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Acne fulminans (AF), a severe acne variant primarily evident in adolescent males, is characterized by the sudden onset of severe and often ulcerating acne with fever and polyarthritis. A case of a 14-year-old initially treated with clindamycin and surgical debridement, highlights the complexity of AF, including challenges in diagnosis, treatment, and the importance of early dermatological consultation. Successful management was achieved through systemic therapy with retinoids and corticosteroids, resulting in significant improvement. This case underscores the necessity of a coordinated effort among dermatologists, endocrinologists, and rheumatologists for effective AF treatment, illustrating the critical role of timely diagnosis and comprehensive care in managing this rare and challenging condition.

The paper characterises music-involving cultural practices in Cracow’s urban parks, squares, streets, and ice rinks in the period of the so-called Galician Autonomy (1866–1918). Typologies of the spaces where music was performed and of open-air events involving music have been proposed. Music repertoires and performers have been discussed. The main sources for this text are press materials, memoirs, regulations, sheet music, and iconography.

This paper considers the online routing, modulation, spectrum, and core allocation problem in elastic optical networks. Three algorithms are proposed to minimize the bandwidth blocking probability while taking into account the impact of interference from established lightpaths. These algorithms are based on a sequence of alternative paths, ordered in terms of increasing lengths, determined by Yen’s algorithm. Each of the algorithms for the selected single or dual lightpath enforces the constraints of spectrum continuity, contiguity of the slots, and non-overlapping of the spectra with the established lightpaths, maximizes the number of bits per symbol, and selects a specific core on each link of the path. Simulation studies performed for two sample networks showed that the crosstalk has a significant impact on the bandwidth blocking probability. The best results were obtained by iterating over all paths and all slots, selecting the lightpath with the lowest average crosstalk per slot, consisting of the most loaded cores.

Roe deer (Capreolus capreolus L.) populations in Poland are characterized by low productivity, which is why their reproductive potential was investigated. The presence of corpora lutea (CL) on the ovaries of females hunted in autumn and winter in the years 2015 and 2016 was assessed. Most animals were post-rut and most often had multiple ovulations. However, in early autumn 2015, 60% of the females had no CL. Therefore, they did not participate in mating at the turn of July/August. Those that did ovulate were found to have one CL. In late autumn, 97% of the females were post-rut, mostly with twin ovulations. This confirmed the occurrence of a late autumn rut. This phenomenon had been suggested in studies but not confirmed. In contrast, almost 100% of roe deer ovulated in summer in 2016. It was hypothesized that the reason for the low mating activity of roe deer in the summer of 2015 was heat stress and limited food resources. The summer was exceptionally hot, with many days in July and August when temperatures exceeded 30 °C. The heat combined with low rainfall led to extreme drought. Meanwhile, July and August are the months of mating activity for roe deer. The late autumn rut allowed the roe deer—a monoestrous species—to limit the consequences of a decrease in mating activity or fertility during the hot summer. Global warming may affect roe deer reproduction, so climatic conditions should be considered in population studies, not only in terms of food availability.

Sambuci folium (elderberry leaves) have been used in traditional medicine, mainly externally, to treat skin diseases and wounds. Therefore, the aim of this study was to screen the biological activity of elderberry leaves (antioxidant potential and possibility of inhibition of tyrosinase and hyaluronidase enzymes) combined with phytochemical analysis. For this purpose, a phytochemical analysis was carried out. Elderberry leaves of 12 varieties (“Sampo”, “Obelisk”, “Dwubarwny”, “Haschberg”, “Haschberg 1”, “Koralowy”, “Sambo”, “Black Beauty”, “Black Tower”, “Golden hybrid”, “Samyl”, “Samyl 1”) in two growth stages. The compounds from the selected groups, phenolic acids (chlorogenic acid) and flavonols (quercetin), were chromatographically determined in hydroalcoholic leaf extracts. All tested elderberry leaf extracts showed antioxidant effects, but the most promising potential: very high compounds content (TPC = 61.85 mg GAE/g), antioxidant (e.g., DPPH IC50 = 1.88 mg/mL; CUPRAC IC0.5 = 0.63 mg/mL) and optimal anti-inflammatory (inhibition of hyaluronidase activity 41.28%) activities were indicated for older leaves of the “Sampo” variety. Additionally, the extract obtained from “Sampo” and “Golden hybrid” variety facilitated the treatment of wounds in the scratch test. In summary, the best multidirectional pro-health effect in treating skin inflammation was specified for “Sampo” leaves II extract (leaves during the flowering period); however, wound treatment was noted as rich in chlorogenic acid younger leaf extracts of the “Golden hybrid” variety.

