum in relation to the control. Additionally, a significant induction of the expressions of isoflavone synthase (IFS) and 6α-hydroxymaackiain 3-O-methyltransferase (HMM) genes, which participate in the regulation of the pisatin biosynthesis pathway, in pea seedlings growing under the influence of sublethal 0.5 mM Pb(NO3)2 and hormetic 0.075 mM Pb(NO3)2 doses of Pb was noted. The obtained results showed that the response of P. sativum seedlings depends on the Pb dose applied, direct contact of the stress factor with the organ and the duration of contact. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Long-term efficacy update of crizotinib in patients with advanced, inoperable inflammatory myofibroblastic tumour from EORTC trial 90101 CREATE

Author

Schöffski, Patrick, Kubickova, Michaela, Wozniak, Agnieszka, Blay, Jean-Yves, Strauss, Sandra J., Stacchiotti, Silvia, Switaj, Tomasz, Bücklein, Veit, Leahy, Michael G., Italiano, Antoine, Isambert, Nicolas, Debiec-Rychter, Maria, Sciot, Raf, Lee, Che-Jui, Speetjens, Frank M., Nzokirantevye, Axelle, Neven, Anouk, and Kasper, Bernd

Published
2021
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11. Randomised phase 2 study comparing the efficacy and safety of the oral tyrosine kinase inhibitor nintedanib with single agent ifosfamide in patients with advanced, inoperable, metastatic soft tissue sarcoma after failure of first-line chemotherapy: EORTC-1506-STBSG “ANITA”

Author

Schöffski, Patrick, Toulmonde, Maud, Estival, Anna, Marquina, Gloria, Dudzisz-Śledź, Monika, Brahmi, Mehdi, Steeghs, Neeltje, Karavasilis, Vasilios, de Haan, Jacco, Wozniak, Agnieszka, Cousin, Sophie, Domènech, Marta, Bovée, Judith V.M.G., Charon-Barra, Céline, Marreaud, Sandrine, Litière, Saskia, De Meulemeester, Laura, Olungu, Christine, and Gelderblom, Hans

Published
2021
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12. Fish Consumption Frequency in the Adult Population in Poland.

Author

Stoś, Katarzyna, Woźniak, Agnieszka, Rychlik, Ewa, and Ołtarzewski, Maciej

Subjects
MARINE fishes, OMEGA-3 fatty acids, SALTWATER fishing, FRESHWATER fishes, SOCIOECONOMIC factors
Abstract

Fish provide energy, protein, and other important nutrients, including n-3 fatty acids, vitamin D, and iodine. However, some species of fish could contain contaminants such as mercury and dioxins. The aim of the study was to assess the frequency of fish consumption in Poland, including of sea and freshwater fish species, referring to some socio-economic determinants. The frequency of consumption was assessed using Food Propensity Questionnaire data from 1489 adults (722 males, 767 females) in 2019–2020. The fish consumption frequency in Polish adults was lower than the recommendation (at least twice a week). About 80% of respondents consumed fish less frequently than recommended. Sea fish were mostly consumed less than once a month (31.8%) or 1–3 times a month (30.9%). Most subjects (44.8%) consumed freshwater fish less than once a month. Consumption also depended educational level, economic status, place of residence, declared health status, and BMI value or BMI status. However, taking into account sex, the occurrence of these relationships was different between men and women. It seems that educational activities and dissemination of proper nutrition principles is necessary in order to increase the consumption of fish in Poland. It is important to emphasize the health benefits of fish consumption in relation to the possible adverse effects of their contamination. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Activity and safety of the multi-target tyrosine kinase inhibitor cabozantinib in patients with metastatic gastrointestinal stromal tumour after treatment with imatinib and sunitinib: European Organisation for Research and Treatment of Cancer phase II trial 1317 ‘CaboGIST’

Author

Schöffski, Patrick, Mir, Olivier, Kasper, Bernd, Papai, Zsuzsanna, Blay, Jean-Yves, Italiano, Antoine, Benson, Charlotte, Kopeckova, Katerina, Ali, Nasim, Dileo, Palma, LeCesne, Axel, Menge, Franka, Cousin, Sophie, Wardelmann, Eva, Wozniak, Agnieszka, Marreaud, Sandrine, Litiere, Saskia, Zaffaroni, Facundo, Nzokirantevye, Axelle, Vanden Bempt, Isabelle, and Gelderblom, Hans