The synthesis of carborane-1,8-naphthalimide conjugates and evaluation of their DNA-binding ability and anticancer activity were performed. A series of 4-carboranyl-3-nitro-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, were synthesised via amidation and reductive amination reactions, and their calf thymus DNA (ct-DNA)-binding properties were investigated using circular dichroism, UV–vis spectroscopy, and thermal denaturation. Results showed that conjugates 34–37 interacted very strongly with ct-DNA (ΔTm = 10.00–13.00 °C), indicating their ability to intercalate with DNA, but did not inhibit the activity of topoisomerase II. The conjugates inhibited the cell growth of the HepG2 cancer cell line in vitro. The same compounds caused the G2M phase arrest. Cell lines treated with these conjugates showed an increase in reactive oxygen species, glutathione, and Fe2+ levels, lipid peroxidation, and mitochondrial membrane potential relative to controls, indicating the involvement of ferroptosis. Furthermore, these conjugates caused lysosomal membrane permeabilization in HepG2 cells but not in MRC-5 cells.

The central-symmetric time-fractional heat conduction equation with heat absorption is investigated in a solid with a spherical hole under time-harmonic heat flux at the boundary. The problem is solved using the auxiliary function, for which the Robin-type boundary condition with a prescribed value of a linear combination of a function and its normal derivative is fulfilled. The Laplace and Fourier sine–cosine integral transformations are employed. Graphical representations of numerical simulation results are given for typical values of the parameters.

Recenzja edycji: Zygmunt Mycielski, znaki zapytania. Wstęp i komentarze Beata Bolesławska-Lewandowska, red. Beata Bolesławska-Lewandowska, Marek Zagańczyk, Kraków 2022.

Niniejszy artykuł porusza tematykę reklamy napojów alkoholowych, czyniąc to w sposób od­mienny, aniżeli miało to do tej pory miejsce w doktrynie. Jego głównym celem jest udzielenie odpowiedzi na pytanie, czy regulacje prawne dotyczące reklamy napojów alkoholowych stanowią przejaw nierównego trak­towania przedsiębiorców zajmujących się produkcją napojów alkoholowych. W pracy wykorzystano metodę dogmatyczno-prawną. Aby zrealizować postawiony cel, konieczne było w pierwszej kolejności omówienie definicji pojęcia napojów alkoholowych, a następnie przeprowadzenie prawnej analizy ograniczeń i zakazów, jakie na mocy ustawy o wychowaniu w trzeźwości i przeciwdziałaniu alkoholizmowi zostały wprowadzone do polskiego porządku prawnego, zwłaszcza w stosunku do reklamy piwa, z jednoczesnym wykorzystaniem dok­tryny i orzecznictwa. Następnie przeanalizowane zakazy oraz ograniczenia przeniesiono na grunt zasady równ­ości wobec prawa i konstytucyjnego zakazu dyskryminacji. W wyniku przeprowadzonych badań obroniono stanowisko, iż reklama piwa może stanowić przejaw nierównego traktowania przedsiębiorców wykonujących działalność gospodarczą w zakresie produkcji napojów alkoholowych innych niż piwo. Umożliwienie reklamo-wania jedynie piwa sprawia, że przedsiębiorcy produkujący inne napoje alkoholowe znajdują się w gorszej pozycji konkurencyjnej niż producenci piwa.

This paper considers the online routing, modulation, spectrum, and core allocation problem in elastic optical networks. Three algorithms are proposed to minimize the bandwidth blocking probability while taking into account the impact of interference from established lightpaths. These algorithms are based on a sequence of alternative paths, ordered in terms of increasing lengths, determined by Yen's algorithm. Each of the algorithms for the selected single or dual lightpath enforces the constraints of spectrum continuity, contiguity of the slots, and non-overlapping of the spectra with the established lightpaths, maximizes the number of bits per symbol, and selects a specific core on each link of the path. Simulation studies performed for two sample networks showed that the crosstalk has a significant impact on the bandwidth blocking probability. The best results were obtained by iterating over all paths and all slots, selecting the lightpath with the lowest average crosstalk per slot, consisting of the most loaded cores. [ABSTRACT FROM AUTHOR]

Reklama na dobre wpisała się w otoczenie, stała się nieodzownym elementem codziennego funkcjonowania. Przybiera rozmaite formy, od reklamy telewizyjnej, przez radiową, po reklamy prasowe. Przedsiębiorcy prześcigają się w skupieniu uwagi jak najszerszego grona potencjalnych klientów. Niepohamowany rozwój konkurencji przesuwa granice – coraz więcej sfer życia zostaje wykorzystywanych w spotach reklamowych. Jedną z takich sfer, do jakich niejednokrotnie odwoływała się reklama, jest sfera duchowości i wiary. W niniejszym opracowaniu uwaga została skupiona na rozważaniach dotyczących reklamy w odniesieniu do obrazy uczuć religijnych. W pierwszej kolejności zostały zdefiniowane pojęcia reklamy i obrazy uczuć religijnych. Następnie przeanalizowana została możliwość obrazy uczuć religijnych poprzez reklamę. Aby uzupełnić całość i nadać opracowaniu praktyczny wydźwięk, autor uzupełnił tę analizę przykładami reklam odnoszących się do sfery duchowości i ocenił je pod kątem obrazy uczuć religijnych.

W dniach 8–9 września 2022 roku w nowoczesnej Sali Rady Miasta Szczecin odbyły się XIV Letnie Warsztaty Doktoranckie „Ochrona interesu prawnego w polskim prawie administracyjnym”. Konferencja, zorganizowana została przez Zespół Badawczy Organizacji i Funkcjonowania Gospodarki Komunalnej Wydziału Prawa i Administracji Uniwersytetu Szczecińskiego, Gminę Miasto Szczecin i Stowarzyszenie Amicus Facultatis Iuris Stetinensis. Partnerami Warsztatów byli Samorządowe Kolegium Odwoławcze w Gorzowie Wielkopolskim i Wojewódzki Sąd Administracyjny w Szczecinie.

This article addresses the issue of advertising of medicinal products from the perspective of protecting the consumer’s interest. As the research problem of the article was chosen to reconstruct the normative pattern of indirect consumer protection against incompatible with the provisions of PrFarm advertising of medicinal products directed to the public. The paper uses the dogmatic-legal method. In order to be able to solve the research problem posed, it was necessary to analyze the current state of the law with reference to doctrine and case law. The chosen research method made it possible to answer the research questions posed in the study concerning, among other things, whether the current form of supervision of advertising of medicinal products (or more precisely: supervision of the legality of advertising of medicinal products) is sufficient, and whether the patient/consumer is effectively protected from inconsistent PrFarm advertising of medicinal products directed to the public. As a result of the study, it was concluded that the current regulations on supervision of advertising of medicinal products to the public are not sufficiently effective, as they do not sufficiently protect the interests of the consumer. The above made it possible to propose changes to the current regulations in the form of introducing ex ante control of advertising of medicinal products to the public.

The increasing average annual temperature value is observed in many cities around the world. More and more often, not only the Southern Europe inhabitants, but also those from the Central and Northern Europe are exposed to thermal stress. Nature Based Solutions (NBS) play a key role in mitigation, i.e. the process of alleviating the negative effects of climate change in highly urbanized areas. The main objective of this study is to answer the question whether the planned spatial activities involving the use of NBS solutions in the New Centre of Lodz contribute to the improvement of the urban spaces’ microclimate and the thermal comfort of people in the external environment. The subject of the work is the microclimate of urban spaces, understood as a climatic conditions set, in particular thermal conditions, in a given, small area. The spatial scope of the work covers a 30-hectare part of the New Centre of Lodz limited by the following streets: Kilińskiego, Narutowicza, Piotrkowska, Tuwima, which is currently undergoing a large-area revitalization process. In order to determine the microclimate conditions and thermal comfort, numerical simulations conducted in the ENVI-met program were used.