Published
2020
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18. Clear-cell Renal Cell Carcinoma: Molecular Characterization of IMDC Risk Groups and Sarcomatoid Tumors

Author

Verbiest, Annelies, Renders, Inne, Caruso, Stefano, Couchy, Gabrielle, Job, Sylvie, Laenen, Annouschka, Verkarre, Virginie, Rioux-Leclercq, Nathalie, Schöffski, Patrick, Vano, Yann, Elaidi, Reza-Thierry, Lerut, Evelyne, Albersen, Maarten, Oudard, Stéphane, Fridman, Wolf-Hervé, Sautès-Fridman, Catherine, Albigès, Laurence, Wozniak, Agnieszka, Zucman-Rossi, Jessica, and Beuselinck, Benoit

Published
2019
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24. OxLDL as a prognostic biomarker of plaque instability in patients qualified for carotid endarterectomy.

Author

Woźniak, Agnieszka, Satała, Joanna, Gorzelak‐Pabiś, Paulina, Pawlos, Agnieszka, Broncel, Marlena, Kaźmierski, Piotr, and Woźniak, Ewelina

Subjects
ATHEROSCLEROTIC plaque, CAROTID endarterectomy, LDL cholesterol, MATRIX metalloproteinases, REGRESSION analysis
Abstract

Atherosclerotic plaque instability increases the risk of stroke. As such, determining the nature of an instability atherosclerotic plaque may speed up qualification for carotid endarterectomy (CEA), thus reducing the risk of acute vascular events. The aim of the study was to determine the diagnostic value of oxidized LDL cholesterol (ox‐LDL), matrix metalloproteinase 9 (MMP‐9) and 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) in serum as a prognostic markers of instability atherosclerotic plaques. Serum was collected from 67 patients who underwent CEA in accordance with the qualification criteria. The levels of ox‐LDL, MMP‐9 and 8‐OHdG were assessed by ELISA. The predictive value of the markers was determined based on an ROC curve, and the cut‐off points with the highest sensitivity and specificity were determined. Patients with unstable atherosclerotic plaque had significantly higher serum ox‐LDL, MMP‐9 and 8‐OHdG values. It was found that in patients before CEA, ox‐LDL >31.4 ng/mL was associated with an 82.5% probability of unstable atherosclerotic plaque, MMP‐9 >113.1 ng/mL with 78.6%, and 8‐OHdG >2.15 ng/mL with 64.7%. Multivariate regression analysis found ox‐LDL to be an independent factor associated with plaque instability. Patients with unstable plaques tend to have higher serum levels of ox‐LDL, MMP‐9 and 8‐OHdG compared to those with stable plaques. The optimal cut‐off point for ox‐LDL (AUC 0.86, p <0.0001) was 31.14 ng/mL, with 91.18% sensitivity and 78.79% specificity. The high sensitivity and specificity of ox‐LDL suggests that it can be used as an independent marker of plaque instability. [ABSTRACT FROM AUTHOR]

Published
2024
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25. The impact of local wind and spatial conditions on geometry blade of wind turbine.

Author

Woźniak, Agnieszka, Kluczek, Aldona, Ślusarczyk, Bogusław, Żegleń, Patrycja, and Górka, Małgorzata

Subjects
*WIND turbine blades, *PROPELLERS, *WIND shear, *ENERGY development, *WIND power, *ENERGY consumption, *WIND turbines, *BAND gaps
Abstract

The research addresses the pressing need to understand wind conditions for optimal wind energy utilization, a crucial aspect of achieving global energy sustainability. While previous studies have focused on assessing wind energy potential and terrain roughness, gaps persist in understanding how wind and spatial conditions affect blade geometry. Therefore, this study aims to investigate the impact of local wind conditions on wind turbine blade geometry, integrating nonuniform wind inflow due to wind shear into the theoretical model. Through the paper, it explores blade design for varying inflow conditions and analyses the relationship between terrain type and blade designs. A novel approach to wind turbine blade design, utilizing a theoretical model that combines the local momentum theorem with insights from propeller vortex theory was adopted. Through the analysis, the authors demonstrate that variations in terrain significantly influence blade geometry, underscoring the necessity for tailored turbine designs based on local conditions. The findings reveal discrepancies in blade geometry across different turbine capacities and terrain types, offering novel insights into wind turbine performance optimization. By tailoring blade geometry to specific locations enhances resource utilization, offering insights for energy policymakers. The research provides validated methods for optimizing turbine geometric parameters, opening avenues for increased local investment in wind energy and promoting distributed energy development. Illustrated with wind plants examples, the paper concludes by outlining future research directions in this field. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Polymorphisms in the Von Hippel–Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors

Author

Verbiest, Annelies, Lambrechts, Diether, Van Brussel, Thomas, Couchy, Gabrielle, Wozniak, Agnieszka, Méjean, Arnaud, Lerut, Evelyne, Oudard, Stéphane, Verkarre, Virginie, Job, Sylvie, de Reynies, Aurélien, Machiels, Jean-Pascal, Patard, Jean-Jacques, Zucman-Rossi, Jessica, and Beuselinck, Benoit

Published
2018
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32. Crizotinib in patients with advanced, inoperable inflammatory myofibroblastic tumours with and without anaplastic lymphoma kinase gene alterations (European Organisation for Research and Treatment of Cancer 90101 CREATE): a multicentre, single-drug, prospective, non-randomised phase 2 trial

Author

Schöffski, Patrick, Sufliarsky, Jozef, Gelderblom, Hans, Blay, Jean-Yves, Strauss, Sandra J, Stacchiotti, Silvia, Rutkowski, Piotr, Lindner, Lars H, Leahy, Michael G, Italiano, Antoine, Isambert, Nicolas, Debiec-Rychter, Maria, Sciot, Raf, Van Cann, Thomas, Marréaud, Sandrine, Nzokirantevye, Axelle, Collette, Sandra, and Wozniak, Agnieszka

Published
2018
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34. The tyrosine kinase inhibitor crizotinib does not have clinically meaningful activity in heavily pre-treated patients with advanced alveolar rhabdomyosarcoma with FOXO rearrangement: European Organisation for Research and Treatment of Cancer phase 2 trial 90101 ‘CREATE’

Author

Schöffski, Patrick, Wozniak, Agnieszka, Leahy, Michael G., Aamdal, Steinar, Rutkowski, Piotr, Bauer, Sebastian, Richter, Stephan, Grünwald, Viktor, Debiec-Rychter, Maria, Sciot, Raf, Geoerger, Birgit, Marréaud, Sandrine, Collette, Sandra, Nzokirantevye, Axelle, and Strauss, Sandra J.

Published
2018
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37. Crizotinib achieves long-lasting disease control in advanced papillary renal-cell carcinoma type 1 patients with MET mutations or amplification. EORTC 90101 CREATE trial

Author

Schöffski, Patrick, Wozniak, Agnieszka, Escudier, Bernard, Rutkowski, Piotr, Anthoney, Alan, Bauer, Sebastian, Sufliarsky, Jozef, van Herpen, Carla, Lindner, Lars H., Grünwald, Viktor, Zakotnik, Branko, Lerut, Evelyne, Debiec-Rychter, Maria, Marréaud, Sandrine, Lia, Michela, Raveloarivahy, Tiana, Collette, Sandra, and Albiges, Laurence

Published
2017
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39. The Influence of Lead and Acyrthosiphon pisum (Harris) on Generation of Pisum sativum Defense Signaling Molecules and Expression of Genes Involved in Their Biosynthesis

Author

Woźniak, Agnieszka, primary, Kęsy, Jacek, additional, Glazińska, Paulina, additional, Glinkowski, Wojciech, additional, Narożna, Dorota, additional, Bocianowski, Jan, additional, Rucińska-Sobkowiak, Renata, additional, Mai, Van Chung, additional, Krzesiński, Włodzimierz, additional, Samardakiewicz, Sławomir, additional, Borowiak-Sobkowiak, Beata, additional, Labudda, Mateusz, additional, Jeandet, Philippe, additional, and Morkunas, Iwona, additional

Published
2023
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43. Hip muscle strength and static balance in patients with snapping hip syndrome – a pilot study

Author

Witke-Woźniak Agnieszka, Wychowański Michał, Dąmbski Tomasz, Szymfel Karina, and Kochański Tomasz

Subjects
strength, stabilography, Medicine
Abstract

Introduction: Snapping hip syndrome (SHS) occurs in 5-10% of the global population. A back and forth skip of the tendon of the dysfunctional muscle across the osseous prominence is the most common symptom of this condition. Mainly young generation suffers from SHS. Depending on the structures that cause an audible snap, snapping hip syndrome may be classified into intra-articular and extra-articular types. The main aim of the research was to assess the strength of the major hip muscles and static balance in patients with snapping hip syndrome.

Published
2016
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