Abstract Background Cystic endometrial hyperplasia-pyometra complex (CEH-P) is one of the most common uteropathies in bitches. In diseases with mild or obscure clinical signs and normal uterine size, a diagnosis based on a clinical assessment might be incorrect. The main aim of the research was to determine the morphological variables accompanying uterine diseases in bitches in microscopic evaluation. Consequently, the obtained results can be used to create a new classification system for uterine pathological changes during the development of the CEH-P, diagnosed by microscopic examination in bitches. Material for the study consisted of the uteri of 120 female dogs, aged 1–16 years, obtained during routine ovariohysterectomies. Macroscopic observation after a longitudinal incision of the uterine horns, allowed a preliminary classification of the uteri into research groups: control group (physiological uteri), and groups GI-III uteri collected form bitches with varying degrees of endometrial pathology. These preliminary classifications were then verified by histological analysis (H&E stain). Results The obtained results made it possible to determine and describe the prevalence (%) of pathological changes characteristic of the analyzed uterine diseases in the examined bitches. Histopathological analyses that were conducted have confirmed preliminary macroscopic evaluation for the control group, group GII (CEH), and group GIII (pyometra). In the uteri of the GI group, a severe congestion of the endometrium has been observed – this is typical of inflammation – which was not confirmed during histopathological examinations. However, these examinations revealed acute endometrial haemorrhage of varying severity. Conclusions Early reproduction disorders in bitches are, in general, not confirmed by clinical signs in the examined animals. The results show that during classification of typical morphological changes in the endometrium over the development of the CEH-P complex in bitches microscopic examinations are required. The obtained results indicate a frequent lack of consistency in the macroscopic assessment and histological analysis of the endometrium, observed in the analyzed uterine diseases, which in most cases is not followed by clinical symptoms. The presented classification of uterine diseases may be useful as a diagnostic tool in reproductive disorders in bitches and in examination in the field of basic research.

Nieznane fakty z biografii Paderewskiego i związanych z nim twórców zostały opisane w szerokim kontekście osobowo-instytucjonalnym z uwypukleniem związków przyczynowo-skutkowych między biograficzno-artystycznymi fenomenami. Udokumentowana źródłowo relacja składa się z dwóch części. W pierwszej - Pobyty Paderewskiego w Krakowie, Kąśnej i Lwowie: 1896–98 – kolejne fragmenty dotyczą krakowskich uroczystości (3 IX 1896 r.) Józefa i Antoniny Szumowskich z udziałem Paderewskiego oraz sprowadzonego przez Edwarda Kerntopfa fortepianu jego rodzinnej firmy, na którym grał wówczas nie tylko Paderewski, ale przedstawiony mu Henryk Melcer, który po raz pierwszy zaprezentował swoją transkrypcje moniuszkowskiej Prząśniczki. Tytuły następnych fragmentów to: pożegnanie Paderewskiego w salonie Żeleńskich 9 IX 1896 r. i jego uczestnicy; lato 1898 r. w Kąśnej i pierwszy zagraniczny przekaz o posiadłości Paderewskiego; Paderewski w salonie Żeleńskiego 27 sierpnia 1898 roku i poznanie „Janka”; „Kantata” Paderewskiego w salonie Żeleńskiego, a wizyta pianisty we Lwowie i Kąśnej w listopadzie 1897 roku. Część druga – koncerty Paderewskiego w Wielkiej Brytanii: 1898–99 – obejmuje krótkie tournée pianisty w grudniu 1898, jego udział w pierwszym London Musical Festival 9 V 1899 r. i pofestiwalowe sukcesy między 10 a 16 maja oraz lipcowe występy w salonach londyńskich potentatów, natomiast w końcu listopada 1899 roku recitale przed czwartym tournée amerykańskim.

Recenzja edycji krytycznej: Józef Elsner, "Król Łokietek, czyli Wiśliczanki". Opera w dwóch aktach. Libretto Ludwik Adam Dmuszewski, wyd. Grzegorz Zieziula, Warszawa 2019

Theoretical background: Professional development plays a key role in succession in family businesses. Succession in family businesses means transferring control and ownership of the company from one generation to the next, and choosing the right successor is very important for the future of the company. Therefore, professional development can be a significant factor influencing this decision. Purpose of the article: The article presents professional development as a selected factor that affects succession in family businesses. Research methods: The primary research method chosen for data collection was a survey in the form of a questionnaire. The survey was done through a free online questionnaire – Google Form. This was intended to reach a wider audience from all over the country, so that the respondents would be as representative group as possible. The respondents were contacted through social media messaging and e-mail. This form of data collection was motivated by the desire to obtain responses primarily from young people. While 402 respondents participated in the survey, 305 responses were considered for analysis. Main findings: The following article presents the results of a survey on awareness of the importance of building a career path and professional development and the actual status of the implementation of plans. The survey also addresses issues of satisfaction with respondents’ current working conditions. The current shortage of workers in the labour market and the deepening demographic decline may cause a situation in which a successor does not become a single member of the immediate family. The best effect can be achieved by linking succession planning with the conscious and thorough construction of a career path and professional development based on the family business. The results of the paper relate to research analysing the career decisions of future managers, take into account the impact of the career path on professional development, and contribute to the understanding of the factors analysed in the succession process. [ABSTRACT FROM AUTHOR